Pescadillo homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pescadillo homolog

Gene product:

Pescadillo N-terminus/BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AK64_LEIMU

TriTrypDb:

LmxM.04.0810

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005730	nucleolus	5	12
GO:0030684	preribosome	3	11
GO:0030687	preribosome, large subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11
GO:0070545	PeBoW complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AK64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK64

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	11
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000470	maturation of LSU-rRNA	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	39	41	PF00675	0.272
CLV_NRD_NRD_1	449	451	PF00675	0.515
CLV_NRD_NRD_1	502	504	PF00675	0.591
CLV_NRD_NRD_1	546	548	PF00675	0.501
CLV_NRD_NRD_1	550	552	PF00675	0.481
CLV_NRD_NRD_1	569	571	PF00675	0.339
CLV_NRD_NRD_1	581	583	PF00675	0.490
CLV_NRD_NRD_1	589	591	PF00675	0.471
CLV_NRD_NRD_1	643	645	PF00675	0.510
CLV_PCSK_KEX2_1	10	12	PF00082	0.510
CLV_PCSK_KEX2_1	307	309	PF00082	0.552
CLV_PCSK_KEX2_1	373	375	PF00082	0.148
CLV_PCSK_KEX2_1	39	41	PF00082	0.272
CLV_PCSK_KEX2_1	502	504	PF00082	0.587
CLV_PCSK_KEX2_1	545	547	PF00082	0.495
CLV_PCSK_KEX2_1	569	571	PF00082	0.476
CLV_PCSK_KEX2_1	575	577	PF00082	0.556
CLV_PCSK_KEX2_1	643	645	PF00082	0.477
CLV_PCSK_KEX2_1	95	97	PF00082	0.272
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.510
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.572
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.148
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.552
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.365
CLV_PCSK_PC7_1	639	645	PF00082	0.535
CLV_PCSK_SKI1_1	10	14	PF00082	0.508
CLV_PCSK_SKI1_1	19	23	PF00082	0.321
CLV_PCSK_SKI1_1	190	194	PF00082	0.315
CLV_PCSK_SKI1_1	246	250	PF00082	0.308
CLV_PCSK_SKI1_1	299	303	PF00082	0.574
CLV_PCSK_SKI1_1	319	323	PF00082	0.248
CLV_PCSK_SKI1_1	348	352	PF00082	0.250
CLV_PCSK_SKI1_1	393	397	PF00082	0.230
CLV_PCSK_SKI1_1	547	551	PF00082	0.581
CLV_PCSK_SKI1_1	610	614	PF00082	0.553
CLV_PCSK_SKI1_1	652	656	PF00082	0.615
CLV_PCSK_SKI1_1	70	74	PF00082	0.272
CLV_PCSK_SKI1_1	92	96	PF00082	0.346
DOC_CYCLIN_RxL_1	316	326	PF00134	0.367
DOC_MAPK_gen_1	525	534	PF00069	0.536
DOC_MAPK_gen_1	582	588	PF00069	0.493
DOC_PP1_RVXF_1	210	216	PF00149	0.272
DOC_PP1_RVXF_1	244	251	PF00149	0.288
DOC_PP1_RVXF_1	321	328	PF00149	0.496
DOC_PP1_RVXF_1	68	75	PF00149	0.288
DOC_PP2B_LxvP_1	394	397	PF13499	0.424
DOC_PP4_FxxP_1	150	153	PF00568	0.272
DOC_USP7_MATH_1	116	120	PF00917	0.413
DOC_USP7_MATH_1	560	564	PF00917	0.377
DOC_USP7_UBL2_3	10	14	PF12436	0.508
DOC_USP7_UBL2_3	433	437	PF12436	0.403
DOC_USP7_UBL2_3	552	556	PF12436	0.559
DOC_USP7_UBL2_3	653	657	PF12436	0.534
DOC_USP7_UBL2_3	664	668	PF12436	0.502
DOC_WW_Pin1_4	149	154	PF00397	0.289
DOC_WW_Pin1_4	409	414	PF00397	0.418
LIG_14-3-3_CanoR_1	117	121	PF00244	0.366
LIG_14-3-3_CanoR_1	323	328	PF00244	0.505
LIG_14-3-3_CanoR_1	348	355	PF00244	0.456
LIG_14-3-3_CanoR_1	518	526	PF00244	0.514
LIG_APCC_Cbox_2	183	189	PF00515	0.391
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	34	38	PF00533	0.272
LIG_Clathr_ClatBox_1	249	253	PF01394	0.308
LIG_Clathr_ClatBox_1	30	34	PF01394	0.288
LIG_EH1_1	446	454	PF00400	0.451
LIG_FHA_1	158	164	PF00498	0.294
LIG_FHA_1	26	32	PF00498	0.293
LIG_FHA_1	324	330	PF00498	0.461
LIG_FHA_1	349	355	PF00498	0.460
LIG_FHA_1	357	363	PF00498	0.412
LIG_FHA_1	511	517	PF00498	0.580
LIG_FHA_1	537	543	PF00498	0.542
LIG_FHA_2	121	127	PF00498	0.301
LIG_FHA_2	157	163	PF00498	0.333
LIG_FHA_2	636	642	PF00498	0.462
LIG_IBAR_NPY_1	661	663	PF08397	0.499
LIG_KLC1_Yacidic_2	239	243	PF13176	0.272
LIG_LIR_Apic_2	379	383	PF02991	0.431
LIG_LIR_Gen_1	193	204	PF02991	0.275
LIG_LIR_Gen_1	236	245	PF02991	0.277
LIG_LIR_Gen_1	456	462	PF02991	0.627
LIG_LIR_Nem_3	126	131	PF02991	0.272
LIG_LIR_Nem_3	180	185	PF02991	0.276
LIG_LIR_Nem_3	193	199	PF02991	0.312
LIG_LIR_Nem_3	236	240	PF02991	0.277
LIG_LIR_Nem_3	320	325	PF02991	0.510
LIG_LIR_Nem_3	35	41	PF02991	0.288
LIG_LIR_Nem_3	456	460	PF02991	0.588
LIG_LIR_Nem_3	660	666	PF02991	0.560
LIG_MYND_1	366	370	PF01753	0.441
LIG_PCNA_PIPBox_1	231	240	PF02747	0.333
LIG_PCNA_yPIPBox_3	224	238	PF02747	0.333
LIG_Pex14_2	17	21	PF04695	0.315
LIG_PTB_Apo_2	451	458	PF02174	0.504
LIG_PTB_Phospho_1	451	457	PF10480	0.501
LIG_REV1ctd_RIR_1	325	333	PF16727	0.478
LIG_SH2_CRK	148	152	PF00017	0.272
LIG_SH2_CRK	597	601	PF00017	0.481
LIG_SH2_CRK	663	667	PF00017	0.500
LIG_SH2_NCK_1	457	461	PF00017	0.552
LIG_SH2_PTP2	232	235	PF00017	0.272
LIG_SH2_PTP2	380	383	PF00017	0.430
LIG_SH2_SRC	353	356	PF00017	0.514
LIG_SH2_SRC	441	444	PF00017	0.665
LIG_SH2_STAP1	204	208	PF00017	0.333
LIG_SH2_STAP1	221	225	PF00017	0.272
LIG_SH2_STAT5	130	133	PF00017	0.333
LIG_SH2_STAT5	185	188	PF00017	0.272
LIG_SH2_STAT5	232	235	PF00017	0.285
LIG_SH2_STAT5	241	244	PF00017	0.305
LIG_SH2_STAT5	353	356	PF00017	0.473
LIG_SH2_STAT5	380	383	PF00017	0.430
LIG_SH2_STAT5	385	388	PF00017	0.430
LIG_SH2_STAT5	441	444	PF00017	0.503
LIG_SH2_STAT5	67	70	PF00017	0.293
LIG_SH3_3	360	366	PF00018	0.445
LIG_SH3_3	477	483	PF00018	0.681
LIG_SH3_3	513	519	PF00018	0.688
LIG_SH3_4	504	511	PF00018	0.683
LIG_TRAF2_1	474	477	PF00917	0.624
LIG_TRAF2_1	506	509	PF00917	0.645
LIG_WRC_WIRS_1	234	239	PF05994	0.333
MOD_CDK_SPxxK_3	149	156	PF00069	0.366
MOD_CK1_1	157	163	PF00069	0.283
MOD_CK1_1	166	172	PF00069	0.272
MOD_CK1_1	306	312	PF00069	0.564
MOD_CK1_1	356	362	PF00069	0.375
MOD_CK1_1	412	418	PF00069	0.491
MOD_CK2_1	120	126	PF00069	0.285
MOD_CK2_1	156	162	PF00069	0.272
MOD_CK2_1	233	239	PF00069	0.272
MOD_CK2_1	306	312	PF00069	0.479
MOD_CK2_1	471	477	PF00069	0.596
MOD_CK2_1	491	497	PF00069	0.638
MOD_CK2_1	57	63	PF00069	0.365
MOD_CK2_1	635	641	PF00069	0.481
MOD_Cter_Amidation	650	653	PF01082	0.592
MOD_GlcNHglycan	168	171	PF01048	0.288
MOD_GlcNHglycan	420	423	PF01048	0.660
MOD_GlcNHglycan	457	460	PF01048	0.527
MOD_GlcNHglycan	493	496	PF01048	0.557
MOD_GlcNHglycan	521	524	PF01048	0.520
MOD_GlcNHglycan	59	62	PF01048	0.272
MOD_GlcNHglycan	600	603	PF01048	0.602
MOD_GSK3_1	116	123	PF00069	0.321
MOD_GSK3_1	165	172	PF00069	0.368
MOD_GSK3_1	323	330	PF00069	0.285
MOD_GSK3_1	412	419	PF00069	0.500
MOD_GSK3_1	550	557	PF00069	0.369
MOD_N-GLC_1	356	361	PF02516	0.288
MOD_NEK2_1	109	114	PF00069	0.312
MOD_NEK2_1	120	125	PF00069	0.225
MOD_NEK2_1	25	30	PF00069	0.293
MOD_NEK2_1	414	419	PF00069	0.646
MOD_NEK2_1	52	57	PF00069	0.288
MOD_NEK2_1	635	640	PF00069	0.482
MOD_NEK2_2	195	200	PF00069	0.288
MOD_PIKK_1	550	556	PF00454	0.464
MOD_PKA_1	569	575	PF00069	0.543
MOD_PKA_2	116	122	PF00069	0.388
MOD_PKA_2	364	370	PF00069	0.430
MOD_PKA_2	550	556	PF00069	0.513
MOD_PKA_2	569	575	PF00069	0.510
MOD_PKB_1	188	196	PF00069	0.374
MOD_Plk_1	157	163	PF00069	0.272
MOD_Plk_1	356	362	PF00069	0.288
MOD_Plk_1	489	495	PF00069	0.529
MOD_Plk_1	530	536	PF00069	0.400
MOD_Plk_2-3	471	477	PF00069	0.612
MOD_Plk_2-3	510	516	PF00069	0.682
MOD_Plk_4	116	122	PF00069	0.288
MOD_Plk_4	140	146	PF00069	0.272
MOD_Plk_4	233	239	PF00069	0.308
MOD_Plk_4	323	329	PF00069	0.286
MOD_Plk_4	530	536	PF00069	0.400
MOD_ProDKin_1	149	155	PF00069	0.289
MOD_ProDKin_1	409	415	PF00069	0.431
MOD_SUMO_for_1	12	15	PF00179	0.288
MOD_SUMO_for_1	208	211	PF00179	0.365
MOD_SUMO_for_1	250	253	PF00179	0.308
MOD_SUMO_rev_2	104	109	PF00179	0.286
MOD_SUMO_rev_2	152	157	PF00179	0.409
MOD_SUMO_rev_2	300	309	PF00179	0.603
MOD_SUMO_rev_2	458	467	PF00179	0.558
MOD_SUMO_rev_2	630	635	PF00179	0.610
TRG_DiLeu_BaEn_1	448	453	PF01217	0.456
TRG_DiLeu_BaEn_1	71	76	PF01217	0.288
TRG_DiLeu_BaEn_2	242	248	PF01217	0.272
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.298
TRG_ENDOCYTIC_2	128	131	PF00928	0.272
TRG_ENDOCYTIC_2	148	151	PF00928	0.272
TRG_ENDOCYTIC_2	204	207	PF00928	0.333
TRG_ENDOCYTIC_2	232	235	PF00928	0.272
TRG_ENDOCYTIC_2	241	244	PF00928	0.272
TRG_ENDOCYTIC_2	375	378	PF00928	0.254
TRG_ENDOCYTIC_2	457	460	PF00928	0.500
TRG_ENDOCYTIC_2	597	600	PF00928	0.509
TRG_ENDOCYTIC_2	663	666	PF00928	0.518
TRG_ER_diArg_1	188	191	PF00400	0.395
TRG_ER_diArg_1	212	215	PF00400	0.272
TRG_ER_diArg_1	38	40	PF00400	0.272
TRG_ER_diArg_1	545	547	PF00400	0.494
TRG_ER_diArg_1	569	571	PF00400	0.387
TRG_ER_diArg_1	643	646	PF00400	0.594
TRG_NES_CRM1_1	243	255	PF08389	0.351
TRG_NLS_Bipartite_1	4	22	PF00514	0.288
TRG_NLS_Bipartite_1	575	594	PF00514	0.517
TRG_NLS_MonoExtC_3	9	14	PF00514	0.507
TRG_NLS_MonoExtN_4	16	22	PF00514	0.288
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q9	Leptomonas seymouri	86%	100%
A0A0S4JN88	Bodo saltans	62%	100%
A0A1X0NKV4	Trypanosomatidae	70%	100%
A0A3R7LRI0	Trypanosoma rangeli	69%	100%
A0A3S5H5C9	Leishmania donovani	96%	100%
A1CHD1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	30%	99%
A1CXF4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	29%	99%
A4H3Z2	Leishmania braziliensis	92%	100%
A4HS78	Leishmania infantum	96%	100%
A4RLI4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	28%	99%
A5DGY0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	32%	100%
A5DYS6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	31%	100%
A6RBB0	Ajellomyces capsulatus (strain NAm1 / WU24)	29%	93%
A6SK81	Botryotinia fuckeliana (strain B05.10)	31%	99%
A7EGB5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	33%	99%
A7TSA8	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	34%	100%
A8N1X3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	29%	100%
A9URZ4	Monosiga brevicollis	30%	100%
B0CQL7	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	31%	100%
B0Y612	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	30%	99%
B2WBA7	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	29%	99%
C9ZY72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
O60164	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O97209	Leishmania major	95%	100%
P0CP58	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	30%	100%
P0CP59	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	30%	100%
Q0CLP9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	30%	99%
Q0V577	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	30%	99%
Q1DLJ4	Coccidioides immitis (strain RS)	30%	98%
Q2HCV1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	100%
Q2UGQ8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	99%
Q4WP65	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	99%
Q59X38	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q5B6K3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	99%
Q6BXL7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	100%
Q6CDK0	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	100%
Q6CQQ1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	100%
Q6FSU1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q75EI5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q7R7N4	Plasmodium yoelii yoelii	22%	100%
Q7SFC2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
Q851S7	Oryza sativa subsp. japonica	29%	100%
Q9LYK7	Arabidopsis thaliana	33%	100%
V5AY93	Trypanosoma cruzi	69%	100%