Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK93_LEIMU

TriTrypDb:

LmxM.04.1120

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.453
CLV_C14_Caspase3-7	413	417	PF00656	0.578
CLV_C14_Caspase3-7	476	480	PF00656	0.702
CLV_C14_Caspase3-7	580	584	PF00656	0.670
CLV_NRD_NRD_1	165	167	PF00675	0.652
CLV_NRD_NRD_1	24	26	PF00675	0.603
CLV_NRD_NRD_1	284	286	PF00675	0.472
CLV_NRD_NRD_1	295	297	PF00675	0.483
CLV_NRD_NRD_1	365	367	PF00675	0.464
CLV_NRD_NRD_1	380	382	PF00675	0.458
CLV_NRD_NRD_1	534	536	PF00675	0.822
CLV_NRD_NRD_1	586	588	PF00675	0.678
CLV_NRD_NRD_1	635	637	PF00675	0.542
CLV_NRD_NRD_1	651	653	PF00675	0.336
CLV_NRD_NRD_1	692	694	PF00675	0.682
CLV_NRD_NRD_1	90	92	PF00675	0.693
CLV_PCSK_KEX2_1	165	167	PF00082	0.652
CLV_PCSK_KEX2_1	238	240	PF00082	0.479
CLV_PCSK_KEX2_1	24	26	PF00082	0.599
CLV_PCSK_KEX2_1	245	247	PF00082	0.503
CLV_PCSK_KEX2_1	369	371	PF00082	0.483
CLV_PCSK_KEX2_1	380	382	PF00082	0.507
CLV_PCSK_KEX2_1	491	493	PF00082	0.502
CLV_PCSK_KEX2_1	534	536	PF00082	0.812
CLV_PCSK_KEX2_1	586	588	PF00082	0.678
CLV_PCSK_KEX2_1	601	603	PF00082	0.568
CLV_PCSK_KEX2_1	634	636	PF00082	0.567
CLV_PCSK_KEX2_1	649	651	PF00082	0.469
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.479
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.503
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.470
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.502
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.652
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.469
CLV_PCSK_PC7_1	161	167	PF00082	0.647
CLV_PCSK_PC7_1	487	493	PF00082	0.503
CLV_PCSK_SKI1_1	242	246	PF00082	0.486
CLV_PCSK_SKI1_1	270	274	PF00082	0.426
CLV_PCSK_SKI1_1	306	310	PF00082	0.488
CLV_PCSK_SKI1_1	355	359	PF00082	0.437
CLV_PCSK_SKI1_1	405	409	PF00082	0.448
CLV_PCSK_SKI1_1	505	509	PF00082	0.605
CLV_PCSK_SKI1_1	534	538	PF00082	0.697
CLV_PCSK_SKI1_1	694	698	PF00082	0.684
CLV_PCSK_SKI1_1	722	726	PF00082	0.637
DEG_APCC_KENBOX_2	667	671	PF00400	0.691
DOC_CKS1_1	19	24	PF01111	0.682
DOC_CKS1_1	724	729	PF01111	0.625
DOC_MAPK_DCC_7	551	561	PF00069	0.670
DOC_MAPK_gen_1	654	662	PF00069	0.585
DOC_PP1_RVXF_1	121	127	PF00149	0.499
DOC_PP1_RVXF_1	633	640	PF00149	0.533
DOC_USP7_MATH_1	117	121	PF00917	0.566
DOC_USP7_MATH_1	129	133	PF00917	0.650
DOC_USP7_MATH_1	140	144	PF00917	0.771
DOC_USP7_MATH_1	164	168	PF00917	0.607
DOC_USP7_MATH_1	17	21	PF00917	0.630
DOC_USP7_MATH_1	490	494	PF00917	0.633
DOC_USP7_MATH_1	510	514	PF00917	0.603
DOC_USP7_MATH_1	52	56	PF00917	0.505
DOC_USP7_MATH_1	524	528	PF00917	0.600
DOC_USP7_MATH_1	560	564	PF00917	0.783
DOC_USP7_MATH_1	566	570	PF00917	0.605
DOC_USP7_MATH_1	610	614	PF00917	0.674
DOC_USP7_MATH_1	618	622	PF00917	0.579
DOC_USP7_MATH_1	626	630	PF00917	0.536
DOC_USP7_MATH_1	66	70	PF00917	0.663
DOC_USP7_UBL2_3	668	672	PF12436	0.695
DOC_WW_Pin1_4	131	136	PF00397	0.614
DOC_WW_Pin1_4	160	165	PF00397	0.609
DOC_WW_Pin1_4	169	174	PF00397	0.626
DOC_WW_Pin1_4	18	23	PF00397	0.605
DOC_WW_Pin1_4	447	452	PF00397	0.629
DOC_WW_Pin1_4	497	502	PF00397	0.678
DOC_WW_Pin1_4	50	55	PF00397	0.505
DOC_WW_Pin1_4	58	63	PF00397	0.555
DOC_WW_Pin1_4	616	621	PF00397	0.595
DOC_WW_Pin1_4	723	728	PF00397	0.629
LIG_14-3-3_CanoR_1	142	150	PF00244	0.630
LIG_14-3-3_CanoR_1	165	173	PF00244	0.594
LIG_14-3-3_CanoR_1	381	391	PF00244	0.451
LIG_14-3-3_CanoR_1	44	50	PF00244	0.666
LIG_14-3-3_CanoR_1	460	468	PF00244	0.526
LIG_14-3-3_CanoR_1	505	514	PF00244	0.632
LIG_14-3-3_CanoR_1	564	574	PF00244	0.518
LIG_14-3-3_CanoR_1	682	687	PF00244	0.537
LIG_BIR_III_2	51	55	PF00653	0.512
LIG_BRCT_BRCA1_1	236	240	PF00533	0.420
LIG_FHA_1	166	172	PF00498	0.536
LIG_FHA_1	451	457	PF00498	0.803
LIG_FHA_1	460	466	PF00498	0.605
LIG_FHA_2	230	236	PF00498	0.427
LIG_FHA_2	27	33	PF00498	0.561
LIG_FHA_2	373	379	PF00498	0.511
LIG_FHA_2	474	480	PF00498	0.674
LIG_FHA_2	589	595	PF00498	0.649
LIG_FHA_2	664	670	PF00498	0.496
LIG_FHA_2	74	80	PF00498	0.578
LIG_LIR_Apic_2	479	485	PF02991	0.697
LIG_LIR_Apic_2	518	524	PF02991	0.615
LIG_LIR_Gen_1	12	23	PF02991	0.635
LIG_LIR_Gen_1	184	191	PF02991	0.470
LIG_LIR_Gen_1	215	225	PF02991	0.404
LIG_LIR_Gen_1	335	342	PF02991	0.428
LIG_LIR_Nem_3	12	18	PF02991	0.637
LIG_LIR_Nem_3	184	188	PF02991	0.493
LIG_LIR_Nem_3	215	220	PF02991	0.404
LIG_LIR_Nem_3	335	341	PF02991	0.428
LIG_MYND_1	717	721	PF01753	0.601
LIG_NRBOX	322	328	PF00104	0.481
LIG_PCNA_yPIPBox_3	221	233	PF02747	0.433
LIG_SH2_CRK	217	221	PF00017	0.427
LIG_SH2_CRK	482	486	PF00017	0.692
LIG_SH2_NCK_1	482	486	PF00017	0.692
LIG_SH2_PTP2	521	524	PF00017	0.611
LIG_SH2_STAP1	195	199	PF00017	0.533
LIG_SH2_STAP1	206	210	PF00017	0.448
LIG_SH2_STAP1	276	280	PF00017	0.438
LIG_SH2_STAP1	78	82	PF00017	0.644
LIG_SH2_STAT3	199	202	PF00017	0.458
LIG_SH2_STAT3	575	578	PF00017	0.585
LIG_SH2_STAT5	521	524	PF00017	0.611
LIG_SH2_STAT5	82	85	PF00017	0.655
LIG_SH3_2	19	24	PF14604	0.682
LIG_SH3_2	673	678	PF14604	0.679
LIG_SH3_3	16	22	PF00018	0.680
LIG_SH3_3	175	181	PF00018	0.630
LIG_SH3_3	527	533	PF00018	0.799
LIG_SH3_3	554	560	PF00018	0.581
LIG_SH3_3	670	676	PF00018	0.684
LIG_SH3_3	721	727	PF00018	0.679
LIG_SUMO_SIM_par_1	226	232	PF11976	0.434
LIG_TRAF2_1	262	265	PF00917	0.449
LIG_UBA3_1	337	346	PF00899	0.497
MOD_CDC14_SPxK_1	454	457	PF00782	0.519
MOD_CDC14_SPxK_1	500	503	PF00782	0.676
MOD_CDK_SPK_2	160	165	PF00069	0.597
MOD_CDK_SPK_2	447	452	PF00069	0.524
MOD_CDK_SPK_2	723	728	PF00069	0.581
MOD_CDK_SPxK_1	160	166	PF00069	0.648
MOD_CDK_SPxK_1	18	24	PF00069	0.607
MOD_CDK_SPxK_1	451	457	PF00069	0.521
MOD_CDK_SPxK_1	497	503	PF00069	0.679
MOD_CDK_SPxxK_3	131	138	PF00069	0.615
MOD_CDK_SPxxK_3	18	25	PF00069	0.604
MOD_CK1_1	127	133	PF00069	0.629
MOD_CK1_1	154	160	PF00069	0.597
MOD_CK1_1	3	9	PF00069	0.639
MOD_CK1_1	332	338	PF00069	0.457
MOD_CK1_1	440	446	PF00069	0.623
MOD_CK1_1	450	456	PF00069	0.627
MOD_CK1_1	513	519	PF00069	0.715
MOD_CK1_1	541	547	PF00069	0.593
MOD_CK1_1	609	615	PF00069	0.551
MOD_CK1_1	688	694	PF00069	0.576
MOD_CK1_1	98	104	PF00069	0.730
MOD_CK2_1	229	235	PF00069	0.428
MOD_CK2_1	372	378	PF00069	0.517
MOD_CK2_1	382	388	PF00069	0.424
MOD_CK2_1	663	669	PF00069	0.619
MOD_CK2_1	723	729	PF00069	0.628
MOD_GlcNHglycan	127	130	PF01048	0.765
MOD_GlcNHglycan	269	273	PF01048	0.509
MOD_GlcNHglycan	434	440	PF01048	0.566
MOD_GlcNHglycan	492	495	PF01048	0.754
MOD_GlcNHglycan	5	8	PF01048	0.606
MOD_GlcNHglycan	515	518	PF01048	0.716
MOD_GlcNHglycan	54	57	PF01048	0.536
MOD_GlcNHglycan	543	546	PF01048	0.591
MOD_GlcNHglycan	603	606	PF01048	0.650
MOD_GlcNHglycan	608	611	PF01048	0.684
MOD_GlcNHglycan	620	623	PF01048	0.506
MOD_GlcNHglycan	628	631	PF01048	0.487
MOD_GlcNHglycan	68	71	PF01048	0.667
MOD_GlcNHglycan	86	89	PF01048	0.538
MOD_GlcNHglycan	92	95	PF01048	0.703
MOD_GSK3_1	1	8	PF00069	0.634
MOD_GSK3_1	125	132	PF00069	0.712
MOD_GSK3_1	149	156	PF00069	0.656
MOD_GSK3_1	160	167	PF00069	0.550
MOD_GSK3_1	246	253	PF00069	0.467
MOD_GSK3_1	314	321	PF00069	0.515
MOD_GSK3_1	332	339	PF00069	0.482
MOD_GSK3_1	435	442	PF00069	0.651
MOD_GSK3_1	443	450	PF00069	0.589
MOD_GSK3_1	534	541	PF00069	0.659
MOD_GSK3_1	555	562	PF00069	0.771
MOD_GSK3_1	606	613	PF00069	0.640
MOD_GSK3_1	626	633	PF00069	0.558
MOD_GSK3_1	78	85	PF00069	0.578
MOD_GSK3_1	86	93	PF00069	0.661
MOD_N-GLC_1	117	122	PF02516	0.596
MOD_N-GLC_1	124	129	PF02516	0.607
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	159	164	PF00069	0.621
MOD_NEK2_1	248	253	PF00069	0.477
MOD_NEK2_1	268	273	PF00069	0.301
MOD_NEK2_1	419	424	PF00069	0.686
MOD_NEK2_1	637	642	PF00069	0.501
MOD_NEK2_1	86	91	PF00069	0.609
MOD_PIKK_1	318	324	PF00454	0.460
MOD_PIKK_1	538	544	PF00454	0.658
MOD_PKA_1	165	171	PF00069	0.647
MOD_PKA_1	534	540	PF00069	0.654
MOD_PKA_1	601	607	PF00069	0.574
MOD_PKA_2	103	109	PF00069	0.562
MOD_PKA_2	164	170	PF00069	0.597
MOD_PKA_2	43	49	PF00069	0.502
MOD_PKA_2	459	465	PF00069	0.529
MOD_PKA_2	534	540	PF00069	0.700
MOD_PKA_2	578	584	PF00069	0.581
MOD_PKA_2	585	591	PF00069	0.638
MOD_PKA_2	601	607	PF00069	0.564
MOD_PKA_2	90	96	PF00069	0.718
MOD_PKB_1	503	511	PF00069	0.629
MOD_Plk_1	117	123	PF00069	0.628
MOD_Plk_1	306	312	PF00069	0.535
MOD_Plk_1	372	378	PF00069	0.544
MOD_Plk_1	38	44	PF00069	0.546
MOD_Plk_1	473	479	PF00069	0.515
MOD_Plk_1	78	84	PF00069	0.587
MOD_Plk_2-3	459	465	PF00069	0.608
MOD_Plk_4	300	306	PF00069	0.443
MOD_Plk_4	322	328	PF00069	0.447
MOD_Plk_4	397	403	PF00069	0.439
MOD_Plk_4	473	479	PF00069	0.518
MOD_Plk_4	510	516	PF00069	0.557
MOD_Plk_4	526	532	PF00069	0.633
MOD_Plk_4	78	84	PF00069	0.668
MOD_ProDKin_1	131	137	PF00069	0.614
MOD_ProDKin_1	160	166	PF00069	0.611
MOD_ProDKin_1	169	175	PF00069	0.625
MOD_ProDKin_1	18	24	PF00069	0.607
MOD_ProDKin_1	447	453	PF00069	0.630
MOD_ProDKin_1	497	503	PF00069	0.679
MOD_ProDKin_1	50	56	PF00069	0.501
MOD_ProDKin_1	58	64	PF00069	0.561
MOD_ProDKin_1	616	622	PF00069	0.595
MOD_ProDKin_1	723	729	PF00069	0.628
MOD_SUMO_for_1	244	247	PF00179	0.449
MOD_SUMO_for_1	266	269	PF00179	0.436
MOD_SUMO_rev_2	231	240	PF00179	0.434
MOD_SUMO_rev_2	264	268	PF00179	0.439
MOD_SUMO_rev_2	292	299	PF00179	0.449
MOD_SUMO_rev_2	349	357	PF00179	0.509
TRG_DiLeu_BaEn_3	235	241	PF01217	0.439
TRG_ENDOCYTIC_2	15	18	PF00928	0.686
TRG_ENDOCYTIC_2	185	188	PF00928	0.488
TRG_ENDOCYTIC_2	195	198	PF00928	0.512
TRG_ENDOCYTIC_2	206	209	PF00928	0.484
TRG_ENDOCYTIC_2	217	220	PF00928	0.464
TRG_ENDOCYTIC_2	276	279	PF00928	0.451
TRG_ER_diArg_1	164	166	PF00400	0.647
TRG_ER_diArg_1	192	195	PF00400	0.469
TRG_ER_diArg_1	23	25	PF00400	0.604
TRG_ER_diArg_1	252	255	PF00400	0.458
TRG_ER_diArg_1	502	505	PF00400	0.640
TRG_ER_diArg_1	533	535	PF00400	0.811
TRG_ER_diArg_1	634	636	PF00400	0.567
TRG_ER_diArg_1	650	652	PF00400	0.343
TRG_NES_CRM1_1	399	413	PF08389	0.445
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I386	Leptomonas seymouri	50%	89%
A0A3S5H5E8	Leishmania donovani	89%	100%
A4H426	Leishmania braziliensis	76%	99%
A4HSB0	Leishmania infantum	89%	100%
O97197	Leishmania major	89%	100%