Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKA9_LEIMU

TriTrypDb:

LmxM.05.0050

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

E9AKA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA9

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006171	cAMP biosynthetic process	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007165	signal transduction	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.427
CLV_C14_Caspase3-7	81	85	PF00656	0.630
CLV_NRD_NRD_1	112	114	PF00675	0.634
CLV_NRD_NRD_1	254	256	PF00675	0.607
CLV_NRD_NRD_1	367	369	PF00675	0.760
CLV_NRD_NRD_1	425	427	PF00675	0.617
CLV_NRD_NRD_1	601	603	PF00675	0.526
CLV_NRD_NRD_1	791	793	PF00675	0.614
CLV_NRD_NRD_1	823	825	PF00675	0.510
CLV_PCSK_KEX2_1	112	114	PF00082	0.616

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC98	Leptomonas seymouri	67%	100%
A0A0S4JP59	Bodo saltans	30%	89%
A0A1X0P3L6	Trypanosomatidae	46%	100%
A0A3S5H5F6	Leishmania donovani	94%	100%
A0A422NYC2	Trypanosoma rangeli	46%	99%
A4H451	Leishmania braziliensis	84%	100%
A4HSC8	Leishmania infantum	94%	100%
C9ZPY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QJJ8	Leishmania major	94%	100%
V5BAC3	Trypanosoma cruzi	45%	99%

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