DUF4476 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK88_LEIMU

TriTrypDb:

LmxM.04.1070

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	25	27	PF00675	0.523
CLV_PCSK_KEX2_1	25	27	PF00082	0.523
CLV_PCSK_KEX2_1	44	46	PF00082	0.545
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DOC_USP7_MATH_1	111	115	PF00917	0.579
DOC_USP7_MATH_1	13	17	PF00917	0.503
DOC_USP7_MATH_1	73	77	PF00917	0.461
DOC_WW_Pin1_4	11	16	PF00397	0.593
LIG_14-3-3_CanoR_1	102	106	PF00244	0.514
LIG_14-3-3_CanoR_1	37	43	PF00244	0.460
LIG_BRCT_BRCA1_1	113	117	PF00533	0.574
LIG_FHA_2	37	43	PF00498	0.486
LIG_FHA_2	49	55	PF00498	0.471
LIG_LIR_Gen_1	104	113	PF02991	0.578
LIG_LIR_Gen_1	65	75	PF02991	0.363
LIG_LIR_Nem_3	104	110	PF02991	0.580
LIG_LIR_Nem_3	65	71	PF02991	0.363
LIG_SH2_CRK	107	111	PF00017	0.471
LIG_SH2_STAT5	112	115	PF00017	0.577
LIG_TYR_ITIM	105	110	PF00017	0.582
MOD_CK1_1	123	129	PF00069	0.632
MOD_CK1_1	36	42	PF00069	0.616
MOD_CK1_1	74	80	PF00069	0.485
MOD_CK1_1	85	91	PF00069	0.526
MOD_CK2_1	48	54	PF00069	0.554
MOD_GlcNHglycan	46	49	PF01048	0.620
MOD_GlcNHglycan	5	8	PF01048	0.549
MOD_GlcNHglycan	73	76	PF01048	0.505
MOD_GlcNHglycan	77	80	PF01048	0.466
MOD_GSK3_1	116	123	PF00069	0.597
MOD_GSK3_1	13	20	PF00069	0.561
MOD_GSK3_1	44	51	PF00069	0.513
MOD_GSK3_1	71	78	PF00069	0.499
MOD_NEK2_1	117	122	PF00069	0.462
MOD_NEK2_1	17	22	PF00069	0.471
MOD_NEK2_1	3	8	PF00069	0.531
MOD_NEK2_1	55	60	PF00069	0.593
MOD_NEK2_1	62	67	PF00069	0.562
MOD_NEK2_1	92	97	PF00069	0.558
MOD_PKA_1	44	50	PF00069	0.514
MOD_PKA_2	101	107	PF00069	0.551
MOD_PKA_2	28	34	PF00069	0.436
MOD_PKA_2	36	42	PF00069	0.427
MOD_PKA_2	44	50	PF00069	0.287
MOD_Plk_1	33	39	PF00069	0.505
MOD_Plk_4	101	107	PF00069	0.559
MOD_ProDKin_1	11	17	PF00069	0.597
MOD_SUMO_rev_2	36	46	PF00179	0.606
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.555
TRG_ENDOCYTIC_2	107	110	PF00928	0.473
TRG_ER_diArg_1	25	27	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB6	Leptomonas seymouri	57%	91%
A0A1X0NLC3	Trypanosomatidae	36%	92%
A0A3S7WNY1	Leishmania donovani	88%	100%
A4H422	Leishmania braziliensis	72%	100%
A4HSA4	Leishmania infantum	89%	100%
C9ZY96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
Q9NF88	Leishmania major	88%	100%
V5AYA9	Trypanosoma cruzi	31%	96%