RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AK47_LEIMU

TriTrypDb:

LmxM.04.0640

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AK47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK47

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.437
CLV_NRD_NRD_1	160	162	PF00675	0.312
CLV_NRD_NRD_1	75	77	PF00675	0.412
CLV_PCSK_KEX2_1	160	162	PF00082	0.312
CLV_PCSK_KEX2_1	75	77	PF00082	0.412
CLV_PCSK_SKI1_1	216	220	PF00082	0.407
CLV_PCSK_SKI1_1	322	326	PF00082	0.658
DEG_Nend_UBRbox_2	1	3	PF02207	0.508
DOC_CYCLIN_yCln2_LP_2	173	179	PF00134	0.529
DOC_MAPK_DCC_7	49	57	PF00069	0.286
DOC_MAPK_gen_1	4	11	PF00069	0.441
DOC_MAPK_MEF2A_6	222	230	PF00069	0.497
DOC_MAPK_MEF2A_6	231	239	PF00069	0.282
DOC_MAPK_MEF2A_6	4	11	PF00069	0.400
DOC_MAPK_MEF2A_6	49	57	PF00069	0.303
DOC_SPAK_OSR1_1	66	70	PF12202	0.363
DOC_USP7_MATH_1	105	109	PF00917	0.652
DOC_USP7_MATH_1	280	284	PF00917	0.363
DOC_USP7_MATH_1	35	39	PF00917	0.455
LIG_14-3-3_CanoR_1	216	225	PF00244	0.633
LIG_14-3-3_CanoR_1	78	88	PF00244	0.629
LIG_Actin_WH2_2	201	218	PF00022	0.610
LIG_APCC_ABBA_1	68	73	PF00400	0.467
LIG_BRCT_BRCA1_1	317	321	PF00533	0.329
LIG_FHA_1	101	107	PF00498	0.547
LIG_FHA_1	202	208	PF00498	0.634
LIG_FHA_1	248	254	PF00498	0.440
LIG_FHA_1	287	293	PF00498	0.363
LIG_FHA_1	310	316	PF00498	0.302
LIG_LIR_Gen_1	238	246	PF02991	0.363
LIG_LIR_Gen_1	89	98	PF02991	0.610
LIG_LIR_Nem_3	156	162	PF02991	0.512
LIG_LIR_Nem_3	300	305	PF02991	0.606
LIG_LIR_Nem_3	318	324	PF02991	0.376
LIG_LIR_Nem_3	82	87	PF02991	0.673
LIG_LIR_Nem_3	89	93	PF02991	0.571
LIG_PDZ_Class_2	321	326	PF00595	0.404
LIG_Pex14_1	63	67	PF04695	0.429
LIG_SH2_CRK	159	163	PF00017	0.468
LIG_SH2_CRK	281	285	PF00017	0.329
LIG_SH2_GRB2like	16	19	PF00017	0.414
LIG_SH2_NCK_1	90	94	PF00017	0.612
LIG_SH2_SRC	16	19	PF00017	0.355
LIG_SH2_SRC	90	93	PF00017	0.544
LIG_SH2_STAP1	281	285	PF00017	0.391
LIG_SH2_STAP1	298	302	PF00017	0.528
LIG_SH2_STAT5	16	19	PF00017	0.445
LIG_SH3_3	127	133	PF00018	0.488
LIG_SH3_3	267	273	PF00018	0.485
LIG_SH3_3	47	53	PF00018	0.268
LIG_SH3_3	99	105	PF00018	0.626
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.539
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.596
LIG_SUMO_SIM_par_1	203	209	PF11976	0.530
LIG_SUMO_SIM_par_1	303	308	PF11976	0.270
LIG_TRAF2_1	107	110	PF00917	0.656
LIG_TRFH_1	242	246	PF08558	0.521
LIG_UBA3_1	189	194	PF00899	0.465
LIG_UBA3_1	320	325	PF00899	0.496
MOD_CK1_1	182	188	PF00069	0.560
MOD_CK1_1	271	277	PF00069	0.333
MOD_CK1_1	36	42	PF00069	0.402
MOD_CK2_1	104	110	PF00069	0.561
MOD_CK2_1	245	251	PF00069	0.436
MOD_CK2_1	86	92	PF00069	0.635
MOD_GlcNHglycan	274	277	PF01048	0.512
MOD_GlcNHglycan	317	320	PF01048	0.329
MOD_GlcNHglycan	38	41	PF01048	0.642
MOD_GSK3_1	100	107	PF00069	0.629
MOD_GSK3_1	17	24	PF00069	0.523
MOD_GSK3_1	268	275	PF00069	0.356
MOD_GSK3_1	305	312	PF00069	0.363
MOD_GSK3_1	35	42	PF00069	0.423
MOD_GSK3_1	79	86	PF00069	0.672
MOD_N-GLC_1	17	22	PF02516	0.613
MOD_NEK2_1	235	240	PF00069	0.302
MOD_NEK2_1	315	320	PF00069	0.303
MOD_PIKK_1	105	111	PF00454	0.680
MOD_PKA_2	100	106	PF00069	0.624
MOD_PKB_1	214	222	PF00069	0.592
MOD_Plk_1	7	13	PF00069	0.459
MOD_Plk_4	203	209	PF00069	0.599
MOD_Plk_4	235	241	PF00069	0.302
MOD_Plk_4	280	286	PF00069	0.320
MOD_Plk_4	305	311	PF00069	0.476
MOD_SUMO_rev_2	318	326	PF00179	0.520
TRG_DiLeu_BaEn_1	169	174	PF01217	0.399
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.594
TRG_ENDOCYTIC_2	159	162	PF00928	0.468
TRG_ENDOCYTIC_2	242	245	PF00928	0.459
TRG_ENDOCYTIC_2	281	284	PF00928	0.329
TRG_ENDOCYTIC_2	90	93	PF00928	0.717
TRG_ER_diArg_1	159	161	PF00400	0.512
TRG_ER_diArg_1	213	216	PF00400	0.582
TRG_ER_diArg_1	4	7	PF00400	0.475
TRG_ER_diArg_1	75	78	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRM4	Leptomonas seymouri	53%	100%
A0A3S7WNQ6	Leishmania donovani	89%	99%
A4H3Y1	Leishmania braziliensis	74%	99%
A4HS60	Leishmania infantum	89%	99%
Q9NED8	Leishmania major	90%	99%