LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AKB5_LEIMU
TriTrypDb:
LmxM.05.0110
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKB5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 4 8 PF00082 0.528
DEG_APCC_DBOX_1 109 117 PF00400 0.505
DEG_APCC_DBOX_1 40 48 PF00400 0.527
DOC_CKS1_1 13 18 PF01111 0.516
DOC_CYCLIN_yCln2_LP_2 13 19 PF00134 0.560
DOC_MAPK_gen_1 81 90 PF00069 0.358
DOC_MAPK_MEF2A_6 4 11 PF00069 0.454
DOC_MAPK_MEF2A_6 46 54 PF00069 0.445
DOC_MAPK_NFAT4_5 4 12 PF00069 0.451
DOC_PP1_RVXF_1 6 12 PF00149 0.550
DOC_USP7_MATH_1 97 101 PF00917 0.494
DOC_WW_Pin1_4 12 17 PF00397 0.489
DOC_WW_Pin1_4 98 103 PF00397 0.473
LIG_AP2alpha_2 118 120 PF02296 0.596
LIG_BRCT_BRCA1_1 116 120 PF00533 0.534
LIG_FHA_1 1 7 PF00498 0.601
LIG_FHA_2 13 19 PF00498 0.589
LIG_NRBOX 8 14 PF00104 0.530
LIG_PTB_Apo_2 11 18 PF02174 0.519
LIG_SH2_STAP1 73 77 PF00017 0.446
LIG_SH3_3 22 28 PF00018 0.484
LIG_WW_3 38 42 PF00397 0.378
MOD_CK1_1 42 48 PF00069 0.522
MOD_CK2_1 29 35 PF00069 0.517
MOD_CK2_1 98 104 PF00069 0.424
MOD_PIKK_1 83 89 PF00454 0.474
MOD_PKA_2 83 89 PF00069 0.469
MOD_Plk_1 42 48 PF00069 0.478
MOD_ProDKin_1 12 18 PF00069 0.495
MOD_ProDKin_1 98 104 PF00069 0.473
TRG_DiLeu_BaEn_1 49 54 PF01217 0.434
TRG_ER_diArg_1 110 113 PF00400 0.560
TRG_ER_diArg_1 78 81 PF00400 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P630 Leptomonas seymouri 71% 100%
A0A1X0P3X1 Trypanosomatidae 32% 85%
A0A3R7LAM0 Trypanosoma rangeli 43% 75%
A0A3S7WNZ5 Leishmania donovani 89% 100%
A4H457 Leishmania braziliensis 85% 100%
A4HSE0 Leishmania infantum 89% 100%
C9ZPX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
Q4QJJ2 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS