RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA helicase

Gene product:

nucleolar RNA helicase II, putative

Species:

Leishmania mexicana

UniProt:

E9AKB8_LEIMU

TriTrypDb:

LmxM.05.0140

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKB8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.411
CLV_C14_Caspase3-7	384	388	PF00656	0.425
CLV_C14_Caspase3-7	418	422	PF00656	0.425
CLV_NRD_NRD_1	3	5	PF00675	0.601
CLV_NRD_NRD_1	318	320	PF00675	0.301
CLV_NRD_NRD_1	434	436	PF00675	0.385
CLV_NRD_NRD_1	490	492	PF00675	0.462
CLV_NRD_NRD_1	50	52	PF00675	0.651
CLV_NRD_NRD_1	682	684	PF00675	0.549
CLV_PCSK_KEX2_1	3	5	PF00082	0.601
CLV_PCSK_KEX2_1	318	320	PF00082	0.301
CLV_PCSK_KEX2_1	490	492	PF00082	0.462
CLV_PCSK_KEX2_1	50	52	PF00082	0.587
CLV_PCSK_KEX2_1	682	684	PF00082	0.549
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.587
CLV_PCSK_SKI1_1	147	151	PF00082	0.290
CLV_PCSK_SKI1_1	220	224	PF00082	0.210
CLV_PCSK_SKI1_1	31	35	PF00082	0.470
CLV_PCSK_SKI1_1	456	460	PF00082	0.353
CLV_PCSK_SKI1_1	490	494	PF00082	0.367
CLV_PCSK_SKI1_1	572	576	PF00082	0.224
CLV_PCSK_SKI1_1	601	605	PF00082	0.237
DOC_ANK_TNKS_1	50	57	PF00023	0.469
DOC_CKS1_1	213	218	PF01111	0.401
DOC_CKS1_1	596	601	PF01111	0.465
DOC_CYCLIN_RxL_1	144	153	PF00134	0.505
DOC_CYCLIN_RxL_1	340	350	PF00134	0.401
DOC_CYCLIN_RxL_1	398	409	PF00134	0.401
DOC_MAPK_DCC_7	401	410	PF00069	0.401
DOC_MAPK_gen_1	157	166	PF00069	0.401
DOC_MAPK_gen_1	203	213	PF00069	0.505
DOC_MAPK_gen_1	351	359	PF00069	0.428
DOC_MAPK_gen_1	386	394	PF00069	0.401
DOC_MAPK_gen_1	432	442	PF00069	0.465
DOC_MAPK_gen_1	453	462	PF00069	0.343
DOC_MAPK_HePTP_8	398	410	PF00069	0.401
DOC_MAPK_MEF2A_6	206	213	PF00069	0.505
DOC_MAPK_MEF2A_6	250	257	PF00069	0.411
DOC_MAPK_MEF2A_6	401	410	PF00069	0.401
DOC_MAPK_MEF2A_6	435	442	PF00069	0.307
DOC_MAPK_NFAT4_5	250	258	PF00069	0.411
DOC_PP1_RVXF_1	134	141	PF00149	0.411
DOC_PP1_RVXF_1	341	348	PF00149	0.401
DOC_PP1_RVXF_1	599	606	PF00149	0.505
DOC_PP1_SILK_1	556	561	PF00149	0.401
DOC_PP2B_LxvP_1	149	152	PF13499	0.413
DOC_PP2B_LxvP_1	403	406	PF13499	0.401
DOC_PP2B_LxvP_1	465	468	PF13499	0.346
DOC_PP2B_LxvP_1	550	553	PF13499	0.411
DOC_PP4_FxxP_1	140	143	PF00568	0.401
DOC_USP7_MATH_1	100	104	PF00917	0.402
DOC_USP7_MATH_1	21	25	PF00917	0.671
DOC_USP7_MATH_1	37	41	PF00917	0.713
DOC_USP7_MATH_1	518	522	PF00917	0.353
DOC_USP7_MATH_1	61	65	PF00917	0.663
DOC_USP7_UBL2_3	34	38	PF12436	0.766
DOC_WW_Pin1_4	212	217	PF00397	0.401
DOC_WW_Pin1_4	533	538	PF00397	0.445
DOC_WW_Pin1_4	595	600	PF00397	0.469
DOC_WW_Pin1_4	64	69	PF00397	0.599
LIG_14-3-3_CanoR_1	122	128	PF00244	0.408
LIG_14-3-3_CanoR_1	309	317	PF00244	0.494
LIG_14-3-3_CanoR_1	594	599	PF00244	0.519
LIG_14-3-3_CanoR_1	601	606	PF00244	0.480
LIG_14-3-3_CanoR_1	86	95	PF00244	0.359
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.468
LIG_BIR_III_2	506	510	PF00653	0.413
LIG_deltaCOP1_diTrp_1	285	292	PF00928	0.474
LIG_FHA_1	122	128	PF00498	0.491
LIG_FHA_1	167	173	PF00498	0.403
LIG_FHA_1	522	528	PF00498	0.439
LIG_FHA_2	280	286	PF00498	0.401
LIG_FHA_2	348	354	PF00498	0.401
LIG_FHA_2	360	366	PF00498	0.425
LIG_FHA_2	416	422	PF00498	0.338
LIG_FHA_2	467	473	PF00498	0.359
LIG_FHA_2	65	71	PF00498	0.663
LIG_LIR_Apic_2	137	143	PF02991	0.401
LIG_LIR_Gen_1	116	121	PF02991	0.411
LIG_LIR_Gen_1	227	238	PF02991	0.419
LIG_LIR_Gen_1	296	307	PF02991	0.360
LIG_LIR_Gen_1	387	398	PF02991	0.411
LIG_LIR_Gen_1	536	544	PF02991	0.496
LIG_LIR_Gen_1	604	613	PF02991	0.505
LIG_LIR_LC3C_4	184	189	PF02991	0.491
LIG_LIR_Nem_3	116	120	PF02991	0.401
LIG_LIR_Nem_3	190	196	PF02991	0.443
LIG_LIR_Nem_3	227	233	PF02991	0.419
LIG_LIR_Nem_3	387	393	PF02991	0.437
LIG_LIR_Nem_3	536	542	PF02991	0.496
LIG_LIR_Nem_3	604	608	PF02991	0.505
LIG_Pex14_1	647	651	PF04695	0.422
LIG_SH2_CRK	193	197	PF00017	0.401
LIG_SH2_CRK	555	559	PF00017	0.468
LIG_SH2_GRB2like	198	201	PF00017	0.505
LIG_SH2_PTP2	539	542	PF00017	0.505
LIG_SH2_STAP1	523	527	PF00017	0.401
LIG_SH2_STAT3	198	201	PF00017	0.401
LIG_SH2_STAT5	449	452	PF00017	0.322
LIG_SH2_STAT5	523	526	PF00017	0.401
LIG_SH2_STAT5	539	542	PF00017	0.401
LIG_SH2_STAT5	555	558	PF00017	0.401
LIG_SH3_3	210	216	PF00018	0.401
LIG_SH3_4	271	278	PF00018	0.344
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.425
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.460
LIG_SUMO_SIM_anti_2	508	515	PF11976	0.363
LIG_SUMO_SIM_anti_2	573	580	PF11976	0.401
LIG_TRAF2_1	199	202	PF00917	0.401
LIG_TRAF2_1	445	448	PF00917	0.416
LIG_TRAF2_1	469	472	PF00917	0.470
LIG_TRAF2_1	5	8	PF00917	0.616
LIG_TRAF2_1	68	71	PF00917	0.779
LIG_TRAF2_1	9	12	PF00917	0.631
LIG_UBA3_1	244	250	PF00899	0.401
LIG_UBA3_1	329	335	PF00899	0.346
LIG_WRC_WIRS_1	382	387	PF05994	0.401
MOD_CDK_SPxK_1	212	218	PF00069	0.401
MOD_CDK_SPxK_1	595	601	PF00069	0.468
MOD_CK1_1	134	140	PF00069	0.401
MOD_CK1_1	324	330	PF00069	0.321
MOD_CK1_1	521	527	PF00069	0.235
MOD_CK1_1	64	70	PF00069	0.676
MOD_CK2_1	279	285	PF00069	0.443
MOD_CK2_1	466	472	PF00069	0.384
MOD_CK2_1	6	12	PF00069	0.548
MOD_CK2_1	64	70	PF00069	0.614
MOD_CK2_1	86	92	PF00069	0.522
MOD_Cter_Amidation	433	436	PF01082	0.309
MOD_GlcNHglycan	133	136	PF01048	0.201
MOD_GlcNHglycan	206	209	PF01048	0.240
MOD_GlcNHglycan	279	282	PF01048	0.192
MOD_GlcNHglycan	337	340	PF01048	0.235
MOD_GlcNHglycan	35	38	PF01048	0.722
MOD_GlcNHglycan	514	517	PF01048	0.335
MOD_GlcNHglycan	520	523	PF01048	0.355
MOD_GlcNHglycan	63	66	PF01048	0.689
MOD_GlcNHglycan	632	635	PF01048	0.622
MOD_GlcNHglycan	644	647	PF01048	0.526
MOD_GlcNHglycan	7	11	PF01048	0.480
MOD_GSK3_1	15	22	PF00069	0.751
MOD_GSK3_1	273	280	PF00069	0.401
MOD_GSK3_1	321	328	PF00069	0.373
MOD_GSK3_1	33	40	PF00069	0.725
MOD_GSK3_1	341	348	PF00069	0.401
MOD_GSK3_1	355	362	PF00069	0.411
MOD_GSK3_1	377	384	PF00069	0.401
MOD_GSK3_1	518	525	PF00069	0.388
MOD_GSK3_1	538	545	PF00069	0.316
MOD_GSK3_1	60	67	PF00069	0.637
MOD_N-GLC_1	263	268	PF02516	0.201
MOD_N-GLC_1	321	326	PF02516	0.408
MOD_N-GLC_1	359	364	PF02516	0.211
MOD_N-GLC_1	525	530	PF02516	0.305
MOD_N-GLC_1	619	624	PF02516	0.664
MOD_N-GLC_2	79	81	PF02516	0.657
MOD_NEK2_1	187	192	PF00069	0.468
MOD_NEK2_1	255	260	PF00069	0.505
MOD_NEK2_1	277	282	PF00069	0.417
MOD_NEK2_1	345	350	PF00069	0.401
MOD_NEK2_1	619	624	PF00069	0.716
MOD_NEK2_2	105	110	PF00069	0.351
MOD_PIKK_1	255	261	PF00454	0.505
MOD_PIKK_1	363	369	PF00454	0.401
MOD_PKA_1	490	496	PF00069	0.455
MOD_PKA_2	121	127	PF00069	0.413
MOD_PKA_2	15	21	PF00069	0.694
MOD_PKA_2	377	383	PF00069	0.401
MOD_PKA_2	490	496	PF00069	0.455
MOD_PKB_1	4	12	PF00069	0.685
MOD_PKB_1	570	578	PF00069	0.411
MOD_Plk_1	324	330	PF00069	0.303
MOD_Plk_1	355	361	PF00069	0.401
MOD_Plk_1	378	384	PF00069	0.401
MOD_Plk_1	572	578	PF00069	0.379
MOD_Plk_4	105	111	PF00069	0.341
MOD_Plk_4	273	279	PF00069	0.401
MOD_Plk_4	288	294	PF00069	0.318
MOD_Plk_4	325	331	PF00069	0.344
MOD_Plk_4	554	560	PF00069	0.421
MOD_Plk_4	93	99	PF00069	0.371
MOD_ProDKin_1	212	218	PF00069	0.401
MOD_ProDKin_1	533	539	PF00069	0.445
MOD_ProDKin_1	595	601	PF00069	0.469
MOD_ProDKin_1	64	70	PF00069	0.600
MOD_SUMO_rev_2	384	391	PF00179	0.423
MOD_SUMO_rev_2	7	14	PF00179	0.662
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.505
TRG_ENDOCYTIC_2	193	196	PF00928	0.401
TRG_ENDOCYTIC_2	539	542	PF00928	0.496
TRG_ENDOCYTIC_2	555	558	PF00928	0.401
TRG_ER_diArg_1	156	159	PF00400	0.338
TRG_ER_diArg_1	2	4	PF00400	0.607
TRG_ER_diArg_1	317	319	PF00400	0.288
TRG_ER_diArg_1	51	54	PF00400	0.504
TRG_ER_diArg_1	569	572	PF00400	0.468
TRG_ER_diArg_1	682	684	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.201

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV7	Leptomonas seymouri	87%	99%
A0A0S4IWD0	Bodo saltans	30%	100%
A0A0S4JPY9	Bodo saltans	75%	100%
A0A1D6GDY8	Zea mays	37%	92%
A0A1D6LAB7	Zea mays	37%	92%
A0A1X0P2M8	Trypanosomatidae	79%	100%
A0A3Q8ID91	Leishmania donovani	31%	100%
A0A3Q8IQY6	Leishmania donovani	32%	100%
A0A3S5H5G1	Leishmania donovani	96%	100%
A0A3S7X1H1	Leishmania donovani	31%	76%
A0A3S7XAN8	Leishmania donovani	31%	100%
A0A3S7XAT8	Leishmania donovani	31%	100%
A0A422NYD5	Trypanosoma rangeli	74%	100%
A0R8U6	Bacillus thuringiensis (strain Al Hakam)	34%	100%
A3LNR6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	31%	100%
A4H460	Leishmania braziliensis	93%	100%
A4HGR1	Leishmania braziliensis	32%	100%
A4HP48	Leishmania braziliensis	30%	100%
A4HP49	Leishmania braziliensis	31%	100%
A4HP82	Leishmania braziliensis	33%	100%
A4HSE3	Leishmania infantum	96%	100%
A4HT33	Leishmania infantum	34%	100%
A4HZF8	Leishmania infantum	27%	100%
A4I3L0	Leishmania infantum	31%	76%
A4I3T6	Leishmania infantum	31%	100%
A4IDF5	Leishmania infantum	31%	100%
A4IDF6	Leishmania infantum	31%	100%
A4IDI7	Leishmania infantum	32%	100%
A5DQF1	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	31%	100%
A6ZSX1	Saccharomyces cerevisiae (strain YJM789)	30%	100%
A7F4L5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	32%	85%
C9ZPX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A1I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A6Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AJG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B2I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B304	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	88%
P33906	Klebsiella pneumoniae	33%	100%
P38712	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P57453	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	33%	100%
P96614	Bacillus subtilis (strain 168)	34%	100%
Q0DM51	Oryza sativa subsp. japonica	37%	90%
Q2FF45	Staphylococcus aureus (strain USA300)	30%	100%
Q2FWH5	Staphylococcus aureus (strain NCTC 8325 / PS 47)	30%	100%
Q2YUH3	Staphylococcus aureus (strain bovine RF122 / ET3-1)	30%	100%
Q39189	Arabidopsis thaliana	39%	100%
Q3B8Q1	Rattus norvegicus	39%	87%
Q41382	Spinacia oleracea	40%	100%
Q49Z29	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	32%	100%
Q4L7W0	Staphylococcus haemolyticus (strain JCSC1435)	31%	100%
Q4Q1N9	Leishmania major	31%	100%
Q4Q1P0	Leishmania major	32%	100%
Q4Q858	Leishmania major	32%	100%
Q4QJI9	Leishmania major	96%	100%
Q4WH83	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	32%	100%
Q5HEB9	Staphylococcus aureus (strain COL)	30%	100%
Q5HME0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	31%	100%
Q5L3G9	Geobacillus kaustophilus (strain HTA426)	35%	100%
Q63GX5	Bacillus cereus (strain ZK / E33L)	34%	100%
Q650T9	Oryza sativa subsp. japonica	38%	98%
Q6CH58	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	100%
Q6FNK8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	100%
Q6G7M9	Staphylococcus aureus (strain MSSA476)	30%	100%
Q6GEZ3	Staphylococcus aureus (strain MRSA252)	31%	100%
Q6HPE6	Bacillus thuringiensis subsp. konkukian (strain 97-27)	34%	100%
Q6NZQ2	Mus musculus	31%	100%
Q73EU1	Bacillus cereus (strain ATCC 10987 / NRS 248)	34%	100%
Q75EW9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q7A0D2	Staphylococcus aureus (strain MW2)	30%	100%
Q7A4G0	Staphylococcus aureus (strain N315)	30%	100%
Q7S5R1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	100%
Q81IT9	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	34%	100%
Q81VG0	Bacillus anthracis	34%	100%
Q8CRP6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	31%	100%
Q8K9H6	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	100%
Q8L7S8	Arabidopsis thaliana	35%	91%
Q8Y8N0	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	35%	100%
Q99MJ9	Mus musculus	40%	93%
Q99SH6	Staphylococcus aureus (strain Mu50 / ATCC 700699)	30%	100%
Q9BQ39	Homo sapiens	39%	93%
Q9DF35	Xenopus laevis	38%	90%
Q9DF36	Xenopus laevis	39%	86%
Q9JIK5	Mus musculus	40%	80%
Q9NR30	Homo sapiens	38%	87%
Q9Z6C9	Limosilactobacillus reuteri	33%	100%
V5BDT6	Trypanosoma cruzi	26%	100%
V5BEY7	Trypanosoma cruzi	74%	100%