Rhomboid-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan S-, family S54, putative

Species:

Leishmania mexicana

UniProt:

E9AK68_LEIMU

TriTrypDb:

LmxM.04.0850

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AK68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK68

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.662
CLV_PCSK_SKI1_1	321	325	PF00082	0.246
DEG_Nend_UBRbox_1	1	4	PF02207	0.611
DEG_SPOP_SBC_1	4	8	PF00917	0.683
DOC_CYCLIN_RxL_1	346	357	PF00134	0.387
DOC_MAPK_gen_1	51	61	PF00069	0.761
DOC_MAPK_MEF2A_6	54	63	PF00069	0.557
DOC_PP1_RVXF_1	293	300	PF00149	0.285
DOC_PP4_FxxP_1	152	155	PF00568	0.592
DOC_USP7_MATH_1	102	106	PF00917	0.762
DOC_USP7_MATH_1	31	35	PF00917	0.754
DOC_USP7_MATH_1	4	8	PF00917	0.690
DOC_USP7_MATH_1	79	83	PF00917	0.714
DOC_WW_Pin1_4	71	76	PF00397	0.660
DOC_WW_Pin1_4	98	103	PF00397	0.749
LIG_14-3-3_CanoR_1	23	29	PF00244	0.664
LIG_14-3-3_CanoR_1	239	243	PF00244	0.329
LIG_14-3-3_CanoR_1	64	68	PF00244	0.633
LIG_BRCT_BRCA1_1	80	84	PF00533	0.647
LIG_Clathr_ClatBox_1	286	290	PF01394	0.285
LIG_deltaCOP1_diTrp_1	181	186	PF00928	0.394
LIG_deltaCOP1_diTrp_1	196	205	PF00928	0.276
LIG_deltaCOP1_diTrp_1	220	227	PF00928	0.246
LIG_deltaCOP1_diTrp_1	318	323	PF00928	0.285
LIG_EH_1	138	142	PF12763	0.616
LIG_EH_1	279	283	PF12763	0.285
LIG_EVH1_1	150	154	PF00568	0.609
LIG_EVH1_2	303	307	PF00568	0.246
LIG_FHA_1	156	162	PF00498	0.446
LIG_FHA_1	309	315	PF00498	0.307
LIG_FHA_1	346	352	PF00498	0.383
LIG_FHA_1	56	62	PF00498	0.656
LIG_FHA_2	323	329	PF00498	0.459
LIG_LIR_Gen_1	196	205	PF02991	0.302
LIG_LIR_Gen_1	241	249	PF02991	0.329
LIG_LIR_Gen_1	311	319	PF02991	0.285
LIG_LIR_Nem_3	180	186	PF02991	0.378
LIG_LIR_Nem_3	196	201	PF02991	0.264
LIG_LIR_Nem_3	241	246	PF02991	0.329
LIG_LIR_Nem_3	311	316	PF02991	0.285
LIG_LIR_Nem_3	318	323	PF02991	0.285
LIG_LYPXL_S_1	201	205	PF13949	0.446
LIG_Pex14_1	198	202	PF04695	0.339
LIG_Pex14_2	152	156	PF04695	0.591
LIG_Pex14_2	205	209	PF04695	0.302
LIG_PTB_Apo_2	204	211	PF02174	0.278
LIG_PTB_Phospho_1	204	210	PF10480	0.278
LIG_SH2_STAT5	149	152	PF00017	0.617
LIG_SH2_STAT5	173	176	PF00017	0.301
LIG_SH2_STAT5	341	344	PF00017	0.304
LIG_SH3_3	148	154	PF00018	0.610
LIG_SH3_3	300	306	PF00018	0.261
LIG_SUMO_SIM_par_1	285	290	PF11976	0.363
LIG_UBA3_1	350	355	PF00899	0.390
MOD_CDC14_SPxK_1	101	104	PF00782	0.740
MOD_CDK_SPK_2	98	103	PF00069	0.749
MOD_CDK_SPxK_1	98	104	PF00069	0.738
MOD_CK1_1	106	112	PF00069	0.704
MOD_CK1_1	13	19	PF00069	0.735
MOD_CK1_1	38	44	PF00069	0.688
MOD_CK1_1	6	12	PF00069	0.747
MOD_CK2_1	322	328	PF00069	0.459
MOD_CMANNOS	222	225	PF00535	0.459
MOD_GlcNHglycan	107	111	PF01048	0.569
MOD_GlcNHglycan	144	147	PF01048	0.481
MOD_GlcNHglycan	16	19	PF01048	0.474
MOD_GlcNHglycan	24	27	PF01048	0.534
MOD_GlcNHglycan	33	36	PF01048	0.421
MOD_GSK3_1	14	21	PF00069	0.742
MOD_GSK3_1	245	252	PF00069	0.312
MOD_GSK3_1	3	10	PF00069	0.638
MOD_GSK3_1	31	38	PF00069	0.629
MOD_GSK3_1	39	46	PF00069	0.699
MOD_GSK3_1	71	78	PF00069	0.681
MOD_GSK3_1	98	105	PF00069	0.772
MOD_NEK2_1	227	232	PF00069	0.246
MOD_NEK2_1	235	240	PF00069	0.246
MOD_NEK2_1	245	250	PF00069	0.285
MOD_NEK2_1	308	313	PF00069	0.285
MOD_NEK2_1	37	42	PF00069	0.632
MOD_NEK2_1	5	10	PF00069	0.672
MOD_NEK2_2	18	23	PF00069	0.609
MOD_NEK2_2	49	54	PF00069	0.671
MOD_NEK2_2	79	84	PF00069	0.580
MOD_PKA_1	103	109	PF00069	0.685
MOD_PKA_2	22	28	PF00069	0.766
MOD_PKA_2	238	244	PF00069	0.329
MOD_PKA_2	63	69	PF00069	0.633
MOD_PKA_2	93	99	PF00069	0.780
MOD_Plk_4	227	233	PF00069	0.260
MOD_Plk_4	238	244	PF00069	0.285
MOD_Plk_4	249	255	PF00069	0.281
MOD_Plk_4	55	61	PF00069	0.715
MOD_Plk_4	63	69	PF00069	0.645
MOD_Plk_4	79	85	PF00069	0.524
MOD_ProDKin_1	71	77	PF00069	0.655
MOD_ProDKin_1	98	104	PF00069	0.751
TRG_ENDOCYTIC_2	149	152	PF00928	0.617
TRG_ENDOCYTIC_2	173	176	PF00928	0.286
TRG_ENDOCYTIC_2	202	205	PF00928	0.249
TRG_ENDOCYTIC_2	264	267	PF00928	0.459
TRG_ER_diArg_1	272	275	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	349	354	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA30	Leptomonas seymouri	79%	94%
A0A0S4IM64	Bodo saltans	70%	100%
A0A1X0NLI4	Trypanosomatidae	76%	100%
A0A3R7RFZ5	Trypanosoma rangeli	66%	100%
A0A3S7WNU2	Leishmania donovani	92%	91%
A4H3Z5	Leishmania braziliensis	91%	100%
A4HS82	Leishmania infantum	92%	91%
C9ZY76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
Q9U0Z8	Leishmania major	93%	100%