Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK41_LEIMU

TriTrypDb:

LmxM.04.0590

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AK41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.446
CLV_NRD_NRD_1	124	126	PF00675	0.478
CLV_NRD_NRD_1	132	134	PF00675	0.504
CLV_NRD_NRD_1	28	30	PF00675	0.716
CLV_NRD_NRD_1	80	82	PF00675	0.557
CLV_PCSK_KEX2_1	124	126	PF00082	0.478
CLV_PCSK_KEX2_1	132	134	PF00082	0.504
CLV_PCSK_KEX2_1	80	82	PF00082	0.557
DOC_MAPK_gen_1	132	141	PF00069	0.722
DOC_PP1_RVXF_1	112	118	PF00149	0.673
DOC_PP2B_LxvP_1	168	171	PF13499	0.517
DOC_USP7_MATH_1	222	226	PF00917	0.465
DOC_USP7_MATH_1	63	67	PF00917	0.490
DOC_USP7_MATH_1	69	73	PF00917	0.606
LIG_14-3-3_CanoR_1	197	203	PF00244	0.739
LIG_14-3-3_CanoR_1	223	227	PF00244	0.411
LIG_BRCT_BRCA1_1	3	7	PF00533	0.354
LIG_BRCT_BRCA1_1	63	67	PF00533	0.222
LIG_deltaCOP1_diTrp_1	21	27	PF00928	0.430
LIG_EH1_1	211	219	PF00400	0.246
LIG_EVH1_1	43	47	PF00568	0.385
LIG_FHA_1	146	152	PF00498	0.546
LIG_FHA_2	13	19	PF00498	0.456
LIG_FHA_2	97	103	PF00498	0.748
LIG_IRF3_LxIS_1	44	51	PF10401	0.526
LIG_LIR_Gen_1	4	11	PF02991	0.490
LIG_LIR_Gen_1	51	59	PF02991	0.513
LIG_LIR_Nem_3	21	27	PF02991	0.510
LIG_LIR_Nem_3	4	10	PF02991	0.490
LIG_LIR_Nem_3	51	55	PF02991	0.513
LIG_MLH1_MIPbox_1	3	7	PF16413	0.562
LIG_SH2_CRK	164	168	PF00017	0.436
LIG_SH2_GRB2like	208	211	PF00017	0.402
LIG_SH2_PTP2	208	211	PF00017	0.411
LIG_SH2_STAP1	164	168	PF00017	0.436
LIG_SH2_STAT5	198	201	PF00017	0.685
LIG_SH2_STAT5	205	208	PF00017	0.620
LIG_SH2_STAT5	6	9	PF00017	0.562
LIG_SH3_3	41	47	PF00018	0.568
LIG_SUMO_SIM_anti_2	148	155	PF11976	0.433
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.513
LIG_SUMO_SIM_par_1	148	155	PF11976	0.420
LIG_SUMO_SIM_par_1	46	51	PF11976	0.514
MOD_CK1_1	37	43	PF00069	0.590
MOD_CK2_1	92	98	PF00069	0.756
MOD_Cter_Amidation	27	30	PF01082	0.789
MOD_GSK3_1	152	159	PF00069	0.411
MOD_GSK3_1	9	16	PF00069	0.462
MOD_GSK3_1	92	99	PF00069	0.753
MOD_NEK2_1	1	6	PF00069	0.459
MOD_NEK2_2	198	203	PF00069	0.676
MOD_PKA_2	222	228	PF00069	0.411
MOD_PKA_2	28	34	PF00069	0.515
MOD_PKA_2	37	43	PF00069	0.532
MOD_PKB_1	32	40	PF00069	0.600
MOD_Plk_4	213	219	PF00069	0.369
MOD_Plk_4	222	228	PF00069	0.343
MOD_Plk_4	6	12	PF00069	0.419
MOD_Plk_4	63	69	PF00069	0.513
TRG_ENDOCYTIC_2	164	167	PF00928	0.500
TRG_ENDOCYTIC_2	208	211	PF00928	0.355
TRG_ER_diArg_1	32	35	PF00400	0.593
TRG_ER_diArg_1	80	82	PF00400	0.757
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB33	Leptomonas seymouri	53%	86%
A0A3S7WNS4	Leishmania donovani	91%	86%
A4H3X9	Leishmania braziliensis	78%	100%
A4HS54	Leishmania infantum	91%	86%
Q95Z83	Leishmania major	90%	100%