Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK46_LEIMU

TriTrypDb:

LmxM.04.0630

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AK46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.407
CLV_PCSK_KEX2_1	106	108	PF00082	0.425
CLV_PCSK_KEX2_1	46	48	PF00082	0.407
CLV_PCSK_KEX2_1	67	69	PF00082	0.516
CLV_PCSK_KEX2_1	77	79	PF00082	0.462
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.504
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.516
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.462
CLV_PCSK_SKI1_1	106	110	PF00082	0.408
CLV_PCSK_SKI1_1	131	135	PF00082	0.414
CLV_PCSK_SKI1_1	47	51	PF00082	0.402
CLV_PCSK_SKI1_1	68	72	PF00082	0.432
DEG_Nend_UBRbox_3	1	3	PF02207	0.603
DOC_MAPK_gen_1	53	62	PF00069	0.614
DOC_MAPK_gen_1	67	76	PF00069	0.571
DOC_PP1_RVXF_1	129	135	PF00149	0.588
DOC_USP7_UBL2_3	32	36	PF12436	0.571
DOC_USP7_UBL2_3	67	71	PF12436	0.600
DOC_USP7_UBL2_3	73	77	PF12436	0.589
DOC_WW_Pin1_4	24	29	PF00397	0.622
LIG_14-3-3_CanoR_1	107	112	PF00244	0.622
LIG_APCC_ABBAyCdc20_2	31	37	PF00400	0.572
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.600
LIG_FHA_1	128	134	PF00498	0.588
LIG_FHA_1	137	143	PF00498	0.604
LIG_FHA_1	24	30	PF00498	0.606
LIG_FHA_1	84	90	PF00498	0.615
LIG_FHA_2	155	161	PF00498	0.588
LIG_FHA_2	54	60	PF00498	0.592
LIG_LIR_Gen_1	127	135	PF02991	0.600
LIG_LIR_Gen_1	158	169	PF02991	0.449
LIG_LIR_Gen_1	59	70	PF02991	0.629
LIG_LIR_Nem_3	127	132	PF02991	0.610
LIG_LIR_Nem_3	158	164	PF02991	0.573
LIG_LIR_Nem_3	59	65	PF02991	0.616
LIG_PCNA_yPIPBox_3	61	70	PF02747	0.629
LIG_Pex14_1	166	170	PF04695	0.285
LIG_Pex14_1	184	188	PF04695	0.405
LIG_SH2_CRK	25	29	PF00017	0.619
LIG_SH2_STAP1	167	171	PF00017	0.304
LIG_SH2_STAP1	81	85	PF00017	0.619
LIG_SH2_STAT5	25	28	PF00017	0.607
LIG_SH3_3	38	44	PF00018	0.586
LIG_SUMO_SIM_par_1	86	92	PF11976	0.624
LIG_TRAF2_1	157	160	PF00917	0.581
LIG_WRC_WIRS_1	12	17	PF05994	0.683
MOD_CDK_SPxxK_3	24	31	PF00069	0.612
MOD_CK1_1	110	116	PF00069	0.610
MOD_CK2_1	154	160	PF00069	0.601
MOD_CK2_1	53	59	PF00069	0.590
MOD_GlcNHglycan	167	170	PF01048	0.175
MOD_GSK3_1	106	113	PF00069	0.609
MOD_GSK3_1	150	157	PF00069	0.622
MOD_GSK3_1	165	172	PF00069	0.432
MOD_GSK3_1	49	56	PF00069	0.685
MOD_GSK3_1	81	88	PF00069	0.618
MOD_N-GLC_1	23	28	PF02516	0.409
MOD_N-GLC_1	4	9	PF02516	0.425
MOD_NEK2_1	170	175	PF00069	0.312
MOD_NEK2_1	177	182	PF00069	0.326
MOD_PKA_1	106	112	PF00069	0.608
MOD_PKA_1	115	121	PF00069	0.598
MOD_PKA_2	106	112	PF00069	0.621
MOD_Plk_1	4	10	PF00069	0.634
MOD_Plk_4	107	113	PF00069	0.607
MOD_Plk_4	160	166	PF00069	0.480
MOD_Plk_4	170	176	PF00069	0.256
MOD_Plk_4	177	183	PF00069	0.150
MOD_Plk_4	93	99	PF00069	0.630
MOD_ProDKin_1	24	30	PF00069	0.616
MOD_SUMO_for_1	99	102	PF00179	0.612
MOD_SUMO_rev_2	101	108	PF00179	0.670
TRG_DiLeu_BaEn_1	137	142	PF01217	0.626
TRG_DiLeu_BaEn_3	159	165	PF01217	0.564
TRG_ENDOCYTIC_2	167	170	PF00928	0.285
TRG_ENDOCYTIC_2	194	197	PF00928	0.391
TRG_ENDOCYTIC_2	35	38	PF00928	0.576
TRG_ER_diArg_1	45	47	PF00400	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGR9	Leptomonas seymouri	94%	99%
A0A0S4IMJ1	Bodo saltans	80%	99%
A0A1X0NKX0	Trypanosomatidae	89%	99%
A0A3S7WNT5	Leishmania donovani	97%	99%
A0A422ND00	Trypanosoma rangeli	86%	99%
A4H3Y0	Leishmania braziliensis	94%	100%
A4HS59	Leishmania infantum	98%	99%
C9ZY55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	99%
Q9NED9	Leishmania major	97%	100%