Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK78_LEIMU

TriTrypDb:

LmxM.04.0970

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.589
CLV_C14_Caspase3-7	305	309	PF00656	0.553
CLV_C14_Caspase3-7	370	374	PF00656	0.413
CLV_C14_Caspase3-7	388	392	PF00656	0.420
CLV_NRD_NRD_1	189	191	PF00675	0.583
CLV_NRD_NRD_1	223	225	PF00675	0.507
CLV_NRD_NRD_1	242	244	PF00675	0.511
CLV_NRD_NRD_1	433	435	PF00675	0.555
CLV_NRD_NRD_1	481	483	PF00675	0.603
CLV_NRD_NRD_1	63	65	PF00675	0.662
CLV_NRD_NRD_1	91	93	PF00675	0.629
CLV_PCSK_FUR_1	21	25	PF00082	0.700
CLV_PCSK_KEX2_1	188	190	PF00082	0.621
CLV_PCSK_KEX2_1	223	225	PF00082	0.509
CLV_PCSK_KEX2_1	23	25	PF00082	0.700
CLV_PCSK_KEX2_1	242	244	PF00082	0.513
CLV_PCSK_KEX2_1	433	435	PF00082	0.555
CLV_PCSK_KEX2_1	481	483	PF00082	0.603
CLV_PCSK_KEX2_1	86	88	PF00082	0.652
CLV_PCSK_KEX2_1	91	93	PF00082	0.652
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.700
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.678
CLV_PCSK_PC7_1	87	93	PF00082	0.604
CLV_PCSK_SKI1_1	34	38	PF00082	0.675
CLV_PCSK_SKI1_1	348	352	PF00082	0.574
DEG_SCF_TRCP1_1	373	379	PF00400	0.488
DEG_SPOP_SBC_1	194	198	PF00917	0.697
DEG_SPOP_SBC_1	54	58	PF00917	0.698
DOC_CKS1_1	121	126	PF01111	0.573
DOC_CKS1_1	200	205	PF01111	0.536
DOC_MAPK_DCC_7	242	251	PF00069	0.589
DOC_MAPK_DCC_7	348	358	PF00069	0.444
DOC_MAPK_gen_1	165	173	PF00069	0.517
DOC_MAPK_MEF2A_6	242	251	PF00069	0.589
DOC_MAPK_MEF2A_6	344	353	PF00069	0.550
DOC_PP2B_LxvP_1	119	122	PF13499	0.660
DOC_PP2B_PxIxI_1	246	252	PF00149	0.530
DOC_PP4_FxxP_1	76	79	PF00568	0.552
DOC_USP7_MATH_1	192	196	PF00917	0.741
DOC_USP7_MATH_1	282	286	PF00917	0.557
DOC_USP7_MATH_1	55	59	PF00917	0.696
DOC_USP7_MATH_1	63	67	PF00917	0.636
DOC_WW_Pin1_4	112	117	PF00397	0.559
DOC_WW_Pin1_4	12	17	PF00397	0.779
DOC_WW_Pin1_4	120	125	PF00397	0.625
DOC_WW_Pin1_4	151	156	PF00397	0.620
DOC_WW_Pin1_4	199	204	PF00397	0.697
DOC_WW_Pin1_4	254	259	PF00397	0.594
DOC_WW_Pin1_4	376	381	PF00397	0.559
DOC_WW_Pin1_4	59	64	PF00397	0.665
DOC_WW_Pin1_4	75	80	PF00397	0.554
DOC_WW_Pin1_4	97	102	PF00397	0.728
LIG_14-3-3_CanoR_1	168	172	PF00244	0.615
LIG_14-3-3_CanoR_1	21	27	PF00244	0.657
LIG_14-3-3_CanoR_1	337	346	PF00244	0.575
LIG_14-3-3_CanoR_1	34	39	PF00244	0.560
LIG_14-3-3_CanoR_1	413	420	PF00244	0.538
LIG_14-3-3_CanoR_1	64	68	PF00244	0.656
LIG_Actin_WH2_2	412	429	PF00022	0.576
LIG_APCC_ABBA_1	412	417	PF00400	0.511
LIG_EVH1_1	76	80	PF00568	0.545
LIG_FHA_1	121	127	PF00498	0.692
LIG_FHA_1	168	174	PF00498	0.814
LIG_FHA_1	98	104	PF00498	0.611
LIG_FHA_2	452	458	PF00498	0.503
LIG_LIR_Apic_2	253	258	PF02991	0.565
LIG_LIR_Apic_2	465	471	PF02991	0.560
LIG_LIR_Nem_3	25	29	PF02991	0.537
LIG_PTAP_UEV_1	202	207	PF05743	0.577
LIG_SH2_CRK	255	259	PF00017	0.570
LIG_SH2_CRK	468	472	PF00017	0.556
LIG_SH2_STAP1	234	238	PF00017	0.417
LIG_SH2_STAP1	393	397	PF00017	0.418
LIG_SH3_1	65	71	PF00018	0.598
LIG_SH3_2	163	168	PF14604	0.503
LIG_SH3_2	68	73	PF14604	0.685
LIG_SH3_3	118	124	PF00018	0.690
LIG_SH3_3	160	166	PF00018	0.618
LIG_SH3_3	188	194	PF00018	0.597
LIG_SH3_3	200	206	PF00018	0.705
LIG_SH3_3	374	380	PF00018	0.494
LIG_SH3_3	39	45	PF00018	0.674
LIG_SH3_3	65	71	PF00018	0.755
LIG_SH3_3	74	80	PF00018	0.616
LIG_TRAF2_1	454	457	PF00917	0.501
LIG_TRFH_1	228	232	PF08558	0.568
LIG_TRFH_1	29	33	PF08558	0.584
LIG_WW_3	15	19	PF00397	0.535
MOD_CDC14_SPxK_1	62	65	PF00782	0.664
MOD_CDK_SPK_2	59	64	PF00069	0.665
MOD_CDK_SPxK_1	12	18	PF00069	0.540
MOD_CDK_SPxK_1	59	65	PF00069	0.667
MOD_CK1_1	140	146	PF00069	0.671
MOD_CK1_1	151	157	PF00069	0.622
MOD_CK1_1	177	183	PF00069	0.675
MOD_CK1_1	195	201	PF00069	0.618
MOD_CK1_1	8	14	PF00069	0.661
MOD_CK1_1	97	103	PF00069	0.664
MOD_CK2_1	327	333	PF00069	0.501
MOD_CK2_1	382	388	PF00069	0.481
MOD_CK2_1	451	457	PF00069	0.520
MOD_CMANNOS	238	241	PF00535	0.398
MOD_Cter_Amidation	186	189	PF01082	0.550
MOD_Cter_Amidation	89	92	PF01082	0.650
MOD_GlcNHglycan	103	106	PF01048	0.696
MOD_GlcNHglycan	128	131	PF01048	0.624
MOD_GlcNHglycan	139	142	PF01048	0.625
MOD_GlcNHglycan	206	209	PF01048	0.661
MOD_GlcNHglycan	288	291	PF01048	0.672
MOD_GlcNHglycan	373	376	PF01048	0.531
MOD_GlcNHglycan	384	387	PF01048	0.418
MOD_GlcNHglycan	65	68	PF01048	0.714
MOD_GlcNHglycan	7	10	PF01048	0.619
MOD_GSK3_1	151	158	PF00069	0.632
MOD_GSK3_1	192	199	PF00069	0.649
MOD_GSK3_1	226	233	PF00069	0.664
MOD_GSK3_1	282	289	PF00069	0.572
MOD_GSK3_1	308	315	PF00069	0.617
MOD_GSK3_1	367	374	PF00069	0.443
MOD_GSK3_1	4	11	PF00069	0.683
MOD_GSK3_1	55	62	PF00069	0.698
MOD_GSK3_1	97	104	PF00069	0.639
MOD_N-GLC_1	226	231	PF02516	0.481
MOD_NEK2_1	126	131	PF00069	0.577
MOD_NEK2_1	327	332	PF00069	0.415
MOD_PKA_1	86	92	PF00069	0.675
MOD_PKA_2	167	173	PF00069	0.579
MOD_PKA_2	63	69	PF00069	0.652
MOD_PKA_2	86	92	PF00069	0.675
MOD_Plk_1	226	232	PF00069	0.474
MOD_Plk_2-3	308	314	PF00069	0.591
MOD_Plk_4	367	373	PF00069	0.424
MOD_ProDKin_1	112	118	PF00069	0.561
MOD_ProDKin_1	12	18	PF00069	0.780
MOD_ProDKin_1	120	126	PF00069	0.626
MOD_ProDKin_1	151	157	PF00069	0.620
MOD_ProDKin_1	199	205	PF00069	0.697
MOD_ProDKin_1	254	260	PF00069	0.589
MOD_ProDKin_1	376	382	PF00069	0.555
MOD_ProDKin_1	59	65	PF00069	0.667
MOD_ProDKin_1	75	81	PF00069	0.552
MOD_ProDKin_1	97	103	PF00069	0.729
TRG_ENDOCYTIC_2	319	322	PF00928	0.533
TRG_ER_diArg_1	188	190	PF00400	0.627
TRG_ER_diArg_1	241	243	PF00400	0.518
TRG_ER_diArg_1	264	267	PF00400	0.537
TRG_ER_diArg_1	433	435	PF00400	0.555
TRG_ER_diArg_1	91	93	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ4	Leptomonas seymouri	39%	97%
A0A3S5H5D8	Leishmania donovani	78%	92%
A4H411	Leishmania braziliensis	66%	100%
A4HS94	Leishmania infantum	78%	99%
Q9U1D2	Leishmania major	79%	100%