Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK72_LEIMU

TriTrypDb:

LmxM.04.0910

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	177	185	PF00400	0.462
DEG_Nend_UBRbox_3	1	3	PF02207	0.522
DEG_SPOP_SBC_1	38	42	PF00917	0.574
DOC_CKS1_1	120	125	PF01111	0.534
DOC_MAPK_MEF2A_6	145	154	PF00069	0.486
DOC_PP2B_LxvP_1	131	134	PF13499	0.538
DOC_USP7_MATH_1	121	125	PF00917	0.525
DOC_USP7_MATH_1	134	138	PF00917	0.566
DOC_USP7_MATH_1	38	42	PF00917	0.621
DOC_USP7_MATH_1	51	55	PF00917	0.535
DOC_USP7_MATH_1	75	79	PF00917	0.550
DOC_WW_Pin1_4	106	111	PF00397	0.538
DOC_WW_Pin1_4	115	120	PF00397	0.600
DOC_WW_Pin1_4	5	10	PF00397	0.744
LIG_14-3-3_CanoR_1	174	182	PF00244	0.498
LIG_14-3-3_CanoR_1	37	47	PF00244	0.581
LIG_EVH1_2	101	105	PF00568	0.460
LIG_LIR_Gen_1	148	157	PF02991	0.444
LIG_LIR_Gen_1	88	97	PF02991	0.595
LIG_LIR_LC3C_4	148	152	PF02991	0.451
LIG_LIR_Nem_3	148	152	PF02991	0.437
LIG_LIR_Nem_3	19	24	PF02991	0.629
LIG_LIR_Nem_3	88	92	PF02991	0.582
LIG_LYPXL_yS_3	21	24	PF13949	0.627
LIG_PDZ_Class_2	190	195	PF00595	0.487
LIG_SH2_CRK	89	93	PF00017	0.598
LIG_SH2_NCK_1	89	93	PF00017	0.598
LIG_SH2_STAP1	164	168	PF00017	0.497
LIG_SH2_STAP1	89	93	PF00017	0.522
LIG_SH2_STAT5	162	165	PF00017	0.599
LIG_SH3_3	117	123	PF00018	0.454
LIG_SH3_3	56	62	PF00018	0.605
LIG_SH3_3	97	103	PF00018	0.588
MOD_CK1_1	113	119	PF00069	0.529
MOD_CK1_1	137	143	PF00069	0.478
MOD_CK1_1	23	29	PF00069	0.548
MOD_CK1_1	40	46	PF00069	0.633
MOD_CK2_1	92	98	PF00069	0.555
MOD_GlcNHglycan	53	56	PF01048	0.597
MOD_GSK3_1	106	113	PF00069	0.541
MOD_GSK3_1	115	122	PF00069	0.594
MOD_GSK3_1	134	141	PF00069	0.472
MOD_GSK3_1	37	44	PF00069	0.699
MOD_N-GLC_1	38	43	PF02516	0.545
MOD_NEK2_1	105	110	PF00069	0.550
MOD_NEK2_1	114	119	PF00069	0.618
MOD_NEK2_1	138	143	PF00069	0.521
MOD_NEK2_1	3	8	PF00069	0.531
MOD_PKA_2	173	179	PF00069	0.514
MOD_Plk_1	138	144	PF00069	0.484
MOD_Plk_2-3	173	179	PF00069	0.544
MOD_Plk_4	110	116	PF00069	0.570
MOD_Plk_4	139	145	PF00069	0.562
MOD_ProDKin_1	106	112	PF00069	0.535
MOD_ProDKin_1	115	121	PF00069	0.595
MOD_ProDKin_1	5	11	PF00069	0.747
MOD_SUMO_rev_2	54	59	PF00179	0.612
TRG_DiLeu_BaEn_1	139	144	PF01217	0.560
TRG_DiLeu_BaEn_1	177	182	PF01217	0.569
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.637
TRG_ENDOCYTIC_2	21	24	PF00928	0.627
TRG_ENDOCYTIC_2	89	92	PF00928	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P497	Leptomonas seymouri	53%	92%
A0A3S7WNU9	Leishmania donovani	83%	79%
A4H3Y4	Leishmania braziliensis	67%	100%
A4HS84	Leishmania infantum	84%	79%
O97008	Leishmania major	83%	100%