RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AK36_LEIMU

TriTrypDb:

LmxM.04.0540

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK36

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005509	calcium ion binding	5	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.532
CLV_C14_Caspase3-7	338	342	PF00656	0.424
CLV_NRD_NRD_1	161	163	PF00675	0.612
CLV_NRD_NRD_1	307	309	PF00675	0.313
CLV_NRD_NRD_1	450	452	PF00675	0.627
CLV_NRD_NRD_1	569	571	PF00675	0.557
CLV_NRD_NRD_1	572	574	PF00675	0.532
CLV_PCSK_FUR_1	570	574	PF00082	0.541
CLV_PCSK_KEX2_1	161	163	PF00082	0.612
CLV_PCSK_KEX2_1	450	452	PF00082	0.623
CLV_PCSK_KEX2_1	571	573	PF00082	0.545
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.522
CLV_PCSK_PC7_1	157	163	PF00082	0.579
CLV_PCSK_SKI1_1	396	400	PF00082	0.412
CLV_PCSK_SKI1_1	403	407	PF00082	0.422
CLV_PCSK_SKI1_1	72	76	PF00082	0.433
DEG_APCC_DBOX_1	277	285	PF00400	0.348
DEG_APCC_DBOX_1	395	403	PF00400	0.404
DEG_APCC_DBOX_1	71	79	PF00400	0.416
DEG_SPOP_SBC_1	542	546	PF00917	0.508
DOC_CYCLIN_RxL_1	68	77	PF00134	0.427
DOC_MAPK_gen_1	68	75	PF00069	0.379
DOC_MAPK_MEF2A_6	293	301	PF00069	0.388
DOC_PP2B_LxvP_1	219	222	PF13499	0.504
DOC_PP2B_LxvP_1	413	416	PF13499	0.441
DOC_PP2B_LxvP_1	446	449	PF13499	0.481
DOC_PP2B_LxvP_1	515	518	PF13499	0.613
DOC_PP4_FxxP_1	11	14	PF00568	0.359
DOC_PP4_FxxP_1	55	58	PF00568	0.320
DOC_USP7_MATH_1	112	116	PF00917	0.707
DOC_USP7_MATH_1	139	143	PF00917	0.628
DOC_USP7_MATH_1	209	213	PF00917	0.729
DOC_USP7_MATH_1	326	330	PF00917	0.443
DOC_USP7_MATH_1	452	456	PF00917	0.525
DOC_USP7_MATH_1	473	477	PF00917	0.504
DOC_USP7_MATH_1	484	488	PF00917	0.555
DOC_USP7_MATH_1	543	547	PF00917	0.530
DOC_USP7_MATH_2	203	209	PF00917	0.601
DOC_WW_Pin1_4	144	149	PF00397	0.782
DOC_WW_Pin1_4	186	191	PF00397	0.602
DOC_WW_Pin1_4	214	219	PF00397	0.636
DOC_WW_Pin1_4	229	234	PF00397	0.751
DOC_WW_Pin1_4	238	243	PF00397	0.630
DOC_WW_Pin1_4	371	376	PF00397	0.382
DOC_WW_Pin1_4	440	445	PF00397	0.614
DOC_WW_Pin1_4	469	474	PF00397	0.488
DOC_WW_Pin1_4	553	558	PF00397	0.576
LIG_14-3-3_CanoR_1	347	351	PF00244	0.418
LIG_14-3-3_CanoR_1	451	457	PF00244	0.507
LIG_APCC_ABBA_1	188	193	PF00400	0.502
LIG_BRCT_BRCA1_1	328	332	PF00533	0.425
LIG_BRCT_BRCA1_1	475	479	PF00533	0.584
LIG_CtBP_PxDLS_1	23	27	PF00389	0.296
LIG_EVH1_2	417	421	PF00568	0.432
LIG_FHA_1	214	220	PF00498	0.672
LIG_FHA_1	271	277	PF00498	0.373
LIG_FHA_1	338	344	PF00498	0.396
LIG_FHA_1	388	394	PF00498	0.407
LIG_FHA_1	542	548	PF00498	0.556
LIG_FHA_2	105	111	PF00498	0.536
LIG_FHA_2	253	259	PF00498	0.306
LIG_FHA_2	300	306	PF00498	0.439
LIG_FHA_2	347	353	PF00498	0.570
LIG_Integrin_RGD_1	576	578	PF01839	0.565
LIG_LIR_Apic_2	18	23	PF02991	0.340
LIG_LIR_Apic_2	502	507	PF02991	0.514
LIG_LIR_Apic_2	54	58	PF02991	0.216
LIG_LIR_Apic_2	8	14	PF02991	0.394
LIG_LIR_Gen_1	298	307	PF02991	0.294
LIG_LIR_Gen_1	390	399	PF02991	0.438
LIG_LIR_Nem_3	168	174	PF02991	0.655
LIG_LIR_Nem_3	247	252	PF02991	0.467
LIG_LIR_Nem_3	350	356	PF02991	0.452
LIG_LIR_Nem_3	361	365	PF02991	0.383
LIG_LIR_Nem_3	390	395	PF02991	0.447
LIG_Pex14_2	286	290	PF04695	0.408
LIG_PROFILIN_1	148	154	PF00235	0.494
LIG_Rb_pABgroove_1	263	271	PF01858	0.418
LIG_SH2_CRK	353	357	PF00017	0.553
LIG_SH2_CRK	491	495	PF00017	0.704
LIG_SH2_CRK	504	508	PF00017	0.554
LIG_SH2_NCK_1	504	508	PF00017	0.517
LIG_SH2_PTP2	171	174	PF00017	0.610
LIG_SH2_PTP2	392	395	PF00017	0.383
LIG_SH2_SRC	171	174	PF00017	0.610
LIG_SH2_SRC	504	507	PF00017	0.516
LIG_SH2_STAP1	339	343	PF00017	0.387
LIG_SH2_STAT3	311	314	PF00017	0.374
LIG_SH2_STAT5	171	174	PF00017	0.610
LIG_SH2_STAT5	311	314	PF00017	0.374
LIG_SH2_STAT5	339	342	PF00017	0.388
LIG_SH2_STAT5	392	395	PF00017	0.383
LIG_SH2_STAT5	87	90	PF00017	0.430
LIG_SH3_1	504	510	PF00018	0.511
LIG_SH3_2	511	516	PF14604	0.609
LIG_SH3_3	145	151	PF00018	0.810
LIG_SH3_3	212	218	PF00018	0.620
LIG_SH3_3	239	245	PF00018	0.679
LIG_SH3_3	504	510	PF00018	0.658
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.485
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.317
LIG_SUMO_SIM_anti_2	294	303	PF11976	0.308
LIG_SUMO_SIM_par_1	77	82	PF11976	0.361
LIG_TRAF2_2	3	8	PF00917	0.414
LIG_UBA3_1	300	309	PF00899	0.414
LIG_WRC_WIRS_1	52	57	PF05994	0.200
MOD_CAAXbox	581	584	PF01239	0.637
MOD_CDC14_SPxK_1	189	192	PF00782	0.588
MOD_CDK_SPxK_1	186	192	PF00069	0.600
MOD_CDK_SPxxK_3	553	560	PF00069	0.610
MOD_CK1_1	131	137	PF00069	0.643
MOD_CK1_1	179	185	PF00069	0.644
MOD_CK1_1	186	192	PF00069	0.560
MOD_CK1_1	194	200	PF00069	0.583
MOD_CK1_1	208	214	PF00069	0.798
MOD_CK1_1	361	367	PF00069	0.243
MOD_CK1_1	424	430	PF00069	0.757
MOD_CK1_1	462	468	PF00069	0.566
MOD_CK1_1	534	540	PF00069	0.503
MOD_CK1_1	556	562	PF00069	0.517
MOD_CK2_1	252	258	PF00069	0.383
MOD_CK2_1	332	338	PF00069	0.410
MOD_CK2_1	346	352	PF00069	0.380
MOD_GlcNHglycan	130	133	PF01048	0.588
MOD_GlcNHglycan	179	182	PF01048	0.656
MOD_GlcNHglycan	185	188	PF01048	0.708
MOD_GlcNHglycan	207	210	PF01048	0.658
MOD_GlcNHglycan	229	232	PF01048	0.655
MOD_GlcNHglycan	238	241	PF01048	0.533
MOD_GlcNHglycan	321	324	PF01048	0.433
MOD_GlcNHglycan	327	331	PF01048	0.432
MOD_GlcNHglycan	424	427	PF01048	0.668
MOD_GlcNHglycan	430	433	PF01048	0.613
MOD_GlcNHglycan	464	467	PF01048	0.600
MOD_GlcNHglycan	469	472	PF01048	0.553
MOD_GlcNHglycan	533	536	PF01048	0.570
MOD_GSK3_1	179	186	PF00069	0.686
MOD_GSK3_1	191	198	PF00069	0.707
MOD_GSK3_1	201	208	PF00069	0.575
MOD_GSK3_1	209	216	PF00069	0.779
MOD_GSK3_1	227	234	PF00069	0.688
MOD_GSK3_1	236	243	PF00069	0.521
MOD_GSK3_1	270	277	PF00069	0.338
MOD_GSK3_1	387	394	PF00069	0.412
MOD_GSK3_1	424	431	PF00069	0.559
MOD_GSK3_1	460	467	PF00069	0.593
MOD_GSK3_1	469	476	PF00069	0.529
MOD_GSK3_1	480	487	PF00069	0.464
MOD_GSK3_1	531	538	PF00069	0.560
MOD_GSK3_1	59	66	PF00069	0.448
MOD_GSK3_1	90	97	PF00069	0.434
MOD_N-GLC_1	209	214	PF02516	0.668
MOD_N-GLC_1	227	232	PF02516	0.642
MOD_N-GLC_1	467	472	PF02516	0.490
MOD_NEK2_1	128	133	PF00069	0.524
MOD_NEK2_1	183	188	PF00069	0.599
MOD_NEK2_1	236	241	PF00069	0.545
MOD_NEK2_1	332	337	PF00069	0.486
MOD_NEK2_1	398	403	PF00069	0.348
MOD_NEK2_1	421	426	PF00069	0.458
MOD_NEK2_1	480	485	PF00069	0.578
MOD_NEK2_1	59	64	PF00069	0.410
MOD_NEK2_1	74	79	PF00069	0.462
MOD_NEK2_2	391	396	PF00069	0.530
MOD_PIKK_1	252	258	PF00454	0.434
MOD_PIKK_1	310	316	PF00454	0.355
MOD_PKA_2	139	145	PF00069	0.605
MOD_PKA_2	183	189	PF00069	0.612
MOD_PKA_2	191	197	PF00069	0.506
MOD_PKA_2	274	280	PF00069	0.371
MOD_PKA_2	346	352	PF00069	0.297
MOD_PKA_2	387	393	PF00069	0.588
MOD_PKA_2	90	96	PF00069	0.450
MOD_Plk_1	209	215	PF00069	0.727
MOD_Plk_1	459	465	PF00069	0.646
MOD_Plk_1	535	541	PF00069	0.500
MOD_Plk_4	543	549	PF00069	0.511
MOD_Plk_4	59	65	PF00069	0.415
MOD_Plk_4	74	80	PF00069	0.447
MOD_ProDKin_1	144	150	PF00069	0.779
MOD_ProDKin_1	186	192	PF00069	0.602
MOD_ProDKin_1	214	220	PF00069	0.638
MOD_ProDKin_1	229	235	PF00069	0.751
MOD_ProDKin_1	238	244	PF00069	0.623
MOD_ProDKin_1	371	377	PF00069	0.377
MOD_ProDKin_1	440	446	PF00069	0.615
MOD_ProDKin_1	469	475	PF00069	0.487
MOD_ProDKin_1	553	559	PF00069	0.578
MOD_SUMO_rev_2	66	70	PF00179	0.413
TRG_DiLeu_BaEn_1	258	263	PF01217	0.403
TRG_ENDOCYTIC_2	171	174	PF00928	0.631
TRG_ENDOCYTIC_2	353	356	PF00928	0.571
TRG_ENDOCYTIC_2	392	395	PF00928	0.396
TRG_ENDOCYTIC_2	491	494	PF00928	0.588
TRG_ER_diArg_1	160	162	PF00400	0.639
TRG_ER_diArg_1	449	451	PF00400	0.497
TRG_ER_diArg_1	570	573	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV78	Leptomonas seymouri	48%	93%
A0A3Q8IMS6	Leishmania donovani	30%	100%
A0A3R7KFH5	Trypanosoma rangeli	28%	100%
A0A3S5H5B1	Leishmania donovani	80%	99%
A4HDK3	Leishmania braziliensis	28%	97%
A4HDK4	Leishmania braziliensis	28%	95%
A4HS49	Leishmania infantum	79%	99%
A4I0X7	Leishmania infantum	27%	100%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O97201	Leishmania major	77%	100%
Q4QAJ3	Leishmania major	29%	91%