NAC-A/B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK59_LEIMU

TriTrypDb:

LmxM.04.0760

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005854	nascent polypeptide-associated complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK59

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.277
CLV_PCSK_KEX2_1	140	142	PF00082	0.252
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.252
CLV_PCSK_SKI1_1	141	145	PF00082	0.255
CLV_PCSK_SKI1_1	258	262	PF00082	0.341
DEG_SCF_FBW7_1	50	55	PF00400	0.528
DOC_CKS1_1	33	38	PF01111	0.515
DOC_MAPK_gen_1	140	151	PF00069	0.477
DOC_MAPK_gen_1	163	170	PF00069	0.456
DOC_MAPK_gen_1	64	73	PF00069	0.537
DOC_MAPK_MEF2A_6	64	73	PF00069	0.537
DOC_MAPK_MEF2A_6	99	108	PF00069	0.564
DOC_MAPK_RevD_3	149	164	PF00069	0.477
DOC_PP2B_LxvP_1	31	34	PF13499	0.533
DOC_PP2B_LxvP_1	44	47	PF13499	0.452
DOC_USP7_MATH_1	136	140	PF00917	0.658
DOC_USP7_MATH_1	208	212	PF00917	0.684
DOC_USP7_MATH_1	214	218	PF00917	0.636
DOC_USP7_MATH_1	220	224	PF00917	0.421
DOC_USP7_MATH_1	252	256	PF00917	0.577
DOC_USP7_MATH_1	45	49	PF00917	0.549
DOC_USP7_MATH_1	52	56	PF00917	0.477
DOC_USP7_UBL2_3	140	144	PF12436	0.456
DOC_USP7_UBL2_3	148	152	PF12436	0.459
DOC_WW_Pin1_4	10	15	PF00397	0.468
DOC_WW_Pin1_4	32	37	PF00397	0.564
DOC_WW_Pin1_4	39	44	PF00397	0.542
DOC_WW_Pin1_4	48	53	PF00397	0.463
DOC_WW_Pin1_4	59	64	PF00397	0.385
LIG_14-3-3_CanoR_1	22	28	PF00244	0.516
LIG_14-3-3_CanoR_1	99	105	PF00244	0.575
LIG_APCC_ABBA_1	186	191	PF00400	0.477
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	166	170	PF00533	0.577
LIG_FHA_1	101	107	PF00498	0.758
LIG_FHA_1	163	169	PF00498	0.427
LIG_FHA_1	183	189	PF00498	0.463
LIG_FHA_1	195	201	PF00498	0.421
LIG_FHA_1	56	62	PF00498	0.532
LIG_FHA_1	64	70	PF00498	0.482
LIG_FHA_2	271	277	PF00498	0.577
LIG_GSK3_LRP6_1	39	44	PF00069	0.521
LIG_LIR_Apic_2	176	181	PF02991	0.477
LIG_LIR_Gen_1	167	178	PF02991	0.547
LIG_LIR_Gen_1	183	194	PF02991	0.383
LIG_LIR_Nem_3	167	173	PF02991	0.547
LIG_LIR_Nem_3	183	189	PF02991	0.371
LIG_RPA_C_Fungi	251	263	PF08784	0.477
LIG_SH2_CRK	178	182	PF00017	0.337
LIG_SH2_STAP1	142	146	PF00017	0.337
LIG_SH3_3	24	30	PF00018	0.349
LIG_SH3_3	31	37	PF00018	0.534
LIG_SH3_3	57	63	PF00018	0.527
LIG_SH3_3	8	14	PF00018	0.480
LIG_SUMO_SIM_par_1	102	107	PF11976	0.702
LIG_TRAF2_1	109	112	PF00917	0.757
LIG_TRAF2_1	120	123	PF00917	0.571
LIG_WRC_WIRS_1	86	91	PF05994	0.535
MOD_CDK_SPK_2	59	64	PF00069	0.525
MOD_CK1_1	215	221	PF00069	0.754
MOD_CK1_1	48	54	PF00069	0.584
MOD_CK1_1	55	61	PF00069	0.508
MOD_CK2_1	106	112	PF00069	0.768
MOD_CK2_1	270	276	PF00069	0.477
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.472
MOD_GlcNHglycan	1	4	PF01048	0.577
MOD_GlcNHglycan	108	111	PF01048	0.544
MOD_GlcNHglycan	195	200	PF01048	0.563
MOD_GlcNHglycan	210	213	PF01048	0.455
MOD_GlcNHglycan	222	225	PF01048	0.567
MOD_GlcNHglycan	47	50	PF01048	0.544
MOD_GSK3_1	100	107	PF00069	0.464
MOD_GSK3_1	158	165	PF00069	0.267
MOD_GSK3_1	208	215	PF00069	0.645
MOD_GSK3_1	48	55	PF00069	0.534
MOD_GSK3_1	59	66	PF00069	0.450
MOD_GSK3_1	85	92	PF00069	0.711
MOD_N-GLC_1	252	257	PF02516	0.477
MOD_NEK2_1	104	109	PF00069	0.467
MOD_NEK2_1	158	163	PF00069	0.267
MOD_NEK2_1	194	199	PF00069	0.475
MOD_NEK2_1	89	94	PF00069	0.750
MOD_PIKK_1	247	253	PF00454	0.477
MOD_PKA_2	162	168	PF00069	0.267
MOD_PKA_2	23	29	PF00069	0.434
MOD_PKA_2	63	69	PF00069	0.715
MOD_Plk_1	195	201	PF00069	0.486
MOD_Plk_1	76	82	PF00069	0.515
MOD_Plk_2-3	123	129	PF00069	0.617
MOD_Plk_4	182	188	PF00069	0.435
MOD_Plk_4	270	276	PF00069	0.477
MOD_Plk_4	52	58	PF00069	0.621
MOD_ProDKin_1	10	16	PF00069	0.468
MOD_ProDKin_1	32	38	PF00069	0.562
MOD_ProDKin_1	39	45	PF00069	0.546
MOD_ProDKin_1	48	54	PF00069	0.462
MOD_ProDKin_1	59	65	PF00069	0.386
MOD_SUMO_for_1	151	154	PF00179	0.337
MOD_SUMO_rev_2	239	245	PF00179	0.427
TRG_DiLeu_BaEn_4	122	128	PF01217	0.757
TRG_ER_diArg_1	22	25	PF00400	0.449
TRG_ER_diArg_1	8	11	PF00400	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HS72	Leishmania infantum	93%	100%
A6R641	Ajellomyces capsulatus (strain NAm1 / WU24)	37%	100%
A6SB28	Botryotinia fuckeliana (strain B05.10)	36%	100%
C9ZY67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
C9ZY68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
O97212	Leishmania major	95%	100%
Q5AYK0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q6CDH0	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	100%