Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK63_LEIMU

TriTrypDb:

LmxM.04.0800

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.556
CLV_NRD_NRD_1	28	30	PF00675	0.434
CLV_NRD_NRD_1	65	67	PF00675	0.630
CLV_NRD_NRD_1	68	70	PF00675	0.625
CLV_NRD_NRD_1	8	10	PF00675	0.591
CLV_PCSK_FUR_1	66	70	PF00082	0.576
CLV_PCSK_KEX2_1	181	183	PF00082	0.564
CLV_PCSK_KEX2_1	28	30	PF00082	0.627
CLV_PCSK_KEX2_1	65	67	PF00082	0.684
CLV_PCSK_KEX2_1	68	70	PF00082	0.704
CLV_PCSK_SKI1_1	274	278	PF00082	0.491
CLV_PCSK_SKI1_1	68	72	PF00082	0.593
CLV_PCSK_SKI1_1	83	87	PF00082	0.603
DEG_Nend_UBRbox_2	1	3	PF02207	0.482
DEG_SPOP_SBC_1	286	290	PF00917	0.646
DOC_MAPK_gen_1	181	187	PF00069	0.545
DOC_MAPK_gen_1	7	15	PF00069	0.550
DOC_MAPK_MEF2A_6	7	15	PF00069	0.545
DOC_PP1_RVXF_1	165	171	PF00149	0.571
DOC_USP7_MATH_1	158	162	PF00917	0.536
DOC_USP7_MATH_1	231	235	PF00917	0.654
DOC_USP7_MATH_1	286	290	PF00917	0.601
DOC_USP7_MATH_1	47	51	PF00917	0.747
DOC_WW_Pin1_4	144	149	PF00397	0.547
DOC_WW_Pin1_4	16	21	PF00397	0.550
DOC_WW_Pin1_4	279	284	PF00397	0.549
LIG_BRCT_BRCA1_1	288	292	PF00533	0.619
LIG_BRCT_BRCA1_2	288	294	PF00533	0.614
LIG_FHA_1	126	132	PF00498	0.566
LIG_FHA_1	145	151	PF00498	0.403
LIG_FHA_1	163	169	PF00498	0.511
LIG_FHA_1	273	279	PF00498	0.513
LIG_FHA_2	21	27	PF00498	0.514
LIG_FHA_2	237	243	PF00498	0.625
LIG_FHA_2	280	286	PF00498	0.531
LIG_FHA_2	59	65	PF00498	0.580
LIG_LIR_Gen_1	27	37	PF02991	0.625
LIG_LIR_Gen_1	296	305	PF02991	0.494
LIG_LIR_Nem_3	27	33	PF02991	0.664
LIG_LIR_Nem_3	296	301	PF02991	0.491
LIG_SH2_CRK	30	34	PF00017	0.614
LIG_SH2_PTP2	12	15	PF00017	0.577
LIG_SH2_SRC	12	15	PF00017	0.577
LIG_SH2_STAT5	12	15	PF00017	0.577
LIG_SH2_STAT5	140	143	PF00017	0.515
LIG_SH2_STAT5	149	152	PF00017	0.485
LIG_SH2_STAT5	257	260	PF00017	0.477
LIG_SH2_STAT5	266	269	PF00017	0.431
LIG_SH3_3	280	286	PF00018	0.531
LIG_SH3_3	8	14	PF00018	0.548
LIG_SUMO_SIM_par_1	259	267	PF11976	0.462
LIG_SUMO_SIM_par_1	84	90	PF11976	0.544
LIG_TRAF2_1	210	213	PF00917	0.571
LIG_TRAF2_1	87	90	PF00917	0.542
LIG_WRC_WIRS_1	1	6	PF05994	0.435
LIG_WRC_WIRS_1	115	120	PF05994	0.546
MOD_CK1_1	104	110	PF00069	0.455
MOD_CK1_1	161	167	PF00069	0.561
MOD_CK1_1	172	178	PF00069	0.572
MOD_CK1_1	50	56	PF00069	0.769
MOD_CK2_1	20	26	PF00069	0.527
MOD_GlcNHglycan	108	111	PF01048	0.665
MOD_GlcNHglycan	120	123	PF01048	0.492
MOD_GlcNHglycan	49	52	PF01048	0.645
MOD_GSK3_1	101	108	PF00069	0.681
MOD_GSK3_1	114	121	PF00069	0.597
MOD_GSK3_1	138	145	PF00069	0.540
MOD_GSK3_1	158	165	PF00069	0.652
MOD_GSK3_1	16	23	PF00069	0.543
MOD_GSK3_1	172	179	PF00069	0.536
MOD_GSK3_1	33	40	PF00069	0.607
MOD_GSK3_1	47	54	PF00069	0.702
MOD_N-GLC_1	170	175	PF02516	0.588
MOD_N-GLC_1	231	236	PF02516	0.673
MOD_NEK2_1	105	110	PF00069	0.656
MOD_NEK2_1	118	123	PF00069	0.463
MOD_NEK2_1	162	167	PF00069	0.556
MOD_NEK2_1	170	175	PF00069	0.538
MOD_PIKK_1	186	192	PF00454	0.657
MOD_PIKK_1	251	257	PF00454	0.525
MOD_PIKK_1	95	101	PF00454	0.652
MOD_PKA_2	236	242	PF00069	0.566
MOD_PKA_2	33	39	PF00069	0.720
MOD_Plk_1	162	168	PF00069	0.649
MOD_Plk_1	218	224	PF00069	0.507
MOD_Plk_2-3	256	262	PF00069	0.497
MOD_Plk_4	114	120	PF00069	0.663
MOD_Plk_4	20	26	PF00069	0.529
MOD_ProDKin_1	144	150	PF00069	0.550
MOD_ProDKin_1	16	22	PF00069	0.544
MOD_ProDKin_1	279	285	PF00069	0.548
TRG_ENDOCYTIC_2	12	15	PF00928	0.577
TRG_ENDOCYTIC_2	30	33	PF00928	0.714
TRG_ER_diArg_1	180	182	PF00400	0.567
TRG_ER_diArg_1	208	211	PF00400	0.475
TRG_ER_diArg_1	28	30	PF00400	0.591
TRG_ER_diArg_1	32	35	PF00400	0.558
TRG_ER_diArg_1	65	68	PF00400	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTL4	Leptomonas seymouri	48%	100%
A0A0S4JP65	Bodo saltans	33%	100%
A0A1X0NLR1	Trypanosomatidae	46%	100%
A0A3R7K5C5	Trypanosoma rangeli	46%	100%
A0A3S5H5C8	Leishmania donovani	95%	100%
A4HS77	Leishmania infantum	95%	85%
C9ZY71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
O97210	Leishmania major	94%	100%
V5DEH0	Trypanosoma cruzi	44%	100%