CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK49_LEIMU

TriTrypDb:

LmxM.04.0660

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AK49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK49

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.533
CLV_NRD_NRD_1	25	27	PF00675	0.542
CLV_PCSK_KEX2_1	25	27	PF00082	0.540
DEG_SPOP_SBC_1	27	31	PF00917	0.562
DOC_PP4_MxPP_1	144	147	PF00568	0.676
DOC_USP7_MATH_1	66	70	PF00917	0.558
DOC_WW_Pin1_4	13	18	PF00397	0.683
LIG_14-3-3_CanoR_1	26	35	PF00244	0.577
LIG_FHA_1	106	112	PF00498	0.519
LIG_Pex14_1	130	134	PF04695	0.444
LIG_PTB_Apo_2	74	81	PF02174	0.579
LIG_PTB_Phospho_1	74	80	PF10480	0.604
LIG_SH2_SRC	78	81	PF00017	0.614
LIG_SH2_STAP1	114	118	PF00017	0.399
LIG_SH2_STAT3	134	137	PF00017	0.440
LIG_SH2_STAT5	134	137	PF00017	0.440
LIG_SH2_STAT5	45	48	PF00017	0.582
LIG_SH2_STAT5	78	81	PF00017	0.616
LIG_SH3_1	140	146	PF00018	0.589
LIG_SH3_3	140	146	PF00018	0.626
LIG_SH3_3	32	38	PF00018	0.705
LIG_SH3_3	43	49	PF00018	0.629
LIG_SH3_3	84	90	PF00018	0.512
LIG_TRAF2_1	100	103	PF00917	0.622
MOD_CDK_SPxK_1	13	19	PF00069	0.488
MOD_CK1_1	124	130	PF00069	0.481
MOD_CK1_1	13	19	PF00069	0.576
MOD_GlcNHglycan	123	126	PF01048	0.536
MOD_GlcNHglycan	55	58	PF01048	0.657
MOD_PIKK_1	106	112	PF00454	0.368
MOD_PIKK_1	133	139	PF00454	0.533
MOD_PIKK_1	85	91	PF00454	0.566
MOD_PKA_2	10	16	PF00069	0.611
MOD_Plk_4	66	72	PF00069	0.548
MOD_ProDKin_1	13	19	PF00069	0.686
TRG_ER_diArg_1	2	5	PF00400	0.563
TRG_ER_diArg_1	25	27	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKW3	Trypanosomatidae	54%	100%
A0A3R7REF5	Trypanosoma rangeli	55%	100%
A0A3S5H5B8	Leishmania donovani	87%	100%
A0A3S5H5B9	Leishmania donovani	82%	97%
A4H401	Leishmania braziliensis	92%	100%
A4HS62	Leishmania infantum	86%	100%
A4HS63	Leishmania infantum	82%	97%
C9ZY60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AK50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	97%
Q9NED5	Leishmania major	95%	100%
Q9NED6	Leishmania major	91%	100%
V5BMV1	Trypanosoma cruzi	60%	100%