Putative paraflagellar rod component par4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component par4, putative

Species:

Leishmania mexicana

UniProt:

E9AKA8_LEIMU

TriTrypDb:

LmxM.05.0040

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

E9AKA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.404
CLV_C14_Caspase3-7	539	543	PF00656	0.531
CLV_NRD_NRD_1	171	173	PF00675	0.509
CLV_NRD_NRD_1	220	222	PF00675	0.512
CLV_NRD_NRD_1	239	241	PF00675	0.436
CLV_NRD_NRD_1	284	286	PF00675	0.496
CLV_NRD_NRD_1	359	361	PF00675	0.361
CLV_NRD_NRD_1	43	45	PF00675	0.447
CLV_NRD_NRD_1	569	571	PF00675	0.553
CLV_NRD_NRD_1	69	71	PF00675	0.555
CLV_PCSK_KEX2_1	171	173	PF00082	0.602
CLV_PCSK_KEX2_1	238	240	PF00082	0.456
CLV_PCSK_KEX2_1	284	286	PF00082	0.414
CLV_PCSK_KEX2_1	325	327	PF00082	0.616
CLV_PCSK_KEX2_1	43	45	PF00082	0.463
CLV_PCSK_KEX2_1	549	551	PF00082	0.453
CLV_PCSK_KEX2_1	69	71	PF00082	0.549
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.477
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.616
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.463
CLV_PCSK_SKI1_1	103	107	PF00082	0.520
CLV_PCSK_SKI1_1	201	205	PF00082	0.590
CLV_PCSK_SKI1_1	222	226	PF00082	0.503
CLV_PCSK_SKI1_1	295	299	PF00082	0.511
CLV_PCSK_SKI1_1	465	469	PF00082	0.638
CLV_PCSK_SKI1_1	476	480	PF00082	0.537
CLV_PCSK_SKI1_1	510	514	PF00082	0.630
CLV_PCSK_SKI1_1	560	564	PF00082	0.420
CLV_PCSK_SKI1_1	9	13	PF00082	0.525
CLV_Separin_Metazoa	491	495	PF03568	0.509
DOC_MAPK_gen_1	15	23	PF00069	0.448
DOC_MAPK_gen_1	221	229	PF00069	0.543
DOC_MAPK_gen_1	510	518	PF00069	0.491
DOC_MAPK_gen_1	568	575	PF00069	0.427
DOC_PP1_RVXF_1	366	372	PF00149	0.415
DOC_USP7_MATH_1	328	332	PF00917	0.463
DOC_USP7_MATH_1	424	428	PF00917	0.336
DOC_USP7_MATH_1	493	497	PF00917	0.619
DOC_USP7_UBL2_3	302	306	PF12436	0.514
DOC_USP7_UBL2_3	5	9	PF12436	0.548
LIG_14-3-3_CanoR_1	221	227	PF00244	0.506
LIG_14-3-3_CanoR_1	568	574	PF00244	0.431
LIG_Actin_WH2_2	460	478	PF00022	0.507
LIG_Actin_WH2_2	505	521	PF00022	0.489
LIG_Actin_WH2_2	534	551	PF00022	0.534
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_CaM_IQ_9	541	557	PF13499	0.541
LIG_Clathr_ClatBox_1	112	116	PF01394	0.424
LIG_FHA_1	296	302	PF00498	0.525
LIG_FHA_1	570	576	PF00498	0.423
LIG_FHA_2	253	259	PF00498	0.565
LIG_FHA_2	273	279	PF00498	0.322
LIG_FHA_2	436	442	PF00498	0.616
LIG_FHA_2	444	450	PF00498	0.399
LIG_FHA_2	559	565	PF00498	0.573
LIG_FHA_2	99	105	PF00498	0.590
LIG_Integrin_isoDGR_2	378	380	PF01839	0.592
LIG_LIR_Gen_1	364	374	PF02991	0.399
LIG_LIR_Gen_1	458	467	PF02991	0.502
LIG_LIR_Nem_3	364	369	PF02991	0.396
LIG_LIR_Nem_3	458	464	PF02991	0.585
LIG_NRBOX	225	231	PF00104	0.529
LIG_NRBOX	353	359	PF00104	0.419
LIG_PCNA_yPIPBox_3	216	230	PF02747	0.556
LIG_PCNA_yPIPBox_3	349	358	PF02747	0.554
LIG_SH2_STAP1	241	245	PF00017	0.475
LIG_SH2_STAP1	432	436	PF00017	0.519
LIG_SH2_STAP1	92	96	PF00017	0.557
LIG_SH2_STAT3	134	137	PF00017	0.476
LIG_SH2_STAT3	432	435	PF00017	0.441
LIG_SH2_STAT3	92	95	PF00017	0.556
LIG_SH2_STAT5	134	137	PF00017	0.408
LIG_SH2_STAT5	307	310	PF00017	0.398
LIG_TRAF2_1	255	258	PF00917	0.457
LIG_TRAF2_1	411	414	PF00917	0.603
LIG_UBA3_1	436	444	PF00899	0.435
LIG_UBA3_1	540	549	PF00899	0.293
LIG_WRC_WIRS_1	273	278	PF05994	0.425
MOD_CK1_1	420	426	PF00069	0.559
MOD_CK1_1	91	97	PF00069	0.585
MOD_CK2_1	252	258	PF00069	0.551
MOD_CK2_1	266	272	PF00069	0.477
MOD_CK2_1	307	313	PF00069	0.475
MOD_CK2_1	36	42	PF00069	0.505
MOD_CK2_1	408	414	PF00069	0.489
MOD_CK2_1	453	459	PF00069	0.430
MOD_CK2_1	551	557	PF00069	0.481
MOD_CK2_1	87	93	PF00069	0.475
MOD_Cter_Amidation	7	10	PF01082	0.560
MOD_GlcNHglycan	182	185	PF01048	0.556
MOD_GlcNHglycan	330	333	PF01048	0.394
MOD_GlcNHglycan	419	422	PF01048	0.585
MOD_GlcNHglycan	82	85	PF01048	0.432
MOD_GSK3_1	307	314	PF00069	0.426
MOD_GSK3_1	404	411	PF00069	0.472
MOD_GSK3_1	420	427	PF00069	0.448
MOD_GSK3_1	449	456	PF00069	0.425
MOD_GSK3_1	76	83	PF00069	0.561
MOD_GSK3_1	87	94	PF00069	0.594
MOD_N-GLC_1	222	227	PF02516	0.559
MOD_N-GLC_1	404	409	PF02516	0.455
MOD_NEK2_1	167	172	PF00069	0.514
MOD_NEK2_1	266	271	PF00069	0.490
MOD_NEK2_1	344	349	PF00069	0.458
MOD_NEK2_1	443	448	PF00069	0.427
MOD_NEK2_1	518	523	PF00069	0.550
MOD_NEK2_1	540	545	PF00069	0.330
MOD_NEK2_2	558	563	PF00069	0.418
MOD_PIKK_1	155	161	PF00454	0.597
MOD_PIKK_1	252	258	PF00454	0.628
MOD_PIKK_1	266	272	PF00454	0.625
MOD_PIKK_1	344	350	PF00454	0.567
MOD_PIKK_1	91	97	PF00454	0.490
MOD_PKA_1	9	15	PF00069	0.608
MOD_PKA_2	127	133	PF00069	0.554
MOD_PKA_2	138	144	PF00069	0.556
MOD_PKA_2	180	186	PF00069	0.535
MOD_PKA_2	250	256	PF00069	0.530
MOD_PKA_2	493	499	PF00069	0.594
MOD_PKA_2	569	575	PF00069	0.598
MOD_PKA_2	79	85	PF00069	0.562
MOD_PKB_1	451	459	PF00069	0.332
MOD_Plk_1	108	114	PF00069	0.329
MOD_Plk_1	144	150	PF00069	0.445
MOD_Plk_1	222	228	PF00069	0.557
MOD_Plk_1	404	410	PF00069	0.584
MOD_Plk_1	494	500	PF00069	0.554
MOD_Plk_1	76	82	PF00069	0.432
MOD_Plk_1	87	93	PF00069	0.379
MOD_Plk_2-3	272	278	PF00069	0.601
MOD_Plk_2-3	88	94	PF00069	0.428
MOD_Plk_4	108	114	PF00069	0.336
MOD_Plk_4	222	228	PF00069	0.501
MOD_Plk_4	367	373	PF00069	0.482
MOD_SUMO_for_1	113	116	PF00179	0.452
MOD_SUMO_for_1	16	19	PF00179	0.384
MOD_SUMO_for_1	276	279	PF00179	0.422
MOD_SUMO_for_1	512	515	PF00179	0.494
MOD_SUMO_for_1	562	565	PF00179	0.462
MOD_SUMO_rev_2	182	190	PF00179	0.490
MOD_SUMO_rev_2	214	224	PF00179	0.549
MOD_SUMO_rev_2	257	266	PF00179	0.517
MOD_SUMO_rev_2	289	297	PF00179	0.428
MOD_SUMO_rev_2	299	308	PF00179	0.547
MOD_SUMO_rev_2	542	551	PF00179	0.581
MOD_SUMO_rev_2	83	91	PF00179	0.541
TRG_DiLeu_BaEn_1	19	24	PF01217	0.489
TRG_DiLeu_BaEn_1	353	358	PF01217	0.429
TRG_DiLeu_BaEn_3	118	124	PF01217	0.468
TRG_DiLeu_BaEn_3	50	56	PF01217	0.502
TRG_DiLeu_BaEn_4	151	157	PF01217	0.480
TRG_DiLeu_BaEn_4	257	263	PF01217	0.470
TRG_DiLeu_LyEn_5	19	24	PF01217	0.369
TRG_ENDOCYTIC_2	461	464	PF00928	0.586
TRG_ER_diArg_1	239	241	PF00400	0.473
TRG_ER_diArg_1	284	286	PF00400	0.306
TRG_ER_diArg_1	450	453	PF00400	0.593
TRG_ER_diArg_1	530	533	PF00400	0.543
TRG_ER_diArg_1	69	71	PF00400	0.561
TRG_NES_CRM1_1	507	520	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW9	Leptomonas seymouri	49%	100%
A0A0S4JPX7	Bodo saltans	34%	99%
A0A1X0P3Y1	Trypanosomatidae	41%	100%
A0A3R7MZM3	Trypanosoma rangeli	40%	100%
A0A3S5H5F5	Leishmania donovani	93%	100%
A4H450	Leishmania braziliensis	79%	100%
A4HSC7	Leishmania infantum	93%	100%
C9ZPY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QJJ9	Leishmania major	92%	100%
V5BJE7	Trypanosoma cruzi	39%	100%