Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK35_LEIMU

TriTrypDb:

LmxM.04.0530

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.625
CLV_MEL_PAP_1	66	72	PF00089	0.566
CLV_NRD_NRD_1	175	177	PF00675	0.610
CLV_NRD_NRD_1	298	300	PF00675	0.407
CLV_NRD_NRD_1	324	326	PF00675	0.640
CLV_NRD_NRD_1	381	383	PF00675	0.569
CLV_PCSK_FUR_1	296	300	PF00082	0.339
CLV_PCSK_KEX2_1	298	300	PF00082	0.404
CLV_PCSK_KEX2_1	324	326	PF00082	0.640
CLV_PCSK_KEX2_1	383	385	PF00082	0.576
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.576
CLV_PCSK_SKI1_1	176	180	PF00082	0.507
CLV_PCSK_SKI1_1	26	30	PF00082	0.629
CLV_PCSK_SKI1_1	298	302	PF00082	0.559
CLV_PCSK_SKI1_1	324	328	PF00082	0.575
CLV_PCSK_SKI1_1	72	76	PF00082	0.416
DEG_APCC_DBOX_1	297	305	PF00400	0.520
DEG_Nend_UBRbox_3	1	3	PF02207	0.526
DEG_SPOP_SBC_1	121	125	PF00917	0.584
DEG_SPOP_SBC_1	37	41	PF00917	0.545
DOC_CDC14_PxL_1	140	148	PF14671	0.540
DOC_CKS1_1	205	210	PF01111	0.536
DOC_CKS1_1	257	262	PF01111	0.625
DOC_CKS1_1	326	331	PF01111	0.430
DOC_CYCLIN_RxL_1	292	302	PF00134	0.567
DOC_CYCLIN_RxL_1	321	328	PF00134	0.425
DOC_CYCLIN_RxL_1	69	80	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.503
DOC_MAPK_gen_1	26	35	PF00069	0.590
DOC_PP2B_LxvP_1	193	196	PF13499	0.511
DOC_PP2B_LxvP_1	84	87	PF13499	0.692
DOC_USP7_MATH_1	113	117	PF00917	0.602
DOC_USP7_MATH_1	121	125	PF00917	0.634
DOC_USP7_MATH_1	212	216	PF00917	0.673
DOC_USP7_MATH_1	237	241	PF00917	0.592
DOC_USP7_MATH_1	340	344	PF00917	0.621
DOC_USP7_MATH_1	361	365	PF00917	0.527
DOC_USP7_MATH_1	37	41	PF00917	0.611
DOC_USP7_MATH_1	58	62	PF00917	0.639
DOC_WW_Pin1_4	122	127	PF00397	0.651
DOC_WW_Pin1_4	15	20	PF00397	0.709
DOC_WW_Pin1_4	204	209	PF00397	0.650
DOC_WW_Pin1_4	233	238	PF00397	0.671
DOC_WW_Pin1_4	256	261	PF00397	0.590
DOC_WW_Pin1_4	325	330	PF00397	0.429
DOC_WW_Pin1_4	38	43	PF00397	0.569
DOC_WW_Pin1_4	77	82	PF00397	0.553
DOC_WW_Pin1_4	86	91	PF00397	0.629
LIG_14-3-3_CanoR_1	209	219	PF00244	0.514
LIG_14-3-3_CanoR_1	350	357	PF00244	0.488
LIG_14-3-3_CanoR_1	49	58	PF00244	0.539
LIG_BIR_III_2	308	312	PF00653	0.506
LIG_CaM_NSCaTE_8	159	166	PF13499	0.470
LIG_CtBP_PxDLS_1	260	264	PF00389	0.539
LIG_FHA_1	131	137	PF00498	0.504
LIG_FHA_1	214	220	PF00498	0.499
LIG_FHA_2	257	263	PF00498	0.622
LIG_FHA_2	376	382	PF00498	0.446
LIG_LIR_Gen_1	156	166	PF02991	0.451
LIG_LIR_Gen_1	59	70	PF02991	0.477
LIG_LIR_Nem_3	156	162	PF02991	0.511
LIG_LIR_Nem_3	59	65	PF02991	0.531
LIG_NRBOX	296	302	PF00104	0.473
LIG_PCNA_PIPBox_1	320	329	PF02747	0.520
LIG_PCNA_yPIPBox_3	317	327	PF02747	0.446
LIG_SH2_CRK	307	311	PF00017	0.577
LIG_SH2_NCK_1	307	311	PF00017	0.577
LIG_SH3_1	202	208	PF00018	0.533
LIG_SH3_1	85	91	PF00018	0.704
LIG_SH3_3	138	144	PF00018	0.517
LIG_SH3_3	16	22	PF00018	0.504
LIG_SH3_3	202	208	PF00018	0.662
LIG_SH3_3	28	34	PF00018	0.517
LIG_SH3_3	84	90	PF00018	0.691
LIG_SH3_3	95	101	PF00018	0.695
LIG_Sin3_3	369	376	PF02671	0.635
LIG_TRAF2_1	196	199	PF00917	0.596
LIG_TRAF2_1	259	262	PF00917	0.538
LIG_TRAF2_1	286	289	PF00917	0.534
LIG_TRAF2_1	311	314	PF00917	0.494
LIG_TRAF2_1	316	319	PF00917	0.466
LIG_WRC_WIRS_1	62	67	PF05994	0.634
MOD_CDK_SPK_2	204	209	PF00069	0.533
MOD_CDK_SPK_2	77	82	PF00069	0.534
MOD_CDK_SPxxK_3	204	211	PF00069	0.532
MOD_CK1_1	125	131	PF00069	0.566
MOD_CK1_1	14	20	PF00069	0.571
MOD_CK1_1	222	228	PF00069	0.548
MOD_CK1_1	240	246	PF00069	0.618
MOD_CK1_1	249	255	PF00069	0.548
MOD_CK1_1	343	349	PF00069	0.632
MOD_CK1_1	352	358	PF00069	0.479
MOD_CK1_1	40	46	PF00069	0.606
MOD_CK1_1	61	67	PF00069	0.646
MOD_CK1_1	99	105	PF00069	0.748
MOD_CK2_1	256	262	PF00069	0.550
MOD_CK2_1	283	289	PF00069	0.534
MOD_CK2_1	360	366	PF00069	0.446
MOD_GlcNHglycan	101	104	PF01048	0.638
MOD_GlcNHglycan	115	118	PF01048	0.604
MOD_GlcNHglycan	127	130	PF01048	0.430
MOD_GlcNHglycan	164	167	PF01048	0.590
MOD_GlcNHglycan	251	254	PF01048	0.650
MOD_GlcNHglycan	341	345	PF01048	0.741
MOD_GlcNHglycan	352	355	PF01048	0.729
MOD_GlcNHglycan	42	45	PF01048	0.631
MOD_GlcNHglycan	53	56	PF01048	0.741
MOD_GSK3_1	11	18	PF00069	0.541
MOD_GSK3_1	113	120	PF00069	0.600
MOD_GSK3_1	121	128	PF00069	0.531
MOD_GSK3_1	233	240	PF00069	0.656
MOD_GSK3_1	261	268	PF00069	0.572
MOD_GSK3_1	345	352	PF00069	0.638
MOD_GSK3_1	36	43	PF00069	0.814
MOD_NEK2_1	13	18	PF00069	0.579
MOD_NEK2_1	130	135	PF00069	0.696
MOD_NEK2_1	221	226	PF00069	0.614
MOD_NEK2_2	24	29	PF00069	0.594
MOD_PKA_2	349	355	PF00069	0.515
MOD_PKA_2	48	54	PF00069	0.558
MOD_PKA_2	68	74	PF00069	0.553
MOD_Plk_1	261	267	PF00069	0.544
MOD_Plk_1	374	380	PF00069	0.445
MOD_Plk_2-3	375	381	PF00069	0.447
MOD_Plk_4	352	358	PF00069	0.476
MOD_Plk_4	61	67	PF00069	0.704
MOD_ProDKin_1	122	128	PF00069	0.646
MOD_ProDKin_1	15	21	PF00069	0.705
MOD_ProDKin_1	204	210	PF00069	0.649
MOD_ProDKin_1	233	239	PF00069	0.670
MOD_ProDKin_1	256	262	PF00069	0.587
MOD_ProDKin_1	325	331	PF00069	0.429
MOD_ProDKin_1	38	44	PF00069	0.567
MOD_ProDKin_1	77	83	PF00069	0.559
MOD_ProDKin_1	86	92	PF00069	0.633
TRG_AP2beta_CARGO_1	59	69	PF09066	0.478
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.541
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.405
TRG_ENDOCYTIC_2	307	310	PF00928	0.665
TRG_ER_diArg_1	296	299	PF00400	0.430
TRG_ER_diArg_1	323	325	PF00400	0.636
TRG_ER_diArg_1	5	8	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N8	Leptomonas seymouri	43%	100%
A0A3S7WNR0	Leishmania donovani	83%	100%
A4H3X3	Leishmania braziliensis	61%	100%
A4HS48	Leishmania infantum	83%	100%
O97202	Leishmania major	80%	100%