COPI associated

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

COPI associated

Gene product:

COPI associated protein, putative

Species:

Leishmania mexicana

UniProt:

E9AK84_LEIMU

TriTrypDb:

LmxM.04.1030

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AK84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	99	103	PF00082	0.391
DEG_SPOP_SBC_1	164	168	PF00917	0.598
DOC_MAPK_gen_1	97	106	PF00069	0.598
DOC_MAPK_MEF2A_6	20	29	PF00069	0.505
DOC_PP2B_LxvP_1	9	12	PF13499	0.694
DOC_USP7_MATH_1	183	187	PF00917	0.762
DOC_WW_Pin1_4	165	170	PF00397	0.739
DOC_WW_Pin1_4	179	184	PF00397	0.659
DOC_WW_Pin1_4	48	53	PF00397	0.431
LIG_14-3-3_CanoR_1	14	22	PF00244	0.666
LIG_14-3-3_CanoR_1	165	169	PF00244	0.665
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BRCT_BRCA1_1	52	56	PF00533	0.316
LIG_EH1_1	25	33	PF00400	0.415
LIG_FHA_1	111	117	PF00498	0.474
LIG_FHA_1	52	58	PF00498	0.289
LIG_FHA_2	112	118	PF00498	0.287
LIG_GBD_Chelix_1	123	131	PF00786	0.383
LIG_LIR_Gen_1	142	150	PF02991	0.705
LIG_LIR_Gen_1	37	46	PF02991	0.353
LIG_LIR_Nem_3	142	146	PF02991	0.555
LIG_LIR_Nem_3	21	25	PF02991	0.679
LIG_LIR_Nem_3	37	41	PF02991	0.384
LIG_LIR_Nem_3	53	59	PF02991	0.282
LIG_Pex14_1	22	26	PF04695	0.525
LIG_Pex14_1	86	90	PF04695	0.679
LIG_Pex14_2	102	106	PF04695	0.395
LIG_SH2_CRK	60	64	PF00017	0.492
LIG_SH2_STAT5	103	106	PF00017	0.358
LIG_SH2_STAT5	44	47	PF00017	0.272
LIG_SH2_STAT5	60	63	PF00017	0.357
LIG_SH2_STAT5	89	92	PF00017	0.609
LIG_SUMO_SIM_anti_2	113	120	PF11976	0.405
LIG_SUMO_SIM_anti_2	30	37	PF11976	0.471
LIG_SUMO_SIM_par_1	107	114	PF11976	0.298
LIG_SUMO_SIM_par_1	30	37	PF11976	0.360
LIG_TRAF2_1	147	150	PF00917	0.713
LIG_WRC_WIRS_1	35	40	PF05994	0.318
MOD_CDK_SPxxK_3	165	172	PF00069	0.721
MOD_CK1_1	13	19	PF00069	0.722
MOD_CK1_1	168	174	PF00069	0.764
MOD_CK1_1	185	191	PF00069	0.695
MOD_CK1_1	48	54	PF00069	0.440
MOD_CK2_1	111	117	PF00069	0.403
MOD_CK2_1	144	150	PF00069	0.566
MOD_CK2_1	185	191	PF00069	0.751
MOD_GlcNHglycan	1	4	PF01048	0.417
MOD_GlcNHglycan	160	163	PF01048	0.597
MOD_GlcNHglycan	179	182	PF01048	0.574
MOD_GlcNHglycan	69	72	PF01048	0.455
MOD_GSK3_1	164	171	PF00069	0.711
MOD_GSK3_1	179	186	PF00069	0.804
MOD_N-GLC_1	172	177	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.671
MOD_NEK2_1	110	115	PF00069	0.326
MOD_NEK2_1	27	32	PF00069	0.379
MOD_NEK2_1	62	67	PF00069	0.492
MOD_NEK2_1	74	79	PF00069	0.520
MOD_PKA_2	13	19	PF00069	0.678
MOD_PKA_2	164	170	PF00069	0.762
MOD_PKA_2	171	177	PF00069	0.630
MOD_Plk_2-3	144	150	PF00069	0.566
MOD_Plk_4	111	117	PF00069	0.333
MOD_Plk_4	27	33	PF00069	0.440
MOD_Plk_4	34	40	PF00069	0.384
MOD_ProDKin_1	165	171	PF00069	0.739
MOD_ProDKin_1	179	185	PF00069	0.659
MOD_ProDKin_1	48	54	PF00069	0.426
MOD_SUMO_rev_2	185	194	PF00179	0.659
TRG_ENDOCYTIC_2	103	106	PF00928	0.358
TRG_ENDOCYTIC_2	60	63	PF00928	0.391
TRG_ENDOCYTIC_2	89	92	PF00928	0.598
TRG_ER_diArg_1	96	99	PF00400	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIQ5	Bodo saltans	24%	100%
A0A1X0NKT5	Trypanosomatidae	32%	90%
A0A3R7M187	Trypanosoma rangeli	31%	87%
A0A3S5H5E3	Leishmania donovani	81%	100%
A4H417	Leishmania braziliensis	49%	69%
A4HSA0	Leishmania infantum	80%	100%
Q9NF92	Leishmania major	77%	100%