Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AK22_LEIMU

TriTrypDb:

LmxM.04.0410

Length:

1037

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AK22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.594
CLV_C14_Caspase3-7	253	257	PF00656	0.540
CLV_C14_Caspase3-7	27	31	PF00656	0.692
CLV_C14_Caspase3-7	53	57	PF00656	0.551
CLV_C14_Caspase3-7	620	624	PF00656	0.741
CLV_NRD_NRD_1	15	17	PF00675	0.712
CLV_NRD_NRD_1	168	170	PF00675	0.615
CLV_NRD_NRD_1	21	23	PF00675	0.678
CLV_NRD_NRD_1	247	249	PF00675	0.670
CLV_NRD_NRD_1	263	265	PF00675	0.612
CLV_NRD_NRD_1	278	280	PF00675	0.574
CLV_NRD_NRD_1	334	336	PF00675	0.704
CLV_NRD_NRD_1	344	346	PF00675	0.644
CLV_NRD_NRD_1	47	49	PF00675	0.701
CLV_NRD_NRD_1	497	499	PF00675	0.708
CLV_NRD_NRD_1	668	670	PF00675	0.713
CLV_PCSK_FUR_1	275	279	PF00082	0.723
CLV_PCSK_KEX2_1	130	132	PF00082	0.708
CLV_PCSK_KEX2_1	15	17	PF00082	0.712
CLV_PCSK_KEX2_1	167	169	PF00082	0.658
CLV_PCSK_KEX2_1	173	175	PF00082	0.588
CLV_PCSK_KEX2_1	21	23	PF00082	0.678
CLV_PCSK_KEX2_1	247	249	PF00082	0.670
CLV_PCSK_KEX2_1	263	265	PF00082	0.612
CLV_PCSK_KEX2_1	277	279	PF00082	0.586
CLV_PCSK_KEX2_1	334	336	PF00082	0.694
CLV_PCSK_KEX2_1	47	49	PF00082	0.701
CLV_PCSK_KEX2_1	497	499	PF00082	0.708
CLV_PCSK_KEX2_1	668	670	PF00082	0.716
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.608
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.550
CLV_PCSK_PC7_1	164	170	PF00082	0.671
CLV_PCSK_PC7_1	273	279	PF00082	0.722
CLV_PCSK_PC7_1	664	670	PF00082	0.718
CLV_PCSK_SKI1_1	669	673	PF00082	0.720
DEG_Nend_UBRbox_1	1	4	PF02207	0.541
DEG_SCF_FBW7_1	688	694	PF00400	0.709
DEG_SPOP_SBC_1	102	106	PF00917	0.597
DEG_SPOP_SBC_1	595	599	PF00917	0.543
DEG_SPOP_SBC_1	739	743	PF00917	0.554
DOC_CKS1_1	258	263	PF01111	0.669
DOC_CKS1_1	688	693	PF01111	0.715
DOC_CKS1_1	864	869	PF01111	0.662
DOC_CKS1_1	959	964	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.503
DOC_MAPK_gen_1	668	674	PF00069	0.717
DOC_MAPK_MEF2A_6	379	386	PF00069	0.538
DOC_PP1_RVXF_1	496	503	PF00149	0.582
DOC_PP2B_LxvP_1	241	244	PF13499	0.518
DOC_PP2B_LxvP_1	517	520	PF13499	0.521
DOC_PP4_FxxP_1	502	505	PF00568	0.473
DOC_USP7_MATH_1	102	106	PF00917	0.730
DOC_USP7_MATH_1	121	125	PF00917	0.527
DOC_USP7_MATH_1	172	176	PF00917	0.673
DOC_USP7_MATH_1	259	263	PF00917	0.657
DOC_USP7_MATH_1	285	289	PF00917	0.723
DOC_USP7_MATH_1	290	294	PF00917	0.676
DOC_USP7_MATH_1	31	35	PF00917	0.686
DOC_USP7_MATH_1	40	44	PF00917	0.589
DOC_USP7_MATH_1	426	430	PF00917	0.643
DOC_USP7_MATH_1	595	599	PF00917	0.604
DOC_USP7_MATH_1	647	651	PF00917	0.644
DOC_USP7_MATH_1	737	741	PF00917	0.589
DOC_USP7_MATH_1	848	852	PF00917	0.661
DOC_USP7_MATH_1	907	911	PF00917	0.701
DOC_USP7_MATH_1	915	919	PF00917	0.628
DOC_USP7_UBL2_3	130	134	PF12436	0.559
DOC_USP7_UBL2_3	342	346	PF12436	0.545
DOC_WW_Pin1_4	104	109	PF00397	0.678
DOC_WW_Pin1_4	117	122	PF00397	0.567
DOC_WW_Pin1_4	213	218	PF00397	0.597
DOC_WW_Pin1_4	223	228	PF00397	0.647
DOC_WW_Pin1_4	257	262	PF00397	0.713
DOC_WW_Pin1_4	278	283	PF00397	0.727
DOC_WW_Pin1_4	286	291	PF00397	0.647
DOC_WW_Pin1_4	421	426	PF00397	0.529
DOC_WW_Pin1_4	440	445	PF00397	0.446
DOC_WW_Pin1_4	466	471	PF00397	0.517
DOC_WW_Pin1_4	538	543	PF00397	0.658
DOC_WW_Pin1_4	549	554	PF00397	0.597
DOC_WW_Pin1_4	562	567	PF00397	0.592
DOC_WW_Pin1_4	596	601	PF00397	0.670
DOC_WW_Pin1_4	609	614	PF00397	0.554
DOC_WW_Pin1_4	628	633	PF00397	0.536
DOC_WW_Pin1_4	635	640	PF00397	0.642
DOC_WW_Pin1_4	681	686	PF00397	0.737
DOC_WW_Pin1_4	687	692	PF00397	0.654
DOC_WW_Pin1_4	725	730	PF00397	0.666
DOC_WW_Pin1_4	735	740	PF00397	0.606
DOC_WW_Pin1_4	774	779	PF00397	0.806
DOC_WW_Pin1_4	844	849	PF00397	0.680
DOC_WW_Pin1_4	852	857	PF00397	0.650
DOC_WW_Pin1_4	858	863	PF00397	0.586
DOC_WW_Pin1_4	958	963	PF00397	0.667
LIG_14-3-3_CanoR_1	1028	1036	PF00244	0.580
LIG_14-3-3_CanoR_1	222	227	PF00244	0.654
LIG_14-3-3_CanoR_1	50	59	PF00244	0.553
LIG_14-3-3_CanoR_1	576	583	PF00244	0.661
LIG_14-3-3_CanoR_1	668	674	PF00244	0.780
LIG_14-3-3_CanoR_1	762	769	PF00244	0.670
LIG_14-3-3_CanoR_1	779	786	PF00244	0.587
LIG_14-3-3_CanoR_1	839	843	PF00244	0.672
LIG_14-3-3_CanoR_1	865	871	PF00244	0.677
LIG_14-3-3_CanoR_1	957	962	PF00244	0.667
LIG_14-3-3_CanoR_1	967	976	PF00244	0.598
LIG_BRCT_BRCA1_1	877	881	PF00533	0.635
LIG_EVH1_1	410	414	PF00568	0.537
LIG_EVH1_2	381	385	PF00568	0.520
LIG_FHA_1	244	250	PF00498	0.707
LIG_FHA_1	309	315	PF00498	0.653
LIG_FHA_1	510	516	PF00498	0.688
LIG_FHA_1	577	583	PF00498	0.657
LIG_FHA_1	600	606	PF00498	0.673
LIG_FHA_1	629	635	PF00498	0.739
LIG_FHA_1	761	767	PF00498	0.606
LIG_FHA_1	942	948	PF00498	0.624
LIG_FHA_1	977	983	PF00498	0.631
LIG_FHA_2	227	233	PF00498	0.541
LIG_FHA_2	620	626	PF00498	0.737
LIG_FHA_2	63	69	PF00498	0.669
LIG_FHA_2	804	810	PF00498	0.644
LIG_FHA_2	88	94	PF00498	0.690
LIG_LIR_Apic_2	609	613	PF02991	0.554
LIG_LIR_Gen_1	144	153	PF02991	0.631
LIG_LIR_Gen_1	809	818	PF02991	0.747
LIG_LIR_Nem_3	144	150	PF02991	0.706
LIG_LIR_Nem_3	809	815	PF02991	0.743
LIG_LYPXL_yS_3	757	760	PF13949	0.696
LIG_SH2_CRK	610	614	PF00017	0.505
LIG_SH2_NCK_1	610	614	PF00017	0.505
LIG_SH2_SRC	1011	1014	PF00017	0.582
LIG_SH2_STAP1	1011	1015	PF00017	0.570
LIG_SH2_STAT5	549	552	PF00017	0.535
LIG_SH2_STAT5	80	83	PF00017	0.542
LIG_SH3_1	279	285	PF00018	0.723
LIG_SH3_1	750	756	PF00018	0.631
LIG_SH3_1	901	907	PF00018	0.618
LIG_SH3_2	333	338	PF14604	0.674
LIG_SH3_2	632	637	PF14604	0.726
LIG_SH3_3	105	111	PF00018	0.541
LIG_SH3_3	279	285	PF00018	0.723
LIG_SH3_3	33	39	PF00018	0.728
LIG_SH3_3	330	336	PF00018	0.671
LIG_SH3_3	351	357	PF00018	0.687
LIG_SH3_3	394	400	PF00018	0.537
LIG_SH3_3	408	414	PF00018	0.583
LIG_SH3_3	438	444	PF00018	0.553
LIG_SH3_3	450	456	PF00018	0.612
LIG_SH3_3	464	470	PF00018	0.568
LIG_SH3_3	479	485	PF00018	0.618
LIG_SH3_3	503	509	PF00018	0.641
LIG_SH3_3	536	542	PF00018	0.691
LIG_SH3_3	602	608	PF00018	0.626
LIG_SH3_3	629	635	PF00018	0.727
LIG_SH3_3	685	691	PF00018	0.709
LIG_SH3_3	750	756	PF00018	0.680
LIG_SH3_3	861	867	PF00018	0.693
LIG_SH3_3	901	907	PF00018	0.733
LIG_SH3_3	982	988	PF00018	0.671
LIG_SUMO_SIM_anti_2	602	607	PF11976	0.567
LIG_SUMO_SIM_anti_2	978	984	PF11976	0.492
LIG_SUMO_SIM_par_1	978	984	PF11976	0.492
LIG_TRAF2_1	205	208	PF00917	0.559
LIG_TRAF2_1	230	233	PF00917	0.657
LIG_WW_1	505	508	PF00397	0.447
LIG_WW_3	249	253	PF00397	0.540
LIG_WW_3	335	339	PF00397	0.546
MOD_CDC14_SPxK_1	424	427	PF00782	0.514
MOD_CDC14_SPxK_1	552	555	PF00782	0.663
MOD_CDK_SPK_2	213	218	PF00069	0.524
MOD_CDK_SPK_2	774	779	PF00069	0.758
MOD_CDK_SPxK_1	257	263	PF00069	0.717
MOD_CDK_SPxK_1	421	427	PF00069	0.527
MOD_CDK_SPxK_1	549	555	PF00069	0.665
MOD_CDK_SPxxK_3	257	264	PF00069	0.719
MOD_CDK_SPxxK_3	858	865	PF00069	0.663
MOD_CDK_SPxxK_3	958	965	PF00069	0.670
MOD_CK1_1	104	110	PF00069	0.664
MOD_CK1_1	124	130	PF00069	0.532
MOD_CK1_1	175	181	PF00069	0.718
MOD_CK1_1	221	227	PF00069	0.608
MOD_CK1_1	24	30	PF00069	0.677
MOD_CK1_1	293	299	PF00069	0.714
MOD_CK1_1	42	48	PF00069	0.571
MOD_CK1_1	477	483	PF00069	0.675
MOD_CK1_1	49	55	PF00069	0.673
MOD_CK1_1	511	517	PF00069	0.547
MOD_CK1_1	531	537	PF00069	0.732
MOD_CK1_1	541	547	PF00069	0.715
MOD_CK1_1	575	581	PF00069	0.723
MOD_CK1_1	584	590	PF00069	0.602
MOD_CK1_1	609	615	PF00069	0.655
MOD_CK1_1	628	634	PF00069	0.693
MOD_CK1_1	650	656	PF00069	0.703
MOD_CK1_1	684	690	PF00069	0.723
MOD_CK1_1	712	718	PF00069	0.707
MOD_CK1_1	740	746	PF00069	0.707
MOD_CK1_1	774	780	PF00069	0.625
MOD_CK1_1	83	89	PF00069	0.679
MOD_CK1_1	918	924	PF00069	0.686
MOD_CK1_1	946	952	PF00069	0.612
MOD_CK1_1	972	978	PF00069	0.667
MOD_CK2_1	1011	1017	PF00069	0.667
MOD_CK2_1	226	232	PF00069	0.540
MOD_CK2_1	650	656	PF00069	0.697
MOD_CK2_1	820	826	PF00069	0.545
MOD_Cter_Amidation	13	16	PF01082	0.721
MOD_Cter_Amidation	45	48	PF01082	0.703
MOD_GlcNHglycan	1008	1011	PF01048	0.593
MOD_GlcNHglycan	174	177	PF01048	0.543
MOD_GlcNHglycan	201	204	PF01048	0.665
MOD_GlcNHglycan	23	26	PF01048	0.711
MOD_GlcNHglycan	252	255	PF01048	0.675
MOD_GlcNHglycan	326	329	PF01048	0.536
MOD_GlcNHglycan	350	353	PF01048	0.649
MOD_GlcNHglycan	358	361	PF01048	0.703
MOD_GlcNHglycan	407	410	PF01048	0.714
MOD_GlcNHglycan	44	47	PF01048	0.583
MOD_GlcNHglycan	53	56	PF01048	0.653
MOD_GlcNHglycan	583	586	PF01048	0.621
MOD_GlcNHglycan	628	631	PF01048	0.809
MOD_GlcNHglycan	669	672	PF01048	0.704
MOD_GlcNHglycan	691	694	PF01048	0.817
MOD_GlcNHglycan	699	702	PF01048	0.737
MOD_GlcNHglycan	71	74	PF01048	0.678
MOD_GlcNHglycan	711	714	PF01048	0.588
MOD_GlcNHglycan	715	718	PF01048	0.569
MOD_GlcNHglycan	735	738	PF01048	0.688
MOD_GlcNHglycan	850	853	PF01048	0.610
MOD_GlcNHglycan	877	880	PF01048	0.688
MOD_GlcNHglycan	881	884	PF01048	0.674
MOD_GlcNHglycan	904	907	PF01048	0.661
MOD_GlcNHglycan	917	920	PF01048	0.662
MOD_GlcNHglycan	948	951	PF01048	0.673
MOD_GlcNHglycan	969	972	PF01048	0.685
MOD_GSK3_1	117	124	PF00069	0.540
MOD_GSK3_1	126	133	PF00069	0.547
MOD_GSK3_1	195	202	PF00069	0.545
MOD_GSK3_1	209	216	PF00069	0.582
MOD_GSK3_1	218	225	PF00069	0.693
MOD_GSK3_1	227	234	PF00069	0.640
MOD_GSK3_1	286	293	PF00069	0.729
MOD_GSK3_1	42	49	PF00069	0.665
MOD_GSK3_1	471	478	PF00069	0.621
MOD_GSK3_1	541	548	PF00069	0.674
MOD_GSK3_1	549	556	PF00069	0.613
MOD_GSK3_1	572	579	PF00069	0.725
MOD_GSK3_1	581	588	PF00069	0.610
MOD_GSK3_1	595	602	PF00069	0.526
MOD_GSK3_1	608	615	PF00069	0.600
MOD_GSK3_1	626	633	PF00069	0.611
MOD_GSK3_1	672	679	PF00069	0.623
MOD_GSK3_1	687	694	PF00069	0.556
MOD_GSK3_1	708	715	PF00069	0.720
MOD_GSK3_1	725	732	PF00069	0.535
MOD_GSK3_1	733	740	PF00069	0.700
MOD_GSK3_1	80	87	PF00069	0.722
MOD_GSK3_1	803	810	PF00069	0.647
MOD_GSK3_1	844	851	PF00069	0.703
MOD_GSK3_1	875	882	PF00069	0.647
MOD_GSK3_1	907	914	PF00069	0.698
MOD_GSK3_1	918	925	PF00069	0.595
MOD_GSK3_1	972	979	PF00069	0.668
MOD_LATS_1	574	580	PF00433	0.677
MOD_N-GLC_1	1006	1011	PF02516	0.593
MOD_N-GLC_1	218	223	PF02516	0.618
MOD_N-GLC_1	572	577	PF02516	0.728
MOD_N-GLC_1	658	663	PF02516	0.543
MOD_N-GLC_1	760	765	PF02516	0.650
MOD_N-GLC_1	84	89	PF02516	0.683
MOD_NEK2_1	23	28	PF00069	0.578
MOD_NEK2_1	545	550	PF00069	0.681
MOD_NEK2_1	567	572	PF00069	0.732
MOD_NEK2_1	667	672	PF00069	0.702
MOD_NEK2_1	709	714	PF00069	0.674
MOD_NEK2_1	807	812	PF00069	0.641
MOD_NEK2_1	857	862	PF00069	0.709
MOD_NEK2_1	969	974	PF00069	0.716
MOD_PIKK_1	141	147	PF00454	0.654
MOD_PIKK_1	308	314	PF00454	0.659
MOD_PK_1	294	300	PF00069	0.708
MOD_PKA_1	130	136	PF00069	0.587
MOD_PKA_1	21	27	PF00069	0.605
MOD_PKA_2	1027	1033	PF00069	0.553
MOD_PKA_2	124	130	PF00069	0.722
MOD_PKA_2	21	27	PF00069	0.605
MOD_PKA_2	221	227	PF00069	0.656
MOD_PKA_2	293	299	PF00069	0.714
MOD_PKA_2	46	52	PF00069	0.740
MOD_PKA_2	575	581	PF00069	0.647
MOD_PKA_2	667	673	PF00069	0.638
MOD_PKA_2	709	715	PF00069	0.721
MOD_PKA_2	761	767	PF00069	0.727
MOD_PKA_2	838	844	PF00069	0.665
MOD_PKA_2	87	93	PF00069	0.623
MOD_PKA_2	915	921	PF00069	0.688
MOD_PKB_1	48	56	PF00069	0.559
MOD_PKB_1	965	973	PF00069	0.680
MOD_Plk_1	1006	1012	PF00069	0.591
MOD_Plk_1	209	215	PF00069	0.653
MOD_Plk_1	231	237	PF00069	0.679
MOD_Plk_1	294	300	PF00069	0.635
MOD_Plk_1	528	534	PF00069	0.776
MOD_Plk_2-3	803	809	PF00069	0.641
MOD_Plk_2-3	820	826	PF00069	0.504
MOD_Plk_4	413	419	PF00069	0.604
MOD_Plk_4	471	477	PF00069	0.658
MOD_Plk_4	511	517	PF00069	0.644
MOD_Plk_4	541	547	PF00069	0.691
MOD_Plk_4	601	607	PF00069	0.580
MOD_Plk_4	803	809	PF00069	0.641
MOD_Plk_4	978	984	PF00069	0.674
MOD_ProDKin_1	104	110	PF00069	0.678
MOD_ProDKin_1	117	123	PF00069	0.570
MOD_ProDKin_1	213	219	PF00069	0.600
MOD_ProDKin_1	223	229	PF00069	0.650
MOD_ProDKin_1	257	263	PF00069	0.717
MOD_ProDKin_1	278	284	PF00069	0.728
MOD_ProDKin_1	286	292	PF00069	0.647
MOD_ProDKin_1	421	427	PF00069	0.527
MOD_ProDKin_1	440	446	PF00069	0.448
MOD_ProDKin_1	466	472	PF00069	0.514
MOD_ProDKin_1	538	544	PF00069	0.658
MOD_ProDKin_1	549	555	PF00069	0.600
MOD_ProDKin_1	562	568	PF00069	0.591
MOD_ProDKin_1	596	602	PF00069	0.668
MOD_ProDKin_1	609	615	PF00069	0.561
MOD_ProDKin_1	628	634	PF00069	0.537
MOD_ProDKin_1	635	641	PF00069	0.643
MOD_ProDKin_1	681	687	PF00069	0.737
MOD_ProDKin_1	691	697	PF00069	0.608
MOD_ProDKin_1	725	731	PF00069	0.667
MOD_ProDKin_1	735	741	PF00069	0.606
MOD_ProDKin_1	774	780	PF00069	0.805
MOD_ProDKin_1	844	850	PF00069	0.681
MOD_ProDKin_1	852	858	PF00069	0.650
MOD_ProDKin_1	863	869	PF00069	0.537
MOD_ProDKin_1	958	964	PF00069	0.670
MOD_SUMO_for_1	801	804	PF00179	0.663
MOD_SUMO_rev_2	318	327	PF00179	0.683
MOD_SUMO_rev_2	489	495	PF00179	0.667
MOD_SUMO_rev_2	978	988	PF00179	0.672
TRG_DiLeu_BaEn_4	490	496	PF01217	0.727
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.547
TRG_ENDOCYTIC_2	757	760	PF00928	0.696
TRG_ENDOCYTIC_2	995	998	PF00928	0.741
TRG_ER_diArg_1	167	169	PF00400	0.740
TRG_ER_diArg_1	20	22	PF00400	0.686
TRG_ER_diArg_1	247	249	PF00400	0.670
TRG_ER_diArg_1	275	278	PF00400	0.613
TRG_ER_diArg_1	333	335	PF00400	0.680
TRG_ER_diArg_1	47	50	PF00400	0.569
TRG_ER_diArg_1	667	669	PF00400	0.722
TRG_NLS_Bipartite_1	334	349	PF00514	0.548
TRG_NLS_MonoExtN_4	342	349	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	886	891	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5A2	Leishmania donovani	84%	93%
A4H3W1	Leishmania braziliensis	62%	100%
A4HS35	Leishmania infantum	84%	93%
Q9NFA7	Leishmania major	82%	100%