Transcriptional repressor TCF25 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcriptional repressor TCF25, putative

Species:

Leishmania mexicana

UniProt:

E9AK89_LEIMU

TriTrypDb:

LmxM.04.1080

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990112	RQC complex	2	1

Expansion

Sequence features

E9AK89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.655
CLV_C14_Caspase3-7	274	278	PF00656	0.586
CLV_C14_Caspase3-7	540	544	PF00656	0.513
CLV_C14_Caspase3-7	665	669	PF00656	0.436
CLV_C14_Caspase3-7	715	719	PF00656	0.436
CLV_C14_Caspase3-7	89	93	PF00656	0.564
CLV_MEL_PAP_1	420	426	PF00089	0.222
CLV_NRD_NRD_1	130	132	PF00675	0.707
CLV_NRD_NRD_1	160	162	PF00675	0.617
CLV_NRD_NRD_1	165	167	PF00675	0.642
CLV_NRD_NRD_1	169	171	PF00675	0.640
CLV_NRD_NRD_1	190	192	PF00675	0.655
CLV_NRD_NRD_1	2	4	PF00675	0.618
CLV_NRD_NRD_1	283	285	PF00675	0.690
CLV_NRD_NRD_1	31	33	PF00675	0.814
CLV_NRD_NRD_1	422	424	PF00675	0.411
CLV_NRD_NRD_1	514	516	PF00675	0.498
CLV_NRD_NRD_1	701	703	PF00675	0.436
CLV_NRD_NRD_1	817	819	PF00675	0.654
CLV_PCSK_FUR_1	493	497	PF00082	0.411
CLV_PCSK_KEX2_1	130	132	PF00082	0.731
CLV_PCSK_KEX2_1	159	161	PF00082	0.618
CLV_PCSK_KEX2_1	165	167	PF00082	0.639
CLV_PCSK_KEX2_1	169	171	PF00082	0.636
CLV_PCSK_KEX2_1	190	192	PF00082	0.655
CLV_PCSK_KEX2_1	2	4	PF00082	0.618
CLV_PCSK_KEX2_1	283	285	PF00082	0.690
CLV_PCSK_KEX2_1	422	424	PF00082	0.411
CLV_PCSK_KEX2_1	458	460	PF00082	0.411
CLV_PCSK_KEX2_1	495	497	PF00082	0.411
CLV_PCSK_KEX2_1	514	516	PF00082	0.411
CLV_PCSK_KEX2_1	701	703	PF00082	0.436
CLV_PCSK_KEX2_1	817	819	PF00082	0.654
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.618
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.411
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.411
CLV_PCSK_PC7_1	161	167	PF00082	0.509
CLV_PCSK_PC7_1	279	285	PF00082	0.677
CLV_PCSK_PC7_1	697	703	PF00082	0.436
CLV_PCSK_SKI1_1	131	135	PF00082	0.578
CLV_PCSK_SKI1_1	45	49	PF00082	0.568
CLV_PCSK_SKI1_1	470	474	PF00082	0.443
CLV_PCSK_SKI1_1	531	535	PF00082	0.513
CLV_PCSK_SKI1_1	591	595	PF00082	0.411
CLV_PCSK_SKI1_1	701	705	PF00082	0.436
CLV_PCSK_SKI1_1	739	743	PF00082	0.665
CLV_PCSK_SKI1_1	810	814	PF00082	0.709
CLV_PCSK_SKI1_1	95	99	PF00082	0.663
DEG_APCC_DBOX_1	809	817	PF00400	0.709
DEG_Nend_UBRbox_1	1	4	PF02207	0.452
DEG_SCF_TRCP1_1	715	720	PF00400	0.842
DEG_SPOP_SBC_1	198	202	PF00917	0.736
DEG_SPOP_SBC_1	77	81	PF00917	0.577
DOC_CKS1_1	312	317	PF01111	0.474
DOC_CYCLIN_RxL_1	467	476	PF00134	0.411
DOC_CYCLIN_RxL_1	807	815	PF00134	0.634
DOC_MAPK_gen_1	288	297	PF00069	0.607
DOC_MAPK_gen_1	468	475	PF00069	0.411
DOC_MAPK_gen_1	493	503	PF00069	0.411
DOC_MAPK_RevD_3	407	423	PF00069	0.424
DOC_MAPK_RevD_3	483	496	PF00069	0.411
DOC_PP2B_LxvP_1	551	554	PF13499	0.513
DOC_PP4_FxxP_1	312	315	PF00568	0.437
DOC_USP7_MATH_1	105	109	PF00917	0.812
DOC_USP7_MATH_1	129	133	PF00917	0.621
DOC_USP7_MATH_1	198	202	PF00917	0.760
DOC_USP7_MATH_1	214	218	PF00917	0.675
DOC_USP7_MATH_1	221	225	PF00917	0.730
DOC_USP7_MATH_1	322	326	PF00917	0.583
DOC_USP7_MATH_1	358	362	PF00917	0.579
DOC_USP7_MATH_1	522	526	PF00917	0.524
DOC_USP7_MATH_1	58	62	PF00917	0.790
DOC_USP7_MATH_1	603	607	PF00917	0.513
DOC_USP7_MATH_1	670	674	PF00917	0.299
DOC_USP7_MATH_1	713	717	PF00917	0.429
DOC_USP7_MATH_1	77	81	PF00917	0.585
DOC_USP7_MATH_1	86	90	PF00917	0.775
DOC_USP7_MATH_1	96	100	PF00917	0.776
DOC_USP7_UBL2_3	41	45	PF12436	0.731
DOC_WW_Pin1_4	203	208	PF00397	0.808
DOC_WW_Pin1_4	277	282	PF00397	0.664
DOC_WW_Pin1_4	311	316	PF00397	0.465
DOC_WW_Pin1_4	50	55	PF00397	0.738
DOC_WW_Pin1_4	601	606	PF00397	0.513
LIG_14-3-3_CanoR_1	130	138	PF00244	0.620
LIG_14-3-3_CanoR_1	357	363	PF00244	0.591
LIG_14-3-3_CanoR_1	422	427	PF00244	0.482
LIG_14-3-3_CanoR_1	439	445	PF00244	0.336
LIG_14-3-3_CanoR_1	470	476	PF00244	0.411
LIG_14-3-3_CanoR_1	598	602	PF00244	0.465
LIG_14-3-3_CanoR_1	701	707	PF00244	0.436
LIG_Actin_WH2_2	442	460	PF00022	0.411
LIG_Actin_WH2_2	527	544	PF00022	0.513
LIG_BIR_III_2	23	27	PF00653	0.769
LIG_BIR_III_2	868	872	PF00653	0.636
LIG_BIR_III_4	627	631	PF00653	0.416
LIG_BRCT_BRCA1_1	293	297	PF00533	0.566
LIG_BRCT_BRCA1_1	303	307	PF00533	0.529
LIG_BRCT_BRCA1_1	351	355	PF00533	0.480
LIG_Clathr_ClatBox_1	472	476	PF01394	0.411
LIG_Clathr_ClatBox_1	484	488	PF01394	0.411
LIG_deltaCOP1_diTrp_1	337	343	PF00928	0.655
LIG_EH1_1	697	705	PF00400	0.513
LIG_eIF4E_1	385	391	PF01652	0.411
LIG_FHA_1	26	32	PF00498	0.800
LIG_FHA_1	290	296	PF00498	0.613
LIG_FHA_1	467	473	PF00498	0.383
LIG_FHA_1	67	73	PF00498	0.749
LIG_FHA_2	10	16	PF00498	0.648
LIG_FHA_2	108	114	PF00498	0.728
LIG_FHA_2	257	263	PF00498	0.482
LIG_FHA_2	329	335	PF00498	0.551
LIG_FHA_2	462	468	PF00498	0.411
LIG_FHA_2	538	544	PF00498	0.411
LIG_FHA_2	721	727	PF00498	0.529
LIG_FHA_2	800	806	PF00498	0.654
LIG_FHA_2	835	841	PF00498	0.552
LIG_LIR_Apic_2	310	315	PF02991	0.438
LIG_LIR_Gen_1	111	121	PF02991	0.748
LIG_LIR_Gen_1	242	251	PF02991	0.600
LIG_LIR_Gen_1	443	453	PF02991	0.389
LIG_LIR_Gen_1	488	494	PF02991	0.411
LIG_LIR_Gen_1	650	659	PF02991	0.411
LIG_LIR_Nem_3	111	117	PF02991	0.754
LIG_LIR_Nem_3	242	248	PF02991	0.612
LIG_LIR_Nem_3	443	449	PF02991	0.389
LIG_LIR_Nem_3	488	492	PF02991	0.411
LIG_LIR_Nem_3	650	655	PF02991	0.411
LIG_LIR_Nem_3	736	741	PF02991	0.569
LIG_LIR_Nem_3	841	847	PF02991	0.737
LIG_LIR_Nem_3	855	861	PF02991	0.761
LIG_OCRL_FandH_1	678	690	PF00620	0.411
LIG_PCNA_yPIPBox_3	439	449	PF02747	0.411
LIG_PTB_Apo_2	552	559	PF02174	0.411
LIG_SH2_CRK	323	327	PF00017	0.482
LIG_SH2_CRK	385	389	PF00017	0.411
LIG_SH2_CRK	489	493	PF00017	0.411
LIG_SH2_CRK	738	742	PF00017	0.651
LIG_SH2_NCK_1	859	863	PF00017	0.741
LIG_SH2_STAP1	395	399	PF00017	0.411
LIG_SH2_STAP1	556	560	PF00017	0.408
LIG_SH2_STAT5	346	349	PF00017	0.544
LIG_SH2_STAT5	489	492	PF00017	0.411
LIG_SH2_STAT5	808	811	PF00017	0.631
LIG_SH3_3	201	207	PF00018	0.846
LIG_SH3_3	474	480	PF00018	0.513
LIG_SH3_3	61	67	PF00018	0.659
LIG_SH3_3	98	104	PF00018	0.750
LIG_SUMO_SIM_anti_2	606	612	PF11976	0.418
LIG_SUMO_SIM_anti_2	690	697	PF11976	0.416
LIG_SUMO_SIM_par_1	471	476	PF11976	0.411
LIG_SUMO_SIM_par_1	482	488	PF11976	0.411
LIG_TRAF2_1	178	181	PF00917	0.703
LIG_TRAF2_1	331	334	PF00917	0.611
LIG_TRAF2_1	364	367	PF00917	0.531
LIG_TYR_ITIM	321	326	PF00017	0.477
LIG_TYR_ITIM	487	492	PF00017	0.411
LIG_WRC_WIRS_1	800	805	PF05994	0.657
MOD_CDK_SPxK_1	277	283	PF00069	0.667
MOD_CDK_SPxK_1	311	317	PF00069	0.473
MOD_CDK_SPxxK_3	277	284	PF00069	0.669
MOD_CK1_1	108	114	PF00069	0.830
MOD_CK1_1	224	230	PF00069	0.811
MOD_CK1_1	440	446	PF00069	0.436
MOD_CK1_1	644	650	PF00069	0.421
MOD_CK1_1	720	726	PF00069	0.662
MOD_CK1_1	728	734	PF00069	0.655
MOD_CK1_1	79	85	PF00069	0.744
MOD_CK1_1	860	866	PF00069	0.739
MOD_CK2_1	115	121	PF00069	0.766
MOD_CK2_1	256	262	PF00069	0.474
MOD_CK2_1	328	334	PF00069	0.591
MOD_CK2_1	461	467	PF00069	0.411
MOD_CK2_1	603	609	PF00069	0.436
MOD_CK2_1	720	726	PF00069	0.621
MOD_CK2_1	78	84	PF00069	0.794
MOD_CK2_1	799	805	PF00069	0.611
MOD_CK2_1	834	840	PF00069	0.552
MOD_GlcNHglycan	107	110	PF01048	0.701
MOD_GlcNHglycan	125	128	PF01048	0.541
MOD_GlcNHglycan	131	134	PF01048	0.620
MOD_GlcNHglycan	223	226	PF01048	0.584
MOD_GlcNHglycan	309	312	PF01048	0.476
MOD_GlcNHglycan	402	405	PF01048	0.411
MOD_GlcNHglycan	426	429	PF01048	0.394
MOD_GlcNHglycan	439	442	PF01048	0.443
MOD_GlcNHglycan	577	582	PF01048	0.374
MOD_GlcNHglycan	60	63	PF01048	0.850
MOD_GlcNHglycan	605	608	PF01048	0.509
MOD_GlcNHglycan	611	614	PF01048	0.418
MOD_GlcNHglycan	664	667	PF01048	0.406
MOD_GlcNHglycan	715	718	PF01048	0.513
MOD_GlcNHglycan	830	834	PF01048	0.821
MOD_GlcNHglycan	862	865	PF01048	0.741
MOD_GlcNHglycan	98	101	PF01048	0.860
MOD_GSK3_1	104	111	PF00069	0.695
MOD_GSK3_1	125	132	PF00069	0.711
MOD_GSK3_1	199	206	PF00069	0.734
MOD_GSK3_1	220	227	PF00069	0.773
MOD_GSK3_1	289	296	PF00069	0.615
MOD_GSK3_1	307	314	PF00069	0.476
MOD_GSK3_1	41	48	PF00069	0.794
MOD_GSK3_1	422	429	PF00069	0.319
MOD_GSK3_1	573	580	PF00069	0.436
MOD_GSK3_1	597	604	PF00069	0.472
MOD_GSK3_1	635	642	PF00069	0.409
MOD_GSK3_1	643	650	PF00069	0.416
MOD_GSK3_1	687	694	PF00069	0.436
MOD_GSK3_1	702	709	PF00069	0.281
MOD_GSK3_1	713	720	PF00069	0.374
MOD_GSK3_1	722	729	PF00069	0.529
MOD_GSK3_1	76	83	PF00069	0.766
MOD_GSK3_1	91	98	PF00069	0.724
MOD_N-GLC_1	41	46	PF02516	0.565
MOD_N-GLC_1	739	744	PF02516	0.612
MOD_NEK2_1	307	312	PF00069	0.480
MOD_NEK2_1	348	353	PF00069	0.578
MOD_NEK2_1	424	429	PF00069	0.409
MOD_NEK2_1	487	492	PF00069	0.411
MOD_NEK2_1	643	648	PF00069	0.436
MOD_NEK2_1	747	752	PF00069	0.603
MOD_NEK2_1	78	83	PF00069	0.792
MOD_NEK2_1	91	96	PF00069	0.619
MOD_NEK2_2	293	298	PF00069	0.551
MOD_NEK2_2	537	542	PF00069	0.513
MOD_PIKK_1	644	650	PF00454	0.511
MOD_PIKK_1	766	772	PF00454	0.481
MOD_PKA_1	159	165	PF00069	0.574
MOD_PKA_1	422	428	PF00069	0.319
MOD_PKA_1	45	51	PF00069	0.758
MOD_PKA_2	129	135	PF00069	0.721
MOD_PKA_2	159	165	PF00069	0.425
MOD_PKA_2	289	295	PF00069	0.629
MOD_PKA_2	31	37	PF00069	0.793
MOD_PKA_2	422	428	PF00069	0.319
MOD_PKA_2	597	603	PF00069	0.313
MOD_PKA_2	711	717	PF00069	0.222
MOD_PKA_2	742	748	PF00069	0.660
MOD_PKA_2	9	15	PF00069	0.632
MOD_PKB_1	737	745	PF00069	0.662
MOD_Plk_1	241	247	PF00069	0.639
MOD_Plk_1	487	493	PF00069	0.411
MOD_Plk_2-3	115	121	PF00069	0.752
MOD_Plk_4	214	220	PF00069	0.658
MOD_Plk_4	293	299	PF00069	0.542
MOD_Plk_4	386	392	PF00069	0.411
MOD_Plk_4	426	432	PF00069	0.473
MOD_Plk_4	440	446	PF00069	0.289
MOD_Plk_4	647	653	PF00069	0.375
MOD_Plk_4	691	697	PF00069	0.319
MOD_Plk_4	742	748	PF00069	0.582
MOD_ProDKin_1	203	209	PF00069	0.804
MOD_ProDKin_1	277	283	PF00069	0.667
MOD_ProDKin_1	311	317	PF00069	0.473
MOD_ProDKin_1	50	56	PF00069	0.733
MOD_ProDKin_1	601	607	PF00069	0.513
MOD_SUMO_rev_2	524	533	PF00179	0.485
TRG_DiLeu_BaEn_1	179	184	PF01217	0.602
TRG_DiLeu_BaEn_1	691	696	PF01217	0.411
TRG_DiLeu_BaEn_4	179	185	PF01217	0.698
TRG_DiLeu_BaEn_4	684	690	PF01217	0.389
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.222
TRG_ENDOCYTIC_2	318	321	PF00928	0.497
TRG_ENDOCYTIC_2	323	326	PF00928	0.455
TRG_ENDOCYTIC_2	346	349	PF00928	0.551
TRG_ENDOCYTIC_2	489	492	PF00928	0.411
TRG_ENDOCYTIC_2	738	741	PF00928	0.556
TRG_ER_diArg_1	1	3	PF00400	0.649
TRG_ER_diArg_1	263	266	PF00400	0.535
TRG_ER_diArg_1	381	384	PF00400	0.436
TRG_ER_diArg_1	421	423	PF00400	0.411
TRG_ER_diArg_1	503	506	PF00400	0.411
TRG_ER_diArg_1	700	702	PF00400	0.436
TRG_ER_diArg_1	816	818	PF00400	0.649
TRG_NLS_MonoCore_2	157	162	PF00514	0.612
TRG_NLS_MonoExtC_3	158	164	PF00514	0.613
TRG_NLS_MonoExtC_3	165	170	PF00514	0.630
TRG_NLS_MonoExtC_3	86	92	PF00514	0.777
TRG_NLS_MonoExtN_4	158	163	PF00514	0.642
TRG_NLS_MonoExtN_4	165	170	PF00514	0.589
TRG_NLS_MonoExtN_4	85	91	PF00514	0.779
TRG_Pf-PMV_PEXEL_1	2	6	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	702	706	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q4	Leptomonas seymouri	49%	100%
A0A3S5H5E5	Leishmania donovani	89%	100%
A4H423	Leishmania braziliensis	79%	100%
A4HSA5	Leishmania infantum	89%	100%
Q9NF87	Leishmania major	89%	100%