Putative tRNA nucleotidyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA nucleotidyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AKA0_LEIMU

TriTrypDb:

LmxM.04.1190

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AKA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKA0

Function

Biological processes
Term	Name	Level	Count
GO:0001680	tRNA 3'-terminal CCA addition	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0031123	RNA 3'-end processing	7	12
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	11
GO:0042780	tRNA 3'-end processing	8	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071076	RNA 3' uridylation	8	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0050265	RNA uridylyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	3
GO:0004810	CCA tRNA nucleotidyltransferase activity	8	3
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	9	3
GO:0070566	adenylyltransferase activity	5	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:1990817	poly(A) RNA polymerase activity	7	3
GO:0052927	CTP:tRNA cytidylyltransferase activity	5	2
GO:0070567	cytidylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.247
CLV_NRD_NRD_1	374	376	PF00675	0.360
CLV_PCSK_KEX2_1	146	148	PF00082	0.247
CLV_PCSK_KEX2_1	301	303	PF00082	0.514
CLV_PCSK_KEX2_1	374	376	PF00082	0.359
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.514
CLV_PCSK_SKI1_1	147	151	PF00082	0.283
CLV_PCSK_SKI1_1	416	420	PF00082	0.391
CLV_PCSK_SKI1_1	44	48	PF00082	0.268
CLV_PCSK_SKI1_1	501	505	PF00082	0.451
CLV_PCSK_SKI1_1	66	70	PF00082	0.330
DEG_APCC_DBOX_1	419	427	PF00400	0.440
DEG_APCC_DBOX_1	43	51	PF00400	0.481
DEG_MDM2_SWIB_1	452	459	PF02201	0.492
DOC_CKS1_1	507	512	PF01111	0.322
DOC_MAPK_gen_1	236	246	PF00069	0.477
DOC_MAPK_gen_1	301	309	PF00069	0.489
DOC_MAPK_gen_1	31	38	PF00069	0.507
DOC_MAPK_gen_1	399	406	PF00069	0.517
DOC_MAPK_gen_1	497	504	PF00069	0.470
DOC_MAPK_MEF2A_6	110	118	PF00069	0.538
DOC_MAPK_MEF2A_6	331	338	PF00069	0.463
DOC_MAPK_MEF2A_6	420	429	PF00069	0.406
DOC_MAPK_MEF2A_6	497	504	PF00069	0.472
DOC_MAPK_NFAT4_5	497	505	PF00069	0.460
DOC_MAPK_RevD_3	266	280	PF00069	0.578
DOC_PP1_RVXF_1	195	202	PF00149	0.322
DOC_PP2B_LxvP_1	339	342	PF13499	0.322
DOC_PP2B_LxvP_1	363	366	PF13499	0.384
DOC_PP2B_LxvP_1	471	474	PF13499	0.529
DOC_USP7_MATH_1	15	19	PF00917	0.458
DOC_USP7_MATH_1	297	301	PF00917	0.547
DOC_USP7_MATH_1	366	370	PF00917	0.300
DOC_USP7_UBL2_3	239	243	PF12436	0.492
DOC_USP7_UBL2_3	401	405	PF12436	0.204
DOC_USP7_UBL2_3	478	482	PF12436	0.510
DOC_USP7_UBL2_3	497	501	PF12436	0.454
DOC_WW_Pin1_4	10	15	PF00397	0.320
DOC_WW_Pin1_4	506	511	PF00397	0.519
LIG_14-3-3_CanoR_1	185	189	PF00244	0.498
LIG_14-3-3_CanoR_1	308	315	PF00244	0.434
LIG_14-3-3_CanoR_1	399	404	PF00244	0.374
LIG_14-3-3_CanoR_1	76	82	PF00244	0.498
LIG_14-3-3_CanoR_1	87	92	PF00244	0.456
LIG_Actin_WH2_2	17	35	PF00022	0.473
LIG_Actin_WH2_2	488	503	PF00022	0.511
LIG_APCC_ABBA_1	293	298	PF00400	0.522
LIG_Clathr_ClatBox_1	5	9	PF01394	0.528
LIG_FHA_1	104	110	PF00498	0.495
LIG_FHA_1	158	164	PF00498	0.454
LIG_FHA_1	165	171	PF00498	0.446
LIG_FHA_1	215	221	PF00498	0.431
LIG_FHA_1	33	39	PF00498	0.328
LIG_FHA_1	346	352	PF00498	0.472
LIG_FHA_1	491	497	PF00498	0.424
LIG_FHA_1	63	69	PF00498	0.515
LIG_FHA_1	88	94	PF00498	0.444
LIG_FHA_2	166	172	PF00498	0.467
LIG_FHA_2	185	191	PF00498	0.243
LIG_FHA_2	507	513	PF00498	0.507
LIG_LIR_Gen_1	117	126	PF02991	0.435
LIG_LIR_Gen_1	18	28	PF02991	0.426
LIG_LIR_Gen_1	240	248	PF02991	0.496
LIG_LIR_Gen_1	378	388	PF02991	0.426
LIG_LIR_Gen_1	453	464	PF02991	0.438
LIG_LIR_Nem_3	117	121	PF02991	0.435
LIG_LIR_Nem_3	18	23	PF02991	0.420
LIG_LIR_Nem_3	378	383	PF02991	0.402
LIG_LIR_Nem_3	453	459	PF02991	0.437
LIG_OCRL_FandH_1	154	166	PF00620	0.515
LIG_Pex14_2	452	456	PF04695	0.496
LIG_REV1ctd_RIR_1	341	349	PF16727	0.511
LIG_SH2_CRK	484	488	PF00017	0.554
LIG_SH2_STAT5	126	129	PF00017	0.457
LIG_SH2_STAT5	166	169	PF00017	0.468
LIG_SH3_3	134	140	PF00018	0.460
LIG_SH3_3	178	184	PF00018	0.489
LIG_SH3_3	309	315	PF00018	0.443
LIG_SH3_3	500	506	PF00018	0.465
LIG_SUMO_SIM_anti_2	221	229	PF11976	0.479
LIG_SUMO_SIM_anti_2	90	95	PF11976	0.440
LIG_SUMO_SIM_par_1	265	270	PF11976	0.506
LIG_SUMO_SIM_par_1	461	467	PF11976	0.491
LIG_TYR_ITIM	428	433	PF00017	0.441
LIG_UBA3_1	224	231	PF00899	0.402
LIG_UBA3_1	495	501	PF00899	0.473
MOD_CK1_1	215	221	PF00069	0.428
MOD_CK1_1	450	456	PF00069	0.493
MOD_CK2_1	165	171	PF00069	0.468
MOD_CK2_1	208	214	PF00069	0.484
MOD_CK2_1	347	353	PF00069	0.433
MOD_Cter_Amidation	277	280	PF01082	0.627
MOD_GlcNHglycan	309	312	PF01048	0.429
MOD_GlcNHglycan	434	438	PF01048	0.468
MOD_GlcNHglycan	441	444	PF01048	0.434
MOD_GSK3_1	120	127	PF00069	0.478
MOD_GSK3_1	208	215	PF00069	0.410
MOD_GSK3_1	347	354	PF00069	0.497
MOD_GSK3_1	446	453	PF00069	0.489
MOD_GSK3_1	58	65	PF00069	0.486
MOD_GSK3_1	85	92	PF00069	0.474
MOD_N-GLC_1	208	213	PF02516	0.421
MOD_N-GLC_1	450	455	PF02516	0.315
MOD_N-GLC_2	357	359	PF02516	0.475
MOD_NEK2_1	212	217	PF00069	0.343
MOD_NEK2_1	267	272	PF00069	0.424
MOD_NEK2_1	307	312	PF00069	0.387
MOD_NEK2_1	32	37	PF00069	0.475
MOD_NEK2_1	439	444	PF00069	0.340
MOD_NEK2_2	15	20	PF00069	0.416
MOD_NEK2_2	394	399	PF00069	0.547
MOD_PKA_2	184	190	PF00069	0.418
MOD_PKA_2	307	313	PF00069	0.488
MOD_PKA_2	75	81	PF00069	0.498
MOD_Plk_1	147	153	PF00069	0.457
MOD_Plk_1	208	214	PF00069	0.420
MOD_Plk_1	220	226	PF00069	0.423
MOD_Plk_1	351	357	PF00069	0.524
MOD_Plk_2-3	347	353	PF00069	0.263
MOD_Plk_4	15	21	PF00069	0.458
MOD_Plk_4	184	190	PF00069	0.449
MOD_Plk_4	220	226	PF00069	0.378
MOD_Plk_4	267	273	PF00069	0.473
MOD_Plk_4	302	308	PF00069	0.472
MOD_Plk_4	399	405	PF00069	0.305
MOD_Plk_4	491	497	PF00069	0.492
MOD_Plk_4	89	95	PF00069	0.467
MOD_ProDKin_1	10	16	PF00069	0.311
MOD_ProDKin_1	506	512	PF00069	0.519
TRG_DiLeu_BaEn_1	435	440	PF01217	0.371
TRG_DiLeu_BaEn_1	461	466	PF01217	0.500
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.367
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.468
TRG_ENDOCYTIC_2	380	383	PF00928	0.389
TRG_ENDOCYTIC_2	430	433	PF00928	0.363
TRG_ER_diArg_1	173	176	PF00400	0.519
TRG_ER_diArg_1	373	375	PF00400	0.377
TRG_NES_CRM1_1	285	298	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUG7	Leptomonas seymouri	68%	99%
A0A0S4JS32	Bodo saltans	33%	100%
A0A0S4JSB5	Bodo saltans	46%	100%
A0A1X0NL45	Trypanosomatidae	47%	99%
A0A3S7WNX9	Leishmania donovani	93%	100%
A0A422NNU3	Trypanosoma rangeli	47%	100%
A0KPN1	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	25%	100%
A1AFX8	Escherichia coli O1:K1 / APEC	24%	100%
A4H434	Leishmania braziliensis	84%	100%
A4HSB8	Leishmania infantum	94%	100%
A4SIG1	Aeromonas salmonicida (strain A449)	25%	100%
A5UCK0	Haemophilus influenzae (strain PittEE)	25%	100%
A5UJ23	Haemophilus influenzae (strain PittGG)	25%	100%
A7ZRT7	Escherichia coli O139:H28 (strain E24377A / ETEC)	25%	100%
A8A4L0	Escherichia coli O9:H4 (strain HS)	24%	100%
A8APT7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	24%	100%
A9MPV9	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	25%	100%
A9N5Y2	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	25%	100%
B1IRR0	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	24%	100%
B1LF48	Escherichia coli (strain SMS-3-5 / SECEC)	24%	100%
B1XG61	Escherichia coli (strain K12 / DH10B)	24%	100%
B2U1G0	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	25%	100%
B4T674	Salmonella newport (strain SL254)	25%	100%
B4TI55	Salmonella heidelberg (strain SL476)	25%	100%
B4TVT8	Salmonella schwarzengrund (strain CVM19633)	25%	100%
B5BG15	Salmonella paratyphi A (strain AKU_12601)	24%	100%
B5F6A0	Salmonella agona (strain SL483)	25%	100%
B5FHT9	Salmonella dublin (strain CT_02021853)	25%	100%
B5QZ40	Salmonella enteritidis PT4 (strain P125109)	25%	100%
B5REG2	Salmonella gallinarum (strain 287/91 / NCTC 13346)	25%	100%
B5YR96	Escherichia coli O157:H7 (strain EC4115 / EHEC)	25%	100%
B6I427	Escherichia coli (strain SE11)	24%	100%
B7LGZ2	Escherichia coli (strain 55989 / EAEC)	25%	100%
B7LQD4	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	24%	100%
B7LZK6	Escherichia coli O8 (strain IAI1)	25%	100%
B7MAD3	Escherichia coli O45:K1 (strain S88 / ExPEC)	24%	100%
B7N0K6	Escherichia coli O81 (strain ED1a)	24%	100%
B7ND45	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	24%	100%
B7NJR9	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	24%	100%
B7UIW4	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	25%	100%
C0PYX7	Salmonella paratyphi C (strain RKS4594)	25%	100%
C1DAG2	Laribacter hongkongensis (strain HLHK9)	28%	100%
C4ZQX3	Escherichia coli (strain K12 / MC4100 / BW2952)	24%	100%
C9ZYB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
O97001	Leishmania major	94%	100%
P06961	Escherichia coli (strain K12)	24%	100%
P45269	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	100%
Q0T0K7	Shigella flexneri serotype 5b (strain 8401)	25%	100%
Q0TD50	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	24%	100%
Q1R6S5	Escherichia coli (strain UTI89 / UPEC)	24%	100%
Q31WX9	Shigella boydii serotype 4 (strain Sb227)	25%	100%
Q32BQ8	Shigella dysenteriae serotype 1 (strain Sd197)	25%	100%
Q3YXI6	Shigella sonnei (strain Ss046)	25%	100%
Q57JQ5	Salmonella choleraesuis (strain SC-B67)	25%	100%
Q5P3T0	Aromatoleum aromaticum (strain EbN1)	25%	100%
Q5PC82	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	24%	100%
Q821A6	Shigella flexneri	25%	100%
Q8CXX6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
Q8XBL4	Escherichia coli O157:H7	25%	100%
Q8Z3M9	Salmonella typhi	27%	100%
Q8ZLY4	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
V5BI79	Trypanosoma cruzi	47%	99%