LeishMANIAdb
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Rrp15p-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Rrp15p-domain-containing protein
Gene product:
Rrp15p, putative
Species:
Leishmania mexicana
UniProt:
E9AKB2_LEIMU
TriTrypDb:
LmxM.05.0080
Length:
201

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0030684 preribosome 3 1
GO:0030687 preribosome, large subunit precursor 4 1
GO:0032991 protein-containing complex 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

E9AKB2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKB2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006364 rRNA processing 8 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0016072 rRNA metabolic process 7 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000460 maturation of 5.8S rRNA 9 1
GO:0000470 maturation of LSU-rRNA 9 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 161 163 PF00675 0.342
CLV_NRD_NRD_1 93 95 PF00675 0.434
CLV_PCSK_KEX2_1 22 24 PF00082 0.620
CLV_PCSK_KEX2_1 34 36 PF00082 0.513
CLV_PCSK_KEX2_1 91 93 PF00082 0.386
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.638
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.566
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.415
CLV_PCSK_SKI1_1 172 176 PF00082 0.337
CLV_PCSK_SKI1_1 188 192 PF00082 0.312
CLV_PCSK_SKI1_1 19 23 PF00082 0.627
CLV_PCSK_SKI1_1 83 87 PF00082 0.475
DOC_MAPK_gen_1 142 151 PF00069 0.413
DOC_USP7_MATH_1 121 125 PF00917 0.400
DOC_USP7_MATH_1 15 19 PF00917 0.470
DOC_USP7_MATH_1 65 69 PF00917 0.467
DOC_USP7_UBL2_3 178 182 PF12436 0.344
DOC_USP7_UBL2_3 34 38 PF12436 0.613
DOC_WW_Pin1_4 33 38 PF00397 0.699
LIG_14-3-3_CanoR_1 107 115 PF00244 0.381
LIG_14-3-3_CanoR_1 142 147 PF00244 0.330
LIG_BIR_II_1 1 5 PF00653 0.591
LIG_FHA_1 146 152 PF00498 0.328
LIG_FHA_2 50 56 PF00498 0.415
LIG_Integrin_RGD_1 6 8 PF01839 0.734
LIG_MAD2 96 104 PF02301 0.475
LIG_SH2_STAP1 139 143 PF00017 0.328
LIG_UBA3_1 154 163 PF00899 0.344
MOD_CDK_SPK_2 33 38 PF00069 0.699
MOD_CK1_1 145 151 PF00069 0.381
MOD_CK1_1 53 59 PF00069 0.428
MOD_CK2_1 105 111 PF00069 0.326
MOD_CK2_1 49 55 PF00069 0.401
MOD_Cter_Amidation 89 92 PF01082 0.362
MOD_GlcNHglycan 164 167 PF01048 0.399
MOD_GlcNHglycan 29 32 PF01048 0.439
MOD_GlcNHglycan 55 58 PF01048 0.428
MOD_GlcNHglycan 74 77 PF01048 0.473
MOD_GSK3_1 154 161 PF00069 0.376
MOD_GSK3_1 23 30 PF00069 0.642
MOD_GSK3_1 49 56 PF00069 0.392
MOD_NEK2_1 154 159 PF00069 0.315
MOD_PIKK_1 121 127 PF00454 0.413
MOD_PK_1 142 148 PF00069 0.385
MOD_PKA_1 162 168 PF00069 0.430
MOD_PKA_1 172 178 PF00069 0.328
MOD_PKA_1 27 33 PF00069 0.554
MOD_PKA_2 106 112 PF00069 0.382
MOD_PKA_2 53 59 PF00069 0.458
MOD_ProDKin_1 33 39 PF00069 0.689
MOD_SUMO_rev_2 165 175 PF00179 0.368
MOD_SUMO_rev_2 176 185 PF00179 0.290
TRG_DiLeu_BaLyEn_6 126 131 PF01217 0.344
TRG_ER_diArg_1 141 144 PF00400 0.328
TRG_ER_diArg_1 92 94 PF00400 0.184
TRG_NLS_MonoExtN_4 14 20 PF00514 0.620
TRG_Pf-PMV_PEXEL_1 129 134 PF00026 0.344

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYI7 Leptomonas seymouri 75% 99%
A0A0S4JT37 Bodo saltans 45% 90%
A0A1X0P2H2 Trypanosomatidae 50% 86%
A0A3R7MSE6 Trypanosoma rangeli 59% 95%
A0A3S7WP07 Leishmania donovani 90% 100%
A4H454 Leishmania braziliensis 88% 100%
A4HSD7 Leishmania infantum 90% 100%
C9ZPX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 92%
Q4QJJ5 Leishmania major 91% 100%
V5BJH6 Trypanosoma cruzi 56% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS