Axonemal_dynein_light_chain_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

axonemal dynein light chain, putative

Species:

Leishmania mexicana

UniProt:

E9AK52_LEIMU

TriTrypDb:

LmxM.04.0690

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK52

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.605
CLV_C14_Caspase3-7	230	234	PF00656	0.527
CLV_C14_Caspase3-7	267	271	PF00656	0.622
CLV_C14_Caspase3-7	312	316	PF00656	0.523
CLV_C14_Caspase3-7	375	379	PF00656	0.598
CLV_C14_Caspase3-7	660	664	PF00656	0.245
CLV_NRD_NRD_1	281	283	PF00675	0.574
CLV_NRD_NRD_1	630	632	PF00675	0.304
CLV_NRD_NRD_1	691	693	PF00675	0.284
CLV_NRD_NRD_1	740	742	PF00675	0.564
CLV_PCSK_KEX2_1	281	283	PF00082	0.574
CLV_PCSK_KEX2_1	630	632	PF00082	0.304
CLV_PCSK_KEX2_1	740	742	PF00082	0.564
CLV_PCSK_PC7_1	277	283	PF00082	0.590
CLV_PCSK_SKI1_1	111	115	PF00082	0.591
CLV_PCSK_SKI1_1	126	130	PF00082	0.501
CLV_PCSK_SKI1_1	2	6	PF00082	0.656
CLV_PCSK_SKI1_1	282	286	PF00082	0.569
CLV_PCSK_SKI1_1	338	342	PF00082	0.529
CLV_PCSK_SKI1_1	616	620	PF00082	0.304
CLV_PCSK_SKI1_1	625	629	PF00082	0.304
CLV_PCSK_SKI1_1	630	634	PF00082	0.304
CLV_PCSK_SKI1_1	643	647	PF00082	0.304
CLV_PCSK_SKI1_1	665	669	PF00082	0.304
CLV_PCSK_SKI1_1	693	697	PF00082	0.347
CLV_PCSK_SKI1_1	706	710	PF00082	0.248
CLV_Separin_Metazoa	305	309	PF03568	0.501
CLV_Separin_Metazoa	613	617	PF03568	0.284
DEG_APCC_DBOX_1	337	345	PF00400	0.595
DEG_APCC_DBOX_1	373	381	PF00400	0.534
DEG_APCC_DBOX_1	462	470	PF00400	0.535
DEG_APCC_DBOX_1	682	690	PF00400	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DEG_SPOP_SBC_1	368	372	PF00917	0.621
DOC_CKS1_1	557	562	PF01111	0.648
DOC_CYCLIN_RxL_1	483	495	PF00134	0.578
DOC_CYCLIN_RxL_1	625	635	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	236	242	PF00134	0.597
DOC_MAPK_gen_1	600	609	PF00069	0.480
DOC_MAPK_MEF2A_6	101	110	PF00069	0.576
DOC_MAPK_MEF2A_6	600	609	PF00069	0.545
DOC_MAPK_RevD_3	618	631	PF00069	0.304
DOC_PP2B_LxvP_1	236	239	PF13499	0.602
DOC_PP4_FxxP_1	263	266	PF00568	0.530
DOC_USP7_MATH_1	219	223	PF00917	0.523
DOC_USP7_MATH_1	280	284	PF00917	0.663
DOC_USP7_MATH_1	3	7	PF00917	0.640
DOC_USP7_MATH_1	354	358	PF00917	0.683
DOC_USP7_MATH_1	436	440	PF00917	0.497
DOC_USP7_MATH_1	511	515	PF00917	0.701
DOC_USP7_MATH_1	536	540	PF00917	0.647
DOC_USP7_MATH_1	59	63	PF00917	0.518
DOC_USP7_MATH_1	70	74	PF00917	0.495
DOC_WW_Pin1_4	145	150	PF00397	0.695
DOC_WW_Pin1_4	262	267	PF00397	0.536
DOC_WW_Pin1_4	493	498	PF00397	0.538
DOC_WW_Pin1_4	514	519	PF00397	0.625
DOC_WW_Pin1_4	521	526	PF00397	0.579
DOC_WW_Pin1_4	556	561	PF00397	0.651
LIG_14-3-3_CanoR_1	126	134	PF00244	0.650
LIG_14-3-3_CanoR_1	185	194	PF00244	0.683
LIG_14-3-3_CanoR_1	251	261	PF00244	0.422
LIG_14-3-3_CanoR_1	281	287	PF00244	0.574
LIG_14-3-3_CanoR_1	308	314	PF00244	0.470
LIG_14-3-3_CanoR_1	374	378	PF00244	0.605
LIG_14-3-3_CanoR_1	455	462	PF00244	0.545
LIG_14-3-3_CanoR_1	503	511	PF00244	0.665
LIG_14-3-3_CanoR_1	616	621	PF00244	0.304
LIG_14-3-3_CanoR_1	650	659	PF00244	0.394
LIG_14-3-3_CanoR_1	740	745	PF00244	0.635
LIG_Actin_RPEL_3	609	628	PF02755	0.394
LIG_Actin_WH2_2	359	376	PF00022	0.592
LIG_Actin_WH2_2	600	618	PF00022	0.476
LIG_BIR_III_4	48	52	PF00653	0.598
LIG_BRCT_BRCA1_1	90	94	PF00533	0.454
LIG_CaM_IQ_9	118	133	PF13499	0.637
LIG_Clathr_ClatBox_1	450	454	PF01394	0.543
LIG_Clathr_ClatBox_1	466	470	PF01394	0.521
LIG_eIF4E_1	336	342	PF01652	0.585
LIG_EVH1_2	382	386	PF00568	0.573
LIG_FHA_1	253	259	PF00498	0.413
LIG_FHA_1	368	374	PF00498	0.621
LIG_FHA_1	37	43	PF00498	0.623
LIG_FHA_1	454	460	PF00498	0.553
LIG_FHA_1	564	570	PF00498	0.672
LIG_FHA_1	590	596	PF00498	0.558
LIG_FHA_1	617	623	PF00498	0.304
LIG_FHA_1	727	733	PF00498	0.476
LIG_FHA_2	130	136	PF00498	0.666
LIG_FHA_2	265	271	PF00498	0.617
LIG_FHA_2	417	423	PF00498	0.494
LIG_FHA_2	430	436	PF00498	0.393
LIG_FHA_2	470	476	PF00498	0.568
LIG_FHA_2	50	56	PF00498	0.690
LIG_FHA_2	93	99	PF00498	0.568
LIG_LIR_Apic_2	157	162	PF02991	0.646
LIG_LIR_Apic_2	260	266	PF02991	0.511
LIG_LIR_Gen_1	300	311	PF02991	0.562
LIG_LIR_Gen_1	439	449	PF02991	0.546
LIG_LIR_Nem_3	300	306	PF02991	0.501
LIG_LIR_Nem_3	439	444	PF02991	0.527
LIG_MYND_3	242	246	PF01753	0.564
LIG_NRBOX	628	634	PF00104	0.369
LIG_PCNA_PIPBox_1	410	419	PF02747	0.489
LIG_RPA_C_Fungi	17	29	PF08784	0.581
LIG_SH2_NCK_1	159	163	PF00017	0.641
LIG_SH2_NCK_1	441	445	PF00017	0.541
LIG_SH2_PTP2	303	306	PF00017	0.552
LIG_SH2_SRC	159	162	PF00017	0.651
LIG_SH2_SRC	164	167	PF00017	0.634
LIG_SH2_SRC	389	392	PF00017	0.499
LIG_SH2_STAT5	261	264	PF00017	0.504
LIG_SH2_STAT5	303	306	PF00017	0.552
LIG_SH2_STAT5	336	339	PF00017	0.577
LIG_SH2_STAT5	389	392	PF00017	0.499
LIG_SH2_STAT5	441	444	PF00017	0.485
LIG_SH2_STAT5	465	468	PF00017	0.533
LIG_SH2_STAT5	688	691	PF00017	0.303
LIG_SH3_1	570	576	PF00018	0.601
LIG_SH3_3	146	152	PF00018	0.800
LIG_SH3_3	328	334	PF00018	0.555
LIG_SH3_3	377	383	PF00018	0.656
LIG_SH3_3	456	462	PF00018	0.544
LIG_SH3_3	494	500	PF00018	0.544
LIG_SH3_3	570	576	PF00018	0.601
LIG_SH3_3	617	623	PF00018	0.304
LIG_SH3_3	75	81	PF00018	0.645
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.557
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.490
LIG_SUMO_SIM_anti_2	552	559	PF11976	0.501
LIG_SUMO_SIM_par_1	309	316	PF11976	0.576
LIG_SUMO_SIM_par_1	448	454	PF11976	0.547
LIG_SUMO_SIM_par_1	618	624	PF11976	0.304
LIG_TRAF2_1	653	656	PF00917	0.272
LIG_TYR_ITIM	301	306	PF00017	0.501
LIG_WW_3	381	385	PF00397	0.509
LIG_WW_3	498	502	PF00397	0.551
MOD_CDC14_SPxK_1	498	501	PF00782	0.552
MOD_CDK_SPK_2	521	526	PF00069	0.531
MOD_CDK_SPxK_1	495	501	PF00069	0.548
MOD_CDK_SPxK_1	556	562	PF00069	0.650
MOD_CDK_SPxxK_3	519	526	PF00069	0.566
MOD_CK1_1	138	144	PF00069	0.655
MOD_CK1_1	186	192	PF00069	0.686
MOD_CK1_1	264	270	PF00069	0.550
MOD_CK1_1	439	445	PF00069	0.476
MOD_CK1_1	493	499	PF00069	0.542
MOD_CK1_1	514	520	PF00069	0.628
MOD_CK1_1	539	545	PF00069	0.564
MOD_CK2_1	192	198	PF00069	0.596
MOD_CK2_1	358	364	PF00069	0.608
MOD_CK2_1	422	428	PF00069	0.450
MOD_CK2_1	429	435	PF00069	0.441
MOD_CK2_1	469	475	PF00069	0.501
MOD_CK2_1	49	55	PF00069	0.654
MOD_CK2_1	59	65	PF00069	0.570
MOD_GlcNHglycan	13	16	PF01048	0.536
MOD_GlcNHglycan	221	224	PF01048	0.724
MOD_GlcNHglycan	267	270	PF01048	0.584
MOD_GlcNHglycan	290	293	PF01048	0.506
MOD_GlcNHglycan	360	363	PF01048	0.606
MOD_GlcNHglycan	48	52	PF01048	0.598
MOD_GlcNHglycan	508	511	PF01048	0.775
MOD_GlcNHglycan	513	516	PF01048	0.658
MOD_GlcNHglycan	543	546	PF01048	0.727
MOD_GlcNHglycan	581	584	PF01048	0.582
MOD_GlcNHglycan	585	588	PF01048	0.559
MOD_GlcNHglycan	68	71	PF01048	0.496
MOD_GSK3_1	126	133	PF00069	0.619
MOD_GSK3_1	140	147	PF00069	0.517
MOD_GSK3_1	150	157	PF00069	0.795
MOD_GSK3_1	261	268	PF00069	0.483
MOD_GSK3_1	309	316	PF00069	0.521
MOD_GSK3_1	354	361	PF00069	0.514
MOD_GSK3_1	368	375	PF00069	0.542
MOD_GSK3_1	47	54	PF00069	0.593
MOD_GSK3_1	489	496	PF00069	0.603
MOD_GSK3_1	535	542	PF00069	0.731
MOD_GSK3_1	552	559	PF00069	0.543
MOD_GSK3_1	579	586	PF00069	0.588
MOD_GSK3_1	66	73	PF00069	0.646
MOD_GSK3_1	88	95	PF00069	0.533
MOD_N-GLC_1	534	539	PF02516	0.626
MOD_NEK2_1	249	254	PF00069	0.503
MOD_NEK2_1	313	318	PF00069	0.601
MOD_NEK2_1	489	494	PF00069	0.558
MOD_NEK2_1	92	97	PF00069	0.588
MOD_NEK2_2	536	541	PF00069	0.582
MOD_NEK2_2	565	570	PF00069	0.662
MOD_PIKK_1	651	657	PF00454	0.304
MOD_PKA_1	740	746	PF00069	0.593
MOD_PKA_2	280	286	PF00069	0.576
MOD_PKA_2	373	379	PF00069	0.604
MOD_PKA_2	454	460	PF00069	0.553
MOD_PKA_2	739	745	PF00069	0.630
MOD_PKB_1	124	132	PF00069	0.644
MOD_Plk_1	154	160	PF00069	0.643
MOD_Plk_1	422	428	PF00069	0.514
MOD_Plk_1	469	475	PF00069	0.505
MOD_Plk_1	59	65	PF00069	0.623
MOD_Plk_1	600	606	PF00069	0.551
MOD_Plk_1	706	712	PF00069	0.344
MOD_Plk_1	88	94	PF00069	0.452
MOD_Plk_2-3	422	428	PF00069	0.491
MOD_Plk_2-3	429	435	PF00069	0.427
MOD_Plk_4	422	428	PF00069	0.506
MOD_Plk_4	516	522	PF00069	0.536
MOD_Plk_4	552	558	PF00069	0.569
MOD_Plk_4	59	65	PF00069	0.520
MOD_Plk_4	605	611	PF00069	0.479
MOD_ProDKin_1	145	151	PF00069	0.696
MOD_ProDKin_1	262	268	PF00069	0.542
MOD_ProDKin_1	493	499	PF00069	0.539
MOD_ProDKin_1	514	520	PF00069	0.626
MOD_ProDKin_1	521	527	PF00069	0.576
MOD_ProDKin_1	556	562	PF00069	0.650
MOD_SUMO_for_1	467	470	PF00179	0.582
MOD_SUMO_rev_2	69	78	PF00179	0.559
MOD_SUMO_rev_2	701	705	PF00179	0.304
TRG_DiLeu_BaEn_1	302	307	PF01217	0.554
TRG_DiLeu_BaEn_1	624	629	PF01217	0.304
TRG_DiLeu_BaEn_4	428	434	PF01217	0.521
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.569
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.369
TRG_DiLeu_BaLyEn_6	721	726	PF01217	0.333
TRG_ENDOCYTIC_2	303	306	PF00928	0.487
TRG_ENDOCYTIC_2	388	391	PF00928	0.520
TRG_ENDOCYTIC_2	441	444	PF00928	0.539
TRG_ER_diArg_1	123	126	PF00400	0.573
TRG_ER_diArg_1	500	503	PF00400	0.558
TRG_ER_diArg_1	629	631	PF00400	0.304
TRG_ER_diArg_1	682	685	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	630	634	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA8	Leptomonas seymouri	46%	99%
A0A3S7WNS6	Leishmania donovani	82%	100%
A4H403	Leishmania braziliensis	69%	96%
A4HS65	Leishmania infantum	82%	100%
Q9NED3	Leishmania major	85%	100%