Tyrosine phospatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phospatase-like protein

Species:

Leishmania mexicana

UniProt:

E9AK67_LEIMU

TriTrypDb:

LmxM.04.0840

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004721	phosphoprotein phosphatase activity	3	4
GO:0004725	protein tyrosine phosphatase activity	4	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.622
CLV_MEL_PAP_1	787	793	PF00089	0.692
CLV_NRD_NRD_1	118	120	PF00675	0.652
CLV_NRD_NRD_1	270	272	PF00675	0.828
CLV_NRD_NRD_1	4	6	PF00675	0.706
CLV_NRD_NRD_1	414	416	PF00675	0.423
CLV_NRD_NRD_1	496	498	PF00675	0.420
CLV_NRD_NRD_1	764	766	PF00675	0.693
CLV_PCSK_KEX2_1	118	120	PF00082	0.652
CLV_PCSK_KEX2_1	270	272	PF00082	0.828
CLV_PCSK_KEX2_1	4	6	PF00082	0.706
CLV_PCSK_KEX2_1	414	416	PF00082	0.423
CLV_PCSK_KEX2_1	556	558	PF00082	0.550
CLV_PCSK_KEX2_1	764	766	PF00082	0.693
CLV_PCSK_KEX2_1	864	866	PF00082	0.835
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.550
CLV_PCSK_PC1ET2_1	864	866	PF00082	0.740
CLV_PCSK_PC7_1	114	120	PF00082	0.579
CLV_PCSK_SKI1_1	486	490	PF00082	0.351
CLV_PCSK_SKI1_1	497	501	PF00082	0.268
CLV_PCSK_SKI1_1	675	679	PF00082	0.498
CLV_PCSK_SKI1_1	861	865	PF00082	0.574
DEG_APCC_DBOX_1	414	422	PF00400	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.560
DEG_SCF_FBW7_1	96	102	PF00400	0.566
DEG_SPOP_SBC_1	146	150	PF00917	0.551
DEG_SPOP_SBC_1	737	741	PF00917	0.708
DEG_SPOP_SBC_1	75	79	PF00917	0.613
DOC_CKS1_1	234	239	PF01111	0.518
DOC_CKS1_1	287	292	PF01111	0.740
DOC_CKS1_1	81	86	PF01111	0.539
DOC_CKS1_1	96	101	PF01111	0.595
DOC_CYCLIN_RxL_1	408	420	PF00134	0.551
DOC_CYCLIN_RxL_1	494	503	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.693
DOC_CYCLIN_yCln2_LP_2	386	389	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	533	536	PF00134	0.551
DOC_MAPK_gen_1	414	424	PF00069	0.551
DOC_MAPK_gen_1	451	458	PF00069	0.551
DOC_MAPK_gen_1	556	564	PF00069	0.542
DOC_MAPK_MEF2A_6	557	566	PF00069	0.545
DOC_MAPK_MEF2A_6	667	674	PF00069	0.566
DOC_PP1_RVXF_1	496	503	PF00149	0.551
DOC_PP2B_LxvP_1	154	157	PF13499	0.502
DOC_PP2B_LxvP_1	386	389	PF13499	0.537
DOC_PP2B_LxvP_1	532	535	PF13499	0.551
DOC_PP2B_LxvP_1	800	803	PF13499	0.633
DOC_PP2B_LxvP_1	94	97	PF13499	0.704
DOC_USP7_MATH_1	157	161	PF00917	0.628
DOC_USP7_MATH_1	293	297	PF00917	0.752
DOC_USP7_MATH_1	59	63	PF00917	0.679
DOC_USP7_MATH_1	602	606	PF00917	0.594
DOC_USP7_MATH_1	621	625	PF00917	0.613
DOC_USP7_MATH_1	694	698	PF00917	0.654
DOC_USP7_MATH_1	712	716	PF00917	0.676
DOC_USP7_MATH_1	729	733	PF00917	0.545
DOC_USP7_MATH_1	736	740	PF00917	0.656
DOC_USP7_MATH_1	781	785	PF00917	0.797
DOC_USP7_MATH_1	824	828	PF00917	0.726
DOC_USP7_MATH_1	834	838	PF00917	0.706
DOC_USP7_MATH_1	852	856	PF00917	0.713
DOC_USP7_MATH_1	863	867	PF00917	0.754
DOC_WW_Pin1_4	104	109	PF00397	0.559
DOC_WW_Pin1_4	147	152	PF00397	0.666
DOC_WW_Pin1_4	183	188	PF00397	0.751
DOC_WW_Pin1_4	217	222	PF00397	0.771
DOC_WW_Pin1_4	223	228	PF00397	0.704
DOC_WW_Pin1_4	229	234	PF00397	0.605
DOC_WW_Pin1_4	286	291	PF00397	0.742
DOC_WW_Pin1_4	300	305	PF00397	0.650
DOC_WW_Pin1_4	34	39	PF00397	0.589
DOC_WW_Pin1_4	690	695	PF00397	0.581
DOC_WW_Pin1_4	70	75	PF00397	0.694
DOC_WW_Pin1_4	714	719	PF00397	0.532
DOC_WW_Pin1_4	76	81	PF00397	0.636
DOC_WW_Pin1_4	88	93	PF00397	0.613
DOC_WW_Pin1_4	95	100	PF00397	0.622
LIG_14-3-3_CanoR_1	118	125	PF00244	0.599
LIG_14-3-3_CanoR_1	159	163	PF00244	0.574
LIG_14-3-3_CanoR_1	258	267	PF00244	0.645
LIG_14-3-3_CanoR_1	353	358	PF00244	0.733
LIG_14-3-3_CanoR_1	419	425	PF00244	0.611
LIG_14-3-3_CanoR_1	557	563	PF00244	0.428
LIG_14-3-3_CanoR_1	594	600	PF00244	0.625
LIG_14-3-3_CanoR_1	749	756	PF00244	0.664
LIG_14-3-3_CanoR_1	765	771	PF00244	0.534
LIG_14-3-3_CanoR_1	790	796	PF00244	0.691
LIG_14-3-3_CterR_2	865	869	PF00244	0.738
LIG_Actin_WH2_2	661	677	PF00022	0.632
LIG_BRCT_BRCA1_1	106	110	PF00533	0.509
LIG_BRCT_BRCA1_1	159	163	PF00533	0.624
LIG_BRCT_BRCA1_1	193	197	PF00533	0.579
LIG_eIF4E_1	528	534	PF01652	0.551
LIG_EVH1_2	388	392	PF00568	0.551
LIG_FHA_1	229	235	PF00498	0.519
LIG_FHA_1	319	325	PF00498	0.546
LIG_FHA_1	328	334	PF00498	0.590
LIG_FHA_1	350	356	PF00498	0.550
LIG_FHA_1	428	434	PF00498	0.551
LIG_FHA_1	487	493	PF00498	0.580
LIG_FHA_1	513	519	PF00498	0.551
LIG_FHA_1	527	533	PF00498	0.445
LIG_FHA_1	559	565	PF00498	0.467
LIG_FHA_1	696	702	PF00498	0.632
LIG_FHA_1	739	745	PF00498	0.693
LIG_FHA_1	77	83	PF00498	0.640
LIG_FHA_1	795	801	PF00498	0.665
LIG_FHA_1	851	857	PF00498	0.548
LIG_FHA_2	310	316	PF00498	0.580
LIG_FHA_2	324	330	PF00498	0.588
LIG_FHA_2	55	61	PF00498	0.639
LIG_FHA_2	752	758	PF00498	0.617
LIG_LIR_Apic_2	150	156	PF02991	0.602
LIG_LIR_Apic_2	527	531	PF02991	0.551
LIG_LIR_Gen_1	510	518	PF02991	0.551
LIG_LIR_Nem_3	107	112	PF02991	0.612
LIG_LIR_Nem_3	160	166	PF02991	0.619
LIG_LIR_Nem_3	510	514	PF02991	0.628
LIG_LIR_Nem_3	754	759	PF02991	0.658
LIG_LYPXL_yS_3	404	407	PF13949	0.551
LIG_MLH1_MIPbox_1	106	110	PF16413	0.509
LIG_MYND_1	531	535	PF01753	0.551
LIG_NRBOX	495	501	PF00104	0.551
LIG_PTB_Apo_2	406	413	PF02174	0.551
LIG_PTB_Apo_2	505	512	PF02174	0.516
LIG_PTB_Phospho_1	406	412	PF10480	0.551
LIG_SH2_CRK	528	532	PF00017	0.551
LIG_SH2_NCK_1	548	552	PF00017	0.543
LIG_SH2_PTP2	662	665	PF00017	0.675
LIG_SH2_SRC	153	156	PF00017	0.516
LIG_SH2_SRC	662	665	PF00017	0.675
LIG_SH2_STAP1	309	313	PF00017	0.565
LIG_SH2_STAT5	109	112	PF00017	0.666
LIG_SH2_STAT5	153	156	PF00017	0.553
LIG_SH2_STAT5	239	242	PF00017	0.699
LIG_SH2_STAT5	412	415	PF00017	0.551
LIG_SH2_STAT5	479	482	PF00017	0.551
LIG_SH2_STAT5	528	531	PF00017	0.573
LIG_SH2_STAT5	662	665	PF00017	0.675
LIG_SH3_3	231	237	PF00018	0.742
LIG_SH3_3	284	290	PF00018	0.745
LIG_SH3_3	301	307	PF00018	0.727
LIG_SH3_3	355	361	PF00018	0.541
LIG_SH3_3	423	429	PF00018	0.624
LIG_SH3_3	533	539	PF00018	0.551
LIG_SH3_3	609	615	PF00018	0.685
LIG_SH3_3	667	673	PF00018	0.623
LIG_SH3_3	78	84	PF00018	0.677
LIG_SH3_3	845	851	PF00018	0.686
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.563
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.551
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.551
LIG_SUMO_SIM_par_1	320	330	PF11976	0.523
LIG_SUMO_SIM_par_1	90	98	PF11976	0.582
LIG_SxIP_EBH_1	806	818	PF03271	0.677
LIG_UBA3_1	493	498	PF00899	0.407
LIG_WW_1	428	431	PF00397	0.412
MOD_CDK_SPxxK_3	217	224	PF00069	0.540
MOD_CDK_SPxxK_3	714	721	PF00069	0.536
MOD_CK1_1	117	123	PF00069	0.547
MOD_CK1_1	149	155	PF00069	0.701
MOD_CK1_1	158	164	PF00069	0.605
MOD_CK1_1	168	174	PF00069	0.642
MOD_CK1_1	186	192	PF00069	0.839
MOD_CK1_1	193	199	PF00069	0.714
MOD_CK1_1	215	221	PF00069	0.687
MOD_CK1_1	243	249	PF00069	0.726
MOD_CK1_1	296	302	PF00069	0.631
MOD_CK1_1	335	341	PF00069	0.623
MOD_CK1_1	37	43	PF00069	0.608
MOD_CK1_1	372	378	PF00069	0.635
MOD_CK1_1	461	467	PF00069	0.412
MOD_CK1_1	604	610	PF00069	0.619
MOD_CK1_1	617	623	PF00069	0.519
MOD_CK1_1	697	703	PF00069	0.718
MOD_CK1_1	711	717	PF00069	0.728
MOD_CK1_1	719	725	PF00069	0.694
MOD_CK1_1	752	758	PF00069	0.755
MOD_CK1_1	820	826	PF00069	0.769
MOD_CK1_1	859	865	PF00069	0.806
MOD_CK2_1	309	315	PF00069	0.564
MOD_CK2_1	685	691	PF00069	0.614
MOD_CK2_1	714	720	PF00069	0.673
MOD_Cter_Amidation	268	271	PF01082	0.717
MOD_GlcNHglycan	119	122	PF01048	0.679
MOD_GlcNHglycan	167	170	PF01048	0.675
MOD_GlcNHglycan	179	182	PF01048	0.659
MOD_GlcNHglycan	208	211	PF01048	0.707
MOD_GlcNHglycan	260	263	PF01048	0.645
MOD_GlcNHglycan	272	275	PF01048	0.745
MOD_GlcNHglycan	295	298	PF01048	0.831
MOD_GlcNHglycan	30	33	PF01048	0.617
MOD_GlcNHglycan	339	342	PF01048	0.684
MOD_GlcNHglycan	371	374	PF01048	0.706
MOD_GlcNHglycan	378	381	PF01048	0.602
MOD_GlcNHglycan	396	399	PF01048	0.376
MOD_GlcNHglycan	570	573	PF01048	0.721
MOD_GlcNHglycan	575	578	PF01048	0.692
MOD_GlcNHglycan	595	598	PF01048	0.681
MOD_GlcNHglycan	616	619	PF01048	0.529
MOD_GlcNHglycan	68	71	PF01048	0.606
MOD_GlcNHglycan	688	691	PF01048	0.687
MOD_GlcNHglycan	710	713	PF01048	0.736
MOD_GlcNHglycan	731	734	PF01048	0.679
MOD_GlcNHglycan	751	754	PF01048	0.541
MOD_GlcNHglycan	783	786	PF01048	0.797
MOD_GlcNHglycan	791	794	PF01048	0.652
MOD_GlcNHglycan	797	800	PF01048	0.547
MOD_GlcNHglycan	803	806	PF01048	0.600
MOD_GlcNHglycan	810	813	PF01048	0.581
MOD_GlcNHglycan	815	818	PF01048	0.613
MOD_GlcNHglycan	819	822	PF01048	0.659
MOD_GlcNHglycan	826	829	PF01048	0.608
MOD_GlcNHglycan	836	839	PF01048	0.528
MOD_GlcNHglycan	85	88	PF01048	0.695
MOD_GSK3_1	128	135	PF00069	0.769
MOD_GSK3_1	145	152	PF00069	0.562
MOD_GSK3_1	165	172	PF00069	0.572
MOD_GSK3_1	186	193	PF00069	0.758
MOD_GSK3_1	212	219	PF00069	0.800
MOD_GSK3_1	229	236	PF00069	0.581
MOD_GSK3_1	28	35	PF00069	0.698
MOD_GSK3_1	292	299	PF00069	0.701
MOD_GSK3_1	323	330	PF00069	0.607
MOD_GSK3_1	331	338	PF00069	0.692
MOD_GSK3_1	349	356	PF00069	0.652
MOD_GSK3_1	37	44	PF00069	0.688
MOD_GSK3_1	372	379	PF00069	0.671
MOD_GSK3_1	564	571	PF00069	0.609
MOD_GSK3_1	573	580	PF00069	0.640
MOD_GSK3_1	617	624	PF00069	0.572
MOD_GSK3_1	66	73	PF00069	0.748
MOD_GSK3_1	686	693	PF00069	0.766
MOD_GSK3_1	707	714	PF00069	0.706
MOD_GSK3_1	745	752	PF00069	0.726
MOD_GSK3_1	76	83	PF00069	0.713
MOD_GSK3_1	766	773	PF00069	0.657
MOD_GSK3_1	803	810	PF00069	0.687
MOD_GSK3_1	813	820	PF00069	0.754
MOD_GSK3_1	852	859	PF00069	0.719
MOD_GSK3_1	88	95	PF00069	0.564
MOD_LATS_1	130	136	PF00433	0.644
MOD_NEK2_1	190	195	PF00069	0.812
MOD_NEK2_1	197	202	PF00069	0.736
MOD_NEK2_1	333	338	PF00069	0.573
MOD_NEK2_1	49	54	PF00069	0.673
MOD_NEK2_1	564	569	PF00069	0.518
MOD_NEK2_1	705	710	PF00069	0.662
MOD_NEK2_1	766	771	PF00069	0.668
MOD_NEK2_1	794	799	PF00069	0.615
MOD_NEK2_2	543	548	PF00069	0.498
MOD_PIKK_1	191	197	PF00454	0.786
MOD_PIKK_1	353	359	PF00454	0.690
MOD_PIKK_1	61	67	PF00454	0.698
MOD_PKA_1	270	276	PF00069	0.714
MOD_PKA_2	117	123	PF00069	0.653
MOD_PKA_2	158	164	PF00069	0.520
MOD_PKA_2	270	276	PF00069	0.773
MOD_PKA_2	341	347	PF00069	0.657
MOD_PKA_2	49	55	PF00069	0.614
MOD_PKA_2	512	518	PF00069	0.412
MOD_PKA_2	564	570	PF00069	0.577
MOD_PKA_2	593	599	PF00069	0.608
MOD_PKA_2	708	714	PF00069	0.670
MOD_PKA_2	789	795	PF00069	0.694
MOD_PKA_2	817	823	PF00069	0.734
MOD_PKB_1	415	423	PF00069	0.412
MOD_Plk_2-3	427	433	PF00069	0.412
MOD_Plk_4	149	155	PF00069	0.560
MOD_Plk_4	158	164	PF00069	0.565
MOD_Plk_4	296	302	PF00069	0.601
MOD_Plk_4	309	315	PF00069	0.637
MOD_Plk_4	318	324	PF00069	0.602
MOD_Plk_4	382	388	PF00069	0.545
MOD_Plk_4	420	426	PF00069	0.412
MOD_Plk_4	543	549	PF00069	0.612
MOD_Plk_4	766	772	PF00069	0.687
MOD_ProDKin_1	104	110	PF00069	0.559
MOD_ProDKin_1	147	153	PF00069	0.670
MOD_ProDKin_1	183	189	PF00069	0.751
MOD_ProDKin_1	217	223	PF00069	0.771
MOD_ProDKin_1	229	235	PF00069	0.601
MOD_ProDKin_1	286	292	PF00069	0.741
MOD_ProDKin_1	300	306	PF00069	0.646
MOD_ProDKin_1	34	40	PF00069	0.593
MOD_ProDKin_1	690	696	PF00069	0.579
MOD_ProDKin_1	70	76	PF00069	0.695
MOD_ProDKin_1	714	720	PF00069	0.535
MOD_ProDKin_1	80	86	PF00069	0.559
MOD_ProDKin_1	88	94	PF00069	0.626
MOD_ProDKin_1	95	101	PF00069	0.608
MOD_SUMO_for_1	452	455	PF00179	0.412
MOD_SUMO_rev_2	427	436	PF00179	0.412
TRG_DiLeu_BaEn_1	465	470	PF01217	0.412
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.412
TRG_ENDOCYTIC_2	109	112	PF00928	0.666
TRG_ENDOCYTIC_2	404	407	PF00928	0.412
TRG_ENDOCYTIC_2	662	665	PF00928	0.675
TRG_ER_diArg_1	413	415	PF00400	0.496
TRG_ER_diArg_1	416	419	PF00400	0.481
TRG_ER_diArg_1	562	565	PF00400	0.525
TRG_ER_diArg_1	764	766	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5D1	Leishmania donovani	84%	99%
A4H3Z4	Leishmania braziliensis	64%	100%
A4HS81	Leishmania infantum	85%	100%
Q9U0Z9	Leishmania major	85%	100%