Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania mexicana

UniProt:

E9AKA2_LEIMU

TriTrypDb:

LmxM.04.1210

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016310	phosphorylation	5	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0004674	protein serine/threonine kinase activity	4	13
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.505
CLV_C14_Caspase3-7	340	344	PF00656	0.665
CLV_NRD_NRD_1	207	209	PF00675	0.304
CLV_NRD_NRD_1	240	242	PF00675	0.345
CLV_PCSK_KEX2_1	207	209	PF00082	0.304
CLV_PCSK_SKI1_1	13	17	PF00082	0.492
CLV_PCSK_SKI1_1	143	147	PF00082	0.299
CLV_PCSK_SKI1_1	180	184	PF00082	0.381
CLV_PCSK_SKI1_1	186	190	PF00082	0.363
CLV_PCSK_SKI1_1	19	23	PF00082	0.469
CLV_PCSK_SKI1_1	345	349	PF00082	0.623
DEG_APCC_DBOX_1	18	26	PF00400	0.434
DEG_APCC_DBOX_1	207	215	PF00400	0.352
DEG_SPOP_SBC_1	2	6	PF00917	0.497
DOC_CKS1_1	71	76	PF01111	0.363
DOC_USP7_MATH_1	2	6	PF00917	0.671
DOC_USP7_UBL2_3	24	28	PF12436	0.394
DOC_USP7_UBL2_3	72	76	PF12436	0.416
DOC_WW_Pin1_4	275	280	PF00397	0.437
DOC_WW_Pin1_4	293	298	PF00397	0.361
DOC_WW_Pin1_4	70	75	PF00397	0.332
LIG_14-3-3_CanoR_1	115	119	PF00244	0.337
LIG_14-3-3_CanoR_1	193	198	PF00244	0.300
LIG_14-3-3_CanoR_1	316	325	PF00244	0.721
LIG_14-3-3_CanoR_1	56	60	PF00244	0.409
LIG_Actin_WH2_2	106	121	PF00022	0.284
LIG_BRCT_BRCA1_1	168	172	PF00533	0.345
LIG_BRCT_BRCA1_1	57	61	PF00533	0.416
LIG_FHA_1	119	125	PF00498	0.274
LIG_FHA_1	21	27	PF00498	0.345
LIG_FHA_2	2	8	PF00498	0.494
LIG_GBD_Chelix_1	124	132	PF00786	0.228
LIG_Integrin_isoDGR_2	54	56	PF01839	0.345
LIG_LIR_Gen_1	249	260	PF02991	0.468
LIG_LIR_Nem_3	191	197	PF02991	0.304
LIG_LIR_Nem_3	249	255	PF02991	0.474
LIG_LIR_Nem_3	33	38	PF02991	0.333
LIG_LIR_Nem_3	91	97	PF02991	0.284
LIG_NRBOX	21	27	PF00104	0.300
LIG_Pex14_2	16	20	PF04695	0.386
LIG_Pex14_2	162	166	PF04695	0.416
LIG_PTB_Apo_2	156	163	PF02174	0.416
LIG_REV1ctd_RIR_1	18	28	PF16727	0.293
LIG_SH2_CRK	252	256	PF00017	0.462
LIG_SH2_CRK	35	39	PF00017	0.300
LIG_SH2_CRK	94	98	PF00017	0.343
LIG_SH2_NCK_1	35	39	PF00017	0.416
LIG_SH2_PTP2	216	219	PF00017	0.300
LIG_SH2_SRC	134	137	PF00017	0.433
LIG_SH2_STAP1	269	273	PF00017	0.357
LIG_SH2_STAT3	87	90	PF00017	0.300
LIG_SH2_STAT5	134	137	PF00017	0.355
LIG_SH2_STAT5	140	143	PF00017	0.308
LIG_SH2_STAT5	187	190	PF00017	0.426
LIG_SH2_STAT5	216	219	PF00017	0.306
LIG_SH2_STAT5	303	306	PF00017	0.521
LIG_SH2_STAT5	87	90	PF00017	0.318
LIG_SH3_4	313	320	PF00018	0.625
LIG_TYR_ITIM	214	219	PF00017	0.284
LIG_TYR_ITIM	250	255	PF00017	0.480
MOD_CDK_SPK_2	293	298	PF00069	0.426
MOD_CDK_SPxK_1	70	76	PF00069	0.376
MOD_CK1_1	117	123	PF00069	0.293
MOD_CK1_1	196	202	PF00069	0.304
MOD_CK1_1	318	324	PF00069	0.692
MOD_CK2_1	1	7	PF00069	0.501
MOD_CK2_1	127	133	PF00069	0.265
MOD_CK2_1	234	240	PF00069	0.345
MOD_CK2_1	293	299	PF00069	0.522
MOD_CK2_1	318	324	PF00069	0.495
MOD_CK2_1	38	44	PF00069	0.300
MOD_GlcNHglycan	228	231	PF01048	0.300
MOD_GlcNHglycan	235	239	PF01048	0.300
MOD_GlcNHglycan	309	312	PF01048	0.412
MOD_GlcNHglycan	339	342	PF01048	0.630
MOD_GlcNHglycan	79	82	PF01048	0.390
MOD_GSK3_1	114	121	PF00069	0.267
MOD_GSK3_1	189	196	PF00069	0.313
MOD_GSK3_1	287	294	PF00069	0.400
MOD_GSK3_1	77	84	PF00069	0.402
MOD_N-GLC_1	307	312	PF02516	0.502
MOD_NEK2_1	118	123	PF00069	0.286
MOD_NEK2_1	166	171	PF00069	0.290
MOD_NEK2_1	188	193	PF00069	0.305
MOD_NEK2_1	20	25	PF00069	0.406
MOD_NEK2_1	250	255	PF00069	0.408
MOD_NEK2_1	287	292	PF00069	0.343
MOD_NEK2_1	351	356	PF00069	0.604
MOD_NEK2_1	97	102	PF00069	0.273
MOD_NEK2_2	114	119	PF00069	0.284
MOD_NEK2_2	81	86	PF00069	0.345
MOD_PIKK_1	201	207	PF00454	0.300
MOD_PIKK_1	250	256	PF00454	0.402
MOD_PK_1	193	199	PF00069	0.386
MOD_PKA_2	114	120	PF00069	0.319
MOD_PKA_2	297	303	PF00069	0.419
MOD_PKA_2	315	321	PF00069	0.698
MOD_PKA_2	55	61	PF00069	0.416
MOD_Plk_1	248	254	PF00069	0.455
MOD_Plk_4	11	17	PF00069	0.483
MOD_Plk_4	118	124	PF00069	0.267
MOD_Plk_4	287	293	PF00069	0.361
MOD_Plk_4	55	61	PF00069	0.416
MOD_ProDKin_1	275	281	PF00069	0.432
MOD_ProDKin_1	293	299	PF00069	0.357
MOD_ProDKin_1	70	76	PF00069	0.332
MOD_SUMO_for_1	48	51	PF00179	0.333
MOD_SUMO_rev_2	235	243	PF00179	0.406
MOD_SUMO_rev_2	340	347	PF00179	0.603
TRG_ENDOCYTIC_2	216	219	PF00928	0.284
TRG_ENDOCYTIC_2	252	255	PF00928	0.459
TRG_ENDOCYTIC_2	35	38	PF00928	0.300
TRG_ENDOCYTIC_2	94	97	PF00928	0.373
TRG_ER_diArg_1	222	225	PF00400	0.375
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	27%	66%
A0A0N0P3F5	Leptomonas seymouri	34%	100%
A0A0N1HU44	Leptomonas seymouri	35%	100%
A0A0N1HU45	Leptomonas seymouri	37%	95%
A0A0N1I2H3	Leptomonas seymouri	85%	100%
A0A0S4IVY6	Bodo saltans	37%	89%
A0A0S4JA30	Bodo saltans	35%	100%
A0A0S4JN06	Bodo saltans	36%	100%
A0A0S4JP58	Bodo saltans	40%	86%
A0A0S4JXJ0	Bodo saltans	53%	100%
A0A1X0NIT3	Trypanosomatidae	35%	100%
A0A1X0NXJ1	Trypanosomatidae	56%	100%
A0A1X0NZS9	Trypanosomatidae	36%	83%
A0A1X0P176	Trypanosomatidae	35%	95%
A0A3Q8IJ66	Leishmania donovani	35%	100%
A0A3Q8ISA0	Leishmania donovani	35%	98%
A0A3R7NLI6	Trypanosoma rangeli	24%	100%
A0A3S5H6C8	Leishmania donovani	23%	77%
A0A3S7WNZ6	Leishmania donovani	96%	100%
A0A3S7WQK7	Leishmania donovani	23%	78%
A0A3S7WZA2	Leishmania donovani	33%	71%
A0A3S7X8X3	Leishmania donovani	37%	100%
A0A422MSV5	Trypanosoma rangeli	61%	100%
A0A422N5C9	Trypanosoma rangeli	36%	100%
A0A422NL83	Trypanosoma rangeli	35%	93%
A0A509AHB6	Plasmodium berghei (strain Anka)	26%	70%
A0JNB0	Bos taurus	22%	69%
A1Y2K1	Sus scrofa	23%	69%
A4H436	Leishmania braziliensis	89%	100%
A4HEI6	Leishmania braziliensis	31%	100%
A4HIT6	Leishmania braziliensis	39%	100%
A4HMD0	Leishmania braziliensis	37%	100%
A4HMD1	Leishmania braziliensis	35%	100%
A4HSC0	Leishmania infantum	96%	100%
A4HTV4	Leishmania infantum	23%	78%
A4HTV5	Leishmania infantum	23%	77%
A4I1K4	Leishmania infantum	33%	71%
A4I638	Leishmania infantum	35%	98%
A4IAZ7	Leishmania infantum	37%	100%
A4IAZ8	Leishmania infantum	35%	100%
A7E3X2	Bos taurus	34%	81%
B9VVJ6	Trypanosoma brucei brucei	37%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	92%
C9ZNJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZNJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A1R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
D0A9B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	79%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	88%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	87%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	94%
E9B5Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
F1RDG9	Danio rerio	23%	68%
O15726	Plasmodium falciparum (isolate Dd2)	35%	100%
O57252	Vaccinia virus (strain Ankara)	31%	100%
O74135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	84%
O76324	Drosophila melanogaster	38%	84%
O96017	Homo sapiens	27%	68%
O96999	Leishmania major	95%	100%
P00527	Avian sarcoma virus (strain Y73)	22%	70%
P06240	Mus musculus	25%	72%
P06241	Homo sapiens	22%	69%
P09324	Gallus gallus	22%	68%
P10936	Xenopus laevis	22%	69%
P13406	Xenopus laevis	23%	69%
P16913	Vaccinia virus (strain Western Reserve)	31%	100%
P17713	Hydra vulgaris	26%	72%
P20505	Vaccinia virus (strain Copenhagen)	31%	100%
P23291	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	68%
P23292	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	67%
P26794	Rattus norvegicus	23%	100%
P27446	Xiphophorus helleri	23%	69%
P29295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	74%
P33800	Variola virus (isolate Human/India/Ind3/1967)	30%	100%
P34516	Caenorhabditis elegans	31%	100%
P35507	Bos taurus	39%	100%
P35508	Bos taurus	37%	89%
P35509	Bos taurus	37%	100%
P39688	Mus musculus	23%	69%
P39962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	70%
P40230	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	69%
P40233	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	83%
P40234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	85%
P40235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P40236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	92%
P42158	Arabidopsis thaliana	36%	82%
P42168	Caenorhabditis elegans	36%	100%
P42169	Caenorhabditis elegans	29%	100%
P42685	Homo sapiens	26%	73%
P42686	Spongilla lacustris	21%	73%
P42689	Spongilla lacustris	24%	100%
P48729	Homo sapiens	38%	100%
P48730	Homo sapiens	37%	89%
P49674	Homo sapiens	37%	88%
P54367	Drosophila melanogaster	35%	100%
P54735	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	73%
P54739	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	68%
P62345	Plasmodium berghei (strain Anka)	26%	70%
P67827	Bos taurus	38%	100%
P67828	Oryctolagus cuniculus	38%	100%
P67829	Ovis aries	38%	100%
P67962	Gallus gallus	38%	100%
P67963	Xenopus laevis	38%	100%
P78368	Homo sapiens	34%	89%
P97633	Rattus norvegicus	37%	100%
Q01621	Rattus norvegicus	24%	72%
Q05876	Gallus gallus	21%	69%
Q06486	Rattus norvegicus	37%	89%
Q0JI49	Oryza sativa subsp. japonica	23%	73%
Q20471	Caenorhabditis elegans	39%	74%
Q2YDN8	Bos taurus	24%	82%
Q32PI1	Bos taurus	34%	93%
Q39050	Arabidopsis thaliana	36%	81%
Q4Q6U1	Leishmania major	35%	100%
Q4Q9T3	Leishmania major	34%	73%
Q4QHY3	Leishmania major	23%	89%
Q4QHY4	Leishmania major	23%	87%
Q4R9A9	Macaca fascicularis	34%	97%
Q54DF7	Dictyostelium discoideum	30%	74%
Q556Y4	Dictyostelium discoideum	39%	86%
Q5BP74	Xenopus laevis	38%	89%
Q5PRD4	Danio rerio	35%	87%
Q5R4V3	Pongo abelii	35%	81%
Q5RC72	Pongo abelii	37%	89%
Q5XF24	Arabidopsis thaliana	36%	79%
Q5ZJS0	Gallus gallus	35%	81%
Q5ZLL1	Gallus gallus	37%	88%
Q62662	Rattus norvegicus	25%	73%
Q62761	Rattus norvegicus	34%	94%
Q62762	Rattus norvegicus	36%	89%
Q62763	Rattus norvegicus	35%	82%
Q62844	Rattus norvegicus	22%	69%
Q66I46	Xenopus tropicalis	23%	79%
Q6EWH2	Danio rerio	23%	69%
Q6K9N1	Oryza sativa subsp. japonica	36%	79%
Q6NRT0	Xenopus laevis	36%	80%
Q6P3K7	Danio rerio	38%	90%
Q6P431	Xenopus laevis	23%	79%
Q6P647	Xenopus tropicalis	38%	89%
Q6QNL9	Eimeria tenella	38%	100%
Q6QNM1	Toxoplasma gondii	35%	100%
Q7RAH3	Plasmodium yoelii yoelii	26%	69%
Q7RBX5	Plasmodium yoelii yoelii	36%	100%
Q7RJG2	Plasmodium yoelii yoelii	26%	70%
Q7T2E3	Danio rerio	38%	91%
Q7ZUS1	Danio rerio	27%	87%
Q80X41	Mus musculus	28%	84%
Q86Y07	Homo sapiens	29%	72%
Q8BK63	Mus musculus	38%	100%
Q8BN21	Mus musculus	28%	73%
Q8BTH8	Mus musculus	35%	80%
Q8BVP5	Mus musculus	36%	89%
Q8C4X2	Mus musculus	34%	87%
Q8IBS5	Plasmodium falciparum (isolate 3D7)	26%	70%
Q8IHZ9	Plasmodium falciparum (isolate 3D7)	36%	100%
Q8IV63	Homo sapiens	26%	78%
Q8K3G5	Mus musculus	26%	81%
Q8LPI7	Arabidopsis thaliana	36%	89%
Q8LPJ1	Arabidopsis thaliana	38%	77%
Q8N752	Homo sapiens	37%	100%
Q8SQR2	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8SS96	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8VYK9	Arabidopsis thaliana	36%	85%
Q8WQ99	Caenorhabditis elegans	39%	90%
Q91FD5	Invertebrate iridescent virus 6	29%	90%
Q922K9	Mus musculus	26%	72%
Q93Z18	Arabidopsis thaliana	36%	89%
Q95LJ0	Felis catus	23%	100%
Q95PZ9	Caenorhabditis elegans	29%	97%
Q99986	Homo sapiens	29%	93%
Q9CAI5	Arabidopsis thaliana	35%	79%
Q9D411	Mus musculus	27%	100%
Q9DC28	Mus musculus	37%	89%
Q9FFH8	Arabidopsis thaliana	38%	77%
Q9HCP0	Homo sapiens	34%	87%
Q9J509	Fowlpox virus (strain NVSL)	27%	100%
Q9J523	Fowlpox virus (strain NVSL)	28%	100%
Q9JMK2	Mus musculus	37%	88%
Q9LSX4	Arabidopsis thaliana	37%	77%
Q9LW62	Arabidopsis thaliana	35%	83%
Q9NHE1	Leishmania major	33%	100%
Q9NHE2	Leishmania major	38%	100%
Q9Y6M4	Homo sapiens	35%	82%
Q9Z265	Mus musculus	26%	67%
Q9ZUP4	Arabidopsis thaliana	37%	85%
Q9ZWB3	Arabidopsis thaliana	37%	78%
V5AIW9	Trypanosoma cruzi	61%	100%
V5BMQ3	Trypanosoma cruzi	37%	92%