Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK73_LEIMU

TriTrypDb:

LmxM.04.0920

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.625
CLV_C14_Caspase3-7	235	239	PF00656	0.696
CLV_C14_Caspase3-7	37	41	PF00656	0.700
CLV_C14_Caspase3-7	417	421	PF00656	0.534
CLV_NRD_NRD_1	154	156	PF00675	0.648
CLV_NRD_NRD_1	19	21	PF00675	0.669
CLV_NRD_NRD_1	246	248	PF00675	0.707
CLV_NRD_NRD_1	50	52	PF00675	0.696
CLV_NRD_NRD_1	92	94	PF00675	0.612
CLV_PCSK_KEX2_1	154	156	PF00082	0.648
CLV_PCSK_KEX2_1	19	21	PF00082	0.669
CLV_PCSK_KEX2_1	246	248	PF00082	0.679
CLV_PCSK_KEX2_1	50	52	PF00082	0.696
CLV_PCSK_SKI1_1	397	401	PF00082	0.604
CLV_PCSK_SKI1_1	561	565	PF00082	0.582
DEG_Nend_UBRbox_1	1	4	PF02207	0.515
DEG_SCF_FBW7_1	30	35	PF00400	0.624
DEG_SPOP_SBC_1	131	135	PF00917	0.634
DEG_SPOP_SBC_1	399	403	PF00917	0.538
DEG_SPOP_SBC_1	64	68	PF00917	0.655
DOC_CYCLIN_yCln2_LP_2	555	558	PF00134	0.496
DOC_MAPK_gen_1	361	370	PF00069	0.688
DOC_MAPK_MEF2A_6	19	26	PF00069	0.663
DOC_MAPK_MEF2A_6	361	370	PF00069	0.688
DOC_PP2B_LxvP_1	117	120	PF13499	0.548
DOC_PP2B_LxvP_1	555	558	PF13499	0.517
DOC_USP7_MATH_1	131	135	PF00917	0.634
DOC_USP7_MATH_1	250	254	PF00917	0.657
DOC_USP7_MATH_1	351	355	PF00917	0.707
DOC_USP7_MATH_1	359	363	PF00917	0.589
DOC_USP7_MATH_1	364	368	PF00917	0.534
DOC_USP7_MATH_1	392	396	PF00917	0.655
DOC_USP7_MATH_1	418	422	PF00917	0.540
DOC_USP7_MATH_1	446	450	PF00917	0.646
DOC_USP7_MATH_1	64	68	PF00917	0.779
DOC_USP7_MATH_1	9	13	PF00917	0.489
DOC_WW_Pin1_4	201	206	PF00397	0.666
DOC_WW_Pin1_4	256	261	PF00397	0.669
DOC_WW_Pin1_4	28	33	PF00397	0.625
DOC_WW_Pin1_4	442	447	PF00397	0.675
LIG_14-3-3_CanoR_1	167	172	PF00244	0.654
LIG_14-3-3_CanoR_1	227	233	PF00244	0.608
LIG_14-3-3_CanoR_1	274	283	PF00244	0.586
LIG_14-3-3_CanoR_1	328	335	PF00244	0.685
LIG_14-3-3_CanoR_1	397	406	PF00244	0.760
LIG_14-3-3_CanoR_1	42	52	PF00244	0.551
LIG_14-3-3_CanoR_1	529	533	PF00244	0.542
LIG_APCC_ABBA_1	301	306	PF00400	0.524
LIG_Clathr_ClatBox_1	431	435	PF01394	0.721
LIG_DLG_GKlike_1	167	174	PF00625	0.542
LIG_FHA_1	33	39	PF00498	0.694
LIG_FHA_1	399	405	PF00498	0.718
LIG_FHA_1	44	50	PF00498	0.578
LIG_FHA_1	522	528	PF00498	0.395
LIG_FHA_1	542	548	PF00498	0.504
LIG_FHA_2	184	190	PF00498	0.541
LIG_FHA_2	314	320	PF00498	0.709
LIG_FHA_2	35	41	PF00498	0.699
LIG_FHA_2	415	421	PF00498	0.601
LIG_FHA_2	460	466	PF00498	0.549
LIG_GBD_Chelix_1	109	117	PF00786	0.514
LIG_LIR_Gen_1	493	503	PF02991	0.755
LIG_LIR_Gen_1	524	532	PF02991	0.478
LIG_LIR_Nem_3	280	286	PF02991	0.571
LIG_LIR_Nem_3	493	498	PF02991	0.767
LIG_LIR_Nem_3	524	528	PF02991	0.591
LIG_NRBOX	112	118	PF00104	0.523
LIG_PDZ_Class_2	575	580	PF00595	0.517
LIG_Pex14_2	104	108	PF04695	0.535
LIG_SH2_PTP2	77	80	PF00017	0.705
LIG_SH2_STAP1	283	287	PF00017	0.560
LIG_SH2_STAP1	495	499	PF00017	0.772
LIG_SH2_STAT3	286	289	PF00017	0.637
LIG_SH2_STAT5	286	289	PF00017	0.629
LIG_SH2_STAT5	495	498	PF00017	0.676
LIG_SH2_STAT5	77	80	PF00017	0.705
LIG_SH3_3	172	178	PF00018	0.602
LIG_SH3_3	27	33	PF00018	0.620
LIG_SH3_3	338	344	PF00018	0.678
LIG_SH3_3	419	425	PF00018	0.628
LIG_SH3_3	504	510	PF00018	0.616
LIG_SH3_3	93	99	PF00018	0.667
LIG_SUMO_SIM_par_1	34	40	PF11976	0.697
LIG_SUMO_SIM_par_1	516	524	PF11976	0.406
LIG_TRAF2_1	450	453	PF00917	0.757
LIG_TYR_ITIM	75	80	PF00017	0.558
LIG_WRC_WIRS_1	522	527	PF05994	0.393
MOD_CDK_SPxxK_3	444	451	PF00069	0.725
MOD_CK1_1	130	136	PF00069	0.774
MOD_CK1_1	165	171	PF00069	0.633
MOD_CK1_1	212	218	PF00069	0.796
MOD_CK1_1	354	360	PF00069	0.705
MOD_CK1_1	395	401	PF00069	0.787
MOD_CK1_1	45	51	PF00069	0.579
MOD_CK1_1	493	499	PF00069	0.671
MOD_CK1_1	63	69	PF00069	0.587
MOD_CK2_1	167	173	PF00069	0.832
MOD_CK2_1	228	234	PF00069	0.595
MOD_CK2_1	446	452	PF00069	0.776
MOD_Cter_Amidation	91	94	PF01082	0.576
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.668
MOD_GlcNHglycan	123	126	PF01048	0.649
MOD_GlcNHglycan	129	132	PF01048	0.639
MOD_GlcNHglycan	13	16	PF01048	0.561
MOD_GlcNHglycan	145	148	PF01048	0.481
MOD_GlcNHglycan	157	161	PF01048	0.607
MOD_GlcNHglycan	201	204	PF01048	0.657
MOD_GlcNHglycan	242	245	PF01048	0.638
MOD_GlcNHglycan	330	333	PF01048	0.682
MOD_GlcNHglycan	353	356	PF01048	0.647
MOD_GlcNHglycan	381	384	PF01048	0.601
MOD_GlcNHglycan	414	417	PF01048	0.688
MOD_GlcNHglycan	62	65	PF01048	0.560
MOD_GSK3_1	127	134	PF00069	0.668
MOD_GSK3_1	162	169	PF00069	0.613
MOD_GSK3_1	195	202	PF00069	0.724
MOD_GSK3_1	209	216	PF00069	0.631
MOD_GSK3_1	221	228	PF00069	0.702
MOD_GSK3_1	266	273	PF00069	0.696
MOD_GSK3_1	28	35	PF00069	0.707
MOD_GSK3_1	379	386	PF00069	0.658
MOD_GSK3_1	395	402	PF00069	0.553
MOD_GSK3_1	410	417	PF00069	0.712
MOD_GSK3_1	442	449	PF00069	0.717
MOD_GSK3_1	459	466	PF00069	0.827
MOD_GSK3_1	493	500	PF00069	0.572
MOD_GSK3_1	60	67	PF00069	0.578
MOD_N-GLC_1	143	148	PF02516	0.677
MOD_N-GLC_1	442	447	PF02516	0.724
MOD_NEK2_1	104	109	PF00069	0.531
MOD_NEK2_1	127	132	PF00069	0.683
MOD_NEK2_1	163	168	PF00069	0.634
MOD_NEK2_1	213	218	PF00069	0.724
MOD_NEK2_2	364	369	PF00069	0.637
MOD_PIKK_1	266	272	PF00454	0.699
MOD_PIKK_1	313	319	PF00454	0.708
MOD_PKA_2	166	172	PF00069	0.650
MOD_PKA_2	384	390	PF00069	0.532
MOD_PKA_2	493	499	PF00069	0.541
MOD_PKA_2	528	534	PF00069	0.541
MOD_Plk_1	104	110	PF00069	0.526
MOD_Plk_1	143	149	PF00069	0.675
MOD_Plk_1	190	196	PF00069	0.537
MOD_Plk_1	209	215	PF00069	0.698
MOD_Plk_1	395	401	PF00069	0.804
MOD_Plk_1	478	484	PF00069	0.685
MOD_Plk_2-3	190	196	PF00069	0.528
MOD_Plk_4	104	110	PF00069	0.526
MOD_Plk_4	213	219	PF00069	0.541
MOD_Plk_4	364	370	PF00069	0.689
MOD_Plk_4	521	527	PF00069	0.475
MOD_ProDKin_1	201	207	PF00069	0.664
MOD_ProDKin_1	256	262	PF00069	0.667
MOD_ProDKin_1	28	34	PF00069	0.626
MOD_ProDKin_1	442	448	PF00069	0.676
TRG_DiLeu_BaEn_2	572	578	PF01217	0.469
TRG_DiLeu_BaEn_4	322	328	PF01217	0.704
TRG_DiLeu_BaEn_4	454	460	PF01217	0.680
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.525
TRG_ENDOCYTIC_2	495	498	PF00928	0.776
TRG_ENDOCYTIC_2	77	80	PF00928	0.549
TRG_ER_diArg_1	154	156	PF00400	0.532
TRG_ER_diArg_1	18	20	PF00400	0.678
TRG_ER_diArg_1	49	51	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V5	Leptomonas seymouri	38%	100%
A0A3S7WNU3	Leishmania donovani	88%	97%
A4H3Y5	Leishmania braziliensis	75%	100%
O97009	Leishmania major	88%	100%