Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK87_LEIMU

TriTrypDb:

LmxM.04.1060

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	184	190	PF00089	0.490
CLV_NRD_NRD_1	176	178	PF00675	0.528
CLV_NRD_NRD_1	280	282	PF00675	0.651
CLV_NRD_NRD_1	88	90	PF00675	0.555
CLV_PCSK_KEX2_1	176	178	PF00082	0.528
CLV_PCSK_KEX2_1	196	198	PF00082	0.488
CLV_PCSK_KEX2_1	280	282	PF00082	0.651
CLV_PCSK_KEX2_1	87	89	PF00082	0.615
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.578
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.615
CLV_PCSK_SKI1_1	196	200	PF00082	0.573
CLV_PCSK_SKI1_1	305	309	PF00082	0.655
DEG_APCC_DBOX_1	279	287	PF00400	0.565
DEG_SCF_FBW7_1	111	118	PF00400	0.532
DEG_SCF_FBW7_1	236	243	PF00400	0.665
DEG_SPOP_SBC_1	319	323	PF00917	0.552
DEG_SPOP_SBC_1	461	465	PF00917	0.544
DOC_CKS1_1	112	117	PF01111	0.535
DOC_CKS1_1	202	207	PF01111	0.580
DOC_CKS1_1	237	242	PF01111	0.621
DOC_MAPK_gen_1	51	60	PF00069	0.507
DOC_MAPK_HePTP_8	48	60	PF00069	0.520
DOC_MAPK_MEF2A_6	51	60	PF00069	0.571
DOC_MAPK_NFAT4_5	53	61	PF00069	0.512
DOC_PP2B_LxvP_1	155	158	PF13499	0.501
DOC_USP7_MATH_1	10	14	PF00917	0.765
DOC_USP7_MATH_1	115	119	PF00917	0.533
DOC_USP7_MATH_1	186	190	PF00917	0.677
DOC_USP7_MATH_1	240	244	PF00917	0.646
DOC_USP7_MATH_1	318	322	PF00917	0.614
DOC_USP7_MATH_1	343	347	PF00917	0.638
DOC_USP7_MATH_1	352	356	PF00917	0.605
DOC_USP7_MATH_1	361	365	PF00917	0.608
DOC_USP7_MATH_1	461	465	PF00917	0.571
DOC_WW_Pin1_4	111	116	PF00397	0.652
DOC_WW_Pin1_4	163	168	PF00397	0.489
DOC_WW_Pin1_4	201	206	PF00397	0.600
DOC_WW_Pin1_4	220	225	PF00397	0.620
DOC_WW_Pin1_4	236	241	PF00397	0.570
DOC_WW_Pin1_4	248	253	PF00397	0.610
DOC_WW_Pin1_4	259	264	PF00397	0.591
DOC_WW_Pin1_4	308	313	PF00397	0.648
DOC_WW_Pin1_4	323	328	PF00397	0.791
DOC_WW_Pin1_4	354	359	PF00397	0.520
DOC_WW_Pin1_4	4	9	PF00397	0.710
DOC_WW_Pin1_4	457	462	PF00397	0.539
DOC_WW_Pin1_4	58	63	PF00397	0.556
LIG_14-3-3_CanoR_1	165	175	PF00244	0.381
LIG_14-3-3_CanoR_1	180	185	PF00244	0.551
LIG_14-3-3_CanoR_1	397	407	PF00244	0.613
LIG_14-3-3_CanoR_1	457	461	PF00244	0.674
LIG_Actin_WH2_2	43	61	PF00022	0.446
LIG_APCC_ABBA_1	438	443	PF00400	0.619
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_BRCT_BRCA1_1	16	20	PF00533	0.646
LIG_BRCT_BRCA1_1	401	405	PF00533	0.644
LIG_FHA_1	193	199	PF00498	0.573
LIG_FHA_1	202	208	PF00498	0.541
LIG_FHA_1	285	291	PF00498	0.567
LIG_FHA_2	101	107	PF00498	0.540
LIG_FHA_2	19	25	PF00498	0.568
LIG_FHA_2	268	274	PF00498	0.557
LIG_FHA_2	324	330	PF00498	0.587
LIG_FHA_2	429	435	PF00498	0.646
LIG_LIR_Apic_2	201	205	PF02991	0.577
LIG_LIR_Gen_1	153	159	PF02991	0.582
LIG_LIR_Gen_1	169	178	PF02991	0.513
LIG_LIR_Nem_3	105	111	PF02991	0.713
LIG_LIR_Nem_3	153	157	PF02991	0.592
LIG_LIR_Nem_3	169	174	PF02991	0.552
LIG_LYPXL_yS_3	108	111	PF13949	0.562
LIG_NRBOX	31	37	PF00104	0.500
LIG_PCNA_yPIPBox_3	23	36	PF02747	0.516
LIG_SH2_STAT5	25	28	PF00017	0.633
LIG_SH3_3	106	112	PF00018	0.588
LIG_SH3_3	145	151	PF00018	0.495
LIG_SH3_3	202	208	PF00018	0.605
LIG_SH3_3	252	258	PF00018	0.708
LIG_SH3_3	333	339	PF00018	0.680
LIG_SH3_3	411	417	PF00018	0.701
LIG_SH3_3	466	472	PF00018	0.727
LIG_SUMO_SIM_par_1	189	195	PF11976	0.502
LIG_TRAF2_1	16	19	PF00917	0.483
LIG_TRAF2_1	332	335	PF00917	0.734
LIG_WRC_WIRS_1	353	358	PF05994	0.516
LIG_WW_3	184	188	PF00397	0.631
MOD_CDK_SPK_2	58	63	PF00069	0.517
MOD_CK1_1	179	185	PF00069	0.411
MOD_CK1_1	2	8	PF00069	0.716
MOD_CK1_1	243	249	PF00069	0.677
MOD_CK1_1	323	329	PF00069	0.618
MOD_CK1_1	450	456	PF00069	0.716
MOD_CK1_1	459	465	PF00069	0.630
MOD_CK2_1	323	329	PF00069	0.586
MOD_CK2_1	379	385	PF00069	0.690
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.516
MOD_DYRK1A_RPxSP_1	457	461	PF00069	0.539
MOD_GlcNHglycan	168	171	PF01048	0.514
MOD_GlcNHglycan	188	191	PF01048	0.528
MOD_GlcNHglycan	224	227	PF01048	0.576
MOD_GlcNHglycan	245	248	PF01048	0.616
MOD_GlcNHglycan	3	7	PF01048	0.715
MOD_GlcNHglycan	322	325	PF01048	0.561
MOD_GlcNHglycan	346	349	PF01048	0.704
MOD_GlcNHglycan	369	375	PF01048	0.669
MOD_GlcNHglycan	382	385	PF01048	0.585
MOD_GlcNHglycan	401	404	PF01048	0.500
MOD_GlcNHglycan	418	421	PF01048	0.538
MOD_GlcNHglycan	464	467	PF01048	0.710
MOD_GSK3_1	10	17	PF00069	0.610
MOD_GSK3_1	111	118	PF00069	0.590
MOD_GSK3_1	166	173	PF00069	0.525
MOD_GSK3_1	176	183	PF00069	0.449
MOD_GSK3_1	2	9	PF00069	0.715
MOD_GSK3_1	218	225	PF00069	0.575
MOD_GSK3_1	236	243	PF00069	0.666
MOD_GSK3_1	319	326	PF00069	0.724
MOD_GSK3_1	424	431	PF00069	0.667
MOD_GSK3_1	446	453	PF00069	0.689
MOD_GSK3_1	455	462	PF00069	0.628
MOD_N-GLC_1	218	223	PF02516	0.544
MOD_N-GLC_1	398	403	PF02516	0.569
MOD_NEK2_1	192	197	PF00069	0.507
MOD_NEK2_1	35	40	PF00069	0.500
MOD_PIKK_1	14	20	PF00454	0.478
MOD_PIKK_1	35	41	PF00454	0.495
MOD_PK_1	180	186	PF00069	0.437
MOD_PKA_1	176	182	PF00069	0.362
MOD_PKA_2	176	182	PF00069	0.503
MOD_PKA_2	186	192	PF00069	0.618
MOD_PKA_2	284	290	PF00069	0.566
MOD_PKA_2	456	462	PF00069	0.676
MOD_Plk_1	18	24	PF00069	0.546
MOD_Plk_2-3	362	368	PF00069	0.721
MOD_Plk_4	170	176	PF00069	0.526
MOD_ProDKin_1	111	117	PF00069	0.647
MOD_ProDKin_1	163	169	PF00069	0.490
MOD_ProDKin_1	201	207	PF00069	0.601
MOD_ProDKin_1	220	226	PF00069	0.618
MOD_ProDKin_1	236	242	PF00069	0.567
MOD_ProDKin_1	248	254	PF00069	0.605
MOD_ProDKin_1	259	265	PF00069	0.591
MOD_ProDKin_1	308	314	PF00069	0.649
MOD_ProDKin_1	323	329	PF00069	0.793
MOD_ProDKin_1	354	360	PF00069	0.523
MOD_ProDKin_1	4	10	PF00069	0.712
MOD_ProDKin_1	457	463	PF00069	0.539
MOD_ProDKin_1	58	64	PF00069	0.551
MOD_SUMO_rev_2	296	302	PF00179	0.683
TRG_ENDOCYTIC_2	108	111	PF00928	0.678
TRG_ENDOCYTIC_2	441	444	PF00928	0.621
TRG_ER_diArg_1	175	177	PF00400	0.523
TRG_ER_diArg_1	52	55	PF00400	0.498
TRG_ER_diArg_1	56	59	PF00400	0.457
TRG_NLS_MonoExtC_3	195	201	PF00514	0.572
TRG_NLS_MonoExtN_4	84	91	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNX2	Leishmania donovani	82%	98%
A4H421	Leishmania braziliensis	61%	100%
A4HSA3	Leishmania infantum	82%	98%
Q9NF89	Leishmania major	81%	100%