Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF974), putative

Species:

Leishmania mexicana

UniProt:

E9AK56_LEIMU

TriTrypDb:

LmxM.04.0730

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030008	TRAPP complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1990072	TRAPPIII protein complex	4	1

Expansion

Sequence features

E9AK56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.356
CLV_C14_Caspase3-7	265	269	PF00656	0.294
CLV_C14_Caspase3-7	561	565	PF00656	0.505
CLV_C14_Caspase3-7	601	605	PF00656	0.702
CLV_NRD_NRD_1	137	139	PF00675	0.428
CLV_NRD_NRD_1	179	181	PF00675	0.424
CLV_NRD_NRD_1	335	337	PF00675	0.377
CLV_NRD_NRD_1	391	393	PF00675	0.467
CLV_NRD_NRD_1	85	87	PF00675	0.614
CLV_PCSK_FUR_1	83	87	PF00082	0.593
CLV_PCSK_KEX2_1	137	139	PF00082	0.245
CLV_PCSK_KEX2_1	179	181	PF00082	0.424
CLV_PCSK_KEX2_1	391	393	PF00082	0.467
CLV_PCSK_KEX2_1	85	87	PF00082	0.614
CLV_PCSK_SKI1_1	149	153	PF00082	0.317
CLV_PCSK_SKI1_1	179	183	PF00082	0.360
CLV_PCSK_SKI1_1	226	230	PF00082	0.324
CLV_PCSK_SKI1_1	305	309	PF00082	0.494
CLV_PCSK_SKI1_1	362	366	PF00082	0.319
CLV_PCSK_SKI1_1	377	381	PF00082	0.380
DEG_Nend_UBRbox_3	1	3	PF02207	0.686
DEG_ODPH_VHL_1	516	529	PF01847	0.462
DEG_SCF_FBW7_1	94	101	PF00400	0.500
DOC_CYCLIN_RxL_1	177	186	PF00134	0.411
DOC_CYCLIN_RxL_1	525	535	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.502
DOC_MAPK_HePTP_8	289	301	PF00069	0.427
DOC_MAPK_MEF2A_6	112	121	PF00069	0.657
DOC_MAPK_MEF2A_6	292	301	PF00069	0.372
DOC_MAPK_MEF2A_6	350	358	PF00069	0.356
DOC_MAPK_MEF2A_6	504	513	PF00069	0.404
DOC_PP1_RVXF_1	224	231	PF00149	0.302
DOC_PP2B_LxvP_1	133	136	PF13499	0.302
DOC_PP2B_LxvP_1	306	309	PF13499	0.354
DOC_PP2B_LxvP_1	356	359	PF13499	0.427
DOC_PP2B_LxvP_1	39	42	PF13499	0.569
DOC_PP2B_LxvP_1	572	575	PF13499	0.500
DOC_SPAK_OSR1_1	166	170	PF12202	0.181
DOC_USP7_MATH_1	13	17	PF00917	0.689
DOC_USP7_MATH_1	262	266	PF00917	0.403
DOC_USP7_MATH_1	346	350	PF00917	0.450
DOC_USP7_MATH_1	98	102	PF00917	0.613
DOC_WW_Pin1_4	391	396	PF00397	0.391
DOC_WW_Pin1_4	476	481	PF00397	0.732
DOC_WW_Pin1_4	485	490	PF00397	0.606
DOC_WW_Pin1_4	564	569	PF00397	0.495
DOC_WW_Pin1_4	94	99	PF00397	0.764
LIG_14-3-3_CanoR_1	184	192	PF00244	0.392
LIG_14-3-3_CanoR_1	252	262	PF00244	0.418
LIG_14-3-3_CanoR_1	274	284	PF00244	0.398
LIG_14-3-3_CanoR_1	377	382	PF00244	0.429
LIG_14-3-3_CanoR_1	396	401	PF00244	0.422
LIG_14-3-3_CanoR_1	456	465	PF00244	0.577
LIG_14-3-3_CanoR_1	566	572	PF00244	0.517
LIG_Actin_WH2_2	164	181	PF00022	0.356
LIG_Actin_WH2_2	236	251	PF00022	0.420
LIG_Actin_WH2_2	362	379	PF00022	0.411
LIG_Actin_WH2_2	420	438	PF00022	0.416
LIG_AP2alpha_2	79	81	PF02296	0.631
LIG_BRCT_BRCA1_1	123	127	PF00533	0.457
LIG_BRCT_BRCA1_1	144	148	PF00533	0.488
LIG_BRCT_BRCA1_1	230	234	PF00533	0.405
LIG_BRCT_BRCA1_1	537	541	PF00533	0.502
LIG_CSL_BTD_1	572	575	PF09270	0.500
LIG_EH1_1	366	374	PF00400	0.420
LIG_FHA_1	114	120	PF00498	0.673
LIG_FHA_1	207	213	PF00498	0.365
LIG_FHA_1	330	336	PF00498	0.436
LIG_FHA_1	366	372	PF00498	0.430
LIG_FHA_1	38	44	PF00498	0.555
LIG_FHA_1	388	394	PF00498	0.430
LIG_FHA_1	436	442	PF00498	0.569
LIG_FHA_1	524	530	PF00498	0.454
LIG_FHA_1	576	582	PF00498	0.574
LIG_FHA_2	342	348	PF00498	0.436
LIG_FHA_2	631	637	PF00498	0.532
LIG_Integrin_RGD_1	599	601	PF01839	0.486
LIG_LIR_Apic_2	217	221	PF02991	0.433
LIG_LIR_Gen_1	194	204	PF02991	0.420
LIG_LIR_Gen_1	79	89	PF02991	0.583
LIG_LIR_Nem_3	145	151	PF02991	0.411
LIG_LIR_Nem_3	194	199	PF02991	0.458
LIG_LIR_Nem_3	279	285	PF02991	0.433
LIG_LIR_Nem_3	491	497	PF02991	0.408
LIG_LIR_Nem_3	71	77	PF02991	0.532
LIG_LIR_Nem_3	79	84	PF02991	0.510
LIG_NRBOX	528	534	PF00104	0.436
LIG_PDZ_Class_2	635	640	PF00595	0.518
LIG_Pex14_1	230	234	PF04695	0.427
LIG_Pex14_2	123	127	PF04695	0.406
LIG_RPA_C_Fungi	161	173	PF08784	0.261
LIG_SH2_CRK	196	200	PF00017	0.420
LIG_SH2_CRK	522	526	PF00017	0.406
LIG_SH2_NCK_1	196	200	PF00017	0.420
LIG_SH2_PTP2	250	253	PF00017	0.420
LIG_SH2_SRC	219	222	PF00017	0.362
LIG_SH2_STAP1	196	200	PF00017	0.420
LIG_SH2_STAP1	210	214	PF00017	0.346
LIG_SH2_STAP1	505	509	PF00017	0.493
LIG_SH2_STAT5	122	125	PF00017	0.412
LIG_SH2_STAT5	196	199	PF00017	0.427
LIG_SH2_STAT5	250	253	PF00017	0.427
LIG_SH2_STAT5	402	405	PF00017	0.323
LIG_SH3_1	477	483	PF00018	0.544
LIG_SH3_2	174	179	PF14604	0.411
LIG_SH3_2	449	454	PF14604	0.498
LIG_SH3_3	1	7	PF00018	0.744
LIG_SH3_3	112	118	PF00018	0.703
LIG_SH3_3	168	174	PF00018	0.445
LIG_SH3_3	348	354	PF00018	0.410
LIG_SH3_3	446	452	PF00018	0.570
LIG_SH3_3	477	483	PF00018	0.748
LIG_SH3_3	568	574	PF00018	0.443
LIG_SUMO_SIM_anti_2	542	547	PF11976	0.408
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.499
LIG_WW_3	451	455	PF00397	0.504
MOD_CDK_SPK_2	391	396	PF00069	0.423
MOD_CK1_1	16	22	PF00069	0.801
MOD_CK1_1	194	200	PF00069	0.427
MOD_CK1_1	205	211	PF00069	0.447
MOD_CK1_1	275	281	PF00069	0.359
MOD_CK1_1	488	494	PF00069	0.532
MOD_CK1_1	535	541	PF00069	0.444
MOD_CK1_1	585	591	PF00069	0.700
MOD_CK1_1	92	98	PF00069	0.754
MOD_CK2_1	266	272	PF00069	0.294
MOD_CK2_1	341	347	PF00069	0.457
MOD_CK2_1	55	61	PF00069	0.599
MOD_GlcNHglycan	101	104	PF01048	0.549
MOD_GlcNHglycan	139	142	PF01048	0.323
MOD_GlcNHglycan	19	22	PF01048	0.763
MOD_GlcNHglycan	220	224	PF01048	0.453
MOD_GlcNHglycan	268	271	PF01048	0.351
MOD_GlcNHglycan	418	421	PF01048	0.473
MOD_GlcNHglycan	443	446	PF01048	0.656
MOD_GlcNHglycan	534	537	PF01048	0.468
MOD_GlcNHglycan	575	578	PF01048	0.684
MOD_GlcNHglycan	584	587	PF01048	0.616
MOD_GSK3_1	13	20	PF00069	0.692
MOD_GSK3_1	154	161	PF00069	0.249
MOD_GSK3_1	202	209	PF00069	0.453
MOD_GSK3_1	229	236	PF00069	0.336
MOD_GSK3_1	262	269	PF00069	0.379
MOD_GSK3_1	272	279	PF00069	0.381
MOD_GSK3_1	387	394	PF00069	0.401
MOD_GSK3_1	535	542	PF00069	0.448
MOD_GSK3_1	607	614	PF00069	0.717
MOD_GSK3_1	89	96	PF00069	0.689
MOD_N-GLC_1	158	163	PF02516	0.410
MOD_N-GLC_1	292	297	PF02516	0.345
MOD_N-GLC_1	497	502	PF02516	0.549
MOD_NEK2_1	121	126	PF00069	0.677
MOD_NEK2_1	154	159	PF00069	0.405
MOD_NEK2_1	17	22	PF00069	0.706
MOD_NEK2_1	228	233	PF00069	0.335
MOD_NEK2_1	301	306	PF00069	0.345
MOD_NEK2_1	365	370	PF00069	0.376
MOD_NEK2_1	435	440	PF00069	0.470
MOD_NEK2_1	45	50	PF00069	0.504
MOD_NEK2_1	532	537	PF00069	0.468
MOD_NEK2_1	539	544	PF00069	0.422
MOD_NEK2_1	580	585	PF00069	0.715
MOD_NEK2_1	611	616	PF00069	0.748
MOD_NEK2_1	99	104	PF00069	0.734
MOD_NEK2_2	230	235	PF00069	0.427
MOD_PIKK_1	160	166	PF00454	0.467
MOD_PIKK_1	48	54	PF00454	0.574
MOD_PKA_1	137	143	PF00069	0.181
MOD_PKA_2	137	143	PF00069	0.181
MOD_PKA_2	183	189	PF00069	0.427
MOD_PKA_2	251	257	PF00069	0.402
MOD_PKA_2	273	279	PF00069	0.471
MOD_PKA_2	285	291	PF00069	0.177
MOD_PKA_2	339	345	PF00069	0.220
MOD_PKA_2	395	401	PF00069	0.287
MOD_PKA_2	435	441	PF00069	0.609
MOD_Plk_1	158	164	PF00069	0.420
MOD_Plk_1	205	211	PF00069	0.473
MOD_Plk_1	292	298	PF00069	0.345
MOD_Plk_1	607	613	PF00069	0.651
MOD_Plk_4	194	200	PF00069	0.420
MOD_Plk_4	377	383	PF00069	0.479
MOD_Plk_4	45	51	PF00069	0.469
MOD_Plk_4	541	547	PF00069	0.404
MOD_Plk_4	567	573	PF00069	0.447
MOD_ProDKin_1	391	397	PF00069	0.391
MOD_ProDKin_1	476	482	PF00069	0.725
MOD_ProDKin_1	485	491	PF00069	0.602
MOD_ProDKin_1	564	570	PF00069	0.496
MOD_ProDKin_1	94	100	PF00069	0.763
MOD_SUMO_for_1	234	237	PF00179	0.427
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.652
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.470
TRG_ENDOCYTIC_2	196	199	PF00928	0.420
TRG_ER_diArg_1	136	138	PF00400	0.245
TRG_ER_diArg_1	178	180	PF00400	0.388
TRG_ER_diArg_1	391	393	PF00400	0.457
TRG_ER_diArg_1	453	456	PF00400	0.511
TRG_ER_diArg_1	83	86	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	553	558	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB8	Leptomonas seymouri	48%	99%
A0A1X0NLJ7	Trypanosomatidae	30%	100%
A0A3R7LPQ4	Trypanosoma rangeli	29%	100%
A0A3S5H5C3	Leishmania donovani	86%	100%
A4H407	Leishmania braziliensis	67%	99%
A4HS69	Leishmania infantum	86%	100%
C9ZY64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
O97215	Leishmania major	86%	100%
V5BIB6	Trypanosoma cruzi	31%	100%