LeishMANIAdb
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Acyltransferase-like protein, copy 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acyltransferase-like protein, copy 2
Gene product:
acyltransferase-like protein, copy 2
Species:
Leishmania mexicana
UniProt:
E9AK86_LEIMU
TriTrypDb:
LmxM.04.1050
Length:
307

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 45
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 28
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24

Expansion

Sequence features

E9AK86
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK86

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 5
GO:0006644 phospholipid metabolic process 4 5
GO:0006650 glycerophospholipid metabolic process 5 5
GO:0006654 phosphatidic acid biosynthetic process 6 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0008610 lipid biosynthetic process 4 5
GO:0008654 phospholipid biosynthetic process 5 5
GO:0009058 biosynthetic process 2 5
GO:0009987 cellular process 1 5
GO:0019637 organophosphate metabolic process 3 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0044249 cellular biosynthetic process 3 5
GO:0044255 cellular lipid metabolic process 3 5
GO:0045017 glycerolipid biosynthetic process 4 5
GO:0046473 phosphatidic acid metabolic process 6 5
GO:0046474 glycerophospholipid biosynthetic process 5 5
GO:0046486 glycerolipid metabolic process 4 5
GO:0071704 organic substance metabolic process 2 5
GO:0090407 organophosphate biosynthetic process 4 5
GO:1901576 organic substance biosynthetic process 3 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 29
GO:0016740 transferase activity 2 29
GO:0016746 acyltransferase activity 3 29
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 8
GO:0008374 O-acyltransferase activity 5 8
GO:0016411 acylglycerol O-acyltransferase activity 6 8
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 8
GO:0042171 lysophosphatidic acid acyltransferase activity 6 8
GO:0071617 lysophospholipid acyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 127 133 PF00089 0.532
CLV_NRD_NRD_1 275 277 PF00675 0.683
CLV_NRD_NRD_1 33 35 PF00675 0.301
CLV_PCSK_FUR_1 273 277 PF00082 0.615
CLV_PCSK_KEX2_1 273 275 PF00082 0.702
CLV_PCSK_KEX2_1 33 35 PF00082 0.277
CLV_PCSK_SKI1_1 284 288 PF00082 0.744
CLV_PCSK_SKI1_1 3 7 PF00082 0.372
DEG_Nend_UBRbox_3 1 3 PF02207 0.230
DOC_CYCLIN_yCln2_LP_2 22 28 PF00134 0.415
DOC_MAPK_gen_1 200 209 PF00069 0.317
DOC_MAPK_gen_1 33 41 PF00069 0.517
DOC_MAPK_MEF2A_6 34 43 PF00069 0.531
DOC_PP1_RVXF_1 47 54 PF00149 0.330
DOC_PP2B_LxvP_1 12 15 PF13499 0.421
DOC_PP2B_LxvP_1 29 32 PF13499 0.607
DOC_PP2B_PxIxI_1 55 61 PF00149 0.271
DOC_USP7_MATH_1 154 158 PF00917 0.203
DOC_USP7_MATH_1 208 212 PF00917 0.320
DOC_USP7_UBL2_3 241 245 PF12436 0.287
DOC_WW_Pin1_4 178 183 PF00397 0.271
DOC_WW_Pin1_4 99 104 PF00397 0.309
LIG_14-3-3_CterR_2 304 307 PF00244 0.409
LIG_Actin_WH2_2 103 121 PF00022 0.348
LIG_AP2alpha_1 92 96 PF02296 0.264
LIG_BRCT_BRCA1_1 168 172 PF00533 0.357
LIG_FHA_1 100 106 PF00498 0.261
LIG_FHA_1 286 292 PF00498 0.400
LIG_FHA_1 8 14 PF00498 0.321
LIG_FHA_2 193 199 PF00498 0.247
LIG_GBD_Chelix_1 247 255 PF00786 0.564
LIG_LIR_Gen_1 192 201 PF02991 0.260
LIG_LIR_Gen_1 90 101 PF02991 0.277
LIG_LIR_Nem_3 187 193 PF02991 0.274
LIG_LIR_Nem_3 90 96 PF02991 0.286
LIG_Pex14_2 124 128 PF04695 0.315
LIG_Pex14_2 134 138 PF04695 0.292
LIG_Pex14_2 48 52 PF04695 0.369
LIG_Pex14_2 92 96 PF04695 0.265
LIG_SH2_CRK 221 225 PF00017 0.249
LIG_SH2_STAP1 46 50 PF00017 0.172
LIG_SH2_STAT5 137 140 PF00017 0.260
LIG_SH2_STAT5 205 208 PF00017 0.282
LIG_SH2_STAT5 21 24 PF00017 0.364
LIG_SH2_STAT5 28 31 PF00017 0.575
LIG_SUMO_SIM_par_1 205 212 PF11976 0.336
LIG_SUMO_SIM_par_1 97 102 PF11976 0.170
LIG_TRAF2_1 268 271 PF00917 0.470
LIG_TYR_ITIM 26 31 PF00017 0.469
LIG_UBA3_1 107 115 PF00899 0.203
LIG_WRC_WIRS_1 185 190 PF05994 0.285
MOD_CK1_1 211 217 PF00069 0.258
MOD_CK1_1 243 249 PF00069 0.401
MOD_CK2_1 192 198 PF00069 0.284
MOD_GSK3_1 109 116 PF00069 0.315
MOD_GSK3_1 174 181 PF00069 0.255
MOD_N-GLC_1 178 183 PF02516 0.471
MOD_N-GLC_1 87 92 PF02516 0.480
MOD_NEK2_1 113 118 PF00069 0.307
MOD_NEK2_1 166 171 PF00069 0.314
MOD_NEK2_1 5 10 PF00069 0.329
MOD_NEK2_1 87 92 PF00069 0.257
MOD_PIKK_1 154 160 PF00454 0.406
MOD_Plk_1 211 217 PF00069 0.350
MOD_Plk_1 87 93 PF00069 0.280
MOD_Plk_4 14 20 PF00069 0.373
MOD_Plk_4 192 198 PF00069 0.324
MOD_Plk_4 88 94 PF00069 0.271
MOD_ProDKin_1 178 184 PF00069 0.271
MOD_ProDKin_1 99 105 PF00069 0.309
MOD_SUMO_rev_2 278 286 PF00179 0.552
TRG_DiLeu_BaLyEn_6 100 105 PF01217 0.170
TRG_ENDOCYTIC_2 190 193 PF00928 0.314
TRG_ENDOCYTIC_2 204 207 PF00928 0.268
TRG_ENDOCYTIC_2 221 224 PF00928 0.361
TRG_ENDOCYTIC_2 28 31 PF00928 0.652
TRG_ER_diArg_1 200 203 PF00400 0.317
TRG_ER_diArg_1 272 275 PF00400 0.482
TRG_ER_diArg_1 32 34 PF00400 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P455 Leptomonas seymouri 69% 90%
A0A0N0P6B0 Leptomonas seymouri 26% 100%
A0A0N1HTP4 Leptomonas seymouri 54% 100%
A0A0N1I6V1 Leptomonas seymouri 39% 100%
A0A0S4IQ05 Bodo saltans 33% 91%
A0A0S4IR22 Bodo saltans 43% 100%
A0A1X0P9F0 Trypanosomatidae 35% 100%
A0A3Q8IFY7 Leishmania donovani 28% 100%
A0A3R7NKA0 Trypanosoma rangeli 35% 100%
A0A3S5H5E4 Leishmania donovani 51% 71%
A0A3S5H7L8 Leishmania donovani 35% 95%
A0A3S7WNW6 Leishmania donovani 87% 86%
A4H418 Leishmania braziliensis 58% 100%
A4H419 Leishmania braziliensis 60% 100%
A4H420 Leishmania braziliensis 72% 100%
A4HHM7 Leishmania braziliensis 37% 100%
A4HKI5 Leishmania braziliensis 29% 100%
A4HSA1 Leishmania infantum 51% 100%
A4HSA2 Leishmania infantum 87% 86%
A4I816 Leishmania infantum 28% 100%
C9ZLI8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AE89 Leishmania major 34% 100%
E9AE90 Leishmania major 35% 100%
Q4Q582 Leishmania major 27% 100%
Q9NF90 Leishmania major 86% 100%
Q9NF91 Leishmania major 53% 100%
V5C201 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS