PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family/PDZ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AK54_LEIMU

TriTrypDb:

LmxM.04.0710

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK54

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009306	protein secretion	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0030254	protein secretion by the type III secretion system	4	10
GO:0032940	secretion by cell	3	10
GO:0033036	macromolecule localization	2	10
GO:0035592	establishment of protein localization to extracellular region	4	10
GO:0045184	establishment of protein localization	3	10
GO:0046903	secretion	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071692	protein localization to extracellular region	5	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071806	protein transmembrane transport	3	10
GO:0140352	export from cell	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.568
CLV_NRD_NRD_1	119	121	PF00675	0.513
CLV_NRD_NRD_1	152	154	PF00675	0.600
CLV_NRD_NRD_1	196	198	PF00675	0.510
CLV_NRD_NRD_1	248	250	PF00675	0.495
CLV_NRD_NRD_1	333	335	PF00675	0.471
CLV_NRD_NRD_1	385	387	PF00675	0.688
CLV_NRD_NRD_1	464	466	PF00675	0.344
CLV_NRD_NRD_1	758	760	PF00675	0.432
CLV_NRD_NRD_1	97	99	PF00675	0.651
CLV_PCSK_FUR_1	150	154	PF00082	0.595
CLV_PCSK_KEX2_1	118	120	PF00082	0.516
CLV_PCSK_KEX2_1	152	154	PF00082	0.602
CLV_PCSK_KEX2_1	195	197	PF00082	0.514
CLV_PCSK_KEX2_1	248	250	PF00082	0.495
CLV_PCSK_KEX2_1	27	29	PF00082	0.478
CLV_PCSK_KEX2_1	333	335	PF00082	0.469
CLV_PCSK_KEX2_1	385	387	PF00082	0.686
CLV_PCSK_KEX2_1	464	466	PF00082	0.344
CLV_PCSK_KEX2_1	696	698	PF00082	0.603
CLV_PCSK_KEX2_1	758	760	PF00082	0.403
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.460
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.603
CLV_PCSK_PC7_1	114	120	PF00082	0.514
CLV_PCSK_SKI1_1	152	156	PF00082	0.518
CLV_PCSK_SKI1_1	226	230	PF00082	0.380
CLV_PCSK_SKI1_1	272	276	PF00082	0.451
CLV_PCSK_SKI1_1	696	700	PF00082	0.391
DEG_APCC_DBOX_1	14	22	PF00400	0.562
DEG_APCC_DBOX_1	223	231	PF00400	0.505
DEG_SPOP_SBC_1	629	633	PF00917	0.489
DEG_SPOP_SBC_1	686	690	PF00917	0.670
DOC_CKS1_1	33	38	PF01111	0.536
DOC_CKS1_1	614	619	PF01111	0.673
DOC_CKS1_1	764	769	PF01111	0.282
DOC_CYCLIN_RxL_1	149	159	PF00134	0.637
DOC_CYCLIN_RxL_1	301	312	PF00134	0.548
DOC_MAPK_DCC_7	696	704	PF00069	0.520
DOC_MAPK_gen_1	150	157	PF00069	0.581
DOC_MAPK_gen_1	222	229	PF00069	0.506
DOC_MAPK_gen_1	27	33	PF00069	0.462
DOC_MAPK_gen_1	392	401	PF00069	0.491
DOC_MAPK_gen_1	464	472	PF00069	0.544
DOC_MAPK_gen_1	696	704	PF00069	0.520
DOC_MAPK_gen_1	774	784	PF00069	0.419
DOC_MAPK_MEF2A_6	696	704	PF00069	0.564
DOC_MAPK_MEF2A_6	777	786	PF00069	0.399
DOC_PP1_RVXF_1	473	479	PF00149	0.424
DOC_PP2B_LxvP_1	563	566	PF13499	0.544
DOC_PP2B_LxvP_1	683	686	PF13499	0.672
DOC_USP7_MATH_1	411	415	PF00917	0.680
DOC_USP7_MATH_1	50	54	PF00917	0.504
DOC_USP7_MATH_1	651	655	PF00917	0.726
DOC_USP7_MATH_1	686	690	PF00917	0.657
DOC_USP7_MATH_1	729	733	PF00917	0.423
DOC_USP7_MATH_1	790	794	PF00917	0.601
DOC_USP7_MATH_1	97	101	PF00917	0.527
DOC_WW_Pin1_4	113	118	PF00397	0.779
DOC_WW_Pin1_4	124	129	PF00397	0.760
DOC_WW_Pin1_4	138	143	PF00397	0.588
DOC_WW_Pin1_4	32	37	PF00397	0.568
DOC_WW_Pin1_4	429	434	PF00397	0.695
DOC_WW_Pin1_4	613	618	PF00397	0.702
DOC_WW_Pin1_4	635	640	PF00397	0.740
DOC_WW_Pin1_4	654	659	PF00397	0.706
DOC_WW_Pin1_4	663	668	PF00397	0.651
DOC_WW_Pin1_4	678	683	PF00397	0.626
DOC_WW_Pin1_4	763	768	PF00397	0.362
LIG_14-3-3_CanoR_1	179	183	PF00244	0.599
LIG_14-3-3_CanoR_1	237	245	PF00244	0.601
LIG_14-3-3_CanoR_1	28	34	PF00244	0.575
LIG_14-3-3_CanoR_1	427	433	PF00244	0.746
LIG_14-3-3_CanoR_1	588	598	PF00244	0.517
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BIR_III_4	373	377	PF00653	0.494
LIG_eIF4E_1	506	512	PF01652	0.482
LIG_eIF4E_1	719	725	PF01652	0.333
LIG_FHA_1	301	307	PF00498	0.321
LIG_FHA_1	481	487	PF00498	0.465
LIG_FHA_1	491	497	PF00498	0.476
LIG_FHA_1	500	506	PF00498	0.555
LIG_FHA_1	590	596	PF00498	0.516
LIG_FHA_1	673	679	PF00498	0.571
LIG_FHA_1	705	711	PF00498	0.438
LIG_FHA_1	783	789	PF00498	0.419
LIG_FHA_1	86	92	PF00498	0.461
LIG_FHA_2	368	374	PF00498	0.674
LIG_LIR_Gen_1	489	500	PF02991	0.464
LIG_LIR_Gen_1	555	564	PF02991	0.482
LIG_LIR_LC3C_4	721	726	PF02991	0.368
LIG_LIR_Nem_3	489	495	PF02991	0.469
LIG_LIR_Nem_3	756	760	PF02991	0.419
LIG_Rb_pABgroove_1	492	500	PF01858	0.548
LIG_SH2_CRK	344	348	PF00017	0.511
LIG_SH2_CRK	492	496	PF00017	0.464
LIG_SH2_CRK	508	512	PF00017	0.464
LIG_SH2_NCK_1	498	502	PF00017	0.544
LIG_SH2_SRC	506	509	PF00017	0.507
LIG_SH2_SRC	719	722	PF00017	0.419
LIG_SH2_STAP1	492	496	PF00017	0.480
LIG_SH2_STAP1	508	512	PF00017	0.403
LIG_SH2_STAP1	530	534	PF00017	0.464
LIG_SH2_STAP1	630	634	PF00017	0.664
LIG_SH2_STAT3	343	346	PF00017	0.559
LIG_SH2_STAT5	492	495	PF00017	0.478
LIG_SH2_STAT5	506	509	PF00017	0.425
LIG_SH2_STAT5	630	633	PF00017	0.723
LIG_SH3_2	93	98	PF14604	0.644
LIG_SH3_3	136	142	PF00018	0.657
LIG_SH3_3	346	352	PF00018	0.481
LIG_SH3_3	5	11	PF00018	0.487
LIG_SH3_3	611	617	PF00018	0.745
LIG_SH3_3	652	658	PF00018	0.530
LIG_SH3_3	90	96	PF00018	0.572
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.503
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.578
LIG_SUMO_SIM_anti_2	721	727	PF11976	0.334
LIG_SUMO_SIM_par_1	153	159	PF11976	0.649
LIG_SUMO_SIM_par_1	483	489	PF11976	0.464
LIG_SUMO_SIM_par_1	87	92	PF11976	0.450
LIG_TRAF2_1	205	208	PF00917	0.578
LIG_TRAF2_1	254	257	PF00917	0.467
LIG_TYR_ITAM	489	511	PF00017	0.464
LIG_UBA3_1	264	272	PF00899	0.542
LIG_WW_3	95	99	PF00397	0.724
MOD_CDC14_SPxK_1	116	119	PF00782	0.504
MOD_CDK_SPK_2	113	118	PF00069	0.690
MOD_CDK_SPxK_1	113	119	PF00069	0.515
MOD_CDK_SPxxK_3	113	120	PF00069	0.691
MOD_CDK_SPxxK_3	32	39	PF00069	0.497
MOD_CDK_SPxxK_3	654	661	PF00069	0.730
MOD_CK1_1	140	146	PF00069	0.663
MOD_CK1_1	32	38	PF00069	0.537
MOD_CK1_1	397	403	PF00069	0.721
MOD_CK1_1	415	421	PF00069	0.616
MOD_CK1_1	432	438	PF00069	0.630
MOD_CK1_1	572	578	PF00069	0.474
MOD_CK1_1	607	613	PF00069	0.773
MOD_CK1_1	632	638	PF00069	0.747
MOD_CK1_1	650	656	PF00069	0.750
MOD_CK1_1	662	668	PF00069	0.654
MOD_CK1_1	691	697	PF00069	0.558
MOD_CK2_1	202	208	PF00069	0.582
MOD_CK2_1	211	217	PF00069	0.585
MOD_Cter_Amidation	25	28	PF01082	0.503
MOD_GlcNHglycan	204	207	PF01048	0.628
MOD_GlcNHglycan	388	391	PF01048	0.683
MOD_GlcNHglycan	559	562	PF01048	0.334
MOD_GlcNHglycan	606	609	PF01048	0.760
MOD_GlcNHglycan	632	635	PF01048	0.797
MOD_GlcNHglycan	643	646	PF01048	0.616
MOD_GlcNHglycan	649	652	PF01048	0.714
MOD_GSK3_1	134	141	PF00069	0.765
MOD_GSK3_1	411	418	PF00069	0.676
MOD_GSK3_1	423	430	PF00069	0.584
MOD_GSK3_1	480	487	PF00069	0.466
MOD_GSK3_1	507	514	PF00069	0.544
MOD_GSK3_1	565	572	PF00069	0.466
MOD_GSK3_1	628	635	PF00069	0.687
MOD_GSK3_1	637	644	PF00069	0.747
MOD_GSK3_1	647	654	PF00069	0.640
MOD_GSK3_1	659	666	PF00069	0.655
MOD_GSK3_1	687	694	PF00069	0.750
MOD_N-GLC_1	691	696	PF02516	0.706
MOD_N-GLC_2	482	484	PF02516	0.265
MOD_NEK2_1	178	183	PF00069	0.597
MOD_NEK2_1	297	302	PF00069	0.565
MOD_NEK2_1	399	404	PF00069	0.780
MOD_NEK2_1	423	428	PF00069	0.646
MOD_NEK2_1	478	483	PF00069	0.505
MOD_NEK2_1	507	512	PF00069	0.473
MOD_NEK2_1	534	539	PF00069	0.590
MOD_NEK2_1	559	564	PF00069	0.466
MOD_NEK2_1	641	646	PF00069	0.688
MOD_NEK2_1	704	709	PF00069	0.473
MOD_NEK2_1	77	82	PF00069	0.530
MOD_NEK2_1	782	787	PF00069	0.368
MOD_NEK2_2	29	34	PF00069	0.560
MOD_OFUCOSY	48	55	PF10250	0.482
MOD_PIKK_1	565	571	PF00454	0.544
MOD_PKA_2	178	184	PF00069	0.630
MOD_PKA_2	202	208	PF00069	0.585
MOD_PKA_2	211	217	PF00069	0.585
MOD_PKA_2	236	242	PF00069	0.515
MOD_PKA_2	38	44	PF00069	0.425
MOD_PKA_2	97	103	PF00069	0.524
MOD_PKB_1	392	400	PF00069	0.490
MOD_Plk_1	490	496	PF00069	0.504
MOD_Plk_1	534	540	PF00069	0.544
MOD_Plk_2-3	367	373	PF00069	0.553
MOD_Plk_4	490	496	PF00069	0.481
MOD_Plk_4	507	513	PF00069	0.385
MOD_Plk_4	534	540	PF00069	0.567
MOD_Plk_4	559	565	PF00069	0.464
MOD_Plk_4	706	712	PF00069	0.459
MOD_Plk_4	729	735	PF00069	0.419
MOD_ProDKin_1	113	119	PF00069	0.779
MOD_ProDKin_1	124	130	PF00069	0.758
MOD_ProDKin_1	138	144	PF00069	0.586
MOD_ProDKin_1	32	38	PF00069	0.567
MOD_ProDKin_1	429	435	PF00069	0.695
MOD_ProDKin_1	613	619	PF00069	0.706
MOD_ProDKin_1	635	641	PF00069	0.741
MOD_ProDKin_1	654	660	PF00069	0.744
MOD_ProDKin_1	663	669	PF00069	0.646
MOD_ProDKin_1	678	684	PF00069	0.628
MOD_ProDKin_1	763	769	PF00069	0.362
MOD_SUMO_for_1	265	268	PF00179	0.523
MOD_SUMO_rev_2	268	274	PF00179	0.540
TRG_DiLeu_BaEn_1	225	230	PF01217	0.327
TRG_DiLeu_BaEn_1	491	496	PF01217	0.544
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.667
TRG_ENDOCYTIC_2	344	347	PF00928	0.469
TRG_ENDOCYTIC_2	492	495	PF00928	0.464
TRG_ENDOCYTIC_2	508	511	PF00928	0.464
TRG_ENDOCYTIC_2	530	533	PF00928	0.464
TRG_ER_diArg_1	117	120	PF00400	0.681
TRG_ER_diArg_1	150	153	PF00400	0.620
TRG_ER_diArg_1	194	197	PF00400	0.567
TRG_ER_diArg_1	308	311	PF00400	0.490
TRG_ER_diArg_1	333	335	PF00400	0.533
TRG_ER_diArg_1	385	387	PF00400	0.555
TRG_ER_diArg_1	392	395	PF00400	0.507
TRG_ER_diArg_1	463	465	PF00400	0.544
TRG_ER_diArg_1	757	759	PF00400	0.421
TRG_NES_CRM1_1	461	474	PF08389	0.342
TRG_NES_CRM1_1	60	74	PF08389	0.541
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	574	579	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	759	763	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I193	Leptomonas seymouri	58%	100%
A0A1X0NMQ4	Trypanosomatidae	36%	100%
A0A3R7NDD0	Trypanosoma rangeli	35%	100%
A0A3S5H5C1	Leishmania donovani	90%	100%
A4H405	Leishmania braziliensis	77%	98%
A4HS67	Leishmania infantum	90%	100%
Q9U110	Leishmania major	88%	100%
V5BIA8	Trypanosoma cruzi	35%	100%