TPR_MLP1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetochore interacting protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AKA5_LEIMU

TriTrypDb:

LmxM.05.0010

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0000922	spindle pole	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.612
CLV_C14_Caspase3-7	73	77	PF00656	0.579
CLV_C14_Caspase3-7	909	913	PF00656	0.590
CLV_NRD_NRD_1	322	324	PF00675	0.534
CLV_NRD_NRD_1	363	365	PF00675	0.662
CLV_NRD_NRD_1	45	47	PF00675	0.513
CLV_NRD_NRD_1	620	622	PF00675	0.613
CLV_NRD_NRD_1	741	743	PF00675	0.624
CLV_NRD_NRD_1	756	758	PF00675	0.463
CLV_NRD_NRD_1	782	784	PF00675	0.619
CLV_NRD_NRD_1	802	804	PF00675	0.403
CLV_NRD_NRD_1	825	827	PF00675	0.592
CLV_NRD_NRD_1	97	99	PF00675	0.521
CLV_PCSK_FUR_1	780	784	PF00082	0.595
CLV_PCSK_KEX2_1	283	285	PF00082	0.498
CLV_PCSK_KEX2_1	322	324	PF00082	0.596
CLV_PCSK_KEX2_1	45	47	PF00082	0.504
CLV_PCSK_KEX2_1	741	743	PF00082	0.647
CLV_PCSK_KEX2_1	756	758	PF00082	0.463
CLV_PCSK_KEX2_1	769	771	PF00082	0.553
CLV_PCSK_KEX2_1	782	784	PF00082	0.528
CLV_PCSK_KEX2_1	802	804	PF00082	0.548
CLV_PCSK_KEX2_1	825	827	PF00082	0.567
CLV_PCSK_KEX2_1	904	906	PF00082	0.642
CLV_PCSK_KEX2_1	97	99	PF00082	0.588
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.585
CLV_PCSK_PC1ET2_1	769	771	PF00082	0.638
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.652
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.642
CLV_PCSK_SKI1_1	17	21	PF00082	0.490
CLV_PCSK_SKI1_1	360	364	PF00082	0.558
CLV_PCSK_SKI1_1	421	425	PF00082	0.636
CLV_PCSK_SKI1_1	48	52	PF00082	0.529
CLV_PCSK_SKI1_1	575	579	PF00082	0.638
CLV_PCSK_SKI1_1	588	592	PF00082	0.678
CLV_PCSK_SKI1_1	645	649	PF00082	0.510
CLV_PCSK_SKI1_1	684	688	PF00082	0.629
CLV_PCSK_SKI1_1	706	710	PF00082	0.679
CLV_PCSK_SKI1_1	729	733	PF00082	0.595
CLV_PCSK_SKI1_1	808	812	PF00082	0.528
CLV_PCSK_SKI1_1	83	87	PF00082	0.568
CLV_Separin_Metazoa	618	622	PF03568	0.551
DEG_APCC_DBOX_1	461	469	PF00400	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.638
DOC_CDC14_PxL_1	897	905	PF14671	0.706
DOC_CYCLIN_RxL_1	243	253	PF00134	0.533
DOC_CYCLIN_RxL_1	679	690	PF00134	0.494
DOC_MAPK_gen_1	204	211	PF00069	0.611
DOC_MAPK_gen_1	269	277	PF00069	0.510
DOC_MAPK_gen_1	322	328	PF00069	0.525
DOC_MAPK_gen_1	45	51	PF00069	0.538
DOC_MAPK_gen_1	56	67	PF00069	0.477
DOC_MAPK_gen_1	663	671	PF00069	0.636
DOC_MAPK_gen_1	741	751	PF00069	0.554
DOC_MAPK_MEF2A_6	167	174	PF00069	0.579
DOC_MAPK_MEF2A_6	270	279	PF00069	0.560
DOC_MAPK_MEF2A_6	665	673	PF00069	0.566
DOC_PP1_RVXF_1	5	12	PF00149	0.560
DOC_USP7_MATH_1	100	104	PF00917	0.477
DOC_USP7_MATH_1	446	450	PF00917	0.408
DOC_USP7_MATH_1	694	698	PF00917	0.632
DOC_USP7_MATH_1	708	712	PF00917	0.562
DOC_USP7_MATH_1	725	729	PF00917	0.541
DOC_USP7_MATH_1	896	900	PF00917	0.667
DOC_USP7_UBL2_3	17	21	PF12436	0.530
DOC_USP7_UBL2_3	183	187	PF12436	0.588
DOC_USP7_UBL2_3	3	7	PF12436	0.577
DOC_USP7_UBL2_3	56	60	PF12436	0.499
DOC_USP7_UBL2_3	769	773	PF12436	0.684
DOC_USP7_UBL2_3	788	792	PF12436	0.442
DOC_USP7_UBL2_3	804	808	PF12436	0.442
DOC_WW_Pin1_4	883	888	PF00397	0.643
LIG_14-3-3_CanoR_1	162	170	PF00244	0.653
LIG_14-3-3_CanoR_1	364	373	PF00244	0.565
LIG_14-3-3_CanoR_1	569	577	PF00244	0.662
LIG_14-3-3_CanoR_1	762	766	PF00244	0.651
LIG_14-3-3_CanoR_1	83	91	PF00244	0.619
LIG_Actin_WH2_2	349	366	PF00022	0.555
LIG_Actin_WH2_2	810	827	PF00022	0.668
LIG_Actin_WH2_2	890	906	PF00022	0.750
LIG_deltaCOP1_diTrp_1	344	347	PF00928	0.672
LIG_FHA_1	148	154	PF00498	0.624
LIG_FHA_1	18	24	PF00498	0.495
LIG_FHA_1	519	525	PF00498	0.491
LIG_FHA_1	537	543	PF00498	0.539
LIG_FHA_1	56	62	PF00498	0.558
LIG_FHA_1	600	606	PF00498	0.602
LIG_FHA_1	672	678	PF00498	0.596
LIG_FHA_1	870	876	PF00498	0.621
LIG_FHA_2	106	112	PF00498	0.548
LIG_FHA_2	153	159	PF00498	0.626
LIG_FHA_2	391	397	PF00498	0.624
LIG_FHA_2	773	779	PF00498	0.604
LIG_LIR_Gen_1	346	356	PF02991	0.650
LIG_LIR_Gen_1	670	681	PF02991	0.500
LIG_LIR_Gen_1	764	771	PF02991	0.653
LIG_LIR_Nem_3	346	352	PF02991	0.656
LIG_LIR_Nem_3	670	676	PF02991	0.512
LIG_LIR_Nem_3	764	768	PF02991	0.646
LIG_NRBOX	750	756	PF00104	0.569
LIG_PCNA_PIPBox_1	655	664	PF02747	0.549
LIG_Pex14_1	345	349	PF04695	0.669
LIG_Pex14_1	846	850	PF04695	0.493
LIG_SH2_NCK_1	650	654	PF00017	0.430
LIG_SUMO_SIM_par_1	395	403	PF11976	0.700
LIG_SUMO_SIM_par_1	478	483	PF11976	0.397
LIG_TRAF2_1	109	112	PF00917	0.624
LIG_TRAF2_1	393	396	PF00917	0.682
LIG_TRAF2_1	775	778	PF00917	0.594
LIG_UBA3_1	249	255	PF00899	0.589
LIG_UBA3_1	676	684	PF00899	0.560
MOD_CK1_1	176	182	PF00069	0.521
MOD_CK1_1	292	298	PF00069	0.562
MOD_CK1_1	366	372	PF00069	0.591
MOD_CK1_1	455	461	PF00069	0.409
MOD_CK1_1	532	538	PF00069	0.548
MOD_CK1_1	571	577	PF00069	0.620
MOD_CK1_1	600	606	PF00069	0.640
MOD_CK1_1	675	681	PF00069	0.570
MOD_CK1_1	764	770	PF00069	0.636
MOD_CK1_1	860	866	PF00069	0.603
MOD_CK1_1	869	875	PF00069	0.584
MOD_CK2_1	105	111	PF00069	0.596
MOD_CK2_1	152	158	PF00069	0.540
MOD_CK2_1	176	182	PF00069	0.573
MOD_CK2_1	347	353	PF00069	0.535
MOD_CK2_1	390	396	PF00069	0.594
MOD_CK2_1	436	442	PF00069	0.651
MOD_CK2_1	577	583	PF00069	0.684
MOD_CK2_1	591	597	PF00069	0.409
MOD_CK2_1	638	644	PF00069	0.566
MOD_CK2_1	686	692	PF00069	0.614
MOD_CK2_1	694	700	PF00069	0.595
MOD_CK2_1	772	778	PF00069	0.578
MOD_CK2_1	816	822	PF00069	0.645
MOD_GlcNHglycan	30	33	PF01048	0.658
MOD_GlcNHglycan	366	369	PF01048	0.603
MOD_GlcNHglycan	438	441	PF01048	0.673
MOD_GlcNHglycan	456	460	PF01048	0.470
MOD_GlcNHglycan	570	573	PF01048	0.615
MOD_GlcNHglycan	602	605	PF01048	0.632
MOD_GlcNHglycan	640	643	PF01048	0.349
MOD_GlcNHglycan	700	704	PF01048	0.667
MOD_GSK3_1	112	119	PF00069	0.566
MOD_GSK3_1	157	164	PF00069	0.545
MOD_GSK3_1	211	218	PF00069	0.611
MOD_GSK3_1	283	290	PF00069	0.573
MOD_GSK3_1	343	350	PF00069	0.614
MOD_GSK3_1	532	539	PF00069	0.568
MOD_GSK3_1	634	641	PF00069	0.516
MOD_GSK3_1	671	678	PF00069	0.567
MOD_GSK3_1	708	715	PF00069	0.735
MOD_GSK3_1	908	915	PF00069	0.619
MOD_N-GLC_1	100	105	PF02516	0.552
MOD_N-GLC_1	121	126	PF02516	0.416
MOD_N-GLC_1	597	602	PF02516	0.629
MOD_N-GLC_1	712	717	PF02516	0.651
MOD_NEK2_1	121	126	PF00069	0.391
MOD_NEK2_1	191	196	PF00069	0.569
MOD_NEK2_1	219	224	PF00069	0.602
MOD_NEK2_1	233	238	PF00069	0.500
MOD_NEK2_1	289	294	PF00069	0.662
MOD_NEK2_1	326	331	PF00069	0.525
MOD_NEK2_1	347	352	PF00069	0.587
MOD_NEK2_1	363	368	PF00069	0.454
MOD_NEK2_1	506	511	PF00069	0.389
MOD_NEK2_1	537	542	PF00069	0.539
MOD_NEK2_1	591	596	PF00069	0.607
MOD_NEK2_1	626	631	PF00069	0.600
MOD_NEK2_1	671	676	PF00069	0.566
MOD_NEK2_1	686	691	PF00069	0.402
MOD_NEK2_2	694	699	PF00069	0.611
MOD_PIKK_1	161	167	PF00454	0.660
MOD_PIKK_1	176	182	PF00454	0.524
MOD_PIKK_1	287	293	PF00454	0.553
MOD_PIKK_1	326	332	PF00454	0.527
MOD_PIKK_1	537	543	PF00454	0.543
MOD_PIKK_1	626	632	PF00454	0.444
MOD_PIKK_1	83	89	PF00454	0.556
MOD_PK_1	866	872	PF00069	0.662
MOD_PKA_1	283	289	PF00069	0.657
MOD_PKA_1	364	370	PF00069	0.568
MOD_PKA_1	56	62	PF00069	0.582
MOD_PKA_1	769	775	PF00069	0.447
MOD_PKA_2	161	167	PF00069	0.655
MOD_PKA_2	283	289	PF00069	0.667
MOD_PKA_2	363	369	PF00069	0.572
MOD_PKA_2	568	574	PF00069	0.649
MOD_PKA_2	761	767	PF00069	0.564
MOD_PKA_2	769	775	PF00069	0.491
MOD_Plk_1	100	106	PF00069	0.555
MOD_Plk_1	116	122	PF00069	0.438
MOD_Plk_1	191	197	PF00069	0.503
MOD_Plk_1	219	225	PF00069	0.668
MOD_Plk_1	233	239	PF00069	0.580
MOD_Plk_1	324	330	PF00069	0.539
MOD_Plk_1	343	349	PF00069	0.534
MOD_Plk_1	518	524	PF00069	0.498
MOD_Plk_1	597	603	PF00069	0.652
MOD_Plk_1	699	705	PF00069	0.638
MOD_Plk_2-3	215	221	PF00069	0.531
MOD_Plk_2-3	761	767	PF00069	0.621
MOD_Plk_4	191	197	PF00069	0.503
MOD_Plk_4	369	375	PF00069	0.521
MOD_Plk_4	491	497	PF00069	0.511
MOD_Plk_4	506	512	PF00069	0.401
MOD_Plk_4	672	678	PF00069	0.615
MOD_Plk_4	750	756	PF00069	0.539
MOD_ProDKin_1	883	889	PF00069	0.644
MOD_SUMO_for_1	135	138	PF00179	0.593
MOD_SUMO_for_1	268	271	PF00179	0.598
MOD_SUMO_for_1	768	771	PF00179	0.593
MOD_SUMO_rev_2	168	177	PF00179	0.563
MOD_SUMO_rev_2	213	219	PF00179	0.610
MOD_SUMO_rev_2	329	338	PF00179	0.623
MOD_SUMO_rev_2	382	390	PF00179	0.633
MOD_SUMO_rev_2	53	58	PF00179	0.534
MOD_SUMO_rev_2	702	711	PF00179	0.639
MOD_SUMO_rev_2	766	775	PF00179	0.636
MOD_SUMO_rev_2	800	810	PF00179	0.520
TRG_DiLeu_BaEn_1	376	381	PF01217	0.584
TRG_DiLeu_BaEn_1	501	506	PF01217	0.609
TRG_DiLeu_BaEn_2	385	391	PF01217	0.379
TRG_DiLeu_BaEn_4	396	402	PF01217	0.641
TRG_DiLeu_BaEn_4	656	662	PF01217	0.616
TRG_ENDOCYTIC_2	349	352	PF00928	0.644
TRG_ENDOCYTIC_2	845	848	PF00928	0.554
TRG_ER_diArg_1	321	323	PF00400	0.614
TRG_ER_diArg_1	44	46	PF00400	0.511
TRG_ER_diArg_1	755	757	PF00400	0.583
TRG_ER_diArg_1	824	826	PF00400	0.681
TRG_ER_diArg_1	96	98	PF00400	0.526
TRG_NES_CRM1_1	190	203	PF08389	0.584
TRG_NLS_Bipartite_1	802	819	PF00514	0.664
TRG_NLS_MonoExtC_3	814	820	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P634	Leptomonas seymouri	50%	100%
A0A3R7LAM9	Trypanosoma rangeli	32%	99%
A0A3S5H5F4	Leishmania donovani	90%	100%
A4H447	Leishmania braziliensis	74%	100%
A4HSC4	Leishmania infantum	90%	100%
C9ZPY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
Q4QJK2	Leishmania major	88%	100%