C-type lectin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AK20_LEIMU

TriTrypDb:

LmxM.04.0390

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AK20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AK20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.692
CLV_C14_Caspase3-7	209	213	PF00656	0.712
CLV_NRD_NRD_1	177	179	PF00675	0.409
CLV_NRD_NRD_1	220	222	PF00675	0.489
CLV_NRD_NRD_1	76	78	PF00675	0.553
CLV_PCSK_KEX2_1	148	150	PF00082	0.675
CLV_PCSK_KEX2_1	177	179	PF00082	0.450
CLV_PCSK_KEX2_1	220	222	PF00082	0.489
CLV_PCSK_KEX2_1	76	78	PF00082	0.523
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.589
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.464
DEG_Nend_UBRbox_4	1	3	PF02207	0.419
DEG_SPOP_SBC_1	114	118	PF00917	0.308
DEG_SPOP_SBC_1	232	236	PF00917	0.571
DOC_MAPK_RevD_3	162	178	PF00069	0.361
DOC_PP2B_LxvP_1	13	16	PF13499	0.466
DOC_USP7_MATH_1	16	20	PF00917	0.451
DOC_USP7_MATH_1	232	236	PF00917	0.643
DOC_USP7_MATH_1	66	70	PF00917	0.351
DOC_WW_Pin1_4	141	146	PF00397	0.553
DOC_WW_Pin1_4	38	43	PF00397	0.382
LIG_14-3-3_CanoR_1	220	225	PF00244	0.715
LIG_14-3-3_CanoR_1	76	81	PF00244	0.320
LIG_BRCT_BRCA1_1	213	217	PF00533	0.671
LIG_deltaCOP1_diTrp_1	75	80	PF00928	0.344
LIG_FHA_1	153	159	PF00498	0.482
LIG_FHA_1	49	55	PF00498	0.332
LIG_FHA_1	77	83	PF00498	0.308
LIG_FHA_2	124	130	PF00498	0.404
LIG_FHA_2	204	210	PF00498	0.562
LIG_LIR_Apic_2	141	146	PF02991	0.455
LIG_LIR_LC3C_4	51	55	PF02991	0.227
LIG_LIR_Nem_3	126	131	PF02991	0.348
LIG_LIR_Nem_3	79	83	PF02991	0.300
LIG_LYPXL_yS_3	131	134	PF13949	0.326
LIG_SH2_CRK	143	147	PF00017	0.493
LIG_SH2_GRB2like	128	131	PF00017	0.358
LIG_SH2_GRB2like	137	140	PF00017	0.337
LIG_SH2_GRB2like	71	74	PF00017	0.338
LIG_SH2_NCK_1	143	147	PF00017	0.458
LIG_SH2_SRC	71	74	PF00017	0.338
LIG_SH2_STAP1	46	50	PF00017	0.365
LIG_SH2_STAT5	46	49	PF00017	0.375
LIG_SH2_STAT5	67	70	PF00017	0.284
LIG_SH2_STAT5	71	74	PF00017	0.310
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.298
LIG_SUMO_SIM_par_1	121	126	PF11976	0.208
LIG_Vh1_VBS_1	158	176	PF01044	0.295
MOD_CDK_SPxxK_3	141	148	PF00069	0.457
MOD_CK1_1	189	195	PF00069	0.712
MOD_CK1_1	197	203	PF00069	0.640
MOD_CK1_1	208	214	PF00069	0.651
MOD_CK1_1	215	221	PF00069	0.692
MOD_CK1_1	222	228	PF00069	0.643
MOD_CK1_1	231	237	PF00069	0.690
MOD_CK2_1	222	228	PF00069	0.684
MOD_CK2_1	78	84	PF00069	0.214
MOD_Cter_Amidation	146	149	PF01082	0.628
MOD_GlcNHglycan	224	227	PF01048	0.485
MOD_GlcNHglycan	230	233	PF01048	0.453
MOD_GlcNHglycan	68	71	PF01048	0.533
MOD_GlcNHglycan	8	11	PF01048	0.556
MOD_GlcNHglycan	99	102	PF01048	0.490
MOD_GSK3_1	186	193	PF00069	0.700
MOD_GSK3_1	197	204	PF00069	0.614
MOD_GSK3_1	208	215	PF00069	0.611
MOD_GSK3_1	216	223	PF00069	0.684
MOD_GSK3_1	224	231	PF00069	0.695
MOD_GSK3_1	33	40	PF00069	0.410
MOD_GSK3_1	44	51	PF00069	0.306
MOD_GSK3_1	88	95	PF00069	0.477
MOD_GSK3_1	97	104	PF00069	0.377
MOD_N-GLC_1	138	143	PF02516	0.716
MOD_N-GLC_1	194	199	PF02516	0.445
MOD_NEK2_1	92	97	PF00069	0.446
MOD_NEK2_2	78	83	PF00069	0.249
MOD_PIKK_1	33	39	PF00454	0.379
MOD_PIKK_1	61	67	PF00454	0.298
MOD_PKA_1	220	226	PF00069	0.686
MOD_PKA_1	76	82	PF00069	0.302
MOD_PKA_2	219	225	PF00069	0.680
MOD_PKA_2	76	82	PF00069	0.314
MOD_Plk_1	194	200	PF00069	0.591
MOD_Plk_4	152	158	PF00069	0.353
MOD_Plk_4	212	218	PF00069	0.651
MOD_Plk_4	88	94	PF00069	0.370
MOD_ProDKin_1	141	147	PF00069	0.553
MOD_ProDKin_1	38	44	PF00069	0.379
MOD_SUMO_rev_2	17	22	PF00179	0.346
TRG_ENDOCYTIC_2	131	134	PF00928	0.304
TRG_ER_diArg_1	76	78	PF00400	0.323
TRG_NLS_MonoExtC_3	176	182	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRH3	Leptomonas seymouri	26%	86%
A0A0N1PAN6	Leptomonas seymouri	26%	83%
A0A0N1PBW5	Leptomonas seymouri	38%	82%
A0A3S7WNP1	Leishmania donovani	84%	98%
A4H3V9	Leishmania braziliensis	67%	100%
A4HS33	Leishmania infantum	85%	98%
Q9XZX6	Leishmania major	82%	100%