DUF1168-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK43_LEIMU

TriTrypDb:

LmxM.04.0610

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.575
CLV_C14_Caspase3-7	156	160	PF00656	0.611
CLV_NRD_NRD_1	115	117	PF00675	0.593
CLV_NRD_NRD_1	94	96	PF00675	0.621
CLV_PCSK_FUR_1	113	117	PF00082	0.579
CLV_PCSK_KEX2_1	112	114	PF00082	0.606
CLV_PCSK_KEX2_1	115	117	PF00082	0.562
CLV_PCSK_KEX2_1	119	121	PF00082	0.414
CLV_PCSK_KEX2_1	94	96	PF00082	0.619
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.575
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.414
CLV_PCSK_PC7_1	115	121	PF00082	0.402
CLV_PCSK_SKI1_1	116	120	PF00082	0.567
DEG_SPOP_SBC_1	147	151	PF00917	0.646
DEG_SPOP_SBC_1	154	158	PF00917	0.585
DOC_CDC14_PxL_1	46	54	PF14671	0.651
DOC_CKS1_1	19	24	PF01111	0.725
DOC_USP7_MATH_1	147	151	PF00917	0.774
DOC_USP7_MATH_1	152	156	PF00917	0.714
DOC_USP7_UBL2_3	119	123	PF12436	0.579
DOC_WW_Pin1_4	18	23	PF00397	0.720
DOC_WW_Pin1_4	2	7	PF00397	0.534
LIG_14-3-3_CanoR_1	41	47	PF00244	0.727
LIG_Actin_WH2_2	39	55	PF00022	0.628
LIG_APCC_ABBAyCdc20_2	94	100	PF00400	0.527
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_CaM_IQ_9	105	121	PF13499	0.532
LIG_FHA_2	19	25	PF00498	0.625
LIG_MYND_1	18	22	PF01753	0.633
LIG_PDZ_Class_3	162	167	PF00595	0.646
LIG_SH2_STAT5	39	42	PF00017	0.587
LIG_SH3_3	13	19	PF00018	0.761
LIG_TRAF2_1	21	24	PF00917	0.622
MOD_CDK_SPxxK_3	18	25	PF00069	0.629
MOD_CK1_1	139	145	PF00069	0.746
MOD_CK1_1	146	152	PF00069	0.713
MOD_CK1_1	153	159	PF00069	0.616
MOD_CK1_1	2	8	PF00069	0.730
MOD_CK2_1	18	24	PF00069	0.631
MOD_Cter_Amidation	120	123	PF01082	0.404
MOD_GlcNHglycan	144	148	PF01048	0.747
MOD_GlcNHglycan	150	153	PF01048	0.651
MOD_GlcNHglycan	6	9	PF01048	0.787
MOD_GSK3_1	130	137	PF00069	0.594
MOD_GSK3_1	139	146	PF00069	0.627
MOD_GSK3_1	148	155	PF00069	0.672
MOD_GSK3_1	60	67	PF00069	0.623
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	148	153	PF00069	0.792
MOD_NEK2_1	52	57	PF00069	0.678
MOD_NEK2_2	42	47	PF00069	0.539
MOD_PK_1	104	110	PF00069	0.524
MOD_PKA_2	52	58	PF00069	0.704
MOD_PKB_1	132	140	PF00069	0.563
MOD_Plk_4	35	41	PF00069	0.660
MOD_ProDKin_1	18	24	PF00069	0.716
MOD_ProDKin_1	2	8	PF00069	0.532
TRG_ER_diArg_1	113	116	PF00400	0.581
TRG_ER_diArg_1	131	134	PF00400	0.526
TRG_ER_diArg_1	50	53	PF00400	0.681
TRG_NLS_Bipartite_1	94	116	PF00514	0.568
TRG_NLS_MonoExtC_3	110	115	PF00514	0.573
TRG_NLS_MonoExtC_3	118	123	PF00514	0.467
TRG_NLS_MonoExtN_4	111	116	PF00514	0.580
TRG_NLS_MonoExtN_4	119	126	PF00514	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNR8	Leishmania donovani	94%	100%
A4H443	Leishmania braziliensis	86%	100%
A4HS56	Leishmania infantum	95%	100%
Q9NEE1	Leishmania major	91%	100%