Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK31_LEIMU

TriTrypDb:

LmxM.04.0490

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AK31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.535
CLV_C14_Caspase3-7	119	123	PF00656	0.533
CLV_NRD_NRD_1	14	16	PF00675	0.467
CLV_NRD_NRD_1	142	144	PF00675	0.566
CLV_NRD_NRD_1	193	195	PF00675	0.683
CLV_NRD_NRD_1	213	215	PF00675	0.495
CLV_NRD_NRD_1	273	275	PF00675	0.755
CLV_NRD_NRD_1	311	313	PF00675	0.596
CLV_NRD_NRD_1	70	72	PF00675	0.622
CLV_PCSK_KEX2_1	14	16	PF00082	0.445
CLV_PCSK_KEX2_1	142	144	PF00082	0.566
CLV_PCSK_KEX2_1	193	195	PF00082	0.683
CLV_PCSK_KEX2_1	27	29	PF00082	0.444
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.466
DEG_APCC_DBOX_1	78	86	PF00400	0.600
DEG_SPOP_SBC_1	230	234	PF00917	0.630
DEG_SPOP_SBC_1	318	322	PF00917	0.484
DOC_CYCLIN_RxL_1	28	39	PF00134	0.540
DOC_MAPK_gen_1	34	40	PF00069	0.487
DOC_PP2B_LxvP_1	95	98	PF13499	0.502
DOC_PP4_FxxP_1	58	61	PF00568	0.507
DOC_USP7_MATH_1	2	6	PF00917	0.484
DOC_USP7_MATH_1	222	226	PF00917	0.680
DOC_USP7_MATH_1	231	235	PF00917	0.639
DOC_USP7_MATH_1	318	322	PF00917	0.594
DOC_USP7_UBL2_3	200	204	PF12436	0.664
DOC_USP7_UBL2_3	290	294	PF12436	0.686
DOC_USP7_UBL2_3	309	313	PF12436	0.566
DOC_USP7_UBL2_3	319	323	PF12436	0.640
LIG_14-3-3_CanoR_1	302	310	PF00244	0.708
LIG_Actin_WH2_2	78	96	PF00022	0.587
LIG_BIR_II_1	1	5	PF00653	0.458
LIG_BIR_III_2	189	193	PF00653	0.649
LIG_FHA_1	21	27	PF00498	0.549
LIG_FHA_1	299	305	PF00498	0.559
LIG_FHA_1	88	94	PF00498	0.545
LIG_FHA_2	104	110	PF00498	0.545
LIG_FHA_2	131	137	PF00498	0.502
LIG_LIR_Apic_2	86	92	PF02991	0.478
LIG_LIR_Gen_1	115	126	PF02991	0.498
LIG_LIR_Gen_1	53	63	PF02991	0.510
LIG_LIR_Nem_3	115	121	PF02991	0.517
LIG_LIR_Nem_3	53	59	PF02991	0.549
LIG_LIR_Nem_3	7	12	PF02991	0.457
LIG_NRP_CendR_1	323	324	PF00754	0.647
LIG_PTB_Apo_2	81	88	PF02174	0.404
LIG_PTB_Phospho_1	81	87	PF10480	0.403
LIG_SH2_CRK	89	93	PF00017	0.594
LIG_SH2_NCK_1	118	122	PF00017	0.608
LIG_SH2_STAT5	183	186	PF00017	0.730
LIG_SH2_STAT5	89	92	PF00017	0.571
LIG_SH3_2	49	54	PF14604	0.605
LIG_SH3_3	105	111	PF00018	0.554
LIG_SH3_3	46	52	PF00018	0.575
LIG_TRAF2_1	162	165	PF00917	0.511
LIG_TRAF2_1	48	51	PF00917	0.604
LIG_TYR_ITIM	116	121	PF00017	0.612
MOD_CK1_1	149	155	PF00069	0.508
MOD_CK1_1	168	174	PF00069	0.484
MOD_CK1_1	226	232	PF00069	0.679
MOD_CK1_1	269	275	PF00069	0.668
MOD_CK1_1	298	304	PF00069	0.618
MOD_CK1_1	4	10	PF00069	0.441
MOD_GlcNHglycan	150	154	PF01048	0.654
MOD_GlcNHglycan	170	173	PF01048	0.705
MOD_GlcNHglycan	201	204	PF01048	0.737
MOD_GlcNHglycan	218	221	PF01048	0.750
MOD_GlcNHglycan	225	228	PF01048	0.589
MOD_GlcNHglycan	281	284	PF01048	0.587
MOD_GlcNHglycan	298	301	PF01048	0.520
MOD_GlcNHglycan	305	308	PF01048	0.541
MOD_GlcNHglycan	44	47	PF01048	0.546
MOD_GSK3_1	222	229	PF00069	0.676
MOD_GSK3_1	298	305	PF00069	0.612
MOD_GSK3_1	83	90	PF00069	0.425
MOD_N-GLC_1	168	173	PF02516	0.618
MOD_N-GLC_1	276	281	PF02516	0.552
MOD_N-GLC_1	83	88	PF02516	0.648
MOD_NEK2_1	1	6	PF00069	0.459
MOD_NEK2_1	295	300	PF00069	0.664
MOD_NEK2_1	36	41	PF00069	0.571
MOD_NEK2_2	22	27	PF00069	0.535
MOD_PK_1	205	211	PF00069	0.612
MOD_PKA_1	205	211	PF00069	0.666
MOD_PKA_2	146	152	PF00069	0.430
MOD_Plk_1	36	42	PF00069	0.545
MOD_Plk_1	83	89	PF00069	0.506
MOD_Plk_4	112	118	PF00069	0.540
MOD_Plk_4	276	282	PF00069	0.553
TRG_ENDOCYTIC_2	118	121	PF00928	0.609
TRG_ER_diArg_1	14	17	PF00400	0.468
TRG_ER_diArg_1	192	194	PF00400	0.656
TRG_NLS_Bipartite_1	10	31	PF00514	0.453
TRG_NLS_Bipartite_1	193	208	PF00514	0.778

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II41	Leptomonas seymouri	62%	100%
A0A1X0NL53	Trypanosomatidae	39%	100%
A0A3S7WNR7	Leishmania donovani	90%	100%
A4H3W9	Leishmania braziliensis	76%	100%
A4HS44	Leishmania infantum	89%	100%
O97206	Leishmania major	86%	98%
V5B9E1	Trypanosoma cruzi	38%	100%