Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKB9_LEIMU

TriTrypDb:

LmxM.05.0150

Length:

442

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	30
GO:0042995	cell projection	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0110165	cellular anatomical entity	1	31
GO:0120025	plasma membrane bounded cell projection	3	30
GO:0016020	membrane	2	2
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AKB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.397
CLV_NRD_NRD_1	27	29	PF00675	0.347
CLV_NRD_NRD_1	378	380	PF00675	0.409
CLV_NRD_NRD_1	5	7	PF00675	0.617
CLV_PCSK_KEX2_1	378	380	PF00082	0.412
CLV_PCSK_SKI1_1	130	134	PF00082	0.363
CLV_PCSK_SKI1_1	158	162	PF00082	0.403
CLV_PCSK_SKI1_1	265	269	PF00082	0.519
CLV_PCSK_SKI1_1	32	36	PF00082	0.355
CLV_PCSK_SKI1_1	361	365	PF00082	0.385
CLV_PCSK_SKI1_1	379	383	PF00082	0.485
CLV_PCSK_SKI1_1	436	440	PF00082	0.412
CLV_PCSK_SKI1_1	50	54	PF00082	0.397
DOC_CYCLIN_RxL_1	276	284	PF00134	0.285
DOC_MAPK_gen_1	358	368	PF00069	0.279
DOC_MAPK_gen_1	378	385	PF00069	0.517
DOC_MAPK_MEF2A_6	378	385	PF00069	0.519
DOC_USP7_MATH_1	110	114	PF00917	0.283
DOC_USP7_MATH_1	240	244	PF00917	0.319
DOC_USP7_MATH_1	82	86	PF00917	0.376
DOC_USP7_UBL2_3	436	440	PF12436	0.541
DOC_USP7_UBL2_3	7	11	PF12436	0.516
DOC_WW_Pin1_4	117	122	PF00397	0.533
LIG_14-3-3_CanoR_1	130	136	PF00244	0.393
LIG_14-3-3_CanoR_1	224	230	PF00244	0.493
LIG_14-3-3_CanoR_1	265	273	PF00244	0.448
LIG_14-3-3_CanoR_1	361	367	PF00244	0.530
LIG_14-3-3_CanoR_1	378	382	PF00244	0.400
LIG_14-3-3_CanoR_1	88	96	PF00244	0.439
LIG_BRCT_BRCA1_1	21	25	PF00533	0.340
LIG_FHA_1	173	179	PF00498	0.265
LIG_FHA_1	200	206	PF00498	0.353
LIG_FHA_1	217	223	PF00498	0.336
LIG_FHA_1	230	236	PF00498	0.231
LIG_FHA_1	275	281	PF00498	0.184
LIG_FHA_1	321	327	PF00498	0.281
LIG_FHA_1	331	337	PF00498	0.273
LIG_FHA_1	358	364	PF00498	0.472
LIG_FHA_1	378	384	PF00498	0.525
LIG_FHA_1	386	392	PF00498	0.559
LIG_FHA_1	406	412	PF00498	0.684
LIG_FHA_1	413	419	PF00498	0.396
LIG_FHA_2	159	165	PF00498	0.312
LIG_FHA_2	36	42	PF00498	0.457
LIG_FHA_2	64	70	PF00498	0.301
LIG_GBD_Chelix_1	410	418	PF00786	0.346
LIG_LIR_Gen_1	131	138	PF02991	0.322
LIG_LIR_Nem_3	131	136	PF02991	0.326
LIG_LIR_Nem_3	164	170	PF02991	0.300
LIG_LIR_Nem_3	254	260	PF02991	0.458
LIG_NRP_CendR_1	439	442	PF00754	0.432
LIG_PCNA_yPIPBox_3	129	141	PF02747	0.446
LIG_SH2_STAT5	204	207	PF00017	0.406
LIG_SH2_STAT5	26	29	PF00017	0.457
LIG_SH2_STAT5	64	67	PF00017	0.416
LIG_SH3_3	9	15	PF00018	0.532
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.407
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.282
LIG_SUMO_SIM_par_1	380	389	PF11976	0.528
LIG_SUMO_SIM_par_1	404	412	PF11976	0.399
LIG_TRAF2_1	422	425	PF00917	0.401
MOD_CK1_1	216	222	PF00069	0.469
MOD_CK1_1	60	66	PF00069	0.420
MOD_CK2_1	68	74	PF00069	0.363
MOD_GlcNHglycan	112	115	PF01048	0.389
MOD_GlcNHglycan	121	124	PF01048	0.499
MOD_GlcNHglycan	3	6	PF01048	0.689
MOD_GlcNHglycan	373	376	PF01048	0.475
MOD_GSK3_1	20	27	PF00069	0.379
MOD_GSK3_1	225	232	PF00069	0.356
MOD_GSK3_1	320	327	PF00069	0.362
MOD_GSK3_1	357	364	PF00069	0.413
MOD_GSK3_1	60	67	PF00069	0.336
MOD_LATS_1	377	383	PF00433	0.507
MOD_N-GLC_1	117	122	PF02516	0.484
MOD_N-GLC_1	128	133	PF02516	0.387
MOD_N-GLC_1	172	177	PF02516	0.395
MOD_N-GLC_1	240	245	PF02516	0.451
MOD_N-GLC_1	281	286	PF02516	0.364
MOD_N-GLC_1	96	101	PF02516	0.297
MOD_NEK2_1	148	153	PF00069	0.351
MOD_NEK2_1	239	244	PF00069	0.431
MOD_NEK2_1	281	286	PF00069	0.327
MOD_NEK2_1	330	335	PF00069	0.359
MOD_NEK2_1	35	40	PF00069	0.515
MOD_NEK2_1	68	73	PF00069	0.310
MOD_NEK2_1	96	101	PF00069	0.374
MOD_NEK2_2	128	133	PF00069	0.367
MOD_NEK2_2	274	279	PF00069	0.393
MOD_PIKK_1	213	219	PF00454	0.525
MOD_PIKK_1	68	74	PF00454	0.319
MOD_PIKK_1	88	94	PF00454	0.425
MOD_PK_1	30	36	PF00069	0.312
MOD_PKA_2	223	229	PF00069	0.505
MOD_PKA_2	357	363	PF00069	0.373
MOD_PKA_2	377	383	PF00069	0.391
MOD_Plk_1	128	134	PF00069	0.358
MOD_Plk_1	143	149	PF00069	0.281
MOD_Plk_1	158	164	PF00069	0.263
MOD_Plk_1	240	246	PF00069	0.401
MOD_Plk_4	143	149	PF00069	0.335
MOD_Plk_4	199	205	PF00069	0.395
MOD_Plk_4	240	246	PF00069	0.452
MOD_Plk_4	30	36	PF00069	0.515
MOD_Plk_4	405	411	PF00069	0.615
MOD_Plk_4	60	66	PF00069	0.358
MOD_Plk_4	82	88	PF00069	0.429
MOD_ProDKin_1	117	123	PF00069	0.536
MOD_SUMO_for_1	17	20	PF00179	0.620
MOD_SUMO_rev_2	308	318	PF00179	0.228
MOD_SUMO_rev_2	341	350	PF00179	0.243
TRG_DiLeu_BaEn_1	406	411	PF01217	0.633
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.352
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.254
TRG_ER_diLys_1	437	442	PF00400	0.561
TRG_NLS_MonoExtC_3	27	32	PF00514	0.530
TRG_NLS_MonoExtC_3	435	440	PF00514	0.493
TRG_NLS_MonoExtN_4	28	33	PF00514	0.401
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	27%	94%
A0A0N1I317	Leptomonas seymouri	26%	100%
A0A0N1PD72	Leptomonas seymouri	71%	99%
A0A0S4IK39	Bodo saltans	24%	70%
A0A0S4IT30	Bodo saltans	25%	66%
A0A0S4JGH2	Bodo saltans	24%	100%
A0A0S4JL85	Bodo saltans	47%	100%
A0A0S4JPV3	Bodo saltans	28%	92%
A0A0S4JV86	Bodo saltans	23%	100%
A0A1X0NTY3	Trypanosomatidae	27%	98%
A0A1X0P364	Trypanosomatidae	52%	100%
A0A3Q8IDE6	Leishmania donovani	28%	100%
A0A3R7L7Y9	Trypanosoma rangeli	27%	99%
A0A3R7P015	Trypanosoma rangeli	52%	93%
A0A3S5H5G2	Leishmania donovani	96%	100%
A0A3S7WZL6	Leishmania donovani	28%	100%
A4H461	Leishmania braziliensis	86%	100%
A4HEQ6	Leishmania braziliensis	26%	100%
A4HFQ6	Leishmania braziliensis	28%	100%
A4HHW0	Leishmania braziliensis	26%	100%
A4HSD0	Leishmania infantum	95%	100%
A4I1Y5	Leishmania infantum	28%	100%
A4I2T1	Leishmania infantum	28%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9ADA9	Leishmania major	28%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	93%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P10775	Sus scrofa	23%	97%
Q4Q9E1	Leishmania major	28%	100%
Q4QBG0	Leishmania major	24%	100%
Q4QJI8	Leishmania major	95%	100%
Q4V8D9	Rattus norvegicus	22%	100%
Q8IZ02	Homo sapiens	24%	95%
Q91VI7	Mus musculus	23%	97%
Q9DAM1	Mus musculus	23%	100%
Q9LE82	Arabidopsis thaliana	25%	83%
Q9M651	Arabidopsis thaliana	26%	81%
V5BC66	Trypanosoma cruzi	29%	67%
V5BJF0	Trypanosoma cruzi	53%	89%
V5BPZ7	Trypanosoma cruzi	29%	98%
V5DHF2	Trypanosoma cruzi	25%	100%