Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

Peptide deformylase 2, putative

Species:

Leishmania mexicana

UniProt:

E9AK65_LEIMU

TriTrypDb:

LmxM.04.0820

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK65

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0006508	proteolysis	4	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	11
GO:0042586	peptide deformylase activity	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0008233	peptidase activity	3	5
GO:0008237	metallopeptidase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.300
CLV_C14_Caspase3-7	95	99	PF00656	0.675
CLV_NRD_NRD_1	133	135	PF00675	0.404
CLV_NRD_NRD_1	279	281	PF00675	0.323
CLV_NRD_NRD_1	335	337	PF00675	0.494
CLV_NRD_NRD_1	367	369	PF00675	0.566
CLV_NRD_NRD_1	373	375	PF00675	0.625
CLV_NRD_NRD_1	88	90	PF00675	0.457
CLV_PCSK_KEX2_1	133	135	PF00082	0.404
CLV_PCSK_KEX2_1	279	281	PF00082	0.338
CLV_PCSK_KEX2_1	373	375	PF00082	0.665
CLV_PCSK_KEX2_1	88	90	PF00082	0.605
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.664
CLV_PCSK_SKI1_1	20	24	PF00082	0.463
CLV_PCSK_SKI1_1	237	241	PF00082	0.357
CLV_PCSK_SKI1_1	251	255	PF00082	0.301
DEG_APCC_DBOX_1	262	270	PF00400	0.338
DEG_APCC_DBOX_1	352	360	PF00400	0.619
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DOC_ANK_TNKS_1	100	107	PF00023	0.627
DOC_CKS1_1	316	321	PF01111	0.483
DOC_MAPK_gen_1	259	266	PF00069	0.338
DOC_MAPK_RevD_3	264	280	PF00069	0.338
DOC_PP2B_LxvP_1	53	56	PF13499	0.743
DOC_PP4_FxxP_1	179	182	PF00568	0.338
DOC_PP4_FxxP_1	317	320	PF00568	0.443
DOC_USP7_MATH_1	119	123	PF00917	0.333
DOC_USP7_MATH_1	157	161	PF00917	0.466
DOC_USP7_MATH_1	224	228	PF00917	0.322
DOC_USP7_MATH_1	262	266	PF00917	0.186
DOC_USP7_MATH_1	97	101	PF00917	0.630
DOC_USP7_UBL2_3	369	373	PF12436	0.611
DOC_WW_Pin1_4	30	35	PF00397	0.728
DOC_WW_Pin1_4	315	320	PF00397	0.362
LIG_14-3-3_CanoR_1	17	26	PF00244	0.741
LIG_14-3-3_CanoR_1	2	9	PF00244	0.672
LIG_14-3-3_CanoR_1	237	242	PF00244	0.338
LIG_14-3-3_CanoR_1	261	267	PF00244	0.186
LIG_14-3-3_CanoR_1	309	313	PF00244	0.393
LIG_14-3-3_CanoR_1	322	329	PF00244	0.429
LIG_14-3-3_CanoR_1	60	68	PF00244	0.670
LIG_14-3-3_CanoR_1	88	96	PF00244	0.492
LIG_BRCT_BRCA1_1	226	230	PF00533	0.322
LIG_BRCT_BRCA1_1	64	68	PF00533	0.731
LIG_EVH1_2	319	323	PF00568	0.429
LIG_FHA_1	21	27	PF00498	0.488
LIG_FHA_1	238	244	PF00498	0.292
LIG_FHA_1	252	258	PF00498	0.373
LIG_FHA_1	276	282	PF00498	0.317
LIG_FHA_2	170	176	PF00498	0.338
LIG_FHA_2	293	299	PF00498	0.444
LIG_FHA_2	355	361	PF00498	0.589
LIG_Integrin_RGD_1	383	385	PF01839	0.701
LIG_LIR_Apic_2	177	182	PF02991	0.321
LIG_LIR_Apic_2	315	320	PF02991	0.373
LIG_LIR_Gen_1	200	209	PF02991	0.466
LIG_LIR_Gen_1	291	298	PF02991	0.454
LIG_LIR_Gen_1	311	321	PF02991	0.412
LIG_LIR_Nem_3	111	116	PF02991	0.515
LIG_LIR_Nem_3	139	143	PF02991	0.422
LIG_LIR_Nem_3	200	204	PF02991	0.466
LIG_LIR_Nem_3	300	306	PF02991	0.431
LIG_LIR_Nem_3	311	317	PF02991	0.368
LIG_LIR_Nem_3	318	324	PF02991	0.414
LIG_LYPXL_S_1	112	116	PF13949	0.186
LIG_LYPXL_yS_3	113	116	PF13949	0.443
LIG_LYPXL_yS_3	156	159	PF13949	0.322
LIG_LYPXL_yS_3	303	306	PF13949	0.409
LIG_Pex14_1	124	128	PF04695	0.338
LIG_Pex14_1	299	303	PF04695	0.438
LIG_PTB_Apo_2	173	180	PF02174	0.440
LIG_Rb_pABgroove_1	168	176	PF01858	0.322
LIG_SH2_CRK	140	144	PF00017	0.484
LIG_SH2_CRK	154	158	PF00017	0.322
LIG_SH2_CRK	321	325	PF00017	0.438
LIG_SH2_SRC	103	106	PF00017	0.591
LIG_SH2_SRC	154	157	PF00017	0.322
LIG_SH2_STAP1	128	132	PF00017	0.438
LIG_SH2_STAT5	103	106	PF00017	0.579
LIG_SH2_STAT5	234	237	PF00017	0.333
LIG_SH2_STAT5	314	317	PF00017	0.352
LIG_SH3_3	42	48	PF00018	0.659
LIG_SH3_3	99	105	PF00018	0.560
LIG_SUMO_SIM_par_1	253	258	PF11976	0.447
LIG_TRAF2_1	108	111	PF00917	0.591
LIG_TRAF2_1	203	206	PF00917	0.478
LIG_TRAF2_1	358	361	PF00917	0.476
LIG_WRC_WIRS_1	55	60	PF05994	0.601
MOD_CDK_SPxxK_3	315	322	PF00069	0.255
MOD_CK1_1	29	35	PF00069	0.713
MOD_CK1_1	297	303	PF00069	0.450
MOD_CK1_1	51	57	PF00069	0.707
MOD_CK1_1	92	98	PF00069	0.578
MOD_CK2_1	262	268	PF00069	0.186
MOD_CK2_1	354	360	PF00069	0.551
MOD_GlcNHglycan	159	162	PF01048	0.391
MOD_GlcNHglycan	227	230	PF01048	0.443
MOD_GlcNHglycan	3	6	PF01048	0.644
MOD_GlcNHglycan	38	42	PF01048	0.739
MOD_GlcNHglycan	392	397	PF01048	0.532
MOD_GlcNHglycan	50	53	PF01048	0.688
MOD_GlcNHglycan	64	67	PF01048	0.647
MOD_GlcNHglycan	73	76	PF01048	0.513
MOD_GSK3_1	157	164	PF00069	0.443
MOD_GSK3_1	26	33	PF00069	0.719
MOD_GSK3_1	308	315	PF00069	0.380
MOD_GSK3_1	62	69	PF00069	0.740
MOD_GSK3_1	88	95	PF00069	0.598
MOD_LATS_1	249	255	PF00433	0.443
MOD_LATS_1	87	93	PF00433	0.453
MOD_N-GLC_2	28	30	PF02516	0.732
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	174	179	PF00069	0.338
MOD_NEK2_1	312	317	PF00069	0.388
MOD_NEK2_1	96	101	PF00069	0.642
MOD_NEK2_2	262	267	PF00069	0.186
MOD_PIKK_1	142	148	PF00454	0.443
MOD_PKA_1	88	94	PF00069	0.457
MOD_PKA_2	1	7	PF00069	0.672
MOD_PKA_2	262	268	PF00069	0.186
MOD_PKA_2	308	314	PF00069	0.384
MOD_PKA_2	88	94	PF00069	0.743
MOD_Plk_1	174	180	PF00069	0.443
MOD_Plk_1	354	360	PF00069	0.577
MOD_Plk_2-3	302	308	PF00069	0.410
MOD_Plk_4	174	180	PF00069	0.320
MOD_Plk_4	197	203	PF00069	0.443
MOD_Plk_4	308	314	PF00069	0.375
MOD_Plk_4	54	60	PF00069	0.712
MOD_ProDKin_1	30	36	PF00069	0.729
MOD_ProDKin_1	315	321	PF00069	0.374
MOD_SUMO_rev_2	200	209	PF00179	0.481
MOD_SUMO_rev_2	330	338	PF00179	0.458
TRG_DiLeu_BaEn_1	139	144	PF01217	0.443
TRG_ENDOCYTIC_2	113	116	PF00928	0.443
TRG_ENDOCYTIC_2	140	143	PF00928	0.380
TRG_ENDOCYTIC_2	156	159	PF00928	0.308
TRG_ENDOCYTIC_2	303	306	PF00928	0.409
TRG_ENDOCYTIC_2	314	317	PF00928	0.371
TRG_ENDOCYTIC_2	321	324	PF00928	0.404
TRG_ER_diArg_1	133	135	PF00400	0.364
TRG_ER_diArg_1	241	244	PF00400	0.332
TRG_ER_diArg_1	260	263	PF00400	0.403
TRG_ER_diArg_1	279	281	PF00400	0.338
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P349	Leptomonas seymouri	80%	96%
A0A0S4JJP7	Bodo saltans	45%	100%
A0A1X0NLE7	Trypanosomatidae	62%	100%
A0A3S5IQR8	Trypanosoma rangeli	64%	100%
A0A3S7WNT3	Leishmania donovani	89%	98%
A4HS79	Leishmania infantum	89%	100%
C9ZY73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q9U112	Leishmania major	88%	100%
V5BDN2	Trypanosoma cruzi	64%	100%