NAC-A/B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK60_LEIMU

TriTrypDb:

LmxM.04.0770

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005854	nascent polypeptide-associated complex	2	13
GO:0032991	protein-containing complex	1	13
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AK60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK60

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.263
CLV_PCSK_KEX2_1	33	35	PF00082	0.250
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.250
CLV_PCSK_SKI1_1	151	155	PF00082	0.301
CLV_PCSK_SKI1_1	34	38	PF00082	0.250
DOC_MAPK_gen_1	33	44	PF00069	0.450
DOC_MAPK_gen_1	56	63	PF00069	0.463
DOC_MAPK_RevD_3	42	57	PF00069	0.463
DOC_USP7_MATH_1	101	105	PF00917	0.629
DOC_USP7_MATH_1	107	111	PF00917	0.679
DOC_USP7_MATH_1	113	117	PF00917	0.496
DOC_USP7_MATH_1	145	149	PF00917	0.535
DOC_USP7_MATH_1	29	33	PF00917	0.551
DOC_USP7_UBL2_3	33	37	PF12436	0.450
DOC_USP7_UBL2_3	41	45	PF12436	0.450
LIG_APCC_ABBA_1	79	84	PF00400	0.450
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BRCT_BRCA1_1	59	63	PF00533	0.481
LIG_FHA_1	56	62	PF00498	0.350
LIG_FHA_1	76	82	PF00498	0.444
LIG_FHA_1	88	94	PF00498	0.451
LIG_FHA_2	164	170	PF00498	0.535
LIG_LIR_Apic_2	69	74	PF02991	0.450
LIG_LIR_Gen_1	60	71	PF02991	0.509
LIG_LIR_Gen_1	76	87	PF02991	0.375
LIG_LIR_Nem_3	60	66	PF02991	0.509
LIG_LIR_Nem_3	76	82	PF02991	0.375
LIG_RPA_C_Fungi	144	156	PF08784	0.417
LIG_SH2_CRK	71	75	PF00017	0.297
LIG_SH2_STAP1	35	39	PF00017	0.297
LIG_TRAF2_1	13	16	PF00917	0.691
LIG_TRAF2_1	2	5	PF00917	0.684
MOD_CK1_1	108	114	PF00069	0.685
MOD_CK2_1	163	169	PF00069	0.417
MOD_GlcNHglycan	1	4	PF01048	0.431
MOD_GlcNHglycan	103	106	PF01048	0.437
MOD_GlcNHglycan	115	118	PF01048	0.636
MOD_GlcNHglycan	88	93	PF01048	0.515
MOD_GSK3_1	101	108	PF00069	0.608
MOD_GSK3_1	51	58	PF00069	0.199
MOD_N-GLC_1	145	150	PF02516	0.417
MOD_NEK2_1	51	56	PF00069	0.285
MOD_NEK2_1	87	92	PF00069	0.459
MOD_PIKK_1	140	146	PF00454	0.342
MOD_PKA_2	55	61	PF00069	0.158
MOD_Plk_1	88	94	PF00069	0.495
MOD_Plk_2-3	16	22	PF00069	0.570
MOD_Plk_4	163	169	PF00069	0.417
MOD_Plk_4	75	81	PF00069	0.381
MOD_SUMO_for_1	44	47	PF00179	0.297
MOD_SUMO_rev_2	132	138	PF00179	0.349
TRG_DiLeu_BaEn_4	15	21	PF01217	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRE4	Leptomonas seymouri	86%	98%
A0A1X0NL03	Trypanosomatidae	63%	94%
A0A3S5H5C5	Leishmania donovani	94%	100%
A0A3S5H5C6	Leishmania donovani	94%	100%
A1CMF8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	39%	84%
A1DLM0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	39%	84%
A2R4V1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	38%	85%
A3GHD3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	32%	98%
A4H3Y9	Leishmania braziliensis	87%	100%
A4HS73	Leishmania infantum	94%	100%
A4RC89	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	86%
A5DGN9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	34%	97%
A5DXK7	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	31%	95%
A6R641	Ajellomyces capsulatus (strain NAm1 / WU24)	38%	83%
A6SB28	Botryotinia fuckeliana (strain B05.10)	38%	81%
A6ZT99	Saccharomyces cerevisiae (strain YJM789)	34%	99%
A7EIZ1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	35%	80%
A7TG43	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	41%	100%
C9ZY67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	91%
C9ZY68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	91%
O97212	Leishmania major	95%	100%
P0C2C7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	38%	85%
P0CP06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	90%
P0CP07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	90%
P38879	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	99%
P87147	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	99%
Q0UKB5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	35%	82%
Q13765	Homo sapiens	45%	80%
Q1DHR3	Coccidioides immitis (strain RS)	38%	84%
Q2H4Z2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	42%	86%
Q2U955	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	37%	85%
Q45FF9	Babesia divergens	34%	87%
Q4I2J8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	82%
Q4P341	Ustilago maydis (strain 521 / FGSC 9021)	30%	91%
Q4WD81	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	84%
Q54U07	Dictyostelium discoideum	31%	100%
Q5ANP2	Candida albicans (strain SC5314 / ATCC MYA-2876)	35%	97%
Q5AYK0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	85%
Q5E9A1	Bos taurus	45%	80%
Q5R9I9	Pongo abelii	47%	80%
Q60817	Mus musculus	45%	80%
Q61UX1	Caenorhabditis briggsae	38%	87%
Q68F90	Xenopus tropicalis	45%	80%
Q6BSN9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	33%	96%
Q6CDH0	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	87%
Q6CWG6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	98%
Q6FJD5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	100%
Q6ICZ8	Arabidopsis thaliana	42%	84%
Q6IP73	Xenopus laevis	45%	81%
Q6QN10	Chinchilla lanigera	44%	80%
Q756T5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	100%
Q7SI17	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	86%
Q86S66	Caenorhabditis elegans	36%	88%
Q8AWF2	Oreochromis niloticus	45%	80%
Q8JIU7	Danio rerio	46%	80%
Q8LGC6	Arabidopsis thaliana	43%	82%
Q94518	Drosophila melanogaster	48%	79%
Q94JX9	Arabidopsis thaliana	42%	79%
Q9BZK3	Homo sapiens	43%	81%
Q9H009	Homo sapiens	42%	80%
Q9LHG9	Arabidopsis thaliana	40%	85%
Q9M612	Pinus taeda	39%	84%
Q9SZY1	Arabidopsis thaliana	39%	81%
Q9U111	Leishmania major	94%	100%
V5BDN6	Trypanosoma cruzi	62%	95%