Anaphase promoting complex, subunit 10-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anaphase promoting complex, subunit 10-like protein

Species:

Leishmania mexicana

UniProt:

E9AK21_LEIMU

TriTrypDb:

LmxM.04.0400

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	11
GO:0000152	nuclear ubiquitin ligase complex	3	11
GO:0005680	anaphase-promoting complex	4	11
GO:0031461	cullin-RING ubiquitin ligase complex	4	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Expansion

Sequence features

E9AK21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK21

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007049	cell cycle	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0030163	protein catabolic process	4	11
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	11
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051301	cell division	2	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:0000209	protein polyubiquitination	8	1
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0070979	protein K11-linked ubiquitination	9	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.367
CLV_PCSK_SKI1_1	35	39	PF00082	0.305
DEG_APCC_DBOX_1	96	104	PF00400	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.561
DEG_SPOP_SBC_1	21	25	PF00917	0.749
DEG_SPOP_SBC_1	234	238	PF00917	0.406
DOC_CKS1_1	102	107	PF01111	0.536
DOC_CKS1_1	37	42	PF01111	0.352
DOC_USP7_MATH_1	21	25	PF00917	0.755
DOC_USP7_MATH_1	211	215	PF00917	0.547
DOC_USP7_MATH_1	234	238	PF00917	0.536
DOC_USP7_MATH_1	241	245	PF00917	0.748
DOC_USP7_MATH_1	30	34	PF00917	0.541
DOC_WW_Pin1_4	101	106	PF00397	0.484
DOC_WW_Pin1_4	119	124	PF00397	0.442
DOC_WW_Pin1_4	213	218	PF00397	0.477
DOC_WW_Pin1_4	36	41	PF00397	0.279
LIG_14-3-3_CanoR_1	35	40	PF00244	0.441
LIG_deltaCOP1_diTrp_1	259	263	PF00928	0.494
LIG_FHA_1	15	21	PF00498	0.654
LIG_FHA_1	37	43	PF00498	0.369
LIG_FHA_2	102	108	PF00498	0.536
LIG_FHA_2	155	161	PF00498	0.491
LIG_FHA_2	263	269	PF00498	0.434
LIG_Integrin_isoDGR_2	277	279	PF01839	0.394
LIG_LIR_Apic_2	213	218	PF02991	0.461
LIG_LIR_Gen_1	150	161	PF02991	0.553
LIG_LIR_Nem_3	150	156	PF02991	0.574
LIG_LIR_Nem_3	33	37	PF02991	0.551
LIG_LYPXL_SIV_4	220	228	PF13949	0.496
LIG_SH2_CRK	215	219	PF00017	0.486
LIG_SH2_GRB2like	112	115	PF00017	0.536
LIG_SH2_NCK_1	221	225	PF00017	0.496
LIG_SH2_SRC	112	115	PF00017	0.496
LIG_SH2_STAP1	221	225	PF00017	0.496
LIG_SH2_STAT5	112	115	PF00017	0.481
LIG_SH2_STAT5	270	273	PF00017	0.279
LIG_SH3_3	214	220	PF00018	0.493
LIG_SH3_3	245	251	PF00018	0.735
LIG_SUMO_SIM_par_1	154	160	PF11976	0.461
LIG_TRAF2_1	147	150	PF00917	0.536
LIG_TRAF2_2	6	11	PF00917	0.462
LIG_TYR_ITIM	219	224	PF00017	0.496
MOD_CDK_SPK_2	119	124	PF00069	0.455
MOD_CK1_1	15	21	PF00069	0.634
MOD_CK1_1	213	219	PF00069	0.511
MOD_CK1_1	23	29	PF00069	0.489
MOD_CK1_1	57	63	PF00069	0.561
MOD_CK1_1	7	13	PF00069	0.698
MOD_CK2_1	101	107	PF00069	0.536
MOD_CK2_1	154	160	PF00069	0.594
MOD_GlcNHglycan	114	117	PF01048	0.322
MOD_GlcNHglycan	14	17	PF01048	0.653
MOD_GlcNHglycan	171	174	PF01048	0.223
MOD_GlcNHglycan	199	202	PF01048	0.235
MOD_GlcNHglycan	208	211	PF01048	0.199
MOD_GlcNHglycan	237	240	PF01048	0.386
MOD_GlcNHglycan	243	246	PF01048	0.627
MOD_GlcNHglycan	25	28	PF01048	0.536
MOD_GlcNHglycan	300	303	PF01048	0.440
MOD_GlcNHglycan	56	59	PF01048	0.269
MOD_GlcNHglycan	65	68	PF01048	0.229
MOD_GSK3_1	206	213	PF00069	0.436
MOD_GSK3_1	21	28	PF00069	0.579
MOD_GSK3_1	298	305	PF00069	0.547
MOD_NEK2_1	169	174	PF00069	0.475
MOD_NEK2_1	262	267	PF00069	0.441
MOD_PIKK_1	4	10	PF00454	0.635
MOD_PKA_2	197	203	PF00069	0.409
MOD_PKA_2	206	212	PF00069	0.371
MOD_PKA_2	232	238	PF00069	0.367
MOD_PKA_2	297	303	PF00069	0.603
MOD_Plk_1	117	123	PF00069	0.442
MOD_Plk_4	262	268	PF00069	0.390
MOD_Plk_4	57	63	PF00069	0.501
MOD_ProDKin_1	101	107	PF00069	0.484
MOD_ProDKin_1	119	125	PF00069	0.442
MOD_ProDKin_1	213	219	PF00069	0.477
MOD_ProDKin_1	36	42	PF00069	0.279
TRG_ENDOCYTIC_2	221	224	PF00928	0.536
TRG_ENDOCYTIC_2	293	296	PF00928	0.588
TRG_ER_diArg_1	193	196	PF00400	0.566
TRG_ER_diArg_1	205	208	PF00400	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G0	Leptomonas seymouri	58%	96%
A0A0S4JNN0	Bodo saltans	32%	100%
A0A1X0P6H6	Trypanosomatidae	36%	100%
A0A3R7LQ45	Trypanosoma rangeli	36%	100%
A0A3S5H5A1	Leishmania donovani	87%	97%
A4H3W0	Leishmania braziliensis	73%	100%
A4HS34	Leishmania infantum	87%	97%
Q9U198	Leishmania major	85%	100%
V5BNI3	Trypanosoma cruzi	35%	100%