Actin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Actin

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AKA4_LEIMU

TriTrypDb:

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

E9AKA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.493
CLV_C14_Caspase3-7	225	229	PF00656	0.502
CLV_NRD_NRD_1	161	163	PF00675	0.302
CLV_NRD_NRD_1	275	277	PF00675	0.293
CLV_NRD_NRD_1	319	321	PF00675	0.293
CLV_PCSK_KEX2_1	161	163	PF00082	0.302
CLV_PCSK_KEX2_1	275	277	PF00082	0.292
CLV_PCSK_KEX2_1	46	48	PF00082	0.293
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.302
CLV_PCSK_SKI1_1	13	17	PF00082	0.293
CLV_PCSK_SKI1_1	168	172	PF00082	0.293
CLV_PCSK_SKI1_1	195	199	PF00082	0.293
CLV_PCSK_SKI1_1	297	301	PF00082	0.384
CLV_PCSK_SKI1_1	47	51	PF00082	0.346
CLV_Separin_Metazoa	192	196	PF03568	0.493
DEG_COP1_1	110	117	PF00400	0.561
DOC_CYCLIN_yClb5_NLxxxL_5	292	298	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.493
DOC_MAPK_gen_1	101	109	PF00069	0.485
DOC_MAPK_gen_1	238	246	PF00069	0.584
DOC_MAPK_gen_1	320	326	PF00069	0.491
DOC_MAPK_gen_1	46	52	PF00069	0.493
DOC_MAPK_MEF2A_6	238	246	PF00069	0.584
DOC_PP4_FxxP_1	112	115	PF00568	0.493
DOC_PP4_FxxP_1	224	227	PF00568	0.493
DOC_PP4_FxxP_1	239	242	PF00568	0.493
LIG_14-3-3_CanoR_1	320	325	PF00244	0.493
LIG_14-3-3_CanoR_1	47	53	PF00244	0.520
LIG_BRCT_BRCA1_1	287	291	PF00533	0.584
LIG_Clathr_ClatBox_1	250	254	PF01394	0.502
LIG_deltaCOP1_diTrp_1	68	75	PF00928	0.493
LIG_EH1_1	172	180	PF00400	0.493
LIG_FHA_1	109	115	PF00498	0.493
LIG_FHA_1	131	137	PF00498	0.490
LIG_FHA_1	143	149	PF00498	0.475
LIG_FHA_1	169	175	PF00498	0.502
LIG_FHA_1	337	343	PF00498	0.520
LIG_FHA_1	34	40	PF00498	0.584
LIG_FHA_2	185	191	PF00498	0.493
LIG_FHA_2	60	66	PF00498	0.493
LIG_LIR_Apic_2	110	115	PF02991	0.493
LIG_LIR_Apic_2	152	157	PF02991	0.493
LIG_LIR_Apic_2	221	227	PF02991	0.493
LIG_LIR_Gen_1	261	272	PF02991	0.493
LIG_LIR_Gen_1	335	342	PF02991	0.493
LIG_LIR_Gen_1	62	70	PF02991	0.493
LIG_LIR_Gen_1	74	83	PF02991	0.493
LIG_LIR_Nem_3	116	121	PF02991	0.561
LIG_LIR_Nem_3	261	267	PF02991	0.493
LIG_LIR_Nem_3	277	282	PF02991	0.493
LIG_LIR_Nem_3	288	294	PF02991	0.493
LIG_LIR_Nem_3	74	79	PF02991	0.486
LIG_Pex14_1	71	75	PF04695	0.493
LIG_Pex14_2	337	341	PF04695	0.493
LIG_PTB_Apo_2	233	240	PF02174	0.502
LIG_SH2_CRK	154	158	PF00017	0.493
LIG_SH2_CRK	264	268	PF00017	0.561
LIG_SH2_CRK	279	283	PF00017	0.493
LIG_SH2_PTP2	118	121	PF00017	0.493
LIG_SH2_PTP2	203	206	PF00017	0.493
LIG_SH2_SRC	347	350	PF00017	0.493
LIG_SH2_STAP1	322	326	PF00017	0.493
LIG_SH2_STAT5	118	121	PF00017	0.493
LIG_SH2_STAT5	173	176	PF00017	0.494
LIG_SH2_STAT5	203	206	PF00017	0.493
LIG_SH2_STAT5	38	41	PF00017	0.561
LIG_SH3_3	17	23	PF00018	0.493
LIG_SH3_3	254	260	PF00018	0.574
LIG_SH3_3	311	317	PF00018	0.489
LIG_SH3_3	91	97	PF00018	0.493
LIG_SUMO_SIM_par_1	123	130	PF11976	0.493
LIG_TRAF2_1	219	222	PF00917	0.562
LIG_TYR_ITAM	261	282	PF00017	0.584
LIG_TYR_ITIM	201	206	PF00017	0.493
LIG_WRC_WIRS_1	109	114	PF05994	0.493
LIG_WRC_WIRS_1	334	339	PF05994	0.493
MOD_CK1_1	126	132	PF00069	0.493
MOD_CK1_1	215	221	PF00069	0.502
MOD_CK1_1	285	291	PF00069	0.493
MOD_CK1_1	329	335	PF00069	0.493
MOD_CK1_1	350	356	PF00069	0.527
MOD_CK2_1	184	190	PF00069	0.493
MOD_CK2_1	215	221	PF00069	0.513
MOD_GlcNHglycan	129	132	PF01048	0.293
MOD_GlcNHglycan	214	217	PF01048	0.290
MOD_GlcNHglycan	284	287	PF01048	0.293
MOD_GlcNHglycan	31	34	PF01048	0.302
MOD_GlcNHglycan	348	352	PF01048	0.327
MOD_GlcNHglycan	6	9	PF01048	0.287
MOD_GSK3_1	123	130	PF00069	0.493
MOD_GSK3_1	181	188	PF00069	0.492
MOD_GSK3_1	282	289	PF00069	0.493
MOD_GSK3_1	29	36	PF00069	0.573
MOD_GSK3_1	326	333	PF00069	0.493
MOD_N-GLC_1	33	38	PF02516	0.384
MOD_N-GLC_2	268	270	PF02516	0.293
MOD_N-GLC_2	357	359	PF02516	0.313
MOD_NEK2_1	108	113	PF00069	0.493
MOD_NEK2_1	127	132	PF00069	0.485
MOD_NEK2_1	178	183	PF00069	0.505
MOD_NEK2_1	212	217	PF00069	0.495
MOD_NEK2_1	29	34	PF00069	0.493
MOD_NEK2_2	123	128	PF00069	0.493
MOD_NEK2_2	286	291	PF00069	0.493
MOD_NEK2_2	33	38	PF00069	0.573
MOD_NEK2_2	48	53	PF00069	0.429
MOD_NEK2_2	71	76	PF00069	0.493
MOD_PIKK_1	102	108	PF00454	0.493
MOD_PK_1	320	326	PF00069	0.493
MOD_PKA_1	320	326	PF00069	0.493
MOD_PKA_2	131	137	PF00069	0.493
MOD_Plk_1	33	39	PF00069	0.584
MOD_Plk_4	113	119	PF00069	0.538
MOD_Plk_4	123	129	PF00069	0.427
MOD_Plk_4	15	21	PF00069	0.493
MOD_Plk_4	246	252	PF00069	0.542
MOD_Plk_4	286	292	PF00069	0.493
MOD_Plk_4	320	326	PF00069	0.493
MOD_Plk_4	33	39	PF00069	0.493
MOD_Plk_4	336	342	PF00069	0.486
MOD_Plk_4	350	356	PF00069	0.479
MOD_Plk_4	71	77	PF00069	0.486
TRG_DiLeu_BaEn_4	221	227	PF01217	0.493
TRG_ENDOCYTIC_2	118	121	PF00928	0.493
TRG_ENDOCYTIC_2	203	206	PF00928	0.493
TRG_ENDOCYTIC_2	264	267	PF00928	0.561
TRG_ENDOCYTIC_2	279	282	PF00928	0.493
TRG_ENDOCYTIC_2	76	79	PF00928	0.493
TRG_ER_diArg_1	160	162	PF00400	0.502
TRG_ER_diArg_1	274	276	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.210

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F8	Leptomonas seymouri	96%	100%
A0A0N0P696	Leptomonas seymouri	30%	88%
A0A0N0P781	Leptomonas seymouri	29%	78%
A0A0N0P8M2	Leptomonas seymouri	36%	83%
A0A0N1I0W8	Leptomonas seymouri	29%	84%
A0A0N1I659	Leptomonas seymouri	27%	72%
A0A0N1IM09	Leptomonas seymouri	26%	78%
A0A0S4IP23	Bodo saltans	36%	89%
A0A0S4ISP2	Bodo saltans	47%	92%
A0A0S4IUQ1	Bodo saltans	23%	89%
A0A0S4IWZ2	Bodo saltans	41%	91%
A0A0S4J183	Bodo saltans	41%	100%
A0A0S4JB16	Bodo saltans	38%	91%
A0A0S4JGI9	Bodo saltans	33%	86%
A0A0S4JGK8	Bodo saltans	38%	91%
A0A0S4JN99	Bodo saltans	35%	93%
A0A0S4JSR2	Bodo saltans	87%	96%
A0A0S4KG45	Bodo saltans	22%	99%
A0A0S4KJ86	Bodo saltans	45%	100%
A0A1L8EV45	Xenopus laevis	36%	86%
A0A1X0NIU0	Trypanosomatidae	39%	92%
A0A1X0NJ12	Trypanosomatidae	30%	76%
A0A1X0NKR1	Trypanosomatidae	89%	96%
A0A1X0NPN8	Trypanosomatidae	35%	88%
A0A1X0NRG7	Trypanosomatidae	47%	93%
A0A1X0NU35	Trypanosomatidae	30%	87%
A0A1X0NVG9	Trypanosomatidae	35%	87%
A0A1X0P3H1	Trypanosomatidae	31%	89%
A0A1X0P6E4	Trypanosomatidae	37%	90%
A0A1X0P9A3	Trypanosomatidae	26%	100%
A0A1X0PA74	Trypanosomatidae	25%	97%
A0A3Q8ICD3	Leishmania donovani	31%	89%
A0A3Q8IEK0	Leishmania donovani	29%	92%
A0A3Q8IGA6	Leishmania donovani	32%	88%
A0A3Q8IHJ0	Leishmania donovani	22%	85%
A0A3Q8IJ53	Leishmania donovani	24%	69%
A0A3R7JX14	Trypanosoma rangeli	51%	93%
A0A3R7KB53	Trypanosoma rangeli	35%	87%
A0A3R7M3Y4	Trypanosoma rangeli	22%	97%
A0A3R7M5N2	Trypanosoma rangeli	32%	95%
A0A3S5IQV3	Trypanosoma rangeli	36%	90%
A0A3S5IR27	Trypanosoma rangeli	27%	100%
A0A3S7WTM5	Leishmania donovani	27%	82%
A0A422MY22	Trypanosoma rangeli	90%	96%
A0A422NGD7	Trypanosoma rangeli	34%	84%
A0A422NI92	Trypanosoma rangeli	32%	86%
A0A422NRB8	Trypanosoma rangeli	29%	84%
A0A422P3Z5	Trypanosoma rangeli	39%	92%
A2AKE7	Mus musculus	34%	100%
A2BDB0	Xenopus laevis	71%	96%
A2WNB0	Oryza sativa subsp. indica	27%	84%
A2X6S3	Oryza sativa subsp. indica	33%	84%
A2XLF2	Oryza sativa subsp. indica	73%	95%
A2XMK6	Oryza sativa subsp. indica	35%	100%
A2XNS1	Oryza sativa subsp. indica	73%	95%
A2YR10	Oryza sativa subsp. indica	35%	81%
A2YUL5	Oryza sativa subsp. indica	40%	93%
A3ANB5	Oryza sativa subsp. japonica	35%	100%
A3C6D7	Oryza sativa subsp. japonica	72%	95%
A4FUX8	Bos taurus	32%	85%
A4H8A4	Leishmania braziliensis	29%	100%
A4HA61	Leishmania braziliensis	29%	100%
A4HHT1	Leishmania braziliensis	23%	100%
A4HMB0	Leishmania braziliensis	24%	100%
A4HPJ8	Leishmania braziliensis	31%	100%
A4HSC2	Leishmania infantum	100%	96%
A4HWL8	Leishmania infantum	27%	82%
A4HWM4	Leishmania infantum	31%	89%
A4HYD8	Leishmania infantum	29%	92%
A4IAE4	Leishmania infantum	22%	100%
A4IAX6	Leishmania infantum	24%	69%
A4ID66	Leishmania infantum	32%	88%
A4IFE3	Bos taurus	50%	96%
A5DQP9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	73%	100%
A7MB62	Bos taurus	43%	91%
A8WAT2	Oryza sativa subsp. indica	31%	74%
C6KJC7	Leishmania donovani	100%	96%
C9ZKK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZLU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	97%
C9ZXR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
C9ZXR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZYB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	96%
C9ZYB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	89%
D0A0S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	90%
D0A6N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
D0A8L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	91%
D0LWX4	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)	35%	95%
E9AQC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	82%
E9AQD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	89%
E9AS71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	75%
E9ATB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	88%
E9B5V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	69%
O00937	Sterkiella cavicola	63%	96%
O13419	Botryotinia fuckeliana	71%	96%
O15998	Ciona savignyi	71%	95%
O16808	Mayetiola destructor	71%	96%
O17320	Crassostrea gigas	72%	96%
O17502	Branchiostoma lanceolatum	69%	95%
O17503	Branchiostoma lanceolatum	71%	96%
O18499	Saccoglossus kowalevskii	71%	96%
O18500	Saccoglossus kowalevskii	71%	96%
O18840	Canis lupus familiaris	71%	96%
O42161	Salmo salar	71%	96%
O65314	Scherffelia dubia	73%	95%
O65315	Coleochaete scutata	73%	95%
O65316	Mesostigma viride	73%	95%
O73723	Takifugu rubripes	36%	86%
O74258	Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1)	73%	96%
O81221	Gossypium hirsutum	73%	95%
O93400	Xenopus laevis	71%	96%
O94241	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
O94630	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	95%
O94805	Homo sapiens	32%	85%
O96019	Homo sapiens	33%	84%
O96621	Dictyostelium discoideum	44%	92%
P00544	Feline sarcoma virus (strain Gardner-Rasheed)	48%	66%
P02572	Drosophila melanogaster	72%	96%
P02574	Drosophila melanogaster	71%	96%
P02576	Physarum polycephalum	71%	96%
P02578	Acanthamoeba castellanii	72%	96%
P02580	Glycine max	70%	96%
P02581	Glycine max	66%	95%
P02582	Zea mays	68%	96%
P02583	Oxytricha fallax	60%	100%
P04751	Xenopus laevis	71%	95%
P04752	Xenopus laevis	71%	95%
P04829	Bombyx mori	72%	96%
P07828	Dictyostelium discoideum	66%	95%
P07829	Dictyostelium discoideum	70%	96%
P07830	Dictyostelium discoideum	71%	96%
P07836	Bombyx mori	71%	96%
P07837	Bombyx mori	71%	96%
P08023	Gallus gallus	71%	95%
P0C539	Oryza sativa subsp. indica	72%	95%
P0C540	Oryza sativa subsp. japonica	72%	96%
P0C542	Oryza sativa subsp. indica	72%	96%
P0CJ46	Arabidopsis thaliana	72%	95%
P0CJ47	Arabidopsis thaliana	72%	95%
P0CM04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	73%
P0CM05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	73%
P0DM41	Caenorhabditis elegans	72%	96%
P0DM42	Caenorhabditis elegans	72%	96%
P10365	Thermomyces lanuginosus	70%	96%
P10981	Drosophila melanogaster	71%	96%
P10984	Caenorhabditis elegans	72%	96%
P10986	Caenorhabditis elegans	72%	96%
P10987	Drosophila melanogaster	72%	96%
P10988	Plasmodium falciparum (isolate NF54)	72%	96%
P10989	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	71%	96%
P10990	Mesocentrotus franciscanus	71%	96%
P10992	Tetrahymena thermophila	70%	96%
P10993	Tetrahymena pyriformis	70%	96%
P10995	Xenopus laevis	71%	95%
P11426	Entamoeba histolytica	71%	96%
P12431	Strongylocentrotus purpuratus	69%	96%
P12432	Trypanosoma brucei brucei	90%	96%
P12433	Trypanosoma brucei brucei	89%	96%
P12715	Sterkiella nova	63%	96%
P12716	Pisaster ochraceus	71%	96%
P12717	Pisaster ochraceus	71%	96%
P13363	Phytophthora megasperma	69%	96%
P14235	Candida albicans	72%	96%
P14883	Plasmodium falciparum (isolate NF54)	72%	96%
P15475	Xenopus borealis	71%	96%
P17126	Hydra vulgaris	72%	96%
P17128	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	73%	96%
P17304	Aplysia californica	72%	96%
P18499	Strongylocentrotus purpuratus	71%	96%
P18600	Artemia sp.	71%	96%
P18601	Artemia sp.	71%	96%
P18602	Artemia sp.	72%	100%
P18603	Artemia sp.	71%	96%
P20359	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	71%	96%
P20360	Euplotes crassus	57%	95%
P20399	Xenopus tropicalis	71%	95%
P20904	Volvox carteri	74%	95%
P22131	Phytophthora infestans	72%	96%
P22132	Phytophthora infestans	70%	96%
P23343	Daucus carota	70%	95%
P23344	Daucus carota	67%	94%
P24263	Physarum polycephalum	63%	98%
P26182	Achlya bisexualis	72%	96%
P26183	Cryptosporidium parvum	72%	96%
P26197	Absidia glauca	72%	95%
P26198	Styela clava	70%	95%
P27130	Halocynthia roretzi	71%	95%
P27131	Naegleria fowleri	72%	96%
P27132	Naegleria fowleri	67%	97%
P29751	Oryctolagus cuniculus	71%	96%
P30161	Costaria costata	71%	100%
P30162	Onchocerca volvulus	72%	96%
P30163	Onchocerca volvulus	73%	96%
P30164	Pisum sativum	72%	96%
P30165	Pisum sativum	72%	96%
P30167	Solanum tuberosum	73%	95%
P30168	Solanum tuberosum	73%	95%
P30169	Solanum tuberosum	67%	95%
P30171	Solanum tuberosum	72%	95%
P30172	Solanum tuberosum	72%	100%
P30173	Solanum tuberosum	73%	95%
P32381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	92%
P32390	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	84%
P32392	Drosophila melanogaster	37%	86%
P35432	Echinococcus granulosus	70%	96%
P38673	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	52%	95%
P38696	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	94%
P41112	Podocoryna carnea	71%	96%
P41113	Podocoryna carnea	71%	96%
P41339	Limulus polyphemus	72%	96%
P41340	Limulus polyphemus	71%	96%
P41341	Limulus polyphemus	72%	96%
P42023	Pneumocystis carinii	55%	94%
P42025	Homo sapiens	51%	96%
P42528	Dictyostelium discoideum	36%	86%
P43239	Pneumocystis carinii	70%	96%
P45520	Leishmania major	99%	96%
P45521	Procambarus clarkii	69%	100%
P45885	Bactrocera dorsalis	71%	96%
P45886	Bactrocera dorsalis	71%	96%
P45887	Bactrocera dorsalis	71%	96%
P45888	Drosophila melanogaster	43%	90%
P45889	Drosophila melanogaster	50%	96%
P45890	Drosophila melanogaster	27%	90%
P45891	Drosophila melanogaster	57%	96%
P46258	Pisum sativum	72%	95%
P47117	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	80%
P48465	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	73%	96%
P48975	Cricetulus griseus	71%	96%
P49055	Carassius auratus	71%	95%
P49128	Aedes aegypti	72%	96%
P49871	Manduca sexta	71%	96%
P50138	Puccinia graminis	73%	96%
P51775	Giardia intestinalis	59%	96%
P53455	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	70%	96%
P53456	Dibothriocephalus dendriticus	71%	96%
P53457	Dibothriocephalus dendriticus	73%	95%
P53458	Dibothriocephalus dendriticus	73%	97%
P53459	Dibothriocephalus dendriticus	73%	97%
P53460	Halocynthia roretzi	71%	95%
P53461	Halocynthia roretzi	71%	96%
P53463	Heliocidaris erythrogramma	72%	96%
P53464	Heliocidaris tuberculata	72%	96%
P53465	Lytechinus pictus	71%	96%
P53466	Lytechinus pictus	72%	96%
P53467	Molgula oculata	71%	95%
P53468	Oxytricha trifallax	64%	96%
P53469	Oxytricha trifallax	62%	96%
P53470	Schistosoma mansoni	73%	96%
P53471	Schistosoma mansoni	72%	96%
P53472	Strongylocentrotus purpuratus	71%	96%
P53473	Strongylocentrotus purpuratus	71%	96%
P53474	Strongylocentrotus purpuratus	71%	96%
P53475	Styela clava	70%	95%
P53476	Toxoplasma gondii	73%	96%
P53477	Trypanosoma cruzi	89%	96%
P53478	Gallus gallus	71%	96%
P53479	Cyprinus carpio	71%	95%
P53480	Takifugu rubripes	71%	95%
P53482	Takifugu rubripes	71%	95%
P53483	Takifugu rubripes	65%	96%
P53485	Takifugu rubripes	71%	96%
P53486	Takifugu rubripes	71%	96%
P53487	Acanthamoeba castellanii	46%	93%
P53488	Gallus gallus	44%	91%
P53489	Caenorhabditis elegans	45%	91%
P53490	Acanthamoeba castellanii	35%	84%
P53491	Acetabularia peniculus	69%	100%
P53492	Arabidopsis thaliana	74%	95%
P53494	Arabidopsis thaliana	73%	95%
P53496	Arabidopsis thaliana	73%	95%
P53497	Arabidopsis thaliana	73%	95%
P53498	Chlamydomonas reinhardtii	73%	95%
P53499	Chondrus crispus	64%	97%
P53500	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	69%	95%
P53501	Drosophila melanogaster	71%	96%
P53502	Fucus distichus	70%	96%
P53503	Oxytricha fallax	58%	100%
P53504	Sorghum bicolor	71%	95%
P53505	Xenopus laevis	71%	96%
P53506	Xenopus laevis	71%	96%
P53689	Phaffia rhodozyma	72%	96%
P55805	Sterkiella nova	63%	96%
P60009	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	73%	96%
P60010	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	73%	96%
P60011	Saccharomyces bayanus	73%	96%
P60706	Gallus gallus	71%	96%
P60707	Trichosurus vulpecula	71%	96%
P60708	Equus caballus	71%	96%
P60709	Homo sapiens	71%	96%
P60710	Mus musculus	71%	96%
P60711	Rattus norvegicus	71%	96%
P60712	Bos taurus	71%	96%
P60713	Ovis aries	71%	96%
P61157	Bos taurus	36%	86%
P61158	Homo sapiens	36%	86%
P61160	Homo sapiens	43%	91%
P61161	Mus musculus	43%	91%
P61162	Canis lupus familiaris	49%	96%
P61163	Homo sapiens	49%	96%
P61164	Mus musculus	49%	96%
P62736	Homo sapiens	71%	95%
P62737	Mus musculus	71%	95%
P62738	Rattus norvegicus	71%	95%
P62739	Bos taurus	71%	95%
P62740	Oryctolagus cuniculus	71%	95%
P63256	Anser anser anser	71%	96%
P63257	Trichosurus vulpecula	71%	96%
P63258	Bos taurus	71%	96%
P63259	Rattus norvegicus	71%	96%
P63260	Mus musculus	71%	96%
P63261	Homo sapiens	71%	96%
P63267	Homo sapiens	71%	96%
P63268	Mus musculus	71%	96%
P63269	Rattus norvegicus	71%	96%
P63270	Gallus gallus	71%	96%
P68032	Homo sapiens	71%	95%
P68033	Mus musculus	71%	95%
P68034	Gallus gallus	71%	95%
P68035	Rattus norvegicus	71%	95%
P68133	Homo sapiens	71%	95%
P68134	Mus musculus	71%	95%
P68135	Oryctolagus cuniculus	71%	95%
P68136	Rattus norvegicus	71%	95%
P68137	Sus scrofa	71%	95%
P68138	Bos taurus	71%	95%
P68139	Gallus gallus	71%	95%
P68140	Takifugu rubripes	71%	95%
P68142	Takifugu rubripes	71%	96%
P68143	Oreochromis mossambicus	71%	96%
P68264	Oreochromis mossambicus	71%	95%
P68555	Taenia solium	71%	96%
P68556	Dibothriocephalus dendriticus	71%	96%
P69002	Heliocidaris erythrogramma	71%	96%
P69003	Heliocidaris tuberculata	71%	96%
P69004	Mesocentrotus franciscanus	71%	96%
P69005	Strongylocentrotus purpuratus	71%	96%
P78711	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	71%	96%
P78712	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	82%
P79818	Oryzias latipes	71%	96%
P80428	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	74%
P81228	Solanum tuberosum	72%	100%
P81229	Solanum tuberosum	72%	100%
P83750	Cyprinus carpio	71%	96%
P83751	Ctenopharyngodon idella	71%	96%
P83967	Drosophila melanogaster	71%	96%
P83968	Drosophila simulans	71%	96%
P83969	Bactrocera dorsalis	71%	96%
P84183	Bombyx mori	72%	96%
P84184	Helicoverpa armigera	72%	96%
P84185	Anopheles gambiae	72%	96%
P84336	Camelus dromedarius	71%	96%
P84856	Chlorocebus pygerythrus	70%	100%
P85515	Rattus norvegicus	49%	96%
P86173	Rattus norvegicus	32%	85%
P86287	Plasmodium falciparum (isolate HB3)	72%	96%
P86288	Plasmodium falciparum (isolate HB3)	72%	96%
P90689	Brugia malayi	71%	96%
P91754	Lumbricus rubellus	70%	97%
P92176	Lumbricus terrestris	72%	96%
P92179	Biomphalaria glabrata	72%	96%
P92182	Lumbricus terrestris	70%	96%
P93371	Nicotiana tabacum	72%	100%
P93372	Nicotiana tabacum	72%	100%
P93373	Nicotiana tabacum	71%	100%
P93374	Nicotiana tabacum	71%	100%
P93375	Nicotiana tabacum	73%	100%
P93376	Nicotiana tabacum	72%	100%
P93584	Solanum tuberosum	72%	100%
P93585	Solanum tuberosum	71%	100%
P93586	Solanum tuberosum	72%	100%
P93587	Solanum tuberosum	72%	100%
P93738	Arabidopsis thaliana	59%	98%
Q00214	Styela plicata	70%	95%
Q00215	Styela plicata	70%	96%
Q03341	Echinococcus granulosus	71%	96%
Q03342	Echinococcus granulosus	71%	100%
Q05214	Nicotiana tabacum	73%	95%
Q07903	Strongylocentrotus purpuratus	71%	96%
Q09443	Caenorhabditis elegans	26%	86%
Q09849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	85%
Q0PGG4	Bos mutus grunniens	71%	96%
Q10AZ4	Oryza sativa subsp. japonica	73%	95%
Q10DV7	Oryza sativa subsp. japonica	73%	95%
Q12509	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	82%
Q25010	Helicoverpa armigera	72%	96%
Q25472	Molgula oculata	71%	95%
Q26065	Placopecten magellanicus	72%	96%
Q2T9W4	Bos taurus	39%	87%
Q2TA43	Bos taurus	48%	95%
Q2U7A3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	69%	96%
Q32KZ2	Bos taurus	43%	82%
Q32L91	Bos taurus	41%	86%
Q39758	Fucus vesiculosus	71%	96%
Q3ZBD2	Bos taurus	25%	86%
Q3ZC07	Bos taurus	71%	95%
Q4FX37	Leishmania major	25%	100%
Q4IPI4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	76%
Q4L0Y2	Spermophilus citellus	71%	96%
Q4P2E8	Ustilago maydis (strain 521 / FGSC 9021)	29%	67%
Q4Q187	Leishmania major	31%	100%
Q4QD95	Leishmania major	28%	100%
Q4QF44	Leishmania major	31%	100%
Q4QF49	Leishmania major	27%	100%
Q4QR76	Rattus norvegicus	43%	86%
Q4R317	Macaca fascicularis	47%	95%
Q4R333	Macaca fascicularis	33%	84%
Q4R561	Macaca fascicularis	71%	96%
Q4R6J9	Macaca fascicularis	49%	96%
Q4R6Q3	Macaca fascicularis	42%	83%
Q4R821	Macaca fascicularis	46%	96%
Q4V7C7	Rattus norvegicus	36%	86%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	77%
Q4WHA3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	77%
Q4YU79	Plasmodium berghei (strain Anka)	70%	96%
Q4Z1L3	Plasmodium berghei (strain Anka)	72%	96%
Q54GX7	Dictyostelium discoideum	71%	96%
Q54HE7	Dictyostelium discoideum	52%	100%
Q54HE9	Dictyostelium discoideum	51%	97%
Q54HF0	Dictyostelium discoideum	60%	94%
Q54HF1	Dictyostelium discoideum	61%	95%
Q54I79	Dictyostelium discoideum	52%	94%
Q54L54	Dictyostelium discoideum	48%	93%
Q553U6	Dictyostelium discoideum	71%	96%
Q554S6	Dictyostelium discoideum	63%	96%
Q55CU2	Dictyostelium discoideum	58%	96%
Q55EU6	Dictyostelium discoideum	71%	100%
Q562R1	Homo sapiens	69%	96%
Q56A35	Danio rerio	44%	91%
Q5AC48	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	77%
Q5AP59	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	81%
Q5AW89	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	76%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	75%
Q5BL41	Xenopus tropicalis	44%	91%
Q5E9B5	Bos taurus	71%	96%
Q5JAK2	Pelophylax lessonae	71%	96%
Q5JWF8	Homo sapiens	33%	100%
Q5M7U6	Rattus norvegicus	43%	91%
Q5NBI2	Oryza sativa subsp. japonica	27%	84%
Q5R1X3	Pan troglodytes	71%	96%
Q5R4K0	Pongo abelii	43%	91%
Q5R6G0	Pongo abelii	71%	96%
Q5R8R1	Pongo abelii	36%	86%
Q5R9Q5	Pongo abelii	71%	95%
Q5XIK1	Rattus norvegicus	46%	96%
Q5ZMQ2	Gallus gallus	71%	96%
Q61JZ2	Caenorhabditis briggsae	44%	92%
Q61WW9	Caenorhabditis briggsae	35%	85%
Q641P0	Mus musculus	35%	86%
Q641W9	Rattus norvegicus	44%	82%
Q6AY16	Rattus norvegicus	38%	88%
Q6BML9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	88%
Q6BXN0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	73%
Q6C061	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	83%
Q6C982	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	93%
Q6CJF4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	87%
Q6FKE7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	23%	86%
Q6K908	Oryza sativa subsp. japonica	33%	84%
Q6NVA9	Xenopus tropicalis	71%	96%
Q6P378	Xenopus tropicalis	71%	96%
Q6P640	Xenopus tropicalis	71%	95%
Q6P8G3	Xenopus tropicalis	71%	95%
Q6QAQ1	Sus scrofa	71%	96%
Q6TCF2	Gaeumannomyces avenae	71%	96%
Q6Z256	Oryza sativa subsp. japonica	40%	93%
Q6ZJW9	Oryza sativa subsp. japonica	35%	81%
Q711N9	Mesocricetus auratus	71%	96%
Q71FK5	Cavia porcellus	71%	96%
Q75D00	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	73%	96%
Q76N69	Chlorocebus aethiops	71%	96%
Q7RME1	Plasmodium yoelii yoelii	72%	96%
Q7RPB4	Plasmodium yoelii yoelii	71%	96%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	81%
Q7SHR0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	77%
Q7SXW6	Danio rerio	44%	91%
Q7XR80	Oryza sativa subsp. japonica	31%	74%
Q7ZTP2	Xenopus laevis	44%	91%
Q7ZVF9	Danio rerio	71%	96%
Q7ZVI7	Danio rerio	71%	96%
Q7ZXV3	Xenopus laevis	44%	91%
Q801P7	Xenopus laevis	36%	86%
Q84M92	Arabidopsis thaliana	35%	82%
Q8BFZ3	Mus musculus	69%	96%
Q8BXF8	Mus musculus	45%	98%
Q8CG27	Mus musculus	37%	87%
Q8I4X0	Plasmodium falciparum (isolate 3D7)	72%	96%
Q8ILW9	Plasmodium falciparum (isolate 3D7)	72%	96%
Q8JJB8	Triakis scyllium	71%	96%
Q8L4Y5	Arabidopsis thaliana	37%	99%
Q8LGE3	Arabidopsis thaliana	29%	86%
Q8R5C5	Mus musculus	51%	96%
Q8RYC2	Arabidopsis thaliana	70%	95%
Q8SWN8	Encephalitozoon cuniculi (strain GB-M1)	69%	96%
Q8TC94	Homo sapiens	37%	87%
Q8TDG2	Homo sapiens	47%	96%
Q8TDY3	Homo sapiens	47%	95%
Q8X119	Exophiala dermatitidis	70%	96%
Q90WD0	Gallus gallus	35%	86%
Q90X97	Atractaspis microlepidota microlepidota	71%	95%
Q91ZK5	Sigmodon hispidus	71%	96%
Q92192	Calanus finmarchicus	68%	100%
Q92193	Crassostrea virginica	70%	100%
Q93129	Branchiostoma belcheri	72%	96%
Q93130	Branchiostoma belcheri	68%	95%
Q93131	Branchiostoma floridae	72%	96%
Q93132	Branchiostoma floridae	68%	95%
Q95JK8	Macaca fascicularis	41%	87%
Q96292	Arabidopsis thaliana	71%	95%
Q96293	Arabidopsis thaliana	71%	95%
Q96481	Solanum lycopersicum	72%	100%
Q96482	Solanum lycopersicum	71%	100%
Q96483	Solanum lycopersicum	72%	100%
Q96484	Solanum lycopersicum	72%	100%
Q964D9	Planorbella trivolvis	71%	96%
Q964E0	Biomphalaria tenagophila	72%	96%
Q964E1	Biomphalaria obstructa	72%	96%
Q964E2	Biomphalaria pfeifferi	72%	96%
Q964E3	Biomphalaria alexandrina	72%	96%
Q98972	Oryzias latipes	71%	95%
Q99023	Hypocrea jecorina	69%	96%
Q99JY9	Mus musculus	36%	86%
Q99MR0	Mus musculus	32%	85%
Q9BYD9	Homo sapiens	46%	97%
Q9BYX7	Homo sapiens	67%	96%
Q9D864	Mus musculus	28%	91%
Q9D9J3	Mus musculus	46%	96%
Q9D9L5	Mus musculus	49%	95%
Q9DEE9	Gallus gallus	28%	91%
Q9FKT0	Arabidopsis thaliana	28%	76%
Q9GZN1	Homo sapiens	27%	91%
Q9H568	Homo sapiens	31%	98%
Q9LSD6	Arabidopsis thaliana	42%	93%
Q9N4I0	Caenorhabditis elegans	35%	85%
Q9NJV4	Naegleria pringsheimi	68%	96%
Q9NZ32	Homo sapiens	24%	86%
Q9P1U1	Homo sapiens	35%	86%
Q9P4D1	Komagataella phaffii (strain GS115 / ATCC 20864)	71%	96%
Q9P7X7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	83%
Q9QY83	Mus musculus	42%	86%
Q9QY84	Mus musculus	44%	82%
Q9QZB7	Mus musculus	24%	86%
Q9SAF1	Arabidopsis thaliana	35%	84%
Q9U1E8	Leishmania major	99%	100%
Q9URS0	Penicillium chrysogenum	70%	96%
Q9UUJ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	92%
Q9UVF3	Yarrowia lipolytica (strain CLIB 122 / E 150)	70%	96%
Q9UVW9	Acremonium chrysogenum	71%	96%
Q9UVX4	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	70%	96%
Q9UVZ8	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	72%	96%
Q9Y614	Homo sapiens	41%	87%
Q9Y615	Homo sapiens	42%	83%
Q9Y701	Suillus bovinus	70%	96%
Q9Y702	Schizophyllum commune	71%	96%
Q9Y707	Suillus bovinus	71%	96%
Q9Y896	Schizophyllum commune	70%	96%
Q9Z2N8	Mus musculus	32%	84%
V5AVP6	Trypanosoma cruzi	34%	100%
V5AW65	Trypanosoma cruzi	51%	92%
V5AZ19	Trypanosoma cruzi	36%	89%
V5BDL0	Trypanosoma cruzi	90%	96%
V5BPS6	Trypanosoma cruzi	27%	100%
V5BPT0	Trypanosoma cruzi	35%	87%
V5BRH8	Trypanosoma cruzi	23%	97%
V5BWS6	Trypanosoma cruzi	34%	94%
V5C0Q2	Trypanosoma cruzi	39%	92%
V5DJL3	Trypanosoma cruzi	31%	85%
V5DTX0	Trypanosoma cruzi	27%	100%