Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK53_LEIMU

TriTrypDb:

LmxM.04.0700

Length:

1076

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1035	1039	PF00656	0.643
CLV_C14_Caspase3-7	127	131	PF00656	0.590
CLV_C14_Caspase3-7	137	141	PF00656	0.608
CLV_C14_Caspase3-7	852	856	PF00656	0.650
CLV_NRD_NRD_1	1059	1061	PF00675	0.613
CLV_NRD_NRD_1	1074	1076	PF00675	0.558
CLV_NRD_NRD_1	167	169	PF00675	0.693
CLV_NRD_NRD_1	509	511	PF00675	0.660
CLV_NRD_NRD_1	623	625	PF00675	0.688
CLV_NRD_NRD_1	633	635	PF00675	0.632
CLV_NRD_NRD_1	641	643	PF00675	0.563
CLV_NRD_NRD_1	645	647	PF00675	0.745
CLV_NRD_NRD_1	79	81	PF00675	0.762
CLV_NRD_NRD_1	848	850	PF00675	0.655
CLV_PCSK_FUR_1	630	634	PF00082	0.692
CLV_PCSK_FUR_1	846	850	PF00082	0.699
CLV_PCSK_KEX2_1	1059	1061	PF00082	0.715
CLV_PCSK_KEX2_1	1074	1076	PF00082	0.542
CLV_PCSK_KEX2_1	167	169	PF00082	0.693
CLV_PCSK_KEX2_1	199	201	PF00082	0.756
CLV_PCSK_KEX2_1	509	511	PF00082	0.660
CLV_PCSK_KEX2_1	623	625	PF00082	0.683
CLV_PCSK_KEX2_1	632	634	PF00082	0.642
CLV_PCSK_KEX2_1	641	643	PF00082	0.570
CLV_PCSK_KEX2_1	645	647	PF00082	0.748
CLV_PCSK_KEX2_1	78	80	PF00082	0.768
CLV_PCSK_KEX2_1	848	850	PF00082	0.660
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.733
CLV_PCSK_PC7_1	1070	1076	PF00082	0.743
CLV_PCSK_PC7_1	641	647	PF00082	0.635
CLV_PCSK_PC7_1	75	81	PF00082	0.698
CLV_PCSK_SKI1_1	532	536	PF00082	0.802
CLV_PCSK_SKI1_1	539	543	PF00082	0.692
CLV_PCSK_SKI1_1	770	774	PF00082	0.693
CLV_PCSK_SKI1_1	888	892	PF00082	0.569
DEG_APCC_DBOX_1	769	777	PF00400	0.691
DEG_APCC_DBOX_1	982	990	PF00400	0.703
DEG_SCF_FBW7_1	255	262	PF00400	0.696
DEG_SPOP_SBC_1	335	339	PF00917	0.573
DOC_ANK_TNKS_1	755	762	PF00023	0.567
DOC_CKS1_1	1020	1025	PF01111	0.556
DOC_CKS1_1	450	455	PF01111	0.732
DOC_CKS1_1	93	98	PF01111	0.684
DOC_CYCLIN_yCln2_LP_2	1021	1027	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.718
DOC_MAPK_DCC_7	416	425	PF00069	0.777
DOC_MAPK_gen_1	775	783	PF00069	0.727
DOC_MAPK_gen_1	82	91	PF00069	0.539
DOC_MAPK_MEF2A_6	416	425	PF00069	0.676
DOC_MAPK_MEF2A_6	84	93	PF00069	0.702
DOC_PP2B_LxvP_1	1021	1024	PF13499	0.500
DOC_PP2B_LxvP_1	781	784	PF13499	0.699
DOC_PP2B_LxvP_1	91	94	PF13499	0.704
DOC_PP4_FxxP_1	320	323	PF00568	0.522
DOC_PP4_FxxP_1	543	546	PF00568	0.836
DOC_SPAK_OSR1_1	440	444	PF12202	0.459
DOC_USP7_MATH_1	128	132	PF00917	0.699
DOC_USP7_MATH_1	153	157	PF00917	0.658
DOC_USP7_MATH_1	229	233	PF00917	0.591
DOC_USP7_MATH_1	24	28	PF00917	0.743
DOC_USP7_MATH_1	298	302	PF00917	0.611
DOC_USP7_MATH_1	335	339	PF00917	0.704
DOC_USP7_MATH_1	35	39	PF00917	0.658
DOC_USP7_MATH_1	375	379	PF00917	0.741
DOC_USP7_MATH_1	518	522	PF00917	0.852
DOC_USP7_MATH_1	622	626	PF00917	0.633
DOC_USP7_MATH_1	718	722	PF00917	0.768
DOC_USP7_MATH_1	748	752	PF00917	0.741
DOC_USP7_MATH_1	979	983	PF00917	0.538
DOC_USP7_MATH_2	310	316	PF00917	0.730
DOC_WW_Pin1_4	1019	1024	PF00397	0.556
DOC_WW_Pin1_4	12	17	PF00397	0.704
DOC_WW_Pin1_4	212	217	PF00397	0.753
DOC_WW_Pin1_4	255	260	PF00397	0.668
DOC_WW_Pin1_4	296	301	PF00397	0.683
DOC_WW_Pin1_4	319	324	PF00397	0.613
DOC_WW_Pin1_4	337	342	PF00397	0.766
DOC_WW_Pin1_4	365	370	PF00397	0.635
DOC_WW_Pin1_4	449	454	PF00397	0.803
DOC_WW_Pin1_4	49	54	PF00397	0.782
DOC_WW_Pin1_4	580	585	PF00397	0.770
DOC_WW_Pin1_4	597	602	PF00397	0.794
DOC_WW_Pin1_4	728	733	PF00397	0.707
DOC_WW_Pin1_4	740	745	PF00397	0.706
DOC_WW_Pin1_4	92	97	PF00397	0.691
DOC_WW_Pin1_4	953	958	PF00397	0.767
LIG_14-3-3_CanoR_1	132	142	PF00244	0.690
LIG_14-3-3_CanoR_1	143	151	PF00244	0.581
LIG_14-3-3_CanoR_1	285	290	PF00244	0.646
LIG_14-3-3_CanoR_1	334	343	PF00244	0.759
LIG_14-3-3_CanoR_1	344	351	PF00244	0.635
LIG_14-3-3_CanoR_1	361	369	PF00244	0.720
LIG_14-3-3_CanoR_1	539	544	PF00244	0.522
LIG_14-3-3_CanoR_1	554	562	PF00244	0.563
LIG_14-3-3_CanoR_1	645	651	PF00244	0.821
LIG_14-3-3_CanoR_1	738	745	PF00244	0.736
LIG_14-3-3_CanoR_1	747	753	PF00244	0.770
LIG_14-3-3_CanoR_1	756	760	PF00244	0.484
LIG_14-3-3_CanoR_1	779	784	PF00244	0.666
LIG_14-3-3_CanoR_1	82	91	PF00244	0.695
LIG_14-3-3_CanoR_1	888	893	PF00244	0.569
LIG_14-3-3_CanoR_1	925	929	PF00244	0.801
LIG_Actin_WH2_2	1054	1072	PF00022	0.618
LIG_APCC_ABBA_1	832	837	PF00400	0.563
LIG_BRCT_BRCA1_1	316	320	PF00533	0.529
LIG_BRCT_BRCA1_1	945	949	PF00533	0.732
LIG_Clathr_ClatBox_1	803	807	PF01394	0.583
LIG_EVH1_1	93	97	PF00568	0.688
LIG_FHA_1	1020	1026	PF00498	0.583
LIG_FHA_1	256	262	PF00498	0.699
LIG_FHA_1	282	288	PF00498	0.762
LIG_FHA_1	346	352	PF00498	0.649
LIG_FHA_1	600	606	PF00498	0.758
LIG_FHA_1	682	688	PF00498	0.608
LIG_FHA_1	706	712	PF00498	0.676
LIG_FHA_2	125	131	PF00498	0.615
LIG_FHA_2	433	439	PF00498	0.702
LIG_FHA_2	454	460	PF00498	0.598
LIG_FHA_2	570	576	PF00498	0.773
LIG_FHA_2	755	761	PF00498	0.668
LIG_GBD_Chelix_1	1061	1069	PF00786	0.612
LIG_GBD_Chelix_1	247	255	PF00786	0.739
LIG_Integrin_RGD_1	1033	1035	PF01839	0.479
LIG_Integrin_RGD_1	510	512	PF01839	0.749
LIG_LIR_Apic_2	317	323	PF02991	0.524
LIG_LIR_Apic_2	447	453	PF02991	0.708
LIG_LIR_Apic_2	542	546	PF02991	0.538
LIG_LIR_Apic_2	565	570	PF02991	0.742
LIG_LIR_Gen_1	315	323	PF02991	0.523
LIG_LIR_Gen_1	385	395	PF02991	0.719
LIG_LIR_Gen_1	614	622	PF02991	0.436
LIG_LIR_Gen_1	674	683	PF02991	0.708
LIG_LIR_Gen_1	685	696	PF02991	0.559
LIG_LIR_Nem_3	284	289	PF02991	0.762
LIG_LIR_Nem_3	315	319	PF02991	0.525
LIG_LIR_Nem_3	385	391	PF02991	0.720
LIG_LIR_Nem_3	614	619	PF02991	0.651
LIG_LIR_Nem_3	674	680	PF02991	0.647
LIG_MYND_1	259	263	PF01753	0.784
LIG_MYND_3	711	715	PF01753	0.776
LIG_NRBOX	1060	1066	PF00104	0.700
LIG_NRBOX	246	252	PF00104	0.730
LIG_NRBOX	386	392	PF00104	0.654
LIG_PCNA_yPIPBox_3	1055	1067	PF02747	0.626
LIG_Pex14_1	316	320	PF04695	0.529
LIG_PROFILIN_1	584	590	PF00235	0.565
LIG_RPA_C_Fungi	751	763	PF08784	0.460
LIG_SH2_CRK	505	509	PF00017	0.808
LIG_SH2_STAT3	835	838	PF00017	0.669
LIG_SH2_STAT5	254	257	PF00017	0.765
LIG_SH2_STAT5	835	838	PF00017	0.640
LIG_SH3_1	213	219	PF00018	0.771
LIG_SH3_1	257	263	PF00018	0.704
LIG_SH3_1	326	332	PF00018	0.747
LIG_SH3_2	329	334	PF14604	0.814
LIG_SH3_2	914	919	PF14604	0.741
LIG_SH3_3	1017	1023	PF00018	0.769
LIG_SH3_3	13	19	PF00018	0.702
LIG_SH3_3	213	219	PF00018	0.829
LIG_SH3_3	257	263	PF00018	0.680
LIG_SH3_3	271	277	PF00018	0.697
LIG_SH3_3	325	331	PF00018	0.788
LIG_SH3_3	418	424	PF00018	0.781
LIG_SH3_3	54	60	PF00018	0.717
LIG_SH3_3	557	563	PF00018	0.810
LIG_SH3_3	581	587	PF00018	0.819
LIG_SH3_3	600	606	PF00018	0.648
LIG_SH3_3	706	712	PF00018	0.676
LIG_SH3_3	726	732	PF00018	0.747
LIG_SH3_3	781	787	PF00018	0.699
LIG_SH3_3	897	903	PF00018	0.524
LIG_SH3_3	91	97	PF00018	0.695
LIG_SH3_3	910	916	PF00018	0.622
LIG_SH3_3	954	960	PF00018	0.745
LIG_SH3_3	962	968	PF00018	0.794
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.747
LIG_SUMO_SIM_anti_2	706	711	PF11976	0.753
LIG_SUMO_SIM_par_1	606	612	PF11976	0.616
LIG_SUMO_SIM_par_1	881	887	PF11976	0.508
LIG_TRAF2_1	445	448	PF00917	0.754
LIG_TRAF2_1	534	537	PF00917	0.701
LIG_TRAF2_1	850	853	PF00917	0.714
LIG_WW_1	915	918	PF00397	0.525
LIG_WW_2	1023	1026	PF00397	0.697
LIG_WW_2	588	591	PF00397	0.569
LIG_WW_3	327	331	PF00397	0.800
LIG_WW_3	341	345	PF00397	0.562
LIG_WW_3	551	555	PF00397	0.679
LIG_WW_3	783	787	PF00397	0.702
MOD_CDK_SPxxK_3	319	326	PF00069	0.547
MOD_CDK_SPxxK_3	337	344	PF00069	0.520
MOD_CDK_SPxxK_3	740	747	PF00069	0.778
MOD_CK1_1	1016	1022	PF00069	0.680
MOD_CK1_1	122	128	PF00069	0.764
MOD_CK1_1	133	139	PF00069	0.618
MOD_CK1_1	15	21	PF00069	0.685
MOD_CK1_1	173	179	PF00069	0.712
MOD_CK1_1	215	221	PF00069	0.574
MOD_CK1_1	27	33	PF00069	0.577
MOD_CK1_1	321	327	PF00069	0.521
MOD_CK1_1	337	343	PF00069	0.672
MOD_CK1_1	363	369	PF00069	0.772
MOD_CK1_1	45	51	PF00069	0.601
MOD_CK1_1	521	527	PF00069	0.709
MOD_CK1_1	626	632	PF00069	0.657
MOD_CK1_1	721	727	PF00069	0.753
MOD_CK1_1	731	737	PF00069	0.648
MOD_CK1_1	740	746	PF00069	0.623
MOD_CK1_1	92	98	PF00069	0.688
MOD_CK1_1	970	976	PF00069	0.662
MOD_CK2_1	432	438	PF00069	0.738
MOD_CK2_1	453	459	PF00069	0.537
MOD_CK2_1	48	54	PF00069	0.727
MOD_CK2_1	569	575	PF00069	0.768
MOD_CK2_1	754	760	PF00069	0.709
MOD_CK2_1	84	90	PF00069	0.775
MOD_GlcNHglycan	132	135	PF01048	0.541
MOD_GlcNHglycan	144	147	PF01048	0.606
MOD_GlcNHglycan	156	159	PF01048	0.800
MOD_GlcNHglycan	160	163	PF01048	0.771
MOD_GlcNHglycan	194	197	PF01048	0.753
MOD_GlcNHglycan	207	210	PF01048	0.687
MOD_GlcNHglycan	302	305	PF01048	0.549
MOD_GlcNHglycan	316	319	PF01048	0.639
MOD_GlcNHglycan	323	326	PF01048	0.725
MOD_GlcNHglycan	345	348	PF01048	0.837
MOD_GlcNHglycan	36	40	PF01048	0.649
MOD_GlcNHglycan	397	401	PF01048	0.604
MOD_GlcNHglycan	44	47	PF01048	0.754
MOD_GlcNHglycan	620	623	PF01048	0.656
MOD_GlcNHglycan	625	628	PF01048	0.766
MOD_GlcNHglycan	739	742	PF01048	0.629
MOD_GlcNHglycan	84	87	PF01048	0.771
MOD_GlcNHglycan	900	903	PF01048	0.595
MOD_GlcNHglycan	969	972	PF01048	0.668
MOD_GlcNHglycan	977	980	PF01048	0.499
MOD_GSK3_1	1049	1056	PF00069	0.467
MOD_GSK3_1	115	122	PF00069	0.771
MOD_GSK3_1	124	131	PF00069	0.647
MOD_GSK3_1	154	161	PF00069	0.840
MOD_GSK3_1	255	262	PF00069	0.685
MOD_GSK3_1	281	288	PF00069	0.700
MOD_GSK3_1	294	301	PF00069	0.592
MOD_GSK3_1	314	321	PF00069	0.556
MOD_GSK3_1	361	368	PF00069	0.764
MOD_GSK3_1	44	51	PF00069	0.775
MOD_GSK3_1	449	456	PF00069	0.707
MOD_GSK3_1	618	625	PF00069	0.702
MOD_GSK3_1	640	647	PF00069	0.637
MOD_GSK3_1	717	724	PF00069	0.754
MOD_GSK3_1	736	743	PF00069	0.563
MOD_GSK3_1	80	87	PF00069	0.689
MOD_GSK3_1	869	876	PF00069	0.441
MOD_GSK3_1	884	891	PF00069	0.549
MOD_GSK3_1	939	946	PF00069	0.686
MOD_GSK3_1	975	982	PF00069	0.711
MOD_N-GLC_1	454	459	PF02516	0.672
MOD_N-GLC_2	444	446	PF02516	0.451
MOD_NEK2_1	142	147	PF00069	0.681
MOD_NEK2_1	345	350	PF00069	0.771
MOD_NEK2_1	402	407	PF00069	0.658
MOD_NEK2_1	637	642	PF00069	0.787
MOD_NEK2_1	754	759	PF00069	0.460
MOD_NEK2_1	873	878	PF00069	0.623
MOD_NEK2_1	884	889	PF00069	0.395
MOD_NEK2_1	89	94	PF00069	0.548
MOD_NEK2_1	896	901	PF00069	0.479
MOD_NEK2_2	718	723	PF00069	0.770
MOD_NEK2_2	748	753	PF00069	0.746
MOD_NEK2_2	917	922	PF00069	0.752
MOD_PIKK_1	298	304	PF00454	0.751
MOD_PIKK_1	375	381	PF00454	0.732
MOD_PIKK_1	553	559	PF00454	0.567
MOD_PIKK_1	939	945	PF00454	0.702
MOD_PIKK_1	972	978	PF00454	0.662
MOD_PK_1	285	291	PF00069	0.647
MOD_PKA_1	623	629	PF00069	0.757
MOD_PKA_1	645	651	PF00069	0.655
MOD_PKA_2	142	148	PF00069	0.619
MOD_PKA_2	343	349	PF00069	0.777
MOD_PKA_2	360	366	PF00069	0.568
MOD_PKA_2	553	559	PF00069	0.567
MOD_PKA_2	617	623	PF00069	0.620
MOD_PKA_2	637	643	PF00069	0.770
MOD_PKA_2	644	650	PF00069	0.728
MOD_PKA_2	737	743	PF00069	0.695
MOD_PKA_2	74	80	PF00069	0.601
MOD_PKA_2	755	761	PF00069	0.543
MOD_PKA_2	787	793	PF00069	0.674
MOD_PKA_2	924	930	PF00069	0.803
MOD_PKB_1	777	785	PF00069	0.738
MOD_PKB_1	78	86	PF00069	0.762
MOD_Plk_1	173	179	PF00069	0.747
MOD_Plk_1	472	478	PF00069	0.539
MOD_Plk_1	89	95	PF00069	0.781
MOD_Plk_2-3	110	116	PF00069	0.549
MOD_Plk_4	1016	1022	PF00069	0.492
MOD_Plk_4	134	140	PF00069	0.630
MOD_Plk_4	518	524	PF00069	0.655
MOD_Plk_4	599	605	PF00069	0.691
MOD_Plk_4	690	696	PF00069	0.688
MOD_Plk_4	705	711	PF00069	0.741
MOD_Plk_4	799	805	PF00069	0.643
MOD_ProDKin_1	1019	1025	PF00069	0.556
MOD_ProDKin_1	12	18	PF00069	0.704
MOD_ProDKin_1	212	218	PF00069	0.755
MOD_ProDKin_1	255	261	PF00069	0.669
MOD_ProDKin_1	296	302	PF00069	0.686
MOD_ProDKin_1	319	325	PF00069	0.612
MOD_ProDKin_1	337	343	PF00069	0.765
MOD_ProDKin_1	365	371	PF00069	0.633
MOD_ProDKin_1	449	455	PF00069	0.807
MOD_ProDKin_1	49	55	PF00069	0.782
MOD_ProDKin_1	580	586	PF00069	0.769
MOD_ProDKin_1	597	603	PF00069	0.789
MOD_ProDKin_1	728	734	PF00069	0.705
MOD_ProDKin_1	740	746	PF00069	0.699
MOD_ProDKin_1	92	98	PF00069	0.688
MOD_ProDKin_1	953	959	PF00069	0.765
TRG_DiLeu_BaEn_1	1057	1062	PF01217	0.583
TRG_DiLeu_BaEn_2	437	443	PF01217	0.748
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.743
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.619
TRG_ENDOCYTIC_2	505	508	PF00928	0.729
TRG_ENDOCYTIC_2	677	680	PF00928	0.666
TRG_ER_diArg_1	1058	1060	PF00400	0.712
TRG_ER_diArg_1	1074	1076	PF00400	0.590
TRG_ER_diArg_1	5	8	PF00400	0.548
TRG_ER_diArg_1	508	510	PF00400	0.655
TRG_ER_diArg_1	630	633	PF00400	0.699
TRG_ER_diArg_1	70	73	PF00400	0.687
TRG_ER_diArg_1	775	778	PF00400	0.606
TRG_ER_diArg_1	78	80	PF00400	0.748
TRG_ER_diArg_1	785	788	PF00400	0.662
TRG_ER_diArg_1	81	84	PF00400	0.713
TRG_NES_CRM1_1	685	700	PF08389	0.692
TRG_Pf-PMV_PEXEL_1	1059	1063	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	1067	1071	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	843	847	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU1	Leptomonas seymouri	33%	100%
A0A3S7WNS9	Leishmania donovani	82%	99%
A4H404	Leishmania braziliensis	62%	98%
A4HS66	Leishmania infantum	81%	100%
Q9NED2	Leishmania major	80%	100%