Putative heat shock protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein, putative

Species:

Leishmania mexicana

UniProt:

E9AK61_LEIMU

TriTrypDb:

LmxM.04.0780

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

E9AK61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.466
CLV_NRD_NRD_1	327	329	PF00675	0.502
CLV_NRD_NRD_1	72	74	PF00675	0.419
CLV_PCSK_KEX2_1	327	329	PF00082	0.499
CLV_PCSK_KEX2_1	72	74	PF00082	0.346
CLV_PCSK_PC7_1	323	329	PF00082	0.390
CLV_PCSK_SKI1_1	84	88	PF00082	0.411
DEG_APCC_DBOX_1	83	91	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DEG_ODPH_VHL_1	268	281	PF01847	0.389
DEG_SPOP_SBC_1	313	317	PF00917	0.710
DOC_CDC14_PxL_1	255	263	PF14671	0.211
DOC_CDC14_PxL_1	376	384	PF14671	0.411
DOC_CDC14_PxL_1	77	85	PF14671	0.222
DOC_MAPK_DCC_7	254	264	PF00069	0.294
DOC_MAPK_gen_1	332	340	PF00069	0.619
DOC_MAPK_gen_1	72	80	PF00069	0.546
DOC_MAPK_MEF2A_6	72	79	PF00069	0.589
DOC_MAPK_MEF2A_6	84	91	PF00069	0.333
DOC_PP2B_LxvP_1	78	81	PF13499	0.411
DOC_PP4_FxxP_1	162	165	PF00568	0.619
DOC_USP7_MATH_1	146	150	PF00917	0.489
DOC_USP7_MATH_1	180	184	PF00917	0.584
DOC_USP7_MATH_1	313	317	PF00917	0.756
DOC_USP7_MATH_1	342	346	PF00917	0.430
DOC_USP7_MATH_1	370	374	PF00917	0.467
DOC_USP7_MATH_1	413	417	PF00917	0.732
DOC_USP7_MATH_1	419	423	PF00917	0.721
DOC_USP7_MATH_1	460	464	PF00917	0.833
DOC_USP7_MATH_2	40	46	PF00917	0.419
DOC_WW_Pin1_4	134	139	PF00397	0.619
DOC_WW_Pin1_4	191	196	PF00397	0.437
DOC_WW_Pin1_4	237	242	PF00397	0.258
DOC_WW_Pin1_4	293	298	PF00397	0.730
DOC_WW_Pin1_4	300	305	PF00397	0.761
DOC_WW_Pin1_4	443	448	PF00397	0.741
LIG_14-3-3_CanoR_1	153	159	PF00244	0.494
LIG_14-3-3_CanoR_1	327	335	PF00244	0.676
LIG_14-3-3_CanoR_1	439	443	PF00244	0.751
LIG_14-3-3_CanoR_1	455	462	PF00244	0.763
LIG_14-3-3_CanoR_1	478	487	PF00244	0.619
LIG_AP2alpha_2	160	162	PF02296	0.619
LIG_BRCT_BRCA1_1	136	140	PF00533	0.536
LIG_deltaCOP1_diTrp_1	42	46	PF00928	0.416
LIG_EH1_1	274	282	PF00400	0.436
LIG_FHA_1	105	111	PF00498	0.411
LIG_FHA_1	26	32	PF00498	0.440
LIG_FHA_1	416	422	PF00498	0.579
LIG_FHA_1	480	486	PF00498	0.659
LIG_FHA_2	118	124	PF00498	0.411
LIG_FHA_2	154	160	PF00498	0.563
LIG_FHA_2	248	254	PF00498	0.311
LIG_IRF3_LxIS_1	26	33	PF10401	0.513
LIG_LIR_Apic_2	159	165	PF02991	0.619
LIG_LIR_Gen_1	211	222	PF02991	0.513
LIG_LIR_Gen_1	263	272	PF02991	0.411
LIG_LIR_Gen_1	373	383	PF02991	0.331
LIG_LIR_Nem_3	211	217	PF02991	0.513
LIG_LIR_Nem_3	221	227	PF02991	0.348
LIG_LIR_Nem_3	263	268	PF02991	0.411
LIG_LIR_Nem_3	273	277	PF02991	0.411
LIG_LIR_Nem_3	373	378	PF02991	0.331
LIG_LIR_Nem_3	45	49	PF02991	0.326
LIG_MYND_1	161	165	PF01753	0.619
LIG_MYND_1	241	245	PF01753	0.211
LIG_NRBOX	1	7	PF00104	0.692
LIG_NRBOX	82	88	PF00104	0.277
LIG_Pex14_1	112	116	PF04695	0.411
LIG_SH2_CRK	220	224	PF00017	0.513
LIG_SH2_PTP2	76	79	PF00017	0.619
LIG_SH2_STAP1	220	224	PF00017	0.513
LIG_SH2_STAP1	361	365	PF00017	0.355
LIG_SH2_STAT5	116	119	PF00017	0.513
LIG_SH2_STAT5	220	223	PF00017	0.375
LIG_SH2_STAT5	224	227	PF00017	0.375
LIG_SH2_STAT5	274	277	PF00017	0.513
LIG_SH2_STAT5	76	79	PF00017	0.619
LIG_SH3_2	196	201	PF14604	0.411
LIG_SH3_3	155	161	PF00018	0.614
LIG_SH3_3	193	199	PF00018	0.428
LIG_SH3_3	235	241	PF00018	0.219
LIG_SH3_3	46	52	PF00018	0.419
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.411
LIG_SUMO_SIM_par_1	279	285	PF11976	0.397
LIG_SUMO_SIM_par_1	58	64	PF11976	0.438
LIG_SUMO_SIM_par_1	76	82	PF11976	0.436
LIG_TRAF2_1	298	301	PF00917	0.785
LIG_TYR_ITIM	272	277	PF00017	0.222
LIG_WRC_WIRS_1	219	224	PF05994	0.389
LIG_WRC_WIRS_1	261	266	PF05994	0.411
MOD_CK1_1	178	184	PF00069	0.572
MOD_CK1_1	194	200	PF00069	0.479
MOD_CK1_1	247	253	PF00069	0.369
MOD_CK1_1	422	428	PF00069	0.730
MOD_CK1_1	440	446	PF00069	0.802
MOD_CK1_1	449	455	PF00069	0.732
MOD_CK2_1	153	159	PF00069	0.577
MOD_CK2_1	171	177	PF00069	0.429
MOD_CK2_1	181	187	PF00069	0.529
MOD_CK2_1	279	285	PF00069	0.513
MOD_CK2_1	295	301	PF00069	0.597
MOD_CK2_1	327	333	PF00069	0.695
MOD_CMANNOS	112	115	PF00535	0.411
MOD_CMANNOS	43	46	PF00535	0.546
MOD_GlcNHglycan	148	151	PF01048	0.281
MOD_GlcNHglycan	183	186	PF01048	0.368
MOD_GlcNHglycan	246	249	PF01048	0.455
MOD_GlcNHglycan	309	312	PF01048	0.445
MOD_GlcNHglycan	344	347	PF01048	0.455
MOD_GlcNHglycan	367	370	PF01048	0.710
MOD_GlcNHglycan	371	375	PF01048	0.648
MOD_GlcNHglycan	415	418	PF01048	0.508
MOD_GlcNHglycan	422	425	PF01048	0.578
MOD_GlcNHglycan	427	430	PF01048	0.618
MOD_GlcNHglycan	451	454	PF01048	0.571
MOD_GSK3_1	130	137	PF00069	0.594
MOD_GSK3_1	171	178	PF00069	0.558
MOD_GSK3_1	244	251	PF00069	0.333
MOD_GSK3_1	26	33	PF00069	0.452
MOD_GSK3_1	284	291	PF00069	0.583
MOD_GSK3_1	292	299	PF00069	0.691
MOD_GSK3_1	411	418	PF00069	0.671
MOD_GSK3_1	438	445	PF00069	0.741
MOD_GSK3_1	449	456	PF00069	0.731
MOD_GSK3_1	466	473	PF00069	0.746
MOD_GSK3_1	63	70	PF00069	0.436
MOD_LATS_1	151	157	PF00433	0.411
MOD_LATS_1	325	331	PF00433	0.644
MOD_N-GLC_1	154	159	PF02516	0.363
MOD_N-GLC_1	191	196	PF02516	0.330
MOD_N-GLC_1	480	485	PF02516	0.424
MOD_NEK2_1	1	6	PF00069	0.742
MOD_NEK2_1	26	31	PF00069	0.407
MOD_NEK2_1	284	289	PF00069	0.608
MOD_NEK2_1	292	297	PF00069	0.694
MOD_NEK2_1	349	354	PF00069	0.389
MOD_NEK2_1	365	370	PF00069	0.487
MOD_NEK2_1	61	66	PF00069	0.443
MOD_OFUCOSY	347	353	PF10250	0.436
MOD_PIKK_1	194	200	PF00454	0.563
MOD_PIKK_1	296	302	PF00454	0.580
MOD_PIKK_1	314	320	PF00454	0.687
MOD_PIKK_1	460	466	PF00454	0.810
MOD_PKA_1	327	333	PF00069	0.629
MOD_PKA_2	327	333	PF00069	0.690
MOD_PKA_2	365	371	PF00069	0.490
MOD_PKA_2	438	444	PF00069	0.800
MOD_PKA_2	460	466	PF00069	0.830
MOD_Plk_1	154	160	PF00069	0.563
MOD_Plk_1	170	176	PF00069	0.419
MOD_Plk_2-3	171	177	PF00069	0.563
MOD_Plk_4	1	7	PF00069	0.689
MOD_Plk_4	127	133	PF00069	0.411
MOD_Plk_4	218	224	PF00069	0.402
MOD_Plk_4	26	32	PF00069	0.383
MOD_Plk_4	260	266	PF00069	0.355
MOD_Plk_4	279	285	PF00069	0.199
MOD_Plk_4	288	294	PF00069	0.466
MOD_Plk_4	63	69	PF00069	0.411
MOD_ProDKin_1	134	140	PF00069	0.619
MOD_ProDKin_1	191	197	PF00069	0.437
MOD_ProDKin_1	237	243	PF00069	0.258
MOD_ProDKin_1	293	299	PF00069	0.732
MOD_ProDKin_1	300	306	PF00069	0.761
MOD_ProDKin_1	443	449	PF00069	0.740
MOD_SUMO_for_1	357	360	PF00179	0.422
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.300
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.308
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.411
TRG_ENDOCYTIC_2	220	223	PF00928	0.411
TRG_ENDOCYTIC_2	224	227	PF00928	0.411
TRG_ENDOCYTIC_2	274	277	PF00928	0.436
TRG_ENDOCYTIC_2	76	79	PF00928	0.546
TRG_ER_diArg_1	327	329	PF00400	0.646
TRG_ER_diArg_1	71	73	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R3	Leptomonas seymouri	46%	90%
A0A3S7WNV0	Leishmania donovani	84%	85%
A4H3Z0	Leishmania braziliensis	68%	100%
A4HS75	Leishmania infantum	85%	85%
O97211	Leishmania major	83%	100%