LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AKA6_LEIMU
TriTrypDb:
LmxM.05.0020
Length:
139

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKA6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 21 23 PF00675 0.635
CLV_PCSK_KEX2_1 20 22 PF00082 0.640
CLV_PCSK_KEX2_1 64 66 PF00082 0.554
CLV_PCSK_KEX2_1 70 72 PF00082 0.480
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.628
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.475
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.480
CLV_PCSK_SKI1_1 107 111 PF00082 0.568
CLV_PCSK_SKI1_1 54 58 PF00082 0.563
CLV_PCSK_SKI1_1 71 75 PF00082 0.488
DEG_Nend_Nbox_1 1 3 PF02207 0.564
DOC_MAPK_DCC_7 31 40 PF00069 0.417
DOC_MAPK_gen_1 20 28 PF00069 0.575
DOC_MAPK_gen_1 54 63 PF00069 0.516
DOC_MAPK_gen_1 70 77 PF00069 0.495
DOC_MAPK_JIP1_4 22 28 PF00069 0.578
DOC_MAPK_MEF2A_6 70 77 PF00069 0.538
DOC_USP7_UBL2_3 132 136 PF12436 0.585
DOC_WW_Pin1_4 33 38 PF00397 0.463
LIG_14-3-3_CanoR_1 12 19 PF00244 0.622
LIG_APCC_ABBA_1 92 97 PF00400 0.573
LIG_FHA_1 70 76 PF00498 0.623
LIG_Integrin_isoDGR_2 29 31 PF01839 0.555
LIG_LIR_Apic_2 120 126 PF02991 0.643
LIG_LIR_Gen_1 72 81 PF02991 0.655
LIG_LIR_Nem_3 72 77 PF02991 0.550
LIG_SH2_STAT3 44 47 PF00017 0.525
LIG_SH2_STAT5 39 42 PF00017 0.509
LIG_SH3_2 49 54 PF14604 0.527
LIG_SH3_3 123 129 PF00018 0.652
LIG_SH3_3 46 52 PF00018 0.520
LIG_SUMO_SIM_par_1 107 112 PF11976 0.541
LIG_UBA3_1 73 80 PF00899 0.629
MOD_GSK3_1 93 100 PF00069 0.634
MOD_NEK2_1 109 114 PF00069 0.477
MOD_NEK2_2 69 74 PF00069 0.501
MOD_PKA_2 11 17 PF00069 0.595
MOD_Plk_4 97 103 PF00069 0.537
MOD_ProDKin_1 33 39 PF00069 0.463
MOD_SUMO_rev_2 96 101 PF00179 0.485
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.531
TRG_ENDOCYTIC_2 95 98 PF00928 0.536
TRG_ER_diArg_1 128 131 PF00400 0.593
TRG_ER_diArg_1 21 23 PF00400 0.661
TRG_ER_diArg_1 40 43 PF00400 0.545
TRG_NLS_MonoExtN_4 18 24 PF00514 0.624

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5P1 Leptomonas seymouri 77% 100%
A0A1X0P377 Trypanosomatidae 68% 100%
A0A3S5ISB2 Trypanosoma rangeli 68% 100%
A0A3S7WNZ0 Leishmania donovani 96% 100%
A4H448 Leishmania braziliensis 88% 100%
A4HSC5 Leishmania infantum 96% 100%
C9ZPY7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
Q4QJK1 Leishmania major 95% 100%
V5BF10 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS