Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK28_LEIMU

TriTrypDb:

LmxM.04.0465

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.581
CLV_C14_Caspase3-7	186	190	PF00656	0.570
CLV_C14_Caspase3-7	280	284	PF00656	0.542
CLV_C14_Caspase3-7	666	670	PF00656	0.528
CLV_C14_Caspase3-7	777	781	PF00656	0.553
CLV_C14_Caspase3-7	794	798	PF00656	0.511
CLV_C14_Caspase3-7	848	852	PF00656	0.545
CLV_NRD_NRD_1	117	119	PF00675	0.538
CLV_NRD_NRD_1	20	22	PF00675	0.437
CLV_NRD_NRD_1	226	228	PF00675	0.524
CLV_NRD_NRD_1	239	241	PF00675	0.563
CLV_NRD_NRD_1	477	479	PF00675	0.618
CLV_NRD_NRD_1	563	565	PF00675	0.505
CLV_NRD_NRD_1	623	625	PF00675	0.627
CLV_NRD_NRD_1	723	725	PF00675	0.524
CLV_NRD_NRD_1	757	759	PF00675	0.576
CLV_NRD_NRD_1	768	770	PF00675	0.575
CLV_PCSK_FUR_1	721	725	PF00082	0.500
CLV_PCSK_KEX2_1	117	119	PF00082	0.503
CLV_PCSK_KEX2_1	20	22	PF00082	0.437
CLV_PCSK_KEX2_1	226	228	PF00082	0.524
CLV_PCSK_KEX2_1	239	241	PF00082	0.563
CLV_PCSK_KEX2_1	562	564	PF00082	0.531
CLV_PCSK_KEX2_1	623	625	PF00082	0.765
CLV_PCSK_KEX2_1	723	725	PF00082	0.524
CLV_PCSK_KEX2_1	748	750	PF00082	0.595
CLV_PCSK_KEX2_1	756	758	PF00082	0.544
CLV_PCSK_KEX2_1	768	770	PF00082	0.514
CLV_PCSK_KEX2_1	80	82	PF00082	0.565
CLV_PCSK_PC1ET2_1	748	750	PF00082	0.595
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.565
CLV_PCSK_SKI1_1	312	316	PF00082	0.519
CLV_PCSK_SKI1_1	344	348	PF00082	0.303
CLV_PCSK_SKI1_1	440	444	PF00082	0.365
CLV_PCSK_SKI1_1	490	494	PF00082	0.342
CLV_PCSK_SKI1_1	64	68	PF00082	0.447
CLV_PCSK_SKI1_1	696	700	PF00082	0.617
CLV_PCSK_SKI1_1	709	713	PF00082	0.530
CLV_PCSK_SKI1_1	748	752	PF00082	0.598
CLV_PCSK_SKI1_1	802	806	PF00082	0.488
DEG_APCC_DBOX_1	63	71	PF00400	0.465
DEG_SCF_FBW7_1	611	616	PF00400	0.521
DEG_SPOP_SBC_1	252	256	PF00917	0.647
DEG_SPOP_SBC_1	278	282	PF00917	0.514
DEG_SPOP_SBC_1	31	35	PF00917	0.589
DEG_SPOP_SBC_1	642	646	PF00917	0.579
DOC_CDC14_PxL_1	324	332	PF14671	0.488
DOC_CKS1_1	106	111	PF01111	0.537
DOC_CKS1_1	153	158	PF01111	0.597
DOC_CKS1_1	159	164	PF01111	0.476
DOC_CKS1_1	498	503	PF01111	0.643
DOC_CKS1_1	610	615	PF01111	0.517
DOC_CYCLIN_RxL_1	706	716	PF00134	0.538
DOC_CYCLIN_RxL_1	799	806	PF00134	0.522
DOC_MAPK_gen_1	226	233	PF00069	0.516
DOC_MAPK_gen_1	537	545	PF00069	0.395
DOC_MAPK_gen_1	748	755	PF00069	0.594
DOC_MAPK_gen_1	80	86	PF00069	0.572
DOC_MAPK_MEF2A_6	226	233	PF00069	0.552
DOC_MAPK_MEF2A_6	748	755	PF00069	0.594
DOC_MAPK_MEF2A_6	97	106	PF00069	0.540
DOC_MAPK_NFAT4_5	748	756	PF00069	0.595
DOC_PP2B_LxvP_1	671	674	PF13499	0.504
DOC_PP4_FxxP_1	761	764	PF00568	0.565
DOC_USP7_MATH_1	100	104	PF00917	0.593
DOC_USP7_MATH_1	183	187	PF00917	0.635
DOC_USP7_MATH_1	198	202	PF00917	0.561
DOC_USP7_MATH_1	244	248	PF00917	0.589
DOC_USP7_MATH_1	253	257	PF00917	0.624
DOC_USP7_MATH_1	278	282	PF00917	0.482
DOC_USP7_MATH_1	360	364	PF00917	0.431
DOC_USP7_MATH_1	37	41	PF00917	0.508
DOC_USP7_MATH_1	613	617	PF00917	0.533
DOC_USP7_MATH_1	672	676	PF00917	0.605
DOC_USP7_MATH_1	808	812	PF00917	0.502
DOC_USP7_MATH_2	37	43	PF00917	0.463
DOC_USP7_MATH_2	729	735	PF00917	0.500
DOC_WW_Pin1_4	105	110	PF00397	0.543
DOC_WW_Pin1_4	123	128	PF00397	0.672
DOC_WW_Pin1_4	152	157	PF00397	0.582
DOC_WW_Pin1_4	158	163	PF00397	0.561
DOC_WW_Pin1_4	231	236	PF00397	0.521
DOC_WW_Pin1_4	248	253	PF00397	0.500
DOC_WW_Pin1_4	329	334	PF00397	0.411
DOC_WW_Pin1_4	456	461	PF00397	0.537
DOC_WW_Pin1_4	493	498	PF00397	0.506
DOC_WW_Pin1_4	609	614	PF00397	0.514
DOC_WW_Pin1_4	655	660	PF00397	0.531
DOC_WW_Pin1_4	762	767	PF00397	0.627
DOC_WW_Pin1_4	815	820	PF00397	0.513
LIG_14-3-3_CanoR_1	20	28	PF00244	0.460
LIG_14-3-3_CanoR_1	211	220	PF00244	0.622
LIG_14-3-3_CanoR_1	296	301	PF00244	0.552
LIG_14-3-3_CanoR_1	476	485	PF00244	0.422
LIG_14-3-3_CanoR_1	600	605	PF00244	0.546
LIG_14-3-3_CanoR_1	650	660	PF00244	0.627
LIG_14-3-3_CanoR_1	663	672	PF00244	0.491
LIG_14-3-3_CanoR_1	756	762	PF00244	0.609
LIG_14-3-3_CanoR_1	837	841	PF00244	0.490
LIG_ActinCP_TwfCPI_2	761	769	PF01115	0.575
LIG_BIR_III_2	669	673	PF00653	0.494
LIG_BRCT_BRCA1_1	625	629	PF00533	0.502
LIG_Clathr_ClatBox_1	464	468	PF01394	0.348
LIG_CtBP_PxDLS_1	659	663	PF00389	0.458
LIG_eIF4E_1	99	105	PF01652	0.515
LIG_FHA_1	159	165	PF00498	0.647
LIG_FHA_1	211	217	PF00498	0.624
LIG_FHA_1	274	280	PF00498	0.547
LIG_FHA_1	319	325	PF00498	0.638
LIG_FHA_1	334	340	PF00498	0.321
LIG_FHA_1	431	437	PF00498	0.368
LIG_FHA_1	46	52	PF00498	0.514
LIG_FHA_1	529	535	PF00498	0.402
LIG_FHA_1	568	574	PF00498	0.394
LIG_FHA_1	693	699	PF00498	0.634
LIG_FHA_1	848	854	PF00498	0.587
LIG_FHA_2	175	181	PF00498	0.584
LIG_FHA_2	36	42	PF00498	0.552
LIG_FHA_2	436	442	PF00498	0.288
LIG_KLC1_Yacidic_2	851	856	PF13176	0.544
LIG_LIR_Apic_2	759	764	PF02991	0.555
LIG_LIR_Apic_2	96	102	PF02991	0.581
LIG_LIR_Gen_1	349	359	PF02991	0.433
LIG_LIR_Gen_1	605	614	PF02991	0.651
LIG_LIR_Gen_1	716	727	PF02991	0.644
LIG_LIR_Nem_3	349	354	PF02991	0.408
LIG_LIR_Nem_3	468	472	PF02991	0.342
LIG_LIR_Nem_3	570	574	PF02991	0.386
LIG_LIR_Nem_3	605	611	PF02991	0.713
LIG_LIR_Nem_3	716	722	PF02991	0.547
LIG_OCRL_FandH_1	111	123	PF00620	0.484
LIG_Pex14_2	101	105	PF04695	0.525
LIG_Pex14_2	489	493	PF04695	0.348
LIG_SH2_CRK	153	157	PF00017	0.567
LIG_SH2_CRK	199	203	PF00017	0.622
LIG_SH2_CRK	565	569	PF00017	0.419
LIG_SH2_SRC	565	568	PF00017	0.412
LIG_SH2_STAP1	199	203	PF00017	0.622
LIG_SH2_STAP1	410	414	PF00017	0.387
LIG_SH2_STAT5	153	156	PF00017	0.569
LIG_SH2_STAT5	470	473	PF00017	0.349
LIG_SH2_STAT5	707	710	PF00017	0.500
LIG_SH3_1	153	159	PF00018	0.576
LIG_SH3_3	153	159	PF00018	0.575
LIG_SH3_3	313	319	PF00018	0.551
LIG_SH3_3	447	453	PF00018	0.485
LIG_SH3_3	457	463	PF00018	0.377
LIG_SH3_3	495	501	PF00018	0.590
LIG_SUMO_SIM_par_1	573	579	PF11976	0.381
LIG_SUMO_SIM_par_1	699	706	PF11976	0.663
LIG_TRAF2_1	178	181	PF00917	0.543
LIG_TRAF2_1	258	261	PF00917	0.581
LIG_TRAF2_1	686	689	PF00917	0.590
LIG_TRAF2_1	7	10	PF00917	0.401
LIG_TRAF2_1	713	716	PF00917	0.477
LIG_TYR_ITIM	197	202	PF00017	0.624
LIG_WRC_WIRS_1	545	550	PF05994	0.366
MOD_CDC14_SPxK_1	765	768	PF00782	0.534
MOD_CDK_SPK_2	105	110	PF00069	0.533
MOD_CDK_SPxK_1	762	768	PF00069	0.526
MOD_CDK_SPxxK_3	762	769	PF00069	0.640
MOD_CK1_1	120	126	PF00069	0.601
MOD_CK1_1	128	134	PF00069	0.663
MOD_CK1_1	169	175	PF00069	0.636
MOD_CK1_1	24	30	PF00069	0.418
MOD_CK1_1	247	253	PF00069	0.695
MOD_CK1_1	254	260	PF00069	0.742
MOD_CK1_1	286	292	PF00069	0.572
MOD_CK1_1	4	10	PF00069	0.462
MOD_CK1_1	422	428	PF00069	0.501
MOD_CK1_1	435	441	PF00069	0.316
MOD_CK1_1	496	502	PF00069	0.533
MOD_CK1_1	522	528	PF00069	0.549
MOD_CK1_1	547	553	PF00069	0.434
MOD_CK1_1	576	582	PF00069	0.399
MOD_CK1_1	654	660	PF00069	0.708
MOD_CK1_1	734	740	PF00069	0.581
MOD_CK2_1	174	180	PF00069	0.584
MOD_CK2_1	255	261	PF00069	0.590
MOD_CK2_1	35	41	PF00069	0.692
MOD_CK2_1	4	10	PF00069	0.397
MOD_CK2_1	673	679	PF00069	0.627
MOD_CK2_1	683	689	PF00069	0.587
MOD_CK2_1	710	716	PF00069	0.471
MOD_Cter_Amidation	560	563	PF01082	0.530
MOD_Cter_Amidation	78	81	PF01082	0.550
MOD_GlcNHglycan	122	125	PF01048	0.614
MOD_GlcNHglycan	185	188	PF01048	0.689
MOD_GlcNHglycan	213	216	PF01048	0.600
MOD_GlcNHglycan	223	226	PF01048	0.630
MOD_GlcNHglycan	285	288	PF01048	0.564
MOD_GlcNHglycan	296	299	PF01048	0.511
MOD_GlcNHglycan	357	360	PF01048	0.499
MOD_GlcNHglycan	396	399	PF01048	0.416
MOD_GlcNHglycan	41	44	PF01048	0.469
MOD_GlcNHglycan	479	482	PF01048	0.434
MOD_GlcNHglycan	6	9	PF01048	0.440
MOD_GlcNHglycan	653	656	PF01048	0.620
MOD_GlcNHglycan	665	668	PF01048	0.496
MOD_GlcNHglycan	675	678	PF01048	0.552
MOD_GlcNHglycan	744	747	PF01048	0.710
MOD_GlcNHglycan	86	89	PF01048	0.589
MOD_GSK3_1	171	178	PF00069	0.619
MOD_GSK3_1	244	251	PF00069	0.700
MOD_GSK3_1	27	34	PF00069	0.585
MOD_GSK3_1	273	280	PF00069	0.557
MOD_GSK3_1	286	293	PF00069	0.544
MOD_GSK3_1	294	301	PF00069	0.569
MOD_GSK3_1	318	325	PF00069	0.593
MOD_GSK3_1	329	336	PF00069	0.363
MOD_GSK3_1	35	42	PF00069	0.490
MOD_GSK3_1	350	357	PF00069	0.408
MOD_GSK3_1	415	422	PF00069	0.497
MOD_GSK3_1	426	433	PF00069	0.461
MOD_GSK3_1	493	500	PF00069	0.511
MOD_GSK3_1	518	525	PF00069	0.574
MOD_GSK3_1	544	551	PF00069	0.371
MOD_GSK3_1	579	586	PF00069	0.477
MOD_GSK3_1	609	616	PF00069	0.485
MOD_GSK3_1	619	626	PF00069	0.571
MOD_GSK3_1	651	658	PF00069	0.673
MOD_GSK3_1	683	690	PF00069	0.626
MOD_GSK3_1	692	699	PF00069	0.562
MOD_GSK3_1	703	710	PF00069	0.537
MOD_GSK3_1	727	734	PF00069	0.563
MOD_N-GLC_1	166	171	PF02516	0.677
MOD_N-GLC_1	211	216	PF02516	0.623
MOD_N-GLC_1	229	234	PF02516	0.550
MOD_N-GLC_1	4	9	PF02516	0.402
MOD_N-GLC_1	414	419	PF02516	0.419
MOD_N-GLC_1	513	518	PF02516	0.457
MOD_N-GLC_1	548	553	PF02516	0.405
MOD_N-GLC_1	651	656	PF02516	0.590
MOD_N-GLC_1	84	89	PF02516	0.526
MOD_NEK2_1	354	359	PF00069	0.425
MOD_NEK2_1	414	419	PF00069	0.482
MOD_NEK2_1	477	482	PF00069	0.441
MOD_NEK2_1	513	518	PF00069	0.638
MOD_NEK2_1	548	553	PF00069	0.405
MOD_NEK2_1	573	578	PF00069	0.377
MOD_NEK2_1	619	624	PF00069	0.612
MOD_NEK2_1	70	75	PF00069	0.432
MOD_NEK2_1	813	818	PF00069	0.519
MOD_NEK2_1	84	89	PF00069	0.496
MOD_NEK2_2	836	841	PF00069	0.532
MOD_PIKK_1	689	695	PF00454	0.581
MOD_PIKK_1	734	740	PF00454	0.513
MOD_PK_1	166	172	PF00069	0.638
MOD_PK_1	296	302	PF00069	0.554
MOD_PK_1	600	606	PF00069	0.488
MOD_PKA_1	117	123	PF00069	0.496
MOD_PKA_1	623	629	PF00069	0.717
MOD_PKA_1	756	762	PF00069	0.542
MOD_PKA_2	117	123	PF00069	0.544
MOD_PKA_2	210	216	PF00069	0.620
MOD_PKA_2	419	425	PF00069	0.526
MOD_PKA_2	477	483	PF00069	0.373
MOD_PKA_2	623	629	PF00069	0.717
MOD_PKA_2	756	762	PF00069	0.542
MOD_PKA_2	786	792	PF00069	0.501
MOD_PKA_2	808	814	PF00069	0.477
MOD_PKA_2	836	842	PF00069	0.488
MOD_Plk_1	166	172	PF00069	0.670
MOD_Plk_1	211	217	PF00069	0.624
MOD_Plk_1	229	235	PF00069	0.615
MOD_Plk_1	414	420	PF00069	0.428
MOD_Plk_1	548	554	PF00069	0.416
MOD_Plk_4	100	106	PF00069	0.535
MOD_Plk_4	286	292	PF00069	0.568
MOD_Plk_4	350	356	PF00069	0.351
MOD_Plk_4	432	438	PF00069	0.312
MOD_Plk_4	703	709	PF00069	0.512
MOD_Plk_4	786	792	PF00069	0.538
MOD_Plk_4	808	814	PF00069	0.484
MOD_ProDKin_1	105	111	PF00069	0.543
MOD_ProDKin_1	123	129	PF00069	0.669
MOD_ProDKin_1	152	158	PF00069	0.580
MOD_ProDKin_1	231	237	PF00069	0.522
MOD_ProDKin_1	248	254	PF00069	0.500
MOD_ProDKin_1	329	335	PF00069	0.408
MOD_ProDKin_1	456	462	PF00069	0.522
MOD_ProDKin_1	493	499	PF00069	0.518
MOD_ProDKin_1	609	615	PF00069	0.518
MOD_ProDKin_1	655	661	PF00069	0.533
MOD_ProDKin_1	762	768	PF00069	0.631
MOD_ProDKin_1	815	821	PF00069	0.507
TRG_DiLeu_BaEn_4	9	15	PF01217	0.432
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.557
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.494
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.449
TRG_DiLeu_BaLyEn_6	749	754	PF01217	0.554
TRG_ENDOCYTIC_2	199	202	PF00928	0.619
TRG_ENDOCYTIC_2	608	611	PF00928	0.505
TRG_ER_diArg_1	226	228	PF00400	0.524
TRG_ER_diArg_1	238	240	PF00400	0.556
TRG_ER_diArg_1	562	564	PF00400	0.531
TRG_ER_diArg_1	721	724	PF00400	0.496
TRG_ER_diArg_1	755	758	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZH0	Leptomonas seymouri	40%	100%
A0A3S5H5A7	Leishmania donovani	82%	97%
A4H3W6	Leishmania braziliensis	68%	99%
E9AG61	Leishmania infantum	82%	85%