ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK45_LEIMU

TriTrypDb:

LmxM.04.0625

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	126	132	PF00089	0.593
CLV_NRD_NRD_1	225	227	PF00675	0.630
CLV_PCSK_SKI1_1	101	105	PF00082	0.538
DEG_SCF_TRCP1_1	25	31	PF00400	0.509
DOC_CKS1_1	279	284	PF01111	0.624
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.593
DOC_PP2B_LxvP_1	124	127	PF13499	0.641
DOC_USP7_MATH_1	128	132	PF00917	0.600
DOC_USP7_MATH_1	143	147	PF00917	0.563
DOC_USP7_MATH_1	241	245	PF00917	0.600
DOC_USP7_MATH_1	274	278	PF00917	0.679
DOC_USP7_MATH_1	280	284	PF00917	0.630
DOC_USP7_MATH_1	323	327	PF00917	0.572
DOC_USP7_UBL2_3	310	314	PF12436	0.598
DOC_WW_Pin1_4	189	194	PF00397	0.572
DOC_WW_Pin1_4	255	260	PF00397	0.774
DOC_WW_Pin1_4	267	272	PF00397	0.609
DOC_WW_Pin1_4	278	283	PF00397	0.721
DOC_WW_Pin1_4	288	293	PF00397	0.774
LIG_14-3-3_CanoR_1	129	133	PF00244	0.613
LIG_14-3-3_CanoR_1	232	238	PF00244	0.593
LIG_14-3-3_CanoR_1	249	259	PF00244	0.525
LIG_14-3-3_CanoR_1	321	329	PF00244	0.666
LIG_14-3-3_CanoR_1	331	338	PF00244	0.563
LIG_14-3-3_CanoR_1	86	95	PF00244	0.344
LIG_BIR_II_1	1	5	PF00653	0.505
LIG_BRCT_BRCA1_1	185	189	PF00533	0.383
LIG_deltaCOP1_diTrp_1	164	169	PF00928	0.519
LIG_deltaCOP1_diTrp_1	182	189	PF00928	0.372
LIG_FHA_1	161	167	PF00498	0.423
LIG_FHA_1	169	175	PF00498	0.469
LIG_FHA_1	304	310	PF00498	0.643
LIG_FHA_1	311	317	PF00498	0.580
LIG_FHA_1	80	86	PF00498	0.531
LIG_FHA_2	137	143	PF00498	0.535
LIG_FHA_2	174	180	PF00498	0.483
LIG_FHA_2	88	94	PF00498	0.342
LIG_LIR_Apic_2	291	297	PF02991	0.649
LIG_LIR_Gen_1	156	166	PF02991	0.371
LIG_LIR_Nem_3	156	162	PF02991	0.384
LIG_LIR_Nem_3	31	35	PF02991	0.479
LIG_LIR_Nem_3	97	102	PF02991	0.479
LIG_SH2_NCK_1	294	298	PF00017	0.638
LIG_SH2_STAT3	302	305	PF00017	0.532
LIG_SH2_STAT5	302	305	PF00017	0.648
LIG_SH3_3	200	206	PF00018	0.675
LIG_SH3_3	260	266	PF00018	0.619
LIG_SH3_3	276	282	PF00018	0.592
LIG_SUMO_SIM_anti_2	209	217	PF11976	0.583
LIG_SUMO_SIM_anti_2	6	14	PF11976	0.359
LIG_SUMO_SIM_par_1	265	270	PF11976	0.645
LIG_SxIP_EBH_1	319	333	PF03271	0.538
LIG_TRFH_1	189	193	PF08558	0.444
LIG_UBA3_1	11	16	PF00899	0.354
MOD_CDK_SPxK_1	189	195	PF00069	0.578
MOD_CK1_1	131	137	PF00069	0.654
MOD_CK1_1	204	210	PF00069	0.574
MOD_CK1_1	217	223	PF00069	0.610
MOD_CK1_1	244	250	PF00069	0.670
MOD_CK1_1	87	93	PF00069	0.338
MOD_CK2_1	135	141	PF00069	0.673
MOD_CK2_1	173	179	PF00069	0.463
MOD_CK2_1	255	261	PF00069	0.659
MOD_CK2_1	87	93	PF00069	0.349
MOD_GlcNHglycan	121	124	PF01048	0.581
MOD_GlcNHglycan	219	222	PF01048	0.692
MOD_GlcNHglycan	234	237	PF01048	0.571
MOD_GlcNHglycan	25	28	PF01048	0.563
MOD_GlcNHglycan	316	319	PF01048	0.531
MOD_GSK3_1	131	138	PF00069	0.724
MOD_GSK3_1	143	150	PF00069	0.537
MOD_GSK3_1	160	167	PF00069	0.455
MOD_GSK3_1	168	175	PF00069	0.526
MOD_GSK3_1	204	211	PF00069	0.627
MOD_GSK3_1	232	239	PF00069	0.626
MOD_GSK3_1	244	251	PF00069	0.695
MOD_GSK3_1	274	281	PF00069	0.688
MOD_GSK3_1	310	317	PF00069	0.601
MOD_LATS_1	199	205	PF00433	0.510
MOD_LATS_1	284	290	PF00433	0.661
MOD_NEK2_1	119	124	PF00069	0.664
MOD_NEK2_1	15	20	PF00069	0.545
MOD_NEK2_1	173	178	PF00069	0.463
MOD_NEK2_1	183	188	PF00069	0.418
MOD_NEK2_1	208	213	PF00069	0.672
MOD_PIKK_1	131	137	PF00454	0.654
MOD_PIKK_1	184	190	PF00454	0.556
MOD_PIKK_1	214	220	PF00454	0.508
MOD_PIKK_1	296	302	PF00454	0.621
MOD_PKA_2	128	134	PF00069	0.671
MOD_PKA_2	194	200	PF00069	0.681
MOD_PKA_2	204	210	PF00069	0.582
MOD_PKA_2	231	237	PF00069	0.594
MOD_PKA_2	248	254	PF00069	0.533
MOD_PKA_2	330	336	PF00069	0.517
MOD_Plk_1	208	214	PF00069	0.620
MOD_Plk_1	79	85	PF00069	0.376
MOD_Plk_4	208	214	PF00069	0.620
MOD_Plk_4	28	34	PF00069	0.497
MOD_ProDKin_1	189	195	PF00069	0.578
MOD_ProDKin_1	255	261	PF00069	0.774
MOD_ProDKin_1	267	273	PF00069	0.609
MOD_ProDKin_1	278	284	PF00069	0.725
MOD_ProDKin_1	288	294	PF00069	0.775
MOD_SUMO_rev_2	109	114	PF00179	0.569
TRG_DiLeu_BaEn_1	7	12	PF01217	0.354
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.637
TRG_PTS1	335	338	PF00515	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5B7	Leishmania donovani	82%	100%
A4H441	Leishmania braziliensis	55%	100%
A4HS58	Leishmania infantum	81%	100%
E9ACP8	Leishmania major	79%	100%