Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nudix hydrolase 2, putative

Species:

Leishmania mexicana

UniProt:

E9AKB3_LEIMU

TriTrypDb:

LmxM.05.0090

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AKB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKB3

Function

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Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016462	pyrophosphatase activity	5	14
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	14
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	14
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.425
CLV_NRD_NRD_1	88	90	PF00675	0.317
CLV_PCSK_KEX2_1	127	129	PF00082	0.385
CLV_PCSK_KEX2_1	166	168	PF00082	0.554
CLV_PCSK_KEX2_1	88	90	PF00082	0.330
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.554
CLV_PCSK_SKI1_1	111	115	PF00082	0.344
CLV_PCSK_SKI1_1	161	165	PF00082	0.412
CLV_PCSK_SKI1_1	167	171	PF00082	0.443
CLV_PCSK_SKI1_1	98	102	PF00082	0.327

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P0	Leptomonas seymouri	70%	100%
A0A0N0P9K0	Leptomonas seymouri	30%	76%
A0A0S4J332	Bodo saltans	44%	70%
A0A1X0P2U2	Trypanosomatidae	59%	100%
A0A3Q8IFW7	Leishmania donovani	29%	73%
A0A3S5H5F7	Leishmania donovani	93%	100%
A0A422NYC4	Trypanosoma rangeli	54%	100%
A0A422P4Y4	Trypanosoma rangeli	32%	75%
A4H455	Leishmania braziliensis	84%	100%
A4HKE1	Leishmania braziliensis	31%	100%

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