Putative cytochrome c oxidase assembly factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly factor, putative

Species:

Leishmania mexicana

UniProt:

E9AK94_LEIMU

TriTrypDb:

LmxM.04.1130

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	16
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AK94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK94

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	10
GO:0006875	obsolete intracellular metal ion homeostasis	6	10
GO:0006878	intracellular copper ion homeostasis	8	10
GO:0008535	respiratory chain complex IV assembly	7	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0017004	cytochrome complex assembly	6	11
GO:0019725	cellular homeostasis	2	10
GO:0022607	cellular component assembly	4	11
GO:0030003	intracellular monoatomic cation homeostasis	5	10
GO:0042592	homeostatic process	3	10
GO:0043933	protein-containing complex organization	4	11
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	10
GO:0048878	chemical homeostasis	4	10
GO:0050801	monoatomic ion homeostasis	5	10
GO:0055065	obsolete metal ion homeostasis	7	10
GO:0055070	copper ion homeostasis	9	10
GO:0055076	obsolete transition metal ion homeostasis	8	10
GO:0055080	monoatomic cation homeostasis	6	10
GO:0055082	intracellular chemical homeostasis	3	10
GO:0065003	protein-containing complex assembly	5	11
GO:0065007	biological regulation	1	10
GO:0065008	regulation of biological quality	2	10
GO:0071840	cellular component organization or biogenesis	2	11
GO:0098771	inorganic ion homeostasis	6	10
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005507	copper ion binding	6	10
GO:0016530	metallochaperone activity	2	10
GO:0016531	copper chaperone activity	3	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0140104	molecular carrier activity	1	10
GO:0003824	catalytic activity	1	4
GO:0016491	oxidoreductase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.431
CLV_NRD_NRD_1	21	23	PF00675	0.395
CLV_NRD_NRD_1	48	50	PF00675	0.529
CLV_PCSK_KEX2_1	194	196	PF00082	0.486
CLV_PCSK_KEX2_1	21	23	PF00082	0.395
CLV_PCSK_KEX2_1	48	50	PF00082	0.522
CLV_PCSK_SKI1_1	121	125	PF00082	0.523
CLV_PCSK_SKI1_1	274	278	PF00082	0.558
CLV_PCSK_SKI1_1	48	52	PF00082	0.493
CLV_PCSK_SKI1_1	99	103	PF00082	0.601
DEG_APCC_DBOX_1	194	202	PF00400	0.206
DOC_CKS1_1	216	221	PF01111	0.206
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.206
DOC_MAPK_DCC_7	179	189	PF00069	0.206
DOC_PP1_RVXF_1	260	267	PF00149	0.252
DOC_USP7_MATH_1	108	112	PF00917	0.386
DOC_USP7_MATH_1	225	229	PF00917	0.206
DOC_USP7_MATH_1	25	29	PF00917	0.588
DOC_USP7_MATH_1	35	39	PF00917	0.555
DOC_WW_Pin1_4	215	220	PF00397	0.228
DOC_WW_Pin1_4	39	44	PF00397	0.729
LIG_14-3-3_CanoR_1	113	117	PF00244	0.397
LIG_14-3-3_CanoR_1	12	20	PF00244	0.596
LIG_14-3-3_CanoR_1	167	175	PF00244	0.325
LIG_AP2alpha_1	263	267	PF02296	0.239
LIG_BRCT_BRCA1_1	145	149	PF00533	0.236
LIG_DCNL_PONY_1	1	4	PF03556	0.506
LIG_deltaCOP1_diTrp_1	290	296	PF00928	0.281
LIG_FHA_1	275	281	PF00498	0.264
LIG_FHA_2	131	137	PF00498	0.219
LIG_LIR_Gen_1	146	154	PF02991	0.236
LIG_LIR_Gen_1	202	212	PF02991	0.246
LIG_LIR_Gen_1	71	82	PF02991	0.492
LIG_LIR_Nem_3	146	152	PF02991	0.209
LIG_LIR_Nem_3	15	20	PF02991	0.585
LIG_LIR_Nem_3	202	207	PF02991	0.227
LIG_LIR_Nem_3	211	215	PF02991	0.220
LIG_LIR_Nem_3	228	232	PF02991	0.223
LIG_LIR_Nem_3	71	77	PF02991	0.638
LIG_Pex14_1	147	151	PF04695	0.236
LIG_Pex14_2	143	147	PF04695	0.206
LIG_Pex14_2	150	154	PF04695	0.206
LIG_Pex14_2	208	212	PF04695	0.206
LIG_Pex14_2	263	267	PF04695	0.239
LIG_REV1ctd_RIR_1	264	274	PF16727	0.266
LIG_SH2_CRK	233	237	PF00017	0.209
LIG_SH2_CRK	80	84	PF00017	0.278
LIG_SH2_NCK_1	233	237	PF00017	0.206
LIG_SH2_STAT5	105	108	PF00017	0.361
LIG_SH2_STAT5	151	154	PF00017	0.240
LIG_SH2_STAT5	204	207	PF00017	0.236
LIG_SH2_STAT5	246	249	PF00017	0.236
LIG_SH3_3	204	210	PF00018	0.256
LIG_SH3_3	213	219	PF00018	0.211
LIG_SH3_3	56	62	PF00018	0.577
LIG_Sin3_3	33	40	PF02671	0.521
LIG_TRAF2_1	236	239	PF00917	0.279
LIG_TRAF2_1	241	244	PF00917	0.221
LIG_TRAF2_2	219	224	PF00917	0.206
MOD_CDK_SPK_2	215	220	PF00069	0.225
MOD_CK1_1	115	121	PF00069	0.406
MOD_CK1_1	28	34	PF00069	0.673
MOD_CK2_1	130	136	PF00069	0.202
MOD_CMANNOS	293	296	PF00535	0.483
MOD_GlcNHglycan	109	113	PF01048	0.576
MOD_GlcNHglycan	27	30	PF01048	0.430
MOD_GlcNHglycan	6	9	PF01048	0.483
MOD_GSK3_1	108	115	PF00069	0.395
MOD_GSK3_1	35	42	PF00069	0.629
MOD_NEK2_1	130	135	PF00069	0.287
MOD_NEK2_1	143	148	PF00069	0.245
MOD_NEK2_1	152	157	PF00069	0.259
MOD_NEK2_1	36	41	PF00069	0.603
MOD_NEK2_1	4	9	PF00069	0.674
MOD_NEK2_1	44	49	PF00069	0.624
MOD_PIKK_1	136	142	PF00454	0.210
MOD_PKA_1	194	200	PF00069	0.233
MOD_PKA_2	112	118	PF00069	0.388
MOD_PKA_2	166	172	PF00069	0.206
MOD_PKA_2	194	200	PF00069	0.232
MOD_Plk_1	248	254	PF00069	0.236
MOD_Plk_4	203	209	PF00069	0.246
MOD_Plk_4	90	96	PF00069	0.339
MOD_ProDKin_1	215	221	PF00069	0.228
MOD_ProDKin_1	39	45	PF00069	0.728
TRG_ENDOCYTIC_2	151	154	PF00928	0.234
TRG_ENDOCYTIC_2	204	207	PF00928	0.244
TRG_ENDOCYTIC_2	232	235	PF00928	0.242
TRG_ENDOCYTIC_2	80	83	PF00928	0.254
TRG_ER_diArg_1	11	14	PF00400	0.615
TRG_ER_diArg_1	119	122	PF00400	0.326
TRG_ER_diArg_1	193	195	PF00400	0.232
TRG_ER_diArg_1	20	22	PF00400	0.578
TRG_NES_CRM1_1	196	211	PF08389	0.261
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G6	Leptomonas seymouri	38%	69%
A0A0N0P3R3	Leptomonas seymouri	85%	95%
A0A0N1I6S1	Leptomonas seymouri	30%	100%
A0A0S4J8R8	Bodo saltans	74%	100%
A0A0S4KH84	Bodo saltans	28%	91%
A0A1X0NLN8	Trypanosomatidae	75%	100%
A0A1X0NWD3	Trypanosomatidae	30%	99%
A0A3Q8ID19	Leishmania donovani	39%	69%
A0A3R7L4G0	Trypanosoma rangeli	30%	100%
A0A3S5H5E9	Leishmania donovani	94%	95%
A0A3S5H786	Leishmania donovani	29%	100%
A4H427	Leishmania braziliensis	87%	100%
A4HF41	Leishmania braziliensis	39%	100%
A4HSB1	Leishmania infantum	95%	95%
A4HYS6	Leishmania infantum	29%	100%
A4I2C5	Leishmania infantum	39%	69%
C9ZYA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9AID5	Leishmania braziliensis	29%	100%
E9AUM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O42899	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O97196	Leishmania major	92%	100%
P38072	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	98%
Q4Q8Z5	Leishmania major	39%	100%
Q4QCW2	Leishmania major	29%	100%
Q5RH02	Danio rerio	34%	100%
Q8VYP0	Arabidopsis thaliana	37%	89%
V5BI84	Trypanosoma cruzi	75%	100%