rRNA biogenesis protein RRP36

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF947), putative

Species:

Leishmania mexicana

UniProt:

E9AK83_LEIMU

TriTrypDb:

LmxM.04.1010

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1

Expansion

Sequence features

E9AK83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK83

Function

Biological processes
Term	Name	Level	Count
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.385
CLV_NRD_NRD_1	119	121	PF00675	0.367
CLV_NRD_NRD_1	128	130	PF00675	0.231
CLV_NRD_NRD_1	167	169	PF00675	0.349
CLV_NRD_NRD_1	28	30	PF00675	0.333
CLV_NRD_NRD_1	40	42	PF00675	0.310
CLV_PCSK_KEX2_1	109	111	PF00082	0.386
CLV_PCSK_KEX2_1	119	121	PF00082	0.324
CLV_PCSK_KEX2_1	137	139	PF00082	0.386
CLV_PCSK_KEX2_1	142	144	PF00082	0.331
CLV_PCSK_KEX2_1	169	171	PF00082	0.379
CLV_PCSK_KEX2_1	28	30	PF00082	0.329
CLV_PCSK_KEX2_1	40	42	PF00082	0.326
CLV_PCSK_KEX2_1	7	9	PF00082	0.460
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.395
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.331
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.403
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.478
CLV_PCSK_PC7_1	138	144	PF00082	0.376
CLV_PCSK_PC7_1	36	42	PF00082	0.463
CLV_PCSK_SKI1_1	115	119	PF00082	0.378
CLV_PCSK_SKI1_1	120	124	PF00082	0.351
CLV_PCSK_SKI1_1	129	133	PF00082	0.293
CLV_PCSK_SKI1_1	143	147	PF00082	0.346
CLV_PCSK_SKI1_1	7	11	PF00082	0.474
CLV_PCSK_SKI1_1	73	77	PF00082	0.415
CLV_Separin_Metazoa	116	120	PF03568	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.186
DOC_CYCLIN_RxL_1	109	121	PF00134	0.443
DOC_MAPK_gen_1	119	125	PF00069	0.385
DOC_PP2B_LxvP_1	77	80	PF13499	0.413
DOC_SPAK_OSR1_1	29	33	PF12202	0.449
DOC_USP7_UBL2_3	126	130	PF12436	0.406
LIG_14-3-3_CanoR_1	109	114	PF00244	0.314
LIG_14-3-3_CanoR_1	143	150	PF00244	0.461
LIG_14-3-3_CanoR_1	82	90	PF00244	0.406
LIG_14-3-3_CanoR_1	92	98	PF00244	0.421
LIG_14-3-3_CterR_2	168	172	PF00244	0.303
LIG_FHA_2	83	89	PF00498	0.317
LIG_LIR_Gen_1	148	155	PF02991	0.329
LIG_LIR_Nem_3	11	17	PF02991	0.340
LIG_LIR_Nem_3	148	153	PF02991	0.329
LIG_PCNA_APIM_2	162	168	PF02747	0.449
LIG_SH2_CRK	14	18	PF00017	0.344
LIG_SH2_STAP1	59	63	PF00017	0.449
LIG_SH2_STAT5	134	137	PF00017	0.413
LIG_SH2_STAT5	165	168	PF00017	0.328
LIG_SH2_STAT5	84	87	PF00017	0.364
LIG_SH2_STAT5	97	100	PF00017	0.397
LIG_SH3_1	130	136	PF00018	0.385
LIG_SH3_2	133	138	PF14604	0.385
LIG_SH3_3	130	136	PF00018	0.366
MOD_CK2_1	54	60	PF00069	0.332
MOD_CK2_1	82	88	PF00069	0.261
MOD_Cter_Amidation	127	130	PF01082	0.363
MOD_GSK3_1	98	105	PF00069	0.403
MOD_NEK2_1	96	101	PF00069	0.363
MOD_PIKK_1	91	97	PF00454	0.338
MOD_PK_1	102	108	PF00069	0.474
MOD_PK_1	109	115	PF00069	0.359
MOD_PKA_1	109	115	PF00069	0.441
MOD_PKA_2	108	114	PF00069	0.328
MOD_PKA_2	91	97	PF00069	0.328
MOD_Plk_1	102	108	PF00069	0.487
MOD_SUMO_for_1	113	116	PF00179	0.319
MOD_SUMO_rev_2	71	78	PF00179	0.430
TRG_ENDOCYTIC_2	14	17	PF00928	0.325
TRG_ENDOCYTIC_2	84	87	PF00928	0.413
TRG_ER_diArg_1	118	120	PF00400	0.363
TRG_ER_diArg_1	167	170	PF00400	0.413
TRG_ER_diArg_1	28	30	PF00400	0.343
TRG_ER_diArg_1	39	41	PF00400	0.302
TRG_NLS_Bipartite_1	114	133	PF00514	0.326
TRG_NLS_MonoExtC_3	128	133	PF00514	0.382
TRG_NLS_MonoExtC_3	167	172	PF00514	0.449
TRG_NLS_MonoExtN_4	126	133	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P373	Leptomonas seymouri	81%	79%
A0A0S4IME8	Bodo saltans	43%	74%
A0A1X0NLQ0	Trypanosomatidae	53%	80%
A0A3S5H5E2	Leishmania donovani	95%	77%
A0A422NNW0	Trypanosoma rangeli	53%	81%
A4H416	Leishmania braziliensis	89%	100%
A4HS99	Leishmania infantum	95%	77%
C9ZY93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	82%
Q9NF94	Leishmania major	94%	100%
V5BDM1	Trypanosoma cruzi	55%	81%