Putative tyrosine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AK38_LEIMU

TriTrypDb:

LmxM.04.0560

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK38

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	9
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0004725	protein tyrosine phosphatase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	138	140	PF00082	0.398
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.398
CLV_PCSK_SKI1_1	44	48	PF00082	0.360
DEG_COP1_1	7	15	PF00400	0.438
DEG_MDM2_SWIB_1	166	173	PF02201	0.587
DEG_SCF_FBW7_1	171	178	PF00400	0.554
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.574
DOC_MAPK_DCC_7	8	17	PF00069	0.435
DOC_MAPK_gen_1	42	49	PF00069	0.541
DOC_MAPK_MEF2A_6	8	17	PF00069	0.435
DOC_PP2B_LxvP_1	162	165	PF13499	0.583
DOC_PP2B_LxvP_1	198	201	PF13499	0.521
DOC_USP7_MATH_1	2	6	PF00917	0.666
DOC_USP7_MATH_1	213	217	PF00917	0.623
DOC_USP7_MATH_1	225	229	PF00917	0.757
DOC_USP7_MATH_1	236	240	PF00917	0.722
DOC_USP7_MATH_1	255	259	PF00917	0.739
DOC_USP7_MATH_1	264	268	PF00917	0.661
DOC_USP7_MATH_1	271	275	PF00917	0.534
DOC_USP7_MATH_1	284	288	PF00917	0.509
DOC_USP7_UBL2_3	203	207	PF12436	0.707
DOC_WW_Pin1_4	160	165	PF00397	0.466
DOC_WW_Pin1_4	171	176	PF00397	0.514
DOC_WW_Pin1_4	267	272	PF00397	0.703
LIG_14-3-3_CanoR_1	139	147	PF00244	0.598
LIG_14-3-3_CanoR_1	176	180	PF00244	0.592
LIG_APCC_ABBA_1	131	136	PF00400	0.525
LIG_FHA_1	113	119	PF00498	0.382
LIG_FHA_1	172	178	PF00498	0.459
LIG_FHA_1	97	103	PF00498	0.560
LIG_LIR_Apic_2	45	51	PF02991	0.501
LIG_LIR_Gen_1	14	25	PF02991	0.522
LIG_LIR_Gen_1	149	160	PF02991	0.517
LIG_LIR_Gen_1	169	177	PF02991	0.475
LIG_LIR_Gen_1	79	89	PF02991	0.501
LIG_LIR_Nem_3	132	137	PF02991	0.488
LIG_LIR_Nem_3	14	20	PF02991	0.522
LIG_LIR_Nem_3	149	155	PF02991	0.483
LIG_LIR_Nem_3	169	173	PF02991	0.472
LIG_LIR_Nem_3	79	84	PF02991	0.501
LIG_Pex14_2	166	170	PF04695	0.575
LIG_SH2_CRK	156	160	PF00017	0.537
LIG_SH2_CRK	196	200	PF00017	0.633
LIG_SH2_CRK	35	39	PF00017	0.496
LIG_SH2_PTP2	152	155	PF00017	0.496
LIG_SH2_SRC	54	57	PF00017	0.501
LIG_SH2_STAP1	196	200	PF00017	0.555
LIG_SH2_STAT5	152	155	PF00017	0.512
LIG_SH2_STAT5	48	51	PF00017	0.501
LIG_SH3_3	249	255	PF00018	0.759
LIG_SH3_3	7	13	PF00018	0.512
LIG_SUMO_SIM_par_1	129	136	PF11976	0.560
LIG_TYR_ITIM	194	199	PF00017	0.635
MOD_CDK_SPK_2	171	176	PF00069	0.616
MOD_CK1_1	129	135	PF00069	0.501
MOD_CK1_1	169	175	PF00069	0.519
MOD_CK1_1	239	245	PF00069	0.716
MOD_CK1_1	267	273	PF00069	0.676
MOD_CK2_1	129	135	PF00069	0.598
MOD_CK2_1	179	185	PF00069	0.509
MOD_CK2_1	284	290	PF00069	0.663
MOD_GlcNHglycan	208	211	PF01048	0.523
MOD_GlcNHglycan	227	230	PF01048	0.705
MOD_GlcNHglycan	238	241	PF01048	0.644
MOD_GlcNHglycan	257	260	PF01048	0.738
MOD_GlcNHglycan	26	29	PF01048	0.306
MOD_GlcNHglycan	262	265	PF01048	0.714
MOD_GlcNHglycan	266	269	PF01048	0.682
MOD_GlcNHglycan	4	7	PF01048	0.618
MOD_GSK3_1	11	18	PF00069	0.584
MOD_GSK3_1	171	178	PF00069	0.474
MOD_GSK3_1	230	237	PF00069	0.744
MOD_GSK3_1	24	31	PF00069	0.412
MOD_GSK3_1	250	257	PF00069	0.758
MOD_GSK3_1	260	267	PF00069	0.825
MOD_GSK3_1	271	278	PF00069	0.714
MOD_N-GLC_1	15	20	PF02516	0.396
MOD_NEK2_1	166	171	PF00069	0.558
MOD_NEK2_1	194	199	PF00069	0.476
MOD_NEK2_1	206	211	PF00069	0.574
MOD_PIKK_1	250	256	PF00454	0.819
MOD_PK_1	42	48	PF00069	0.560
MOD_PKA_2	175	181	PF00069	0.608
MOD_Plk_1	15	21	PF00069	0.586
MOD_Plk_4	114	120	PF00069	0.602
MOD_Plk_4	129	135	PF00069	0.377
MOD_Plk_4	166	172	PF00069	0.470
MOD_Plk_4	175	181	PF00069	0.446
MOD_Plk_4	194	200	PF00069	0.566
MOD_Plk_4	271	277	PF00069	0.734
MOD_ProDKin_1	160	166	PF00069	0.467
MOD_ProDKin_1	171	177	PF00069	0.506
MOD_ProDKin_1	267	273	PF00069	0.700
MOD_SUMO_rev_2	132	140	PF00179	0.598
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.602
TRG_ENDOCYTIC_2	137	140	PF00928	0.488
TRG_ENDOCYTIC_2	152	155	PF00928	0.483
TRG_ENDOCYTIC_2	156	159	PF00928	0.541
TRG_ENDOCYTIC_2	196	199	PF00928	0.575
TRG_ENDOCYTIC_2	35	38	PF00928	0.496
TRG_ER_diArg_1	41	44	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JUF6	Bodo saltans	62%	94%
A0A3S5H5B2	Leishmania donovani	87%	94%
A0A422N9L9	Trypanosoma rangeli	77%	91%
A4H3X6	Leishmania braziliensis	81%	98%
A4HS51	Leishmania infantum	87%	94%
C9ZY49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	91%
Q95Z86	Leishmania major	87%	100%