Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK55_LEIMU

TriTrypDb:

LmxM.04.0720

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.523
CLV_C14_Caspase3-7	62	66	PF00656	0.765
CLV_NRD_NRD_1	137	139	PF00675	0.400
CLV_NRD_NRD_1	191	193	PF00675	0.766
CLV_NRD_NRD_1	283	285	PF00675	0.818
CLV_NRD_NRD_1	367	369	PF00675	0.668
CLV_NRD_NRD_1	85	87	PF00675	0.600
CLV_PCSK_KEX2_1	137	139	PF00082	0.400
CLV_PCSK_KEX2_1	283	285	PF00082	0.658
CLV_PCSK_KEX2_1	367	369	PF00082	0.668
CLV_PCSK_KEX2_1	85	87	PF00082	0.603
CLV_PCSK_SKI1_1	118	122	PF00082	0.437
CLV_PCSK_SKI1_1	193	197	PF00082	0.847
CLV_PCSK_SKI1_1	454	458	PF00082	0.744
CLV_PCSK_SKI1_1	85	89	PF00082	0.637
DEG_APCC_DBOX_1	105	113	PF00400	0.677
DEG_SPOP_SBC_1	324	328	PF00917	0.748
DEG_SPOP_SBC_1	44	48	PF00917	0.605
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.644
DOC_MAPK_RevD_3	124	138	PF00069	0.411
DOC_PP1_RVXF_1	218	225	PF00149	0.513
DOC_PP2B_LxvP_1	497	500	PF13499	0.719
DOC_USP7_MATH_1	102	106	PF00917	0.523
DOC_USP7_MATH_1	18	22	PF00917	0.610
DOC_USP7_MATH_1	180	184	PF00917	0.797
DOC_USP7_MATH_1	200	204	PF00917	0.734
DOC_USP7_MATH_1	324	328	PF00917	0.810
DOC_USP7_MATH_1	329	333	PF00917	0.779
DOC_USP7_MATH_1	44	48	PF00917	0.619
DOC_USP7_MATH_1	500	504	PF00917	0.711
DOC_USP7_MATH_1	59	63	PF00917	0.730
DOC_USP7_MATH_1	592	596	PF00917	0.730
DOC_USP7_MATH_1	605	609	PF00917	0.561
DOC_USP7_MATH_1	667	671	PF00917	0.788
DOC_WW_Pin1_4	14	19	PF00397	0.658
DOC_WW_Pin1_4	152	157	PF00397	0.830
DOC_WW_Pin1_4	22	27	PF00397	0.633
DOC_WW_Pin1_4	230	235	PF00397	0.736
DOC_WW_Pin1_4	333	338	PF00397	0.749
DOC_WW_Pin1_4	360	365	PF00397	0.630
DOC_WW_Pin1_4	408	413	PF00397	0.554
DOC_WW_Pin1_4	441	446	PF00397	0.782
DOC_WW_Pin1_4	98	103	PF00397	0.537
LIG_14-3-3_CanoR_1	192	198	PF00244	0.762
LIG_14-3-3_CanoR_1	263	272	PF00244	0.771
LIG_14-3-3_CanoR_1	283	289	PF00244	0.607
LIG_14-3-3_CanoR_1	42	49	PF00244	0.768
LIG_14-3-3_CanoR_1	454	464	PF00244	0.748
LIG_14-3-3_CanoR_1	501	508	PF00244	0.616
LIG_14-3-3_CanoR_1	620	625	PF00244	0.814
LIG_14-3-3_CanoR_1	85	95	PF00244	0.622
LIG_Actin_WH2_2	105	120	PF00022	0.446
LIG_Actin_WH2_2	351	369	PF00022	0.661
LIG_APCC_ABBA_1	387	392	PF00400	0.555
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_BIR_III_4	27	31	PF00653	0.750
LIG_BRCT_BRCA1_1	460	464	PF00533	0.750
LIG_BRCT_BRCA1_1	508	512	PF00533	0.514
LIG_deltaCOP1_diTrp_1	556	560	PF00928	0.709
LIG_FHA_1	158	164	PF00498	0.837
LIG_FHA_1	326	332	PF00498	0.838
LIG_FHA_1	519	525	PF00498	0.723
LIG_FHA_1	630	636	PF00498	0.782
LIG_FHA_2	285	291	PF00498	0.681
LIG_FHA_2	3	9	PF00498	0.831
LIG_FHA_2	594	600	PF00498	0.723
LIG_LIR_Apic_2	178	182	PF02991	0.848
LIG_LIR_Nem_3	554	560	PF02991	0.773
LIG_SH2_CRK	285	289	PF00017	0.753
LIG_SH2_CRK	322	326	PF00017	0.738
LIG_SH2_NCK_1	285	289	PF00017	0.626
LIG_SH2_STAP1	644	648	PF00017	0.593
LIG_SH2_STAT3	571	574	PF00017	0.555
LIG_SH2_STAT5	31	34	PF00017	0.548
LIG_SH2_STAT5	662	665	PF00017	0.794
LIG_SH3_3	153	159	PF00018	0.745
LIG_SH3_3	228	234	PF00018	0.656
LIG_SH3_3	388	394	PF00018	0.679
LIG_SH3_3	485	491	PF00018	0.723
LIG_SH3_3	76	82	PF00018	0.734
LIG_SUMO_SIM_anti_2	444	451	PF11976	0.530
LIG_SUMO_SIM_par_1	159	165	PF11976	0.555
LIG_TRAF2_1	357	360	PF00917	0.573
MOD_CDK_SPxxK_3	360	367	PF00069	0.556
MOD_CK1_1	101	107	PF00069	0.725
MOD_CK1_1	14	20	PF00069	0.760
MOD_CK1_1	162	168	PF00069	0.788
MOD_CK1_1	188	194	PF00069	0.762
MOD_CK1_1	2	8	PF00069	0.688
MOD_CK1_1	214	220	PF00069	0.768
MOD_CK1_1	286	292	PF00069	0.586
MOD_CK1_1	311	317	PF00069	0.780
MOD_CK1_1	327	333	PF00069	0.577
MOD_CK1_1	370	376	PF00069	0.660
MOD_CK1_1	408	414	PF00069	0.552
MOD_CK1_1	435	441	PF00069	0.727
MOD_CK1_1	444	450	PF00069	0.612
MOD_CK1_1	45	51	PF00069	0.743
MOD_CK1_1	504	510	PF00069	0.769
MOD_CK1_1	559	565	PF00069	0.785
MOD_CK1_1	586	592	PF00069	0.818
MOD_CK1_1	647	653	PF00069	0.785
MOD_CK1_1	665	671	PF00069	0.492
MOD_CK2_1	108	114	PF00069	0.601
MOD_CK2_1	593	599	PF00069	0.731
MOD_CK2_1	620	626	PF00069	0.657
MOD_GlcNHglycan	187	190	PF01048	0.758
MOD_GlcNHglycan	214	217	PF01048	0.705
MOD_GlcNHglycan	234	237	PF01048	0.563
MOD_GlcNHglycan	248	251	PF01048	0.734
MOD_GlcNHglycan	256	259	PF01048	0.737
MOD_GlcNHglycan	310	313	PF01048	0.720
MOD_GlcNHglycan	360	363	PF01048	0.702
MOD_GlcNHglycan	370	373	PF01048	0.655
MOD_GlcNHglycan	407	410	PF01048	0.730
MOD_GlcNHglycan	437	440	PF01048	0.827
MOD_GlcNHglycan	450	453	PF01048	0.600
MOD_GlcNHglycan	458	461	PF01048	0.808
MOD_GlcNHglycan	467	470	PF01048	0.651
MOD_GlcNHglycan	484	487	PF01048	0.513
MOD_GlcNHglycan	508	511	PF01048	0.793
MOD_GlcNHglycan	553	556	PF01048	0.605
MOD_GlcNHglycan	590	593	PF01048	0.624
MOD_GlcNHglycan	61	64	PF01048	0.797
MOD_GlcNHglycan	617	620	PF01048	0.792
MOD_GlcNHglycan	664	667	PF01048	0.706
MOD_GlcNHglycan	88	91	PF01048	0.569
MOD_GSK3_1	14	21	PF00069	0.723
MOD_GSK3_1	244	251	PF00069	0.610
MOD_GSK3_1	263	270	PF00069	0.681
MOD_GSK3_1	323	330	PF00069	0.815
MOD_GSK3_1	366	373	PF00069	0.641
MOD_GSK3_1	429	436	PF00069	0.747
MOD_GSK3_1	43	50	PF00069	0.688
MOD_GSK3_1	437	444	PF00069	0.672
MOD_GSK3_1	454	461	PF00069	0.608
MOD_GSK3_1	500	507	PF00069	0.766
MOD_GSK3_1	514	521	PF00069	0.605
MOD_GSK3_1	537	544	PF00069	0.534
MOD_GSK3_1	54	61	PF00069	0.658
MOD_GSK3_1	559	566	PF00069	0.743
MOD_GSK3_1	579	586	PF00069	0.778
MOD_GSK3_1	588	595	PF00069	0.720
MOD_GSK3_1	615	622	PF00069	0.767
MOD_GSK3_1	629	636	PF00069	0.737
MOD_GSK3_1	640	647	PF00069	0.638
MOD_GSK3_1	650	657	PF00069	0.609
MOD_GSK3_1	665	672	PF00069	0.549
MOD_GSK3_1	98	105	PF00069	0.728
MOD_LATS_1	281	287	PF00433	0.527
MOD_N-GLC_1	14	19	PF02516	0.658
MOD_N-GLC_1	405	410	PF02516	0.575
MOD_N-GLC_1	519	524	PF02516	0.646
MOD_N-GLC_1	525	530	PF02516	0.652
MOD_N-GLC_1	586	591	PF02516	0.744
MOD_N-GLC_2	661	663	PF02516	0.798
MOD_NEK2_1	248	253	PF00069	0.673
MOD_NEK2_1	325	330	PF00069	0.808
MOD_NEK2_1	342	347	PF00069	0.548
MOD_NEK2_1	358	363	PF00069	0.579
MOD_NEK2_1	366	371	PF00069	0.749
MOD_NEK2_1	464	469	PF00069	0.705
MOD_NEK2_1	493	498	PF00069	0.813
MOD_NEK2_1	506	511	PF00069	0.654
MOD_NEK2_1	563	568	PF00069	0.780
MOD_NEK2_1	579	584	PF00069	0.531
MOD_NEK2_1	610	615	PF00069	0.498
MOD_NEK2_1	656	661	PF00069	0.723
MOD_NEK2_2	605	610	PF00069	0.502
MOD_PIKK_1	342	348	PF00454	0.787
MOD_PIKK_1	37	43	PF00454	0.744
MOD_PIKK_1	80	86	PF00454	0.742
MOD_PKA_1	118	124	PF00069	0.423
MOD_PKA_1	283	289	PF00069	0.621
MOD_PKA_1	367	373	PF00069	0.563
MOD_PKA_2	11	17	PF00069	0.684
MOD_PKA_2	262	268	PF00069	0.857
MOD_PKA_2	283	289	PF00069	0.621
MOD_PKA_2	366	372	PF00069	0.672
MOD_PKA_2	37	43	PF00069	0.728
MOD_PKA_2	462	468	PF00069	0.745
MOD_PKA_2	500	506	PF00069	0.794
MOD_PKA_2	619	625	PF00069	0.811
MOD_PKB_1	261	269	PF00069	0.776
MOD_Plk_1	244	250	PF00069	0.559
MOD_Plk_1	429	435	PF00069	0.740
MOD_Plk_1	519	525	PF00069	0.630
MOD_Plk_2-3	108	114	PF00069	0.551
MOD_Plk_4	108	114	PF00069	0.654
MOD_Plk_4	311	317	PF00069	0.690
MOD_Plk_4	437	443	PF00069	0.671
MOD_Plk_4	444	450	PF00069	0.644
MOD_Plk_4	519	525	PF00069	0.703
MOD_Plk_4	605	611	PF00069	0.523
MOD_Plk_4	633	639	PF00069	0.693
MOD_ProDKin_1	14	20	PF00069	0.657
MOD_ProDKin_1	152	158	PF00069	0.827
MOD_ProDKin_1	22	28	PF00069	0.632
MOD_ProDKin_1	230	236	PF00069	0.741
MOD_ProDKin_1	333	339	PF00069	0.746
MOD_ProDKin_1	360	366	PF00069	0.632
MOD_ProDKin_1	408	414	PF00069	0.552
MOD_ProDKin_1	441	447	PF00069	0.783
MOD_ProDKin_1	98	104	PF00069	0.535
MOD_SUMO_rev_2	239	246	PF00179	0.558
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.699
TRG_ENDOCYTIC_2	285	288	PF00928	0.786
TRG_ENDOCYTIC_2	322	325	PF00928	0.737
TRG_ENDOCYTIC_2	624	627	PF00928	0.726
TRG_ER_diArg_1	136	138	PF00400	0.407
TRG_ER_diArg_1	261	264	PF00400	0.857
TRG_ER_diArg_1	283	285	PF00400	0.735
TRG_ER_diArg_1	366	368	PF00400	0.671
TRG_ER_diArg_1	481	484	PF00400	0.684
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5C2	Leishmania donovani	69%	95%
A4H406	Leishmania braziliensis	46%	94%
A4HS68	Leishmania infantum	69%	95%
O97216	Leishmania major	69%	99%